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4840897 Modified human insulin and its use as starting material for the preparation of human insulin  
A novel modified human insulin of the general formula: ##STR1## wherein R is a hydrophobic or charged amino acid or a di- or tripeptide group, comprising a hydrophobic or charged amino acid or an...
4840785 Mammal intestinal hormone precursor and its use  
A mammal intestinal hormone precursor having the following peptide structure: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-L-M- Ala-Arg-Leu-Gl n -Arg-Leu-Leu-Gln-Gly-Leu-Val-Gly-N-O,...
4839465 Di-(D-tryptophyl and/or tetrahydropyridoindolylcarbonyl)-containing peptide amides and process for preparation thereof  
Di(D-tryptophyl and/or tetrahydropyridoindolylcarbonyl)-containing peptide amides useful as Substance P agonists and/or antagonists and as antihypertensives and/or analgesics and a process for...
4839283 Method of expressing alpha-1-antitrypsin in yeast  
A method is provided for expressing human alpha-1-antitrypsin in yeast utilizing a wild-type strain and a hyperproduction mutant, GK100.
4839169 Synergistic combination of t-PA and prostacyclin  
A combination of t-PA and a prostaglandin of use in removing or inhibiting the formation of a blood clot in a mammal.
4839343 Preparation containing hexatriacontapeptides and methods of use  
Preparation containing hexatriacontapeptides suitable for intravenous administration to human or other animal subjects are disclosed. such compositions are effective in treating life-threatening...
4839293 DNA encoding streptavidin, streptavidin produced therefrom, fused polypeptides which include amino acid sequences present in streptavidin and uses thereof  
DNA which encodes the polypeptide streptavidin has been isolated as a fragment 2 kb in length derived from a restriction endonuclease digestion of the chromosomal DNA of Streptomyces avidinii. The...
4837304 Inhibitor of ribonucleotide reductase  
A series of oligopeptides each of which contains a D-amino acid has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting...
4837203 Pharmacologically active compounds and use  
The peptides of the formula X--Tyr--X2 --Gly--Phe(4NO2)--Pro--NH2wherein X is hydrogen or an amidino group and X2 is D-S-methylmethionyl or D-arginyl, together with their pharmacologically...
4837306 Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen  
The invention provides a method for selecting hybridomas which produce antibodies specific to domains of a cell surface antigen which is usually not accessible at the surface of intact cells. The...
4837303 Novel somatostatin derivatives  
Somatostatin derivatives of general Formula I ##STR1## wherein at least one of the residues X represents a moiety, bound to the free amino group of alanine or lysine, of Formula II ##STR2## with R...
4835255 T-cell membrane protein  
A 16.7 kilodalton membrane protein which is produced in mature, but no early-stage, T cells has been discovered. The protein has four distinct amphipathic domains, each having an amino acid...
4835256 Human gamma interferon polypeptide having glutamine as the ninth n-terminal amino acid  
Disclosed is a novel DNA which shows complementarity to human interferon-γ mRNA, a recombinant plasmid containing the DNA, a microorganism containing the recombinant plasmid and a method of...
4835139 Process for increasing the antagonistic effect of peptidic compounds on hormone-dependent diseases  
The antagonistic effect of the releasing hormone of LH and FSH or of one of its synthetic analogues selected from the group (pyro) Glu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 (pyro)...
4835251 Method of chain combination  
Production of human relaxin or novel human relaxin analogs by combination of a human relaxin A-chain and B-chain comprises combining the reduced form of the human relaxin A-chain and the reduced...
4835254 Process for reducing methionine sulfoxide residues in peptides or proteins  
This application discloses a process for reducing methionine sulfoxide residues in peptides and proteins to methionine residues. The process comprises subjecting said peptide or protein to a...
4833125 Method of increasing bone mass  
A method for increasing bone mass in a human afflicted with osteoporosis or a similar disease which comprises administering to the human so afflicated an effective amount of a composition...
4833152 Anti-hypertensive agents  
Novel inhibitors of angiotensin coverting enzyme having the general formula R - A - S - Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.
4833127 Novel CSF and method for obtaining the same  
A novel colony stimulating factor (CSF) that has the ability to promote the differentiation and proliferation of human bone marrow cells to neutrophiles, and a method for obtaining the same are...
4833071 Peptide composition as anitgen for detection of antibodies to HTLV-I, as a vaccine for ATL and methods therefor  
The present invention relates to a method for the detection and diagonosis of ATL (adult T cell leukemia/lypmphoma) condition by the use of chemically synthesized peptide composition. The peptide...
4832959 Preparation of polypeptides having human γ-interferon activity  
Partial sequences of human-γ-interferon, comprising aminoacid sequences 5 to 127, 1 to 127 and 5 to 146, having biological activity. These partial sequences can be obtained by a genetic...
4833072 Antigentic peptides and process for their preparation  
The present invention relates to antigenic peptides of the formula H--Val--X--Y FORMULA Iwherein X is a polypeptide residue selected from the group consisting of: Val-Pro-Arg-Arg-Lys-Ala-Lys-Ile;...
4833166 Growth hormone releasing hormone complementary peptides  
The present invention provides synthetic peptides and fragments and analogs thereof complementary to growth hormone releasing hormone, and antibodies raised against such peptides. The present...
4830962 Recombinant diphtheria toxin fragments  
Recombinant vectors which are effective in expressing DNA sequences encoding specific fragments of diphtheria toxins at high levels in recombinant host cells are disclosed. Both a fragment...
