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8173859 |
Epilepsy model animal
An epilepsy model animal (CHRNA4:S284L) developing spontaneous epileptic seizure during sleep, which is a nonhuman animal established by ontogenesis of a totipotent cell into which a polynucleotide...
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8173861 |
Transgenic pig model for a hereditary neurodegenerative autosomal dominant disease
The present invention discloses a non-human animal model for a hereditary autosomal dominant disease. The non-human animal model expresses at least one phenotype associated with the disease and is...
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8119854 |
Role of proteoglycans in drug dependence
The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may...
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8076532 |
Transgenic mouse defective in WW45 function and use in screening compounds for anti-tunour activity
Mechanisms regulating cell proliferation stop and differentiation initiation during the development stage of mammalian embryo, and the proteins involved therein, are presented. Differentiation...
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8067666 |
Model animal causing the white hair development and methods relating thereto
A model rodent animal with a phenotype in which hair growing after birth is black, with the animal spontaneously developing white hair after aging. By way of example, the model rodent animal may...
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8058502 |
Increasing lifespan by modulation of WWP-1 and UBC-18
Ubiquitin ligase wwp-1 and ubiquitin conjugating enzyme ubc-18 are identified in nematodes as mediators of dietary restriction induced longevity and therefore as targets for modulation of lifespan...
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8012456 |
Biological models capable of exhibiting secondary disease manifestations and useful for developing therapeutic drugs, diagnostic products and therapeutic or diagnostic procedures, methods of using same, and cells, tissues and organs derived therefrom
This invention provides novel animal models for a human pathogen that is capable of exhibiting analogous secondary disease manifestation. Other animal models for a human pathogen are provided by...
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7989675 |
Method of identifying compounds using a transgenic pig model of cystic fibrosis
The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of...
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7973211 |
Animal model for hyperpigmentation
An animal model for hyperpigmentations in which the formation of hyperpigmentations in human skin is faithfully simulated is provided. An animal model for hyperpigmentations, wherein a black...
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7968762 |
Immune-compromised transgenic mice expressing human hepatocyte growth factor (hHGF)
A transgenic animal model for evaluating growth, survival and/or metastasis of xenotransplanted normal or tumor cells or tissue is disclosed, in which a human growth factor, hHGF stimulates growth...
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7960606 |
Mouse model of chronic heart failure and coronary atherosclerosis regression
An animal model has been developed where the animals can survive myocardial infarctions caused by diet-induced coronary atherosclerosis, and live with chronic heart failure. This animal model is a...
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7931902 |
Gene disruptions, compositions and methods relating thereto
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
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7919673 |
Transgenic pig with altered incretin function
The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor....
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7902421 |
Animal model for schizophrenia
The invention is an animal model which exhibits neuropathological and behavioral features associated with human schizophrenia. The invention also encompasses an in vivo method of preparing an...
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7897834 |
Mutation in the rat adenomatous polyposis coli gene within the human mutation hotspot region
A rat with a disrupted Apc (adenomatous polyposis coli) gene is provided. The mutation can include an A to T transversion changing a lysine to a stop codon at codon 1137. Methods of generating the...
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7897833 |
Animal model for pigment spots
An animal model for pigment spots in which the formation of pigment spots in human skin is faithfully simulated is provided. An animal model for pigment spots, wherein a black person's skin is...
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7884260 |
Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination
This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or...
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7863499 |
Model of infantile spasm syndrome
Provided are non-human mammals treated with doxorubicin, lipopolysaccharide (LPS), and p-chlorophenylalanine (PCPA), where the mammal exhibits a symptom characteristic of infantile spasms. Also...
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7847147 |
Mouse developing visceral fat type obesity and diabetes
An object of the present invention is to provide a mouse which has the characteristics of early developing visceral fat type obesity and also has concurrent diabetes and hyperlipemia and in which...
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7847148 |
Oasis gene-deficient mouse
A mouse that is deficient in the function of the gene for OASIS, and a method for screening for, or evaluating a pharmacological efficacy of, therapeutic agents for osteoporosis using the mouse.
