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4861710 Recombinant DNA clone encoding laminin receptor  
The invention provides a recombinant cDNA clone encoding cell surface receptor for laminin, as well as a probe and methods of using that probe to diagnose the aggressiveness of a carcinoma or the...
4861756 Synthetic pulmonary surfactant  
Certain polypeptide-phospholipid complexes consisting of the amphipathic, helical portion of human apo A and its analogs and a phospholipid are useful in the treatment of neonatal respiratory...
4861726 Method of thioacylation peptide sequencing with acylation of thiazoloinones  
A protein micro sequencing method for use in conjunction with the thiocylation degradation of polypeptides and proteins is disclosed. The process involves reaction of the N-terminal amino acid of...
4861717 Microorganisms and plasmids for the constitutive formation of creatinamidinohydrolase and processes for the production thereof  
The present invention provides a micro-organism of the species Escherichia coli or Pseudomonas putida, wherein it constitutively forms creatinamidinohydrolase.The present invention also provides a...
4859765 Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture  
The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a...
4859654 Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents  
Polypeptides and derivatives thereof containing homocyclostatine and cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.
4859600 Recombinant procaryotic cell containing correctly processed human growth hormone  
The production of mature hGH in E coli and Pseudomonas strains transformed by a plasmid which encodes pre hGH (comprising the signal polypeptide and the hormone itself) is described. These...
4857637 Methods and compositions for immunologically modulating growth hormone receptor activity  
The activity of growth-associated receptors is modulated in vivo in a controlled and reproducible fashion by immunizing animals against target growth-associated receptors. This is accomplished by...
4857508 Novel platelet-aggregation inhibitor peptide derivatives  
Novel tetrapeptide derivatives are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the sequence X-Gly-Asp-Y wherein X is illustrated by arginine and...
4857634 Peptides useful in vaccination against enteroviruses  
A synthetic peptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus and especially by a poliovirus, is the peptide coded for by codons 286-290 in the...
4855405 Glutamate receptor inhibitor  
A novel glutamate receptor inhibitor obtained from Joro spider venom glands, and its manufacturing method.
4855406 Oncogene-related peptides  
Disclosed are an oncogene-related peptide characterized in that the peptide comprises a portion of the amino acid sequence of a gene product coded for by an oncogene, an antigen or immunogen...
4855231 Regulatory region for heterologous gene expression in yeast  
Novel DNA sequences which are responsive to the presence of methanol, catabolite non-repressing carbon sources and carbon source starvation are provided. In addition, novel constructs including...
4855407 Solid phase process for synthesizing peptides  
Thymosin α1 and other peptide amides are synthesized in the solid phase using methylbenzhydrylamine resin as the support and hydrogen bromide as the deprotecting and cleaving agents. The...
4855409 Novel polypeptides and method of producing same  
A novel polypeptide which is at least equivalent in biological activity to IFN-γ and is resistant to dimerization and polymerization, a transformant which carries a DNA coding for a novel...
4855486 Blocked, marked amino acids  
A method is provided for quantitatively monitoring the deprotection and coupling reactions employed in the solid phase synthesis of peptides. The method entails synthesizing a peptide on a support...
4855303 Fluorine containing renin inhibitors  
Polypeptides containing fluorinated cyclostatine derivatives as antihypertensive agents.
4855224 Molecularly cloned diagnostic product and method of use  
A molecularly cloned diagnostic product in the form of a polypeptide with antigenic determinants capable of specifically binding complementary antibody, the polypeptide being expressed from a...
4853220 Protein isolated from blood, process for preparing said protein, aantibodies against said new protein, and pharmaceutical compositions containing said protein or said antibodies  
The invention relates to Tetranectin, a new protein isolated from blood. Its structure comprises four polypeptide chains having the formula shown in the attached drawing.Tetranectin plays a role...
4853332 Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins  
Muteins of biologically active proteins such as IFN-β and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to...
4853333 Production of rotavirus in yeast  
There is disclosed a DNA transfer vector capable of replication in either a yeast cell or a bacterial cell and having inserted therein a DNA segment coding for human WA rotavirus surface antigen...
4853219 Antibodies to angiogenin: immunotherapeutic agents  
This invention relates to the production of antibodies to angiogenin or to fragments thereof and to methods of inhibiting angiogenesis in mammals by administering to mammals such antibodies or Fab...
4853871 Computer-based method for designing stablized proteins  
A computer-based method evaluates the structure of a protein to thereby identify sites in the protein molecule at which the natural amino acid residues can be replaced with cysteine residues in...
4851341 Immunoaffinity purification system  
A process is disclosed for purifying a recombinant fusion protein having an N-terminal identification sequence comprising multiple anionic amino acid residues, comprising forming a complex of the...
4851349 Expression vectors encoding cardionatrin and cardiodilatin  
A recombinant DNA vector containing a DNA sequence which encodes a peptide having the physiological properties of cardionatrin ad cardiodilatin.
4851334 Monoclonal antibodies specific to in vivo fragments derived from human fibrinogen, human fibrin I or human fibrin II  
Hybridoma for production of monoclonal antibody to an antigen found on the peptide fragment of the Bβ chain of human fibrinogen or fibrin I containing amino acid residues 1-42. The hybridoma is...
