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4798827 Synergistin derivatives and pharmaceutical compositions which contain them  
The invention provides new synergistin derivatives of formula ##STR1## in which Y is hydrogen or dimethylamino and R is a 3- or 4-quinuclidinyl radical, the isomers thereof and their mixtures, and...
4798885 Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain  
DNA encoding the prepro inhibin α and β chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also...
4798787 Peptide antibodies and their use in detecting oncogene products  
Antibodies exhibit specificity toward single amino acid differences between proteins. These antibodies may be produced by synthesizing a peptide of the appropriate amino acid sequence contained in...
4797472 New peptide derivatives  
Tripeptide derivatives, characterized by the general formula: R1 --X--D--Arg--A--Arg--NH--R2wherein R1 is hydrogen, α- or β-naphtyl residue, lower alkyl residue which may be substituted with a...
4797469 Synthesis of hGRF (Somatocrinin) in liquid phase and intermediate peptides  
A process for the synthesis, in liquid phase and by fragments, of hGRF 1-44 and hGRF 1-40. This process consists in coupling, one after the other and in the order of the sequence of the GRF, (1)...
4795803 Adhesin antigens, antibodies and DNA fragment encoding the antigen, methods and means for diagnosis and immunization etc.  
An antigen which, as its major immunizing component, comprises a determinant of an adhesin polypeptide or an immunogenically active subsequence thereof or a precursor therefor which is convertible...
4795804 Bone morphogenetic agents  
The production and isolation of bone morphogenetic peptide agents displaying the osteoinductive and immunoreactive activity of bone morphogenetic protein (BMP) and deriving from natural, synthetic...
4794169 Pentapeptides with cell growth regulatory effects and a process for the preparation thereof  
New pentapeptide of the formula ##STR1## in which X1 and X2 are the same or different and are OH or NH2, Y is H or OH, X3 is CO or CH2, one of the groups Z1 and Z2 is H and the other is H or CH3,...
4794103 Pharmaceutical compositions containing peptides of the cholecystokinin-cerulein group for the therapy of shock conditions and of respiratory and cardiocirculatory insufficiencies  
Pharmaceutical compositions containing a polypeptide of the cholecystokinin-cerulein group are effective in the treatment of shock conditions and of respiratory and cardiocirculatory...
4794150 Synthesis of peptide analogs  
A novel polymeric disc, wafer or similarly shaped resin for carrying out the synthsis of peptide analogs via solid phase peptide synthesis techniques is provided. The polymeric disc or wafer of...
4793995 Modified (1-56) beta interferons  
Modified beta interferons containing amino acid substitutions in the beta interferon amino acids 1 to 56 are described. These modified beta interferons exhibit changes in the antiviral, cell...
4794168 Leukemia-associated virus immunogen, vaccine and assay  
The present invention relates to a leukemia-associated virus immunogens, vaccines, antibody combining sites and assays. The immunogens are relatively short polypeptides with peptide sequences...
4792602 Adaptors, and synthesis and cloning of proinsulin genes  
A human-like proinsulin gene and its analogs, have been synthesized by a combination of chemical and enzymatic methods. A number of different human-like proinsulin gene analogs with altered...
4792520 Methods and kits for identifying mutagenic agents and molecular mutations in DNA in mammalian cells  
A new and improved cell assay has been developed for mutagens and potential carcinogens to precisely identify the predominant type of mutation(s) each such compound induces in the DNA of cells....
4790988 Method and compositions for the treatment of thrombotic episodes  
Fibrinogen degradation product pentapeptide 6A and its variants are used in the treatment of thrombi, in particular myocardial infarcts. In a preferred embodiment pentapeptide 6A and tissue...
4791100 Novel polypeptides with a blood coagulation-inhibiting action, processes for their preparation and isolation, their use and agents containing them  
The invention relates to a polypeptide of the formula ##STR1## in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings...
4789702 Feline leukemia virus vaccine  
Polypeptides that are synthesized or expressed directly in microorganisms, include an amino acid sequence that is homologous to at least a portion of gp70 envelope protein of FELV, and are...
4788178 Use of gonadoliberin and gonadoliberin agonists for the treatment of climacteric complaints  
The invention relates to the use of gonadoliberin and gonadoliberin agonists for the treatment of climacteric complaints and pathological conditions in which the level of parathyroid hormone is...
4786719 DNA sequence  
A DNA sequence comprising a polynucleotide segment consisting of a DNA sequence (A) shown below and a DNA sequence complementary thereto: ##STR1## wherein A represents deoxyadenosine-5'-phosphate,...
4786684 Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis  
A method for the synthesis of sulfydryl-containing peptides which comprises forming a benzylthioether-linked solid support-bound thiol compound having at least one functional group for generating...
4786718 Method of preparing antibodies to characterize oncogenes  
Experiments designed to define the differences between the 21 oncogene of DNA isolated from human bladder cancer cells and its corresponding proto-oncogene are described herein. By a series of in...
4784948 Production of streptococcal m protein immunogens and molecular probes  
Methods and compositions are provided for the cloning and expression of Streptococcus pyogenes M protein genes, and, in particular, types 5, 6 and 24 genes in single-cell host organisms. The...
4784949 Universal dominant selectable marker cassette  
A novel universal dominant selectable marker cassette is disclosed. The marker comprises the coding sequences for aminoglycoside phosphotransferase I (APH-I) which has been modified and truncated...
4784988 Peptides correlated to lysozyme  
A peptide made up of at least 3 amino acids comprised in sequential form in the following structure: ##STR1## where Y may be absent or represent a glycine residue, where the amino acids ##STR2##...
4785080 Labeled analytes  
A highly sensitive, immunoassay method for determining the amount of an analyte in a sample containing a known analyte in an unknown concentration is provided. Sample; a polypeptide-labeled analog...
4784950 Expression of factor VII activity in mammalian cells  
Methods are disclosed for producing proteins having biological activity for blood coagulation mediated by Factor VIIa. The proteins are produced by mammalian host cells which have been stably...
4784987 GRF analogs VI  
The invention provides peptides which are potent in stimulating the release of pituitary GH in fish and amphibians which have a substantial portion or all of the following sequence: R1 -R2 -R3 -R4...
4784941 Expression and diagnostic use of pENV-3 encoded peptides which are immunologically reactive with antibodies to LAV  
A method of expressing peptides which are immunologically reactive with antibodies to LAV is disclosed. The peptides are produced by bacterial host cells transformed with a recombinant plasmid...
4783412 Hybrid DNA synthesis of epidermal growth factor  
DNA sequences and methods of obtaining DNA sequences which include a sequence encoding for mammalian epidermal growth factor are provided. The DNA sequences may be used in cloning and expression...
4783415 Gene coding for signal peptides and utilization thereof  
A DNA segment of a gene coding for a signal peptide is disclosed the segment is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host by...
4783524 Growth factors  
This invention relates to novel peptides having utility for promotion of growth and/or lactation in animals, to processes and DNA useful in production of such peptides, and to methods utilizing...
4783523 Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides  
A bioelastomer containing elastomeric units comprising tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units...
4782135 Composition of matter and process  
Novel antibiotics didemnins A, B and C (didemnins), and nordidemnins A, B and C (nordidemnins) which can be obtained from a marine organism. These antibiotics are active against a variety of DNA...
4782139 Selective chemical removal of a protein amino-terminal residue  
The invention relates to a process and compounds useful therein for producing a compound having an amino acid sequence defining a biologically active peptide or protein from a compound of the...
4782136 Synthetic peptide compounds producing anitbodies binding to human LDH-C.sub .  
Synthetic peptide compounds are provided which are capable of producing antibodies binding to the lactate dehydrogenase enzyme of human serum (LDH-C4). The peptide compounds comprise antigenic...
4782043 Renin inhibitors containing a C-terminal amide cycle  
Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
4782022 Nitrogen fixation regulator genes  
Isolation and characterization of a gene which activated nitrogen fixation genes of Rhizobium meliloti when that bacterium is in a symbiotic relationship with a plant is disclosed. This newly...
4782137 Synthesis of protein with an identification peptide, and hybrid polypeptide incorporating same  
A hybrid polypeptide composed of an identification peptide and a desired functional protein are produced by recombinant DNA techniques. A DNA expression vector is constructed that includes...
4782042 Antibiotic A 40926 mannosyl aglycon  
The present invention concerns a new antibiotic substance denominated antibiotic A 40926 mannosyl aglycon and the addition salts thereof, a process for preparing it from antibiotic A 40926 complex...
4782044 Composition containing cordiodilatin or fragments thereof and methods of obtaining cardiodilatin  
This invention teaches therapeutic compositions containing the hormone cardiodilatin of active fragments thereof, as well as methods for obtaining the cardiodilatin. The compositions are useful in...
4780401 Novel monoclonal antibodies to human renin and hybridoma cells, processes for their preparation and their applications  
The invention relates to novel monoclonal antibodies having a high affinity for human renin, derivatives thereof, processes for the preparation of these antibodies and their derivatives, hybridoma...
4780530 Novel interferon alphas  
Novel IFNαS51B10 and IFNαS17H9 of this invention are prepared from BALL-1 cell induced with Sendai virus according to the well known recombinant DNA technique. Further, this invention relates to a...
4780313 Method of stimulating the immune system with a mixture of substances having IL-2 activity and muramyldipeptide  
The combined use of an IL-2-active substance with a muramyldipeptide exhibiting a remarkably potent immunostimulant activity than the single use of the active ingredient is disclosed.
4778877 Novel inhibitor peptides II  
An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
4778784 Cyclic peptide and method of use for inducing an immunological response to hepatitis B virus  
A composition for eliciting production of antibody to hepatitis B surface antigen and method of neutralizing the infectivity of hepatitis type B virus. A cyclic polypeptide is prepared having a...
4778878 Novel inhibitor peptides I  
An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
4778846 Affinity chromatography sorbent  
A novel process for the isolation and purification of vancomycin class antibiotics which utilized affinity chromatography by the formation of a sorption complex between the antibiotic and an...
4777127 Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus  
A human endogenous retrovirus-related Mv-75,000 protein, containing the decapeptide sequence Glutamic Acid-Asparagine-Proline-Serine-Glutamine-Phenylalanine-Tyros ine-Glutamic...
4777241 Proteinaceous substance showing antitumorous action and its preparing method  
A proteinaceous substance having the following biochemical characteristics: (A) a strong cytolytic activity against mouse tumor cells L-929, but not cytotoxic activity for normal cells such as...
4777243 Immuno stimulant substances derived from bovine casein and compositions containing the same  
New immunostimulant substances are obtained by hydrolysing delipidized bovine casein with a proteolytic enzyme and fractionating the product.