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5693530 Marek's disease virus nucleotide sequence and methods of use  
A novel nucleotide sequence in the genome of Marek's disease virus (MDV) containing an open reading frame, whose expression is associated with lytic infection and tumor cell development in...
5693612 Cyclopeptides of the formula I  
The invention relates to novel cyclopeptides of the formula I cyclo-(Arg-A-Asp-R1 -R2) Iin which A, R1 and R2 have the meaning given in claim 1, and their salts.These compounds act as integrin...
5691368 Substituted oxazolidine calpain and/or cathepsin B inhibitors  
This invention relates to oxazolidine inhibitors of calpain and/or cathepsin B and to compositions containing them. As inhibitors of calpain and/or cathepsin B, the compounds are useful in the...
5688511 Cellular protein TDP-43 and regulation of HIV-1 gene expression  
Compositions including a polypeptide or nucleic acid sequence encoding a polypeptide that binds TAR DNA (particularly the region -18 to +28 of HIV-LTR DNA) and that does not bind to TAR RNA...
5686577 T cell factors influencing B cell development  
The present invention relates to an isolated protein or polypeptide capable of production by T cells and capable of ultimately activating production of B cells. The present invention further...
5686416 Increasing blood-brain barrier permeability with permeabilizer peptides  
Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or...
5683688 Unglycosylated recombinant human lymphotoxin polypeptides and compositions  
Biologically active lymphotoxin polypeptides are synthesized in recombinant cell culture. Novel nucleic acid and vectors incorporating same are provided. The compositions and processes herein...
5681723 Mutant interleukin 6 with improved biological activity over wild interleukin 6  
The present invention is drawn to mutant interleukin 6, which has the amino acid arginine in position 176, replacing serine in position 176 with wild-type interleukin 6. The mutant interleukin 6...
5681719 DNA encoding N- and C- terminally truncated colony stimulating factor-1 variants  
DNA for new forms of CSF-1 are provided which relate to N-terminal and C-terminal truncations. Specifically, N-∇3 terminal truncations of the short and long forms of CSF-1 have been found to be...
5679548 Methods for producing polypeptide metal binding sites and compositions thereof  
The present invention describes methods for producing metal binding sites on polypeptides, and particularly for producing metal binding sites within the CDR regions of immunoglobulin heavy or...
5679772 Mammalian retinol-binding protein receptors  
Isolated receptors for lipocalins and retinol binding proteins are disclosed, as are nucleic acid sequences coding for these molecules, and antibodies which bind to these receptors. Various uses...
5677149 Interleukin-3 (IL-3) mutant polypeptides and their recombinant production  
Disclosed are recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins) having one to three amino acid substitutions in the core sequence (residues 15-125) of the native (133...
5677419 Cyclic vasoactive peptide analogs  
Analogs of porcine Vasoactive Intestinal Peptide are disclosed. The analogs have been cyclized by the covalent attachment, via an amide bond, of the side-chain carboxy terminus of one amino acid...
5674977 Branched synthetic peptide conjugate  
The invention is a branched synthetic peptide conjugate which can be designed to bind to a target cell surface receptor, to penetrate into target cells, and to deliver a diagnostic probe or...
5672684 Recombinant human rotavirus VP7 serotype 4  
An isolated gene encoding all or part of the VP7 protein of human rotavirus serotype 4 is claimed. Also claimed in a DNA transfer vector which contains the gene or a portion or sub-unit and a host...
5670625 Elk ligand fusion proteins  
elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is...
5670365 Identification of, and uses for, nematicidal bacillus thuringiensis genes, toxins, and isolates  
Disclosed and claimed are novel nucleotide primers for the identification of genes encoding toxins active against nematodes and coleopterans. The primers are useful in PCR techniques to produce...
5668108 Preparation of functional human factor VIII and pharmaceutical treatment therewith  
Functional human factor VIII produced recombinantly is used in the treatment of human beings diagnosed to be deficient in factor VIII coagulant activity. Also provided are DNA isolates and...
5665346 Human interleukin-8 analogs  
The present invention provides human interleukin-8 (IL-8) analogs that are modified in the Glu4 Leu5 Arg6 region, and have a core structure corresponding to the IL-8 (7-51) sequence are provided....
5665870 Method of purifying keratinocyte growth factor (KGF)  
Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of...
5663292 Cyclic CRF analogs  
Improved CRF antagonist peptides have the formula: ##STR1## wherein R30 is Cys or Glu; R33 is Cys, Lys or Orn; provided that when R30 is Cys, R33 is Cys and when R30 is Glu, R33 is Lys or Orn. The...
5661007 Bone morphogenetic protein-9 compositions  
Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed, The proteins may be used in the treatment of bone and cartilage defects and in wound healing...
5661129 Organic nitrates containing a disulfide group as cardiovascular agents  
The invention relates to novel nitrates containing a disulphide group, and to processes for their preparation. The compounds can be used for the therapy of disorders of the cardiovascular system.
5656596 Method of treating lesions in a nervous system  
The invention relates to a neurite-promoting factor released by glial cells, to related proteins and fragments thereof retaining their neurite-promoting activity, to DNAs coding for the amino acid...
5652338 Neutrophil chemotactic factor  
An isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA...
5651963 Heterodimers forms of CSF-1 and pharmaceutical compositions thereof  
The present invention relates to the production of CSF-1 heterodimers and pharmaceutical formulations of the heterodimers. The heterodimers can be formed using CSF-1 monomers that have variations...