4851387 5-substituted amino-4-hydroxy-pentanoic acid derivatives and their use  
A 5-substituted amino-4-hydroxy-pentanoic acid derivative having the formula: ##STR1## wherein R1 is a hydrogen atom or an N-protecting group, R2, R3 and R5 may be any of a variety of groups...
4851385 LHRH antagonist analogs having low histamine-release activity  
Antagonist analogs of luteinizing hormone-releasing hormone (LHRH) having N-alkylated basic amino acid residues at the 8 position, 8 and 6 positions, 8 and 5 positions, and 8, 6 and 5 positions,...
4851509 Biologically active substances and compositions containing the same  
New immunostimulant substances are obtained by hydrolysing delipidized bovine casein with a proteolytic enzyme and fractionating the product.
4851512 Novel human interleukin-2 polypeptide derivative  
Novel human IL-2 polypeptide derivatives characterized by deletion of at least one amino acid from the amino acid sequence of the human IL-2 polypeptide, recombinant plasmids containing DNAs...
4851388 Heptanoyl-glu-asp-ala-amino acid immunostimulants  
Peptides useful as antiinfective agents, immunomodulators for stimulation of host defenses in patients with an increased risk of bacterial infections, intermediates and process therefor.
RE32992 Peptide process for preparation thereof and use thereof  
The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure:...
4849349 Genes for biologically active proteins  
The cDNA of a new proteinase inhibitor was isolated from a cDNA library of human liver biopsy material using a synthetic Oligonucleotide probe. The cDNA can be expressed by introduction of the...
4849359 Fish growth hormone polypeptide  
According to the present invention, a recombinant DNA incorporated with a DNA coding for a fish growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained and they...
4849351 Multiple reading frame Escherichia coli expression vectors  
Vector plasmids are constructed to provide sites for insertion of a structural gene in phase with three reading frames downstream from the promoter of alkaline phosphatase gene of Escherichia coli.
4849408 Method of treatment of cerebral disturbances with oligopeptides containing tryptophan  
The use of tryptophan containing oligopeptides for the treatment of cerebral disturbances in particular sleeplessness and depression is disclosed. The use of glycyl tryptophan, if desired, in...
4847081 Synthetic bovine parainfluenza viral proteins  
A method is disclosed for constructing a synthetic gene for the production of a viral protein or portion thereof. The method is useful for genes found on minus-strand RNA viral genomes, such as...
4847201 DNA encoding for CSF-1 and accompanying recombinant systems  
A colony stimulating factor, CSF-1, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by...
4845195 Inhibitor of ribonucleotide reductase  
The pentapeptide Val Val Asn Asp Leu has been found to be the shortest peptide sequence that inhibits the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby...
4845076 DNA sequences coding for proteins having the biological activity of HUSI-type I inhibitors, biotechnological methods for the preparation of said proteins and pharmaceutical compositions containing said proteins  
There are described DNA sequences from the genome of mammals, in particular from the human genome, coding for proteins having the biological activity of HUSI-type I inhibitors. There are further...
4844895 Composition containing a peptide fragment of platelet factor four and method for restoring suppressed immune responses  
Compositions and methods for modulating immune responses in mammals comprising immunomodulating-effective amounts of PF4 or a biologically active peptide fragment of platelet factor 4 are...
4845077 Method of inducing ovulation  
A method of inducing ovulation by administering exogenous human menopausal gonadotropins employs FSH as the exogenous human menopausal gonadotripin in the absence of exogenous LH, preferably in...
4845080 Human calcitonin peptide with salmon calcitonin-like characteristics  
The invention relates to a substance from the calcitonin group, which substance can be isolated from the human body or can be obtained in a different manner, but clearly differs from the known...
4845196 Modified interferon gammas  
Described are modified human gamma interferons, genes coding for their synthesis and plasmids containing and capable of expressing these genes.
4843011 Monoclonal antibodies for binding HTLV-III proteins, and cell lines for their production  
Monoclonal antibodies, and hybridoma cell lines for their production, that bind with a high degree of specificity proteins associated with HTLV-III virus are presently disclosed. In particular,...
4843146 Immunologically active polypeptides useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antisporozoite antibodies  
Immunologically active polypeptides constituted, towards the N-terminated end, by an Asn-Val-Asp-Pro-Asn-Ala-Asn-Pro sequence repeated three times and, towards the C-terminated end, by at least...
4843006 RecA promoter dependent polypeptide production  
This invention relates to the expression and accumulation in bacterial cells of heterologous polypeptides under the control of the recA promoter/operator region. One such polypeptide comprises a...
4843064 GRF analogs V  
The invention provides peptides which are particularly potent in stimulating the release of pituitary GH in fish and amphibians and which have a substantial portion or all of the following...
4842996 Probes comprising modified adenine groups, their preparation and their uses  
The invention relates to a probe constituted by an oligonucleotide fragment of structure predetermined by the application envisaged, wherein at least a part of the adenine groups therein is...
4840935 Peptide amino-alcohol derivatives containing a tetrasubstituted carbon atom, inhibiting renin and acid proteases, process for obtention and therapeutical use  
The present invention relates to peptide amino-alcohol derivatives containing a tetra substituted carbon atom. Said peptides inhibit the renin and acid proteases. The invention also relates to the...