4828994 Bacillus strains with reduced extracellular protease levels  
Bacillus strains having reduced levels of extracellular protease are produced by replacing the native chromosomal DNA sequence comprising the gene for an extracellular protease, such as...
4829051 N-substituted derivatives of 1-desaminovasopressin  
Novel analogs of biologically active vasopressin and its synthetic analogs having improved activity are represented by the structural formula: ##STR1## wherein A hydrogen; is hydroxy or lower...
4828990 Method for purifying an interferon  
A method of purifying a polypeptide having a physiological activity such as one having interferon activities from a culture mixture of a microorganism obtained by a recombinant DNA technique and...
4826763 Process for preparing glucagon or fragments or derivatives thereof in yeast  
Glucagon or fragments or derivatives thereof are prepared by cultivation of a yeat strain transformed with a replicable expression vehicle comprising a gene encoding the expression of such...
4826613 Lubricating oil containing dispersant viscosity index improver  
Lubricating oil of improved dispersancy and viscosity index contains ethylene-propylene polymer bearing glycidyl methacrylate graft which as been functionalized with mercaptoacetic acid.
4826957 Immunogenic recombinant yeast expression product and method for purifying it  
Described is an immunogenic polypeptide that is a portion of the P. vivax circumsporozoite expressed by a recombinant yeast.
4824667 Thymidine kinase deletion mutants of bovine herpesvirus-1, vaccines against infectious bovine rhinotracheitis containing same and methods for the production and use of same  
Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The...
4824937 Synthetic natriuretic peptides  
Synthetic natriuretic peptides (SNP) composed of 23 amino acid residues of which residues 2-23 have the natural L-configuration while the amino-terminal residue is derived from an unnatural amino...
4824936 (19-Alanine) calcitonin  
New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an alanine in position 19 instead of the natural leucine or phenylalanine found in...
4822731 Process for labeling single-stranded nucleic acids and hybridizaiton probes  
Nucleic acids may be labeled by complexing the alkylating moiety of a labeling reagent into a single-stranded nucleic acid to form a complex and activating the complex to cause covalent bonding...
4822608 Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof  
Methods and compositions are described for the treatment of mammalian infections, including bacterial, viral and cancerous infections, in which hymenoptera venom or proteinaceous or polypeptide...
4822773 Enhancement of absorption of drugs from gastrointestinal tract using choline ester salts  
Choline ester salts are used as drug absorption enhancing agents for orally and rectally administered drugs.
4822606 Immunosuppressive synthetic peptides and analogs thereof based on retroviral envelope sequences  
Novel peptides having immunosuppressive or immunoregulatory activity are disclosed.
4822774 Physiologically active peptide  
A peptide is novel and useful for the bronchodilative activity and the hypotensive activity, having the following structure:...
4820638 Novel alpha interferon species produced by recombinant means  
A novel species of alpha interferon is taught. The alpha interferon amino acid sequence is disclosed and a gene corresponding thereto. The alpha interferon gene is expressed in Escherichia coli.
4820804 Analogs of [1,7-di-alanine, des-19-leucine]calcitonin  
New hypocalcaemic peptides are disclosed of the formula ##STR1## wherein X represents H for the replacement of the N alpha amino group or acyl groups for the acylation of the N alpha amino group,...
4820691 Amino acid 1,2-diketo derivatives as renin inhibitors  
Compounds of the formula ##STR1## are disclosed. These compounds interevene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.
4818769 Method of controlling stress-related disease in livestock by administration of human IL-2  
Disclosed herein is a method of mitigating stress-related syndromes in livestock, such as shipping fever in cattle, by administration of human IL-2.
4818698 Polypeptides and preparation process thereof  
A polypeptide represented by the following general formula (I): X1 Ala Thr Lys Ala Val X2 Val Leu Lys Gly Asp Gly Pro Val Gln Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val Trp...
4818432 3-substituted biphenyl compound  
A novel 3-substituted biphenyl compound useful as a component of chiral liquid crystal compositions useful for light-switching elements by the use of ferroelectric liquid crystals; a chiral liquid...
4818748 Renin inhibitors and aminoacid and aminoaldehyde derivatives  
Anti-hypertensive compounds of the formula ##STR1## in which A represents hydrogen, C1 -C8 -alkyl, C7 -C14 -aralkyl, phenylsulphonyl, tolylsulphonyl or C1 -C8 -alkylsulfphonyl, or represents an...
4818694 Production of herpes simplex viral protein  
Methods and composition are provided for the cloning and expression of a Herpes Simplex Virus (HSV) glycoprotein (gD) gene in single-cell host organisms. Also described are methods for culturing...
4816441 Peptides and compositions  
Peptides of the formula R1 -His-Asp-Glu-Ala-R wherein R1 is Ala-Gln, and R is a polypeptide residue with up to 50 amino acid residues, and wherein one, more or all of the amino acid residues in R1...
4816449 Immunotherapeutic anti-inflammatory peptide agents  
Anti-inflammatory peptides of the formula A-B-C-D-E, useful in treating allergies, autoimmune diseases, and other disorders, and methods for using them are described.
4816559 Biologically active peptides TAN-866  
The iron-containing biologically active peptide TAN-866 produced by microorganisms belonging to the genus Pseudomonas and its iron free compounds have antibacterial activity mainly against...
4816442 Method of inhibiting tumor growth sensitive to CIF-βtreatment  
Polypeptides called cartilage-inducing factors (CIFs) that are found in bone and have heretofore been identified as having in vitro cartilage-inducing activity. TGF-β activity, and...