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RE35450 Soluble human interleukin-1 receptors, compositions and method of use  
Soluble human Interleukin-1 receptor proteins (shuIL-1Rs) and methods of using shuIL-1Rs to suppress immune or inflamatory responses in a mammal.
5601826 Peptide which produces protective immunity against tetanus  
The invention provides an immunogen against tetanus toxin including a peptide having a single, linear, antigenic, tetanus-toxin-specific epitope. The epitope is derived from the heavy chain C...
5595884 Papillomavirus E2 transactivation repressor proteins and DNA  
This invention relates to E2 trans-activation repressors which interfere with normal functioning of the native full-length E2 transcriptional activation protein of the papillomavirus. This...
5596072 Method of refolding human IL-13  
Nucleic acids encoding human IL-13, and purified IL-13 proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both...
5591827 Interleukin-6 receptor antagonists  
This invention provides a class of interleukin-6 (IL-6) muteins which act as IL-6 receptor antagonists, thereby inhibiting the normal function of naturally-occurring IL-6. These IL-6 receptor...
5585259 Ecotin as a factor Xa, XIa, and XIIa inhibitor  
Pharmaceutical composition containing Ecotin in a therapeutically effective amount for inhibition of blood coagulation.
5585344 Liver-derived receptors for advanced glycosylation endproducts and uses thereof  
The present invention relates to receptors for advanced glycosylation endproducts derived from rat liver membranes, and that specifically comprise proteins determined to possess molecular masses...
5585475 Calmodulin-binding peptides and nucleic acids encoding them  
Peptides capable of binding calmodulin are disclosed. The peptides surprisingly do not exhibit strict α-helical conformations.
5583209 Hybrid human/porcine factor VIII  
A hybrid human/porcine coagulation factor VIII is produced by isolation and recombination of human and porcine factor VIII subunits, or by genetic engineering of the human and porcine factor VIII...
5578708 Bone-associated transcription control factor-like protein  
Bone-associated proteins derived from bone of mammals, including mice and human beings, named OSF-6. The protein is the novel natural type mammal protein, which can play an important role in bone...
5576290 Compositions and methods for the diagnosis and treatment of psychogenic erectile dysfunction  
The present invention is directed to a group of linear and cyclic peptides having the structures: ##STR1## These peptides, when systemically administered to animals will bring about a sexual...
5573924 CD27 ligand  
CD27 ligand (CD27L) polypeptide and DNA sequences, vectors and transformed host cells useful in providing CD27L polypeptides. The CD27L polypeptide binds to the CD27 receptor.
5573935 Protein tyrosine kinase A6  
A novel protein tyrosine kinase (A6) exhibiting no significant similarity to any known kinase. This protein in widely expressed throughout the body and is present in a variety of vertebrates. The...
5574132 Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV)  
This invention relates to novel peptides and mixtures thereof useful for detecting HCV infections. These peptides are also useful as active ingredients in vaccines against HCV infection.
5571893 Cardiac hypertrophy factor  
Isolated CHF, isolated DNA encoding CHF, and recombinant or synthetic methods of preparing CHF are disclosed, These CHF molecules are shown to influence hypertrophic activity and neurological...
5563044 Process for the enzymatic preparation of GRF(1-44)NH2  
GRF(1-44)-NH2 is prepared by the trypsin catalyzed enzymatic coupling of Leu-NH2 to GRF(1-43)-OH. The latter compound may be obtained by recombinant DNA synthesis. Thus the present method provides...
5563121 Peptide linkage unit  
A peptide linkage unit is employed for joining peptide and pseudopeptide sequences, including peptides and pseudopeptides that inhibit aspartic proteinase enzymes. The peptide linkage unit...
5556939 TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications  
Technetium or rhenium radionuclide labelled chelate-hexapeptide complexes are useful for the selective detection or treatment of tumors with somatostatin receptors. In particular, compounds of...
5556836 Use of D-glucopyranuronic acids and their derivatives for incorporation in pharmacologically active peptides and their salts  
Use of 7-amino-L-glycero-L-gulo-2,6-anhydro-7-desoxy-heptonic acid and 2-benzoxycarbonylamino-01 -methyl-2-desoxy-β-glucopyranuronic acid, their derivatives and the enantiomorphous compounds for...
5552521 Process for preparing certain aza cyclohexapeptides  
There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.
5552528 Bovine b-endothelial cell growth factor  
Bovine β-endothelial cell growth factor (β-ECGF) having an apparent molecular weight of 20,000 daltons can be purified at least 16,300 fold from bovine brain using heparin-Sepharose affinity...
5550041 Caffeine demethylate gene-containing DNA fragment and microbial process for producing 3-methyl-7-alkylxanthine  
A DNA fragment containing a caffeine demethylase gene produced by a microorganism belonging to the genus Pseudomonas and capable of assimilating caffeine and a process for producing a...
5550214 Isolated antigenic oncogene peptide fragments and uses  
An isolated antigenic peptide fragment that is an isolated oncogene protein fragment is disclosed. The isolated peptide fragment of the invention is a peptide either 9 or 10 amino acid residues in...
5548061 Human endothelin-3 precursor protein  
Disclosed are (1) a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3, (2) a precursor protein and a mature peptide of endothelin-2 or human endothelin-3, (3) a...
5543497 Genes encoding and method of expressing a novel enzyme: phthalyl amidase  
Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides DNA compounds encoding the...
5543496 Cyclic bradykinin antagonist peptides  
Cyclic compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acid substitutions are made at postions 2 and 5 or 6 to facilitate the cyclization of the...
