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8324151 Treatment of sepsis and septic shock using ghrelin and growth hormone  
Methods are disclosed for treating sepsis and septic shock using a combination of ghrelin and growth hormone, and for using ghrelin to reduce organ and tissue injury and improve survival after...
8324163 Methods for treating reperfusion injuries using flagellin  
The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.
8303962 Antibacterial and antifungal peptides  
This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various...
8268784 Neuropeptide-2 receptor (Y-2R) agonists and uses thereof  
Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those...
8257502 Plants with reduced activity of a starch phosphorylating enzyme  
The present invention relates to plant cells and plants, which are genetically modified, wherein the genetic modification leads to the reduction of the activity of a starch phosphorylating OK1...
8241901 Method of secretory expression of lysostaphin in Escherichia coli at high level  
A method of secretory expression of lysostaphin in Escherichia coli at high level, which comprises constructing a expression vector by cloning a sequence encoding a signal peptide which is...
8207234 Methods for treating diabetic foot ulcers  
The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.
8207233 Methods for treating diabetic foot ulcers  
The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.
8188216 Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery  
A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond; where part (B) is a bivalent radical, a —(CH2)z—...
8133976 Methods of use of the TACI/TACI-L interaction  
The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate molecules to determine potential...
8114830 Polypeptoid pulmonary surfactants  
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and...
8105603 Polypeptides that bind APRIL  
The present invention relates to polypeptides that inhibit APRIL and/or BAFF binding to BCMA, nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The...
8093363 Tumor necrosis factor-gamma  
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also...
8063182 Human TNF receptor fusion protein  
The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts,...
8063016 Retro-inverso peptides derived from interleukin-6  
This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is...
8013112 Compositions comprising human brain natriuretic peptide (BNP) fragments  
The present invention relates among other things to a composition comprising at least two (2) human BNP fragments, wherein each of the human BNP fragments of the composition are cross-linked to at...
8008440 Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery  
A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond;where part (B) is a bivalent radical, a —(CH2)z— bivalent...
8007592 Plants with increased activity of a starch phosphorylating enzyme  
The present invention relates to plant cells and plants, which are genetically modified, whereby the genetic modification leads to an increase in the activity of a starch-phosphorylating OK1...
7999075 Methods for identifying compounds that regulate beta-arrestin signaling complexes  
A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling...
7960123 Multimarker panel based on PIGF for diabetes types 1 and 2  
The present invention relates to a method and means for diagnosing or risk stratification of co-morbidities, particularly cardiovascular complications in diabetes patients. The invention...
7955590 Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens  
Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen...
7951371 Soluble lymphotoxin-β receptor fusion protein and methods for inhibiting lymphotoxin β-receptor signaling  
This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are...
7927605 Environmentally regulated genes of Streptococcus suis  
The invention relates to the field of the diagnosis of and vaccination against Streptococcal infections, and to the detection of virulence markers of Streptococci. The invention discloses a method...
7888311 Uranium-chelating peptides and uses thereof  
The invention concerns uranium-chelating peptides as well as their uses for decontaminating soils and water, and for detecting and treating people contaminated by uranium. Said peptides have a...
7879577 Modified polypeptides stabilized in a desired conformation and methods for producing same  
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to...
7872100 Nitrile hydratases from metagenome libraries  
The present invention is concerned with the preparation of novel nitrile hydratases. These latter are preferably obtained from nonculturable organisms by means of a PCR-based screening, in...
7855175 Peptides that bind to the erythropoietin receptor  
The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat...
7834258 Dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same  
The present invention relates to a method producing dimer of chimeric recombinant binding domain-heterogeneous functional group fusion([B-F fusion]2) by using covalent disulfide-bond-bridge...
7812126 DIRS1 polypeptides  
Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of...
7807397 Diagnostic method for disorders using copeptin  
The use of copeptin as diagnostic marker for the determination of the release of vasopressin, especially in connection with disorders associated with non-physiological alterations of vasopressin...
7799339 Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents  
The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
7795399 Stable therapeutic proteins  
The invention relates to storable medicaments produced from pharmaceutical active ingredient preparations which are virus safe. Said medicaments contain at least one intact therapeutic protein...
7790675 Method for increasing frataxin expression  
Use of human erythropoietin or a derivative of erythropoietin having the biological activity of human erythropoietin of increasing the expression of frataxin for the production of a pharmaceutical...
7785588 Anti-neurturin receptor-A antibody compositions comprising cytokines or neurotrophic factors  
NTNRα, NTNRα extracellular domain (ECD), NTNRα variants, chimeric NTNRα (e.g., NTNRα immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are...
7785579 Modified tumor necrosis factor  
Modifying TNF with polyethyleneglycol (PEG) having an approximate weight average molecular weight in the range of about 10,000 to about 40,000, preferably in the range of about 20,000 to 30,000,...
7763704 Sushi peptide multimer  
Endotoxin, also known as lipopolysaccharides (LPS), is the major mediator of septic shock due to Gram-negative bacterial infection. Chemically synthesized S3 peptide, derived from Sushi3 domain of...
7741289 Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof  
The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each...
7732413 Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof  
The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each...
7722880 Immunoreactive 38-KDA ferric binding protein of ehrlichia canis and uses thereof  
The present invention is directed to the cloning, sequencing, expression, and characterization of an immunoreactive ferric binding protein (Fbp) (38-kDa) protein of Ehrlichia canis encoded by a...
7704958 Methods and compositions for inhibiting apoptosis using serine protease inhibitors  
The instant invention provides a method of treating an animal suffering a disease characterized by excessive apoptosis by administering a therapeutically effective amount of at least one serine...
7705119 Compositions and methods useful for treating circulatory and hypovolemic shock  
Polypeptides, compositions, and methods for treating shock are described. A isolated polypeptide, Deltorphin-E, can be administered without concomitant fluid resuscitation, before, concurrently...
7700562 Use of —furin—“convertase” inhibitors in the treatment of fibrosis and scarring  
The present invention relates to use of convertase inhibitors for the reduction of scarring during the healing of wounds and also for reducing fibrosis in the treatment of fibrotic conditions.
7674604 Modified polypeptides stabilized in a desired conformation and methods for producing same  
The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to...
7674769 Treatment of severe pneumonia by administration of tissue factor pathway inhibitor (TFPI)  
Methods for prophylactically or therapeutically treating severe pneumonia involve administration of tissue factor pathway inhibitor (TFPI) or a TFPI analog to patients suffering from or at risk of...
7642244 Neuropeptide-2 receptor (Y-2R) agonists and uses thereof  
Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those...
7632819 Methods and compositions for inhibiting PKC delta cleavage for treatment and prevention of neurodegeneration and apoptosis  
Methods and compositions are provided which inhibit the apoptotic activity associated with oxidative stress in many disease states. According to the invention, inhibition of chemical cleavage of...
7605121 Oligopeptide lyophilisate, their preparation and use  
A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the...
7597886 Tumor necrosis factor-gamma  
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also...
7585836 Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy  
The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices...
7569660 Recombinant prion-like proteins and materials comprising same  
The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected...