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4816560 Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them  
New partially retro-inverted tuftsin analogues of general formula I ##STR1## wherein R represents the side-chain of the amino acids threonine, methionine or leucine R1 represents the side-chain of...
4816438 Insulin-selective somatostatin analogs  
Anglerfish somatostatin-28 has the formula: ##STR1## Anglerfish somatostation-28 is insulin-selective when administered in vivo and is useful for the treatment of insulinoma. The 14-residue...
4816444 Cell growth inhibitory substance  
A potent cell growth inhibitory substance obtained from the Indian Ocean sea hare Dolabella, herein denominated "dolastatin 10"; and pharmaceutical preparations containing same; and methods useful...
4816397 Multichain polypeptides or proteins and processes for their production  
Multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the...
4816565 Interleukin 2 receptor and a method for production thereof  
Interleukin 2 receptor protein having the following properties: (a) molecular weight: 40 to 43 kd, (b) pI of 5.2 to 4.4, (c) amino acid sequence (N-terminal): ##STR1##
4816513 Automated polypeptide synthesis process  
An apparatus is provided for automatically constructing a polypeptide of high purity, up to 50 amino acids in length, using only single couplings. The apparatus includes an activation system for...
4816567 Recombinant immunoglobin preparations  
Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically...
4816443 Piptides having ANF activity  
Novel peptides having potent natriuretic activity are disclosed with the following amino acid sequence: ##STR1## wherein Z is H, acetyl, Boc or Ser-Leu, E is Phe, NMP, OMT, ChA, F is Gly or DAl, G...
4814432 Inhibitor of ribonucleotide reductase  
A series of peptides has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication.
4812557 Stable composition of interleukin-2 and human serum albumin  
The present invention provides an interleukin-2 composition which comprises human serum albumin, a reducing compound or a combination thereof and is adjusted as showing pH of 3 to 6 as a solution....
4812554 Somatostatin peptide conjugate  
The specification discloses: 1. Recombinant microbial cloning vehicles comprising heterologous DNA coding for the expression of mammalian hormone (e.g., somatostatin) and other polypeptides,...
4812442 Tripeptide renin inhibitors  
Enzyme tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive...
4812555 Peptides possessing renin inhibitory activity  
New peptides of the formula I X--Z--NR2 --CHR3 --CHOH--(CHR4)n --CO--Ewherein X, Z, R2, R3, R4, E and n are as defined herein and their salts inhibit the activity of human plasma renin.
4812556 Synthetic peptide antigen for the detection of HIV-2 infection  
A synthetic peptide antigen corresponding to a region of the glycoprotein gp41 encoded by the env gene of HIV-2 is provided. The peptide which is immunologically reactive with HIV-2 specific...
4812559 Vaccine against varicella-zoster virus  
A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. This gene can hybrid select messenger RNA which encodes...
4810780 Protein having phospholipase A2 inhibitory activity  
Protein having a phospholipase A2 inhibitory activity which has the nature to be induced from cells upon administration of glucocorticoid and has a phospholipase A2 inhibitory activity.
4810491 Polypeptides useful in vaccination against enteroviruses  
A synthetic polypeptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus, is an octapeptide coded for by codons 93-100 in the RNA sequence coded for the...
4810692 Immunosuppressant substances, process for their preparation and pharmaceutical compositions containing them  
The invention provides two novel immunosuppressant cyclodepsipeptides of formula: ##STR1## in which X is chlorine or hydrogen. These compounds may be made by culturing Streptomyces sp. S-16328...
4810779 Decapeptides having hypotensive action and process for their preparation  
New decapeptides having hypotensive action are disclosed, which can be defined by the formula: GLp-Leu-Trp-Pro-X-Pro-Y-Z-Pro-Pro-OH (I)wherein: X=Arg or Orn Y=His or Gln Z=Ile or Valwith the...
4810693 Method for inducing biological coverings in wounds  
Methods are disclosed for (a) enhancing the formation of a natural biological dressing composed primarily of serum proteins; (b) enhancing the reestablishment for free, full-thickness skin grafts...
4810492 Flavivirus antigen  
There is disclosed an antigen comprising at least part of an amino acid sence of the antigen of a flavivirus, which part contains at least one of epitopes of the flavivirus antigen. The present...
4810777 Antimicrobial compounds  
A new class of broad spectrum antibiotic polypeptides termed "Magainin" have been described. These peptides have a molecular weight of about 2500 or less, are highly water soluble, non-cytolyic to...
4810648 Haloarylnitrile degrading gene, its use, and cells containing the gene  
Nitrilase enzymes specific for the hyrdolsis of the nitrile group of bromoxynil, nucleotide sequences encoding for such enzymes, and transformed cells in which the nitrilase expression if foreign...
4808537 Methanol inducible genes obtained from pichia and methods of use  
A method for isolating and cloning methanol inducible genes from Pichia is taught. The regulatory regions are useful for the methanol regulated expression of heterologous genes.
4808701 Cyclic peptides having appetite regulating activity  
Cyclic peptides with appetite regulating activity.
4808702 Decapeptides produced from bioadhesive polyphenolic proteins  
Methods are described for the preparation and isolation of novel decapeptides of the formula: ##STR1## wherein each X is independently selected from the group comprising hydroxyl and hydrogen,...
4808536 Immunochemical method for detection of antibody against HTLV-III core protein based upon recombinant HTLV-III gag gene encoded protein  
Immunochemical assays for detection of antibodies against HTLV-III core proteins are described. The assays are based upon recombinant HTLV-III core proteins expressed by cloned DNA segments of the...
4808703 Novel 3-(4'-aminobutylamino) propylaminobleomycin derivatives  
Disclosed is a 3-(4'-aminobutylamino) propylaminobleomycin having low pulmonary toxicity, which expressed by the following general formula [BX]--NH--(CH2)3 --A--(CH2)4 --Bwherein [BX] represents a...
4806473 Process for enzymatic production of peptides  
A peptide having the formula A--Bwherein A represents an N-terminal protected amino acid residue or an optionally N-terminal protected peptide residue and B represents an optionally C-terminal...
4806336 Human intestinal hormone and its use  
A human intestinal hormone having the following peptide structure: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu- Gly-Ala-Arg-Le u-Gln-Arg-Leu-Gln-Gly-Leu-Val-NH 2 ; compositions...
4806492 Polypeptide tumor inhibitors and antibodies thereto  
Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in...
4804650 Analogs of atrial natriuretic peptides  
Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or...
4804746 Antibodies to human leukemia virus-related peptides and a process for production of the antibodies  
An antibody of a human leukemia virus-related peptide obtained by collecting an antibody produced in a mammal body by administering to the mammal an antigen prepared by reacting a human leukemia...
4804742 Amide analogs of calcitonin  
New peptides are disclosed which have biological activity of the same type as known calcitonins and which are amide analogs of natural calcitonins.
4804743 Proline-containing renin inhibitors  
This invention concerns novel renin-inhibitory peptides containing proline which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Intermediates and...
4803261 Method for synthesizing a peptide containing a non-peptide  
This invention features a method for the solid phase synthesis of non-peptide bonds (CH2 --NH) in polypeptide chains. These polypeptides are synthesized by standard procedures and the non-peptide...
4803156 Peptide-beta-lactamase conjugates for enzyme-linked immunoassays  
A reagent for an ELISA determination of an antibody, the reagent comprising a peptide covalently linked to beta-lactamase. The reagent can be used in the following method to detect antibodies in a...
4801537 Vector for expression of polypeptides in bacilli  
A replicable plasmidic expression vector, capable of high levels of expression and secretion of polypeptides in a bacillus is disclosed. The vector contains a DNA sequence comprising the promoter...
4801580 Peptide, process for preparation thereof and use thereof  
The invention relates to novel peptides, of pharmacological activity, of the formula: ##STR1## wherein R1 is hydrogen, Rb1 is methyl, R2 is carboxy, carboxymethylcarbamoyl, 1-carboxyethylcarbamoyl...
4801574 In-situ activation of CuO/ZnO/Al2 O3 catalysts in the liquid phase  
The present invention relates to a method of activation of a CuO/ZnO/Al2 O3 catalyst slurried in a chemically inert liquid. Successful activation of the catalyst requires the use of a process in...
4801536 Method for producing heterologous proteins  
This invention concerns a method for producing a heterologous protein in a bacterial host cell such that the protein is exported from the host cell into the culture medium. The method involves...
4801579 Novel cystine compounds, their preparation and use  
Novel cystine compounds of the general formula I are proposed wherein the independently of one another each represent a, preferably natural, L-amino acid, in particular glycine, alanine, proline,...
4801614 Process for using endogenous enkephalins and endorphins to inhibit growth of tumerous cells  
A process for the therapeutic treatment of cancer patients involving stimulation and promotion of the natural immune system (both T cell and NK cell activity) resisting and inhibiting tumorous...
4801612 Method of inhibiting inflammatory response  
Many malignant neoplasias are treated by radiation therapy which can result in painful inflammation of the covering skin and/or mucosal membranes. Similarly, skin disorder patients receiving U.V....
4801684 Process for obtaining insulin precursors from reaction mixtures resulting from the folding of insulin precursors from the corresponding S-sulfonates  
A process for the preparation of insulin precursors of the formula (I) ##STR1## in which R is hydrogen or the presequence Pm --Qn --, in which P is a sequence of naturally occurring amino acids...
4801576 Method of inhibiting blood clotting with desulfatohirudins  
The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof. The desulfatohirudins of this...
4800119 Resilient, wear-and weather-resistant composite surface material  
A resilient, composite surface material which is resistant to the effects of weather and traffic. It is constructed of a layer of resilient, shock-attenuating, closed-cell, elastomeric foam; a...
4800085 Slow-release composite and process for producing the same  
A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl- tyrosyl-D-leucyl-leucyl-arginyl-proline ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same...
4798789 cDNA clones coding for polypeptides exhibiting murine interleukin-2 activity  
Plasmid vectors are provided that carry complementary DNA (cDNA) clones cng for polypeptides exhibiting murine interleukin-2 activity. One of these polypeptides is 168 amino acids in length,...
4798821 Antihypertensive therapy for diabetics  
Process and compositions for lowering blood pressure in diabetic by employing a cyclopeptide compound is described.