5532340 Tumor suppressor protein PRB2, related gene products, and DNA encoding therefor  
The invention provides a tumor suppressor protein of the retinoblastoma family (pRb2) which binds to the E1A transforming domain and to DNA encoding for the pRb2 protein.
5529984 Endoparasiticidal compositions based on open-chain hexadepsipeptides  
This invention relates to a method of combatting endoparasites which comprises administering an endoparasiticidally effective amount of a hexadepsipetide of the formula ##STR1## to a human or...
5521156 Cyclic neurokinin A antagonists  
Antagonists of neurokinin A which are novel cyclic hexapeptide and octapeptide compounds are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as...
5519114 Retroviral superantigens, superantigen peptides, and methods of use  
The subject invention concerns novel superantigen proteins and peptides and methods of use of these superantigens. Specifically exemplified are peptide agonists from mouse mammary tumor virus,...
5516656 Production of a new hirudin analog and anticoagulant pharmaceutical composition containing the same  
Provided is a chimeric HV1/HV3 hirudin analog useful as an anti-coagulant, exhibiting higher anti-thrombin activity and less tendency to cause bleeding than hirudin HV1. Also provided are a method...
5516512 N- and C-terminal truncation and deletion mutants of human interleukin-3  
Biologically active deletion and substitution mutants of hIL-3 are provided. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus...
5516759 LHRH antagonists having lactam groups at the N-terminus  
Peptides possessing LHRH antagonistic activity, and useful for the controlling the release of LHRH in mammals are decapeptide analogues of LHRH having a lactam group at the N-terminus of the...
5516757 Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use  
There are disclosed novel semi-synthetic lipopeptides of the formula (Seq. ID Nos. 1-6) ##STR1## wherein the substituents are defined herein, which show utility as antifungal and anti-Pneumocystis...
5512455 Atrial natriuretic peptide receptor protein  
Purified native Atrial Naturetic Peptide (ANP) receptor protein is provided, as well as synthetic ANP receptor and methods of making and using ANP receptor protein and antibodies.
5512661 Multitrophic and multifunctional chimeric neurotrophic factors  
The present invention relates to chimeric neurotrophic factors which comprise at least a portion of a naturally occurring cellular factor and a portion of at least one other molecule such that the...
5512660 Purified ICAM-2 and fragment thereof  
The present invention relates to intercellular adhesion molecules (ICAM-2) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as...
5510458 CRF antagonists  
Disclosed are improved CRF peptide antagonists such as those having the formula: Y-D-Phe-Xaa13 -Leu-Leu-Arg-Xaa17 -Xaa18 -Leu-Xaa20 -Nle-Xaa22 -Xaa23 -Xaa24 -Xaa25 -Xaa26 -Leu-Xaa28 -Xaa29...
5510462 IL-1βprotein precursor  
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically,...
5508176 Recombinant DNA, transformed host microorganism and method for producing a polypeptide having mutarotase activity  
A polypeptide having mutarotase activity is obtained from a host microorganism that has been transformed with a molecule having a recombinant DNA sequence. The molecule having a recombinant DNA...
5506339 Octapeptide analogs of somatostatin having threonine at the sixth position  
A compound of the formula: ##STR1## wherein each A1 and A2, independently, is H, C1-12 alkyl, C7-10 phenylalkyl, R1 CO (where R1 is C1-20 alkyl, C3-20 alkenyl, C3-20 alkinyl, phenyl, naphthyl, or...
5500355 Protease, reverse transcriptase and endonuclease of HIV-1 and RSV method for producing these enzymes  
Disclosed is a method for producing retroviral proteins which are protease, everse transcriptase and endonuclease. The method is characterized by the consecutive expression and processing of...
5494895 Scorpion peptide margatoxin with immunosuppressant activity  
A thirty-nine amino acid peptide, Margatoxin (MgTX), is purified to homogeneity from venom of the scorpion Centruroides margaritatus. The gene encoding MgTX is constructed and this gene is...
5494663 Treatment of microbial infection with interleukin 1 polypeptides  
DNAs encoding polypeptides having interleukin 1, vectors inserted with said DNAs, hosts transformed with said recombinant vectors, polypeptides having interleukin 1 activity which are produced by...
5492813 Muteins of β-galactosidase fragments having increased activity  
Muteins of enzyme acceptor polypeptide fragments of β-galactosidase are provided which exhibit substantially increased kinetic complementation activity with no significant loss in stability. A...
5493006 Cyclic CRF analogs  
Improved CRF peptide antagonists have the formula: ##STR1## wherein R20 is Cys or Glu; R23 is Cys, Lys or Orn; provided that when R20 is Cys, R23 is Cys and when R20 is Glu, R23 is Lys or Orn; or...
5489430 Poultry mycoplasma antigen, gene thereof and recombinant vectors containing the gene as well as vaccines utilizing the same  
A highly effective vaccine for Mycoplasma gallisepticum infection utilizing a substantially pure protein capable of reacting with Mycoplasma gallisepticum immunized serum or Mycoplasma...
5487898 Compositions and method for the sublingual or buccal administration therapeutic agents  
Pharmaceutical compositions for the sublingual or buccal administration of therapeutic agents which are normally degraded upon oral administration comprise such a therapeutic agent, a solvent,...
5484887 Homogeneous interleukin 1  
Interleukin 1 has been purified by use of various techniques including ion exchange chromatography and dye-ligand affinity chromatography. By these techniques, interleukin 1 has been purified to...
5482708 Fusion protein from feline leukaemia virus GP70 as vaccine  
A vaccine against feline leukaemia virus (FeLV) comprises a protein formed of two proteins derived from FeLV gp70 which are not adjacent in the native protein, particularly VR1 and VR5 and...