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5476922 Methods and compositions for the preparation and use of autocrine growth factors  
Autocrine growth factors and isoforms of those factors have been identified, isolated, purified and manipulated. Nucleic acid segments coding for the factors, and antibodies directed to the...
5470947 CHRH antagonists with low histamine release  
Antide is the decapeptide, N--Ac--D--2--Nal,D--pClPhe, D--3--Pal, Ser,NicLys, D--NicLys, Leu, ILys, Pro, D--Ala,NH2 which is an antagonist of luteinizing hormone releasing hormone (LHRH). This...
5470970 Maspin, a serpin with tumor suppresing activity  
An isolated DNA encoding a polypeptide substantially identical to maspin (SEQ ID NO:1); a substantially purified preparation of maspin; an antibody specific for maspin; and use of such DNAs and...
5464756 Processes and compositions for the isolation of human relaxin  
A process is provided for cleaving a polypeptide into at least two polypeptide components comprising treating a reduced, free-cysteine form of the polypeptide with a cleaving agent under...
5462925 Transforming growth factor β2,3  
A heterodimeric form of TGF-β is described. This 25 KD molecule is active in an in vitro assay of inhibition of epithelial cell growth. The protein may be isolated from bone. When reduced, the...
5461142 Phosphorylated derivatives of cardiodilatin/ANF peptides  
Described are derivatives of the precursor peptide of the cardiodilatin/atrial sodiuretic factor (CDD-ANF) or fragments thereof which comprise at least the amino acid sequence of alpha-hANaP. The...
5461034 Osteogenic growth polypeptides identified from regenerating bone marrow  
A biochemically pure polypeptide(s), termed osteogenic growth polypeptide (OGP), which exhibits stimulatory effects on osteoblastic cells, in vivo bone formation and hemopoietic reconstruction....
5457046 Enzyme capable of degrading cellullose or hemicellulose  
A cellulose- or hemicellulose-degrading enzyme which is derivable from a fungus other than Trichoderma or Phanerochaete, and which comprises a carbohydrate binding domain homologous to a terminal...
5451521 Procoagulant proteins  
This invention relates to recombinant Factor VIII:c variants, methods to produce the variants and pharmaceutical compositions containing same. The variants of this invention are characterized by...
5446130 Parathyroid hormone antagonists  
Peptide derivatives of the following general formula (I): ##STR1## wherein AAA is deletion or Ser, BBB is deletion or Glu, CCC is deletion, Ile, Phe, Leu, cyclohexylalanine, D-alle or Lys...
5444151 Platelet derived growth factor antagonists  
The invention describes antagonists for PDGF. The antagonists contain amino acids, and may be monomers or dimers. Especially preferred are dimers which bind the PDGF receptors, but prevent...
5441935 Growth factor receptors  
A 75-85 Kd glycopolypeptide, capable of acting as a receptor for polypeptide of the bombesin type, is isolated from the surface of Swiss 3T3 cells. Certain antagonists and antibodies to the...
5439688 Process for preparing a pharmaceutical composition  
A pharmaceutical composition is prepared in the form of microparticles or of an implant comprising a biodegradable polymer selected from poly-1,4-butylene succinate, poly-2,3-butylene succinate,...
5430018 Cyclohexapeptide with basic nitrogen containing alkylamide groups  
Certain aminoalkyl substituted amides which have a cyclohexapeptidyl group and which are found to have antibiotic activity with physical properties suitable for use in therapeutic compositions are...
5430016 Insulin compounds and compositions  
Novel insulin compounds having a desirably protracted insulin action and/or antigenicity are provided.The novel insulin compounds are represented by the formula II: ##STR1## wherein E individually...
5420252 Human antithrombin III mutants  
A novel human antithrombin III (AT III) mutant having a high antithrombin activity in the absence of heparin and effective in the treatment of thrombotic disorders as an anticoagulant, which is...