5650492 P-40 homodimer of interleukin-12  
Analysis of the culture media of p40-transfected COS cells indicated the presence of 40 kDa monomers and 80 kDa disulfide-linked homodimers. Examination of partially purified p40 recombinant...
5650495 Protein having an affinity for a heparin-binding growth factor  
An isolated protein having the amino terminal sequence of SEQ ID No. 1 and having a molecular weight of about 200 KDa is described. This animal brain-derived protein binds to OSF-1 (HBGF-8), which...
5646244 Cyclodepsipeptide compound  
A compound of the formula: ##STR1## wherein A is benzyl group which has suitable substituent (s), Aa, B and D are each lower alkyl, C is hydrogen or lower alkyl,or a salt thereof.The compound or...
5643876 Biologically active synthetic magainin peptides  
A class of broad spectrum bioactive polypeptides termed "Magainin" have been described. These peptides have a molecular weight of about 2500 or less, are highly water soluble, amphiphilic and...
5643754 Nucleic acids encoding a leptospira outer membrane protein  
An antigenic preparation is provided which contains a 63 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism. Also...
5643877 Compounds comprising gonadotropin releasing hormone (GnRH) and methods for controlling reproduction in fish  
Novel peptide hormones which influence the release of gonadotropins by the pituitary gland in fish are disclosed. Methods in which such peptides may be administered to fish to control their...
5639638 DNA molecules encoding bone morpogenetic protein-11  
Purified Bone Morphogenetic Protein-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be...
5637488 HIV protease gene and method for its expression  
The invention is a synthetic DNA sequence for encoding a specific enzyme or protease. The protease is essential for the completion (replication) of an infective human immunodeficiency virus (HIV)....
5637480 DNA molecules encoding bone morphogenetic protein-10  
Purified Bone Morphogenetic Protein-10 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used...
5633150 Preparation of functional human factor VIII  
Functional human factor VIII produced recombinantly is used in the treatment of human beings diagnosed to be deficient in factor VIII coagulant activity. Also provided are DNA isolates and...
5633263 Linear somatostatin analogs  
Linear peptide analogs of somatostatin having the formula: ##STR1## As an example, D-Phe-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr is covered by the above formula (i.e., R1 is H, R2 is H, A1 is D-Phe, A2 is...
5633227 Secretory leukocyte protease inhibitor as an inhibitor of tryptase  
This invention concerns methods of treating mast-cell mediated conditions in mammals, the methods comprising administering to the mammals pharmacologically active fragments or muteins of SLPI;...
5633230 Treatment of cytomegalovirus infection  
Described herein are anti-cytomegalovirus peptides. In a preferred embodiment, the peptide is acetyl-[D-Arg]9 -NH2. The use of these peptides, either per se or in combination with other anti-CMV...
5629176 Human Kunitz-type protease inhibitor variants  
A variant of the C-terminal Kunitz-type protease inhibitor domain of the α3 chain of human type VI collagen, the variant comprising the following amino acid sequence X1 X16 Asp Ile Cys Lys Leu Pro...
5627267 Cytokine designated elk ligand  
elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is...
5618913 Insulin analogues  
Novel rapid-acting human insulin analogues are provided having less tendency to self-association into dimers, tetramers, hexamers, or polymers. The novel human insulin analogues are formed by...
5618696 Human kunitz-type protease inhibitor and variants thereof  
The present invention relates to a human Kunitz-type protease inhibitor comprising the following amino acid sequence Asp Leu Leu Pro Asn Val Cys Ala Phe Pro Met Glu Lys Gly Pro Cys Gln Thr Tyr Met...
5618789 Functional human factor VIII  
Functional human factor VIII produced recombinantly is used in the treatment of human beings diagnosed to be deficient in factor VIII coagulant activity. Also provided are DNA isolates and...
RE35492 Wound treatment employing biologically active ion channel forming peptides and proteins  
A process for treating a wound in a host which comprises administering to the host having a wound at least one biologically active amphiphilic peptide. The peptide is an ion channel-forming...
5616494 Thermus aquaticus DNA polymerase lacking the n-terminal 235 amino acids of taq DNA polymerase  
A vector which includes nucleic acid which encodes a DNA polymerase having an identical amino acid sequence to that of the DNA polymerase of Thermus aquaticus termed Taq DNA polymerase, except...
5610278 Process for producing a coagulation active complex of factor VIII fragments  
A coagulation active complex of Factor VIII fragments is produced by causing coagulation inactive FVIII heavy chain to react with coagulation inactive FVIII light chain in the presence of a...
5605884 Factor VIII formulations in high ionic strength media  
Stable, highly purified Factor VIII protein formulations are provided in high ionic strength media which comprises: sodium chloride, potassium chloride or mixtures thereof; calcium chloride; and...
5604293 Recombinant human basic fibroblast growth factor  
The DNA sequences encoding human and bovine acidic and basic fibroblast growth factors (FGF) can be recombinantly expressed to obtain practical amounts of proteins useful in effecting wound...
5601973 Seroreactive regions on HPV 16 proteins E1 and E2  
The invention relates to seroreactive regions on proteins E1 and E2 of human papillomavirus (HPV) 16.The application also relates to a vaccine which contains such peptides which contain the...