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4957739 Pharmaceutical compositions of a 105 kD P. Haemolytica derived antigen useful for treatment of Shipping Fever  
Novel compositions are disclosed for use in the treatment or diagnosis of bovine pasteurellosis, commonly referred to as Shipping Fever. Cell-free Pasteurella haemolytica supernatants are employed...
4935235 Non-passageable viruses  
What is disclosed is a protein immunoreactive with antibodies raised against HBsAg, which protein has the formula: X-S-Y, S represents a peptide residue of the hepatitis B virus S-protein, Y is OH...
4923964 Human splenin  
The present invention is directed to the protein human splenin (hsP), substantially free of material associated with the protein in its natural environment in the human spleen. In particular, the...
4919930 Synthetic M proteins-streptococci type 5  
Synthetic peptide segments of protein Pep M5 containing epitopes capable of evoking type specific opsonic antibodies against streptococci when covalently linked to a protein carrier.
4886663 Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof  
A synthetic polypeptide having at least about 10% of the immunological activity of biologic heat-stable enterotoxin of E. coli. The synthetic polypeptide includes at least 14 amino acids in the...
4879212 Peptide composition and method for the detection of antibodies to HTLV-III  
The present invention relates to a method for the detection and diagnosis of AIDS (acquired immune deficiency syndrome) ARC (AIDS Related Complex) and pre-AIDS conditions in body fluids by the use...
4876243 Vasopressin compounds  
Vasopressin-like peptide whose structures have been modified by an alpha-methyl amino acid at the 4 or 7 position are set forth. These compounds have potent vasopressin antagonist activities.
4876089 Feline leukemia virus protein vaccines  
Methods and compositions are provided for the efficient production of a polypeptide having immunological reactivity corresponding to that of naturally-occurring envelope glycoproteins of feline...
4873312 Method for purifying interferon and composition of matter produced thereby  
A composition of matter consisting of recombinant human immune interferon having a near-UV circular dichroic spectrum in aqueous solution at neutral pH with positive bands at about 259 nm, 266 nm,...
4871663 Exporession vector for human TnF  
The present invention provides a vector plasmid capable of efficient tumor necrosis factor (TNF) production, a process capable of efficient TNF production in a host transformed with said plasmid...
4871716 Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof  
Novel magnetically responsive hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide and particulate magnetically...
4871717 Peptides  
Heptapeptide analogs of somatastatin which inhibit secretion of growth hormone.
4871835 Analogs of hGH having antagonistic activity, and uses thereof  
Analogs of hGH having the activity of naturally occurring hGH and a similar amino acid sequence varying from the sequence of natural hGh by the addition of one or more amino acids, e.g. methione...
4870006 Antigenic material for a chagas' disease detection system  
T. Cruzi polypeptide antigens that react with serum from chagasic individuals and does not cross-react with serum from uninfected individuals or individuals infected with related parasites such as...
4870008 Secretory expression in eukaryotes  
Methods and compositions are provided for producing polypeptide sequences in high yield by employing DNA constructs, wherein the DNA sequence encoding from the polypeptide of interest in preceded...
4870055 Segmented polypeptide bioelastomers to modulate elastic modulus  
A method of increasing the modulus of elasticity of a biopolymer is disclosed, which comprises incorporating a hexameric unit of the formula --X--(APGVGV)n --Y--wherein A is a peptide-forming...
4870013 SV40 early and RSV promoters useful in saccharomyces expression  
Expression vectors containing coding sequences under the control of SV40 early and RSV promoters are disclosed as useful in producing proteins in saccharomyces yeasts. Construction of such...
4870160 Polypeptides with laminin activity  
A composition which can bind heparin and promote cellular adhesion is provided which consists essentially of a polypeptide of the formula: arg-tyr-val-leu-pro-arg- This invention was made with...
4870161 Reagents and probes for distinguishing and isolating different GTP-binding proteins  
Substantially pure, synthetic peptides corresponding to specific epitopic sites of various G-proteins and antibodies having binding affinity specifically for said epitopic sites have been...
4870023 Recombinant baculovirus occlusion bodies in vaccines and biological insecticides  
The present invention is directed to recombinant baculoviruses which encode fusion polyhedrin proteins capable of forming occlusion bodies containing foreign peptides. The recombinant...
4870015 Method and composition for producing lectin in microorganisms  
Methods and compositions for the construction of a recombinant vector containing plant or animal lectin DNA sequences, such vector being capable of being replicated, transcribed and translated in...
4868125 Promoter  
Disclosed is a novel promoter wherein a 5' flanking region of a promoter (referred to as promoter A hereinafter) is replaced with a 5' flanking region of another promoter (referred to as promoter...
4867973 Antibody-therapeutic agent conjugates  
This invention relates to antibody-therapeutic agent conjugates having a therapeutic agent covalently attached to an antibody or antibody fragment. Also described are methods for intermediates in...
4868171 Antibiotic A 40926 N-acylaminoglucuronyl aglycons and antiobiotic A 40926 aglycon  
The present invention concerns new antibiotic substances denominated antibiotic A 40926 N-acylaminoglucuronyl aglycon complex AB, antibiotic A 40926 N-acylaminoglucuronyl aglycon factor A,...
4867974 Agent for preventing plant virus diseases  
Agent for preventing plant virus diseases such as tobacco mosaic viruses, potato viruses, cucumber mosaic viruses, etc. of this invention is obtained from a new agent containing polylysine as an...
4868113 Recombinant DNA vector encoding human endothelial cell growth factor  
Endothelial cell growth factor is achieved through the application of recombinant DNA technology to prepare cloning vehicles encoding the ECGF protein and procedures are disclosed for recovering...
4868286 Translation inhibiting peptide  
A peptide that causes a suppression in protein synthesis by halting the translation of mRNA into protein, the peptide having a Stokes radius of less than 16 Angstroms, a molecular weight,...
4868112 Novel procoagulant proteins  
Novel procoagulant proteins are disclosed which comprise the amino acid sequence: A-X-Bwherein region A represents the polypeptide sequence Ala-20 through Arg-759 substantially as shown in Table...
4868287 Inhibition of mineral deposition by polyanionic/hydrophobic peptides and derivatives thereof having a clustered block copolymer structure  
A poly-amino acid compound capable of inhibiting mineral deposition, which has the structure: poly (X)n poly (Y)mwhere each X is a residue independently selected from the group consisting of...
4868119 Hematopoietic growth factors  
A novel family of primate CSF-1-like polypeptides is provided via recombinant techniques.
4866038 Method of stimulating integumental melanocytes by topical application of analogs of alpha-msh  
A method for stimulating integumental melanocytes by the topical application of alpha-MSH analogs, and compositions comprising said analogs for use in the method are described.
4866040 Aminocarnitine directed pharmaceutical agents  
Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e.g. skeletal muscle or the heart. The pharmaceutically active...
4866161 Inhibition of tartar deposition by polyanionic/hydrophobic peptides and derivatives thereof which have a clustered block copolymer structure  
A method of treating a tooth so as to inhibit deposition of a mineral thereon, which comprises contacting the tooth with a mineral deposition inhibitory effective amount of a poly-amino acid...
4865982 Cloned streptomycete gene  
A DNA fragment from Streptomyces sp. which contains the XP55 gene expression unit.
4865970 Method of detecting ribosomal protein antibodies in systemic lupus erythematosus  
This invention provides methods for the diagnosis of systemic lupus erythematosus in patients, the sera of which contain antibodies reactive against ribosomal proteins P0, P1 and P2. A peptide...
4866039 Peptides containing the 18 to 23 residues of vasoactive intestinal peptide, and analogues  
Peptides comprising, in sequence, units selected from the amino acid residues 17 to 24 of VIP, and consisting at least of the amino acid residues 18 to 23, or an analogue thereof wherein one or...
4864017 Novel renin inhibiting peptides having a dihyroxyethylene isostere transition state insert  
The present invention provides novel renin-inhibiting peptides of the formula X-A6 -B7 -C8 -D9 -E10 -F11 -G12 -H13 - I14 -Z, wherein the E10 -F11 moiety is a dihydroxyethylene isostere, X and Z...
4863905 Renin inhibitors II  
The invention concerns novel renin-inhibiting peptides which are modified as isosteres. These peptides are useful for treating renin-associated hypertension and hyperaldosteronism. Processes for...
4863899 Biologically active polypeptides  
Novel biologically active polypeptides, including a new class of transforming growth factor (TGF) polypeptides, which exhibit cell growth promoting properties are disclosed, as well as a process...
4863857 Polypeptide complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known  
A method for determining the amino acid sequence of a polypeptide complementary to at least a portion of an original peptide or protein. In one aspect the method involves: (a) determining a first...
4863900 Method for reducing viral transmission with poly-L-histidine  
A composition for reducing the transmissability of viral infection from a subject infected therewith which comprises a topically applicable, pharmaceutically acceptable carrier and a viricidally...
4863855 Novel cloning vehicles for polypeptide expression in microbial hosts  
Methods and compositions are provided for regulated expression of polypeptides in transformed bacterial hosts. A novel class of plasmid cloning vehicles includes a DNA sequence coding for the...
4863903 Substituted 5-amino-4-hydroxyvaleryl derivatives  
Compounds of the formula ##STR1## in which R1 represents hydrogen or acyl, X1 represents an optionally N-alkylated amino acid residue that is bonded N-terminally to R1 and C-terminally to X2, X2...
4863850 Method for diagnosis of rheumatoid arthritis  
A substantially pure rheumatoid arthritis specific protein (RASP) and an antibody against the rheumatoid arthritis specific protein (anti-RASP antibody) are disclosed. The RASP is found...
4861864 Rotavirus antigens  
A soluble form of the neutralizing antigen or rotavirus is provided. The antigen is formed by cloning DNA coding for VP7 protein into an expression vector and preparing deletion mutants coding for...
4861718 Gene coding for thermostable beta-galactosidase, bacillus subtilis having the gene, enzyme coded by the gene and a process for the production thereof  
A novel gene coding for thermostable β-galactosidase, novel recombinant DNA in which a DNA fragment containing the above gene is inserted, novel Bacillus subtilis in which the above recombinant...
4861707 Human immunodeficiency virus antigen  
A recombinant peptide displaying the antigenicity of Human Immunodeficiency Virus (HIV) viral antigens is disclosed. The peptide comprises an antigenic segment having about 150 to about 400 amino...
4861865 Novel antithrombin peptide  
A novel synthetic peptide with potent antithrombin activity is provided which has the following amino acid sequence: ##STR1##
4861708 Restriction fragment analysis of individuals using cardiovascular system probes  
Polymorphisms in the renin, kallikrein, and ANF gene regions are predictive for hypertension in individual human subjects.
4861755 Peptides with vasorelaxant, natriuretic and diuretic effects a process for their preparation, agents containing them, and their use  
The invention relates to new peptides of the formula ##STR1## in which X, A, B, C, N', E, F, G and Z have the meanings indicated in the description, to a process for their preparation, to agents...