5420243 Biologically active TGF-β2 peptides  
The invention relates to peptides corresponding to regions of the amino acid sequence of TGF-β1 or TGF-β2 which retain, either in monomeric or polymeric forms, at least some of the biological...
5416195 Polypeptide derivatives of granulocyte colony stimulating factor  
Derivatives of naturally occurring G-CSF having at least one of the biological properties of naturally occurring G-CSF, and a solution stability of at least 35% at 5 mg/ml are disclosed in which...
5414071 Human cytokine IL-9  
Provided by the present invention is a novel cytokine, IL-9, an approximately 144 amino acid protein, characterized by an apparent molecular weight of between 20 to 30 kD and having biological...
5403586 LHRH-TraTp fusion proteins  
This invention relates to the preparation of novel fusion proteins which comprise an analogue of LHRH and TraTp or an analogue of TraTp. The fusion proteins of the invention are useful as...
5399669 Interleukin-2 polypeptides  
Recombinantly produced interleukin-2 exhibits human IL-2 activity, has a molecular weight of about 15,000 daltons, is activity stable at a pH of 2-9 and is resistant to elevated temperatures. The...
5399345 Muteins of the granulocyte colony stimulating factor  
A granulocyte stimulating factor (G-CSF) or a G-CSF variant differs from natural G-CSF in that one or several amino acids of the sequence ##STR1## at position 50 to 56 of the mature G-CSF with 174...
5397772 Vasodilatory peptides from the salivary gland of the sand fly Lutzomyia longipalpis  
Disclosed are proteins derived from the sand fly Lutzomyia longipalpis capable of inducing vasodilation in mammals, and data characterizing the proteins and nucleic acid encoding the proteins....
5397695 Attachment of compounds to polymeric particles using carbamoylonium compounds and a kit containing same  
Useful materials for diagnostic tests, affinity chromatography, enzymatic reactions and immunoassays are prepared by covalently attaching reactive compounds containing reactive amino or sulfhydryl...
5393870 Analogs of human granulocyte-macrophage colony stimulating factor  
Amplified expression of recombinant DNA products is achieved in hosts expressing proteases that cleave at multi-basic amino acid residues. To this end, cDNAs encoding granulocyte-macrophage colony...
5389536 Lipase from Pseudomonas mendocina having cutinase activity  
A substantially enzymatically pure hydrolase is provided which is secreted by and isolatable from Pseudomonas mendocina ATCC 53552. Cloning the gene expressing the hydrolase into a suitable...
5389613 Method of treating prostate adenocarcinoma, prostate benign hypertrophia and endometriosis  
A novel method of treating prostate adenocarcinoma, prostate benign hypertrophia, endometriosis, dysmenorrhea, hirsuitism, hormono-dependant mammary tumors, treatment and prevention of precocious...
5378814 Hepatitis delta viral polypeptides  
The entire genome of the hepatitis D virus has been shown to be a circular single-stranded RNA of 1679 bases. Several open reading frames in both the genomic and complementary strands indicate...
5378805 Immunoreactive HTLV-I/II ENV and POL peptides  
The present invention relates a peptide having specific immunoreactivity to antibodies to HTLV-I, HTLV-II, or combinations thereof comprising a peptide selected from the group consisting of: Env-1...
5376639 Treatment of sarcoma with interleukin 1α polypeptides  
DNAs encoding polypeptides having interleukin 1, vectors inserted with said DNAs, hosts transformed with said recombinant vectors, polypeptides having interleukin 1 activity which are produced by...
5376370 Monoclonal antibody - specific merozoite antigens  
Disclosed herein is a P. falciparum merozoite antigenic polypeptide of approximate molecular weight 185,000. The polypeptide and processing fragments are specific to, and isolable using, a...
5374620 Growth-promoting composition and its use  
A combined formulation for IGF-I and growth hormone (GH) is useful for enhancing growth of a mammal. This formulation, which may be administered by infusion or injection to enhance growth,...
5374518 Monoclonal antibody for differentiating HIV-2 from HIM-1 seropositive individuals  
A mouse monoclonal antibody is provided which detects HIV-2 seropositive individuals and differentiates them from HIV-1 seropositive individuals. The monoclonal antibody is specific for an epitope...
5372933 Polypeptides that mimic receptor-induced binding sites, and methods of using same  
Receptor-induced binding sites (RIBS) expressed in a ligand when that ligand is bound in a complex with a receptor are disclosed, as are polypeptides that correspond in amino acid residue sequence...
5372809 Antigenic matrix metalloproteinase peptides  
A family of metalloproteinases exist which cleave extracellular matrix molecules. These metalloproteinases are secreted in a latent inactive form and require activation in order to specifically...
5373089 Oxytocin antagonist  
A novel compound is disclosed for inhibiting the effects of oxytocin in a female mammal. As an analog of oxytocin the compound is named [(S)PMP1,D-Trp2,Pen6,Arg8 ] oxytocin. This compound can be...
5371184 Radiolabelled peptide compounds  
A diagnostic composition suitable for administration to a warm-blooded animal comprising hirudin or a molecule capable of interacting with the hirudin receptor labeled with a radionuclide by means...
5371193 Mammalian cytokine, IL-11  
A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune...
5370870 Method for protection against reactive oxygen species  
Methods suitable for the protection inhibtion and prevention of the deleterious effects of reactive oxygen species are provided, wherein an effective amount of a protective agent(s) selected from...
5367064 α-1-antichymotrypsin, analogues and methods of production  
The invention provides α-1-antichymotrypsin and protein preparations comprising human α-1-antichymotrypsin produced by E. coli cells transformed with a DNA sequence encoding human...
5364757 Methods of supporting a diagnosis of systemic lupus erythematosus  
The present invention relates to the discovery of a novel retroviral particle associated with autoimmune disease. New methods of diagnosis and treatment of autoimmune disease, novel cell lines...
5360788 Personal care composition containing pyrithione and a basic lipopeptide  
This invention relates to personal care compositions, and, more specifically, to a composition comprising a pyrithione salt or acid, a basic lipopeptide, and a suitable carrier. The pyrithione...
5359034 Cysteine depleted IL-6 muteins  
Muteins of IL-6 and truncated IL-6 are prepared by recombinant DNA techniques. In the muteins, the cysteine residues that occur at positions, or at positions corresponding to positions, 45 and 51...
5359039 Isolated poxvirus A53R-equivalent tumor necrosis factor antagonists  
Isolated viral proteins, and pharmaceutical compositions made therefrom, are disclosed which are capable of binding to Tumor Necrosis Factor, thereby functioning as Tumor Necrosis Factor...
5359035 Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)  
Bifunctional proteins, obtainable by genetic manipulation, composed of an interleukin-2 and a granulocyte macrophage colony stimulating factor constituent have the biological activity of both...
5356772 Process for preparing an improved western blot immunoassay  
The present invention encompasses an improved immunoassay method which involves the simultaneous transfer of multiple antigens onto a single solid support. The antigens which may be utilized by...
5354676 Recombinant modified thermostable NAD-dependent dehydrogenases and process for their production  
A recombinant thermophilic NAD-dependent dehydrogenase having a hydrophobic amino acid at position 104 and/or 102. The enzymes are effective in catalysing the dehydrogenation of homologues of...
5352576 Method of determining the presence and titers of anti HIV-1 ag27bodies  
Disclosed is a method for determining the presence in mammalian serum of antibodies against specific strains of HIV through the use of SP-10 peptides. The method incorporates the use of SP-10...
5350574 Derivatives of cyclosporina A, antibodies directed thereto and uses thereof  
This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reactive group. This invention also provides...
5350671 HCV immunoassays employing C domain antigens  
Immunoassays for the detection of antibodies to HCV are provided which employ "C" domain antigens. Immunoassay kits comprising such antigens are also provided.