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7847146 |
Model for neurodegenerative disorders
The present invention discloses a double transgenic fly that expresses both Tau protein and the human Aβ42 peptide of human amyloid-β precursor protein (APP). The double transgenic flies of the p...
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7795495 |
Transgenic mice for screening for inhibitors of protein aggregation and methods for making and using them
The methodologies of the present invention demonstrate that a critical balance between pro- and anti-amyloidogenic molecules exists that regulates amyloid formation and cell death in Alzheimer's...
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7772458 |
Animal model for chronic obstructive pulmonary disease and cystic fibrosis
A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter ...
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7767879 |
Transgenic animal model of neurodegenerative disorders
The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology...
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7745690 |
Transgenic nonhuman mammal representing the pathologic conditions of human rheumatoid arthritis
It is intended to provide a transgenic nonhuman mammal well representing the pathologic conditions of human rheumatoid arthritis. A transgenic nonhuman mammal is obtained by transferring a foreign...
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7705199 |
Compositions and methods for treatment of autoimmune and related diseases
Compositions and methods are provided for treatment of autoimmune and other related diseases. 3d, a point mutation of the protein uncoordinated-93b (unc-93B), unc-93A, unc-93B, and unc-93C,...
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7700824 |
Methods
A non-human animal which has a reduced amount of functional TAZ polypeptide and/or TAZ-like polypeptide, or a reduced amount of nucleic acid encoding said polypeptide. A method for generating a...
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7652191 |
Nonhuman mammals exhibiting PTSD-like behavior
The invention relates to production of maladapted animals characterized by PTSD like behavior from a population by behavioral conditioning. The method includes determining a baseline behavioral...
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7638679 |
Tolerance and chronic hepatitis C virus
This invention provides a model for the induction of immunological tolerance to antigens. The tolerance model of the invention can be used for screening candidate drugs effective in modulating...
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7638678 |
Animal model for perimenopause and menopause and methods of inducing ovarian failure
The present invention relates to an animal model for human perimenopause and menopause. Also provided by the present invention are methods of making the animal model and methods of screening using...
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7625549 |
Determining the risk of human anti-human antibodies in transgenic mice
The present embodiments relate to methods of identifying and creating human or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are...
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7560609 |
Diabetic model
The invention relates to an animal model for diabetes and a method for obtaining said animal model. The invention also relates to the uses of the animal model for screening for or testing compounds...
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7554003 |
Invertebrate animal model with neurodegenerative phenotype for screening and testing substances
The present invention claims an invertebrate animal that has been modified to express a set of genes, the set comprising the gene coding for a modified version of the gamma subunit of AMP-activated...
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7531714 |
Melusin a muscle specific protein, as a drug target for prevention and treatment of heart failure
The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be...
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7514592 |
Inducible heart attack animal model
An animal model of coronary heart disease has been developed where myocardial infarct can be induced by altering the animal's diet. In all embodiments, this animal model is a result of reduced...
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7514594 |
Transgenic animal model of bone mass modulation
The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing...
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7507871 |
Rat model of diabetic nephropathy
A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound's effect of diabetic nephropathy is disclosed. In one embodiment,...
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7495147 |
Neuregulin-1 transgenic mouse and methods of use
Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides;...
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7465269 |
Bone growth stimulator
A bone growth stimulator is provided. In one embodiment, the device has an elliptically shaped transducer coil. The coil provides increased therapeutic benefit to a wearer. An elliptically shaped...
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7462757 |
Animal with gene hypoexpression
The present invention relates to non-human animal embryonic stem cells in which a lecithin:cholesterol acyltransferase-like lysophospholipase endogenous gene is inactivated; non-human animals...
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7459602 |
Mammalian cancer cell and transgenic mammal carrying human protooncogene and kit for diagnosing cancer using said protooncogene
The present invention provides a mammalian cell transfected with an expression vector comprising a human protooncogene which has the nucleotide sequence of SEQ ID NO: 1; a mammalian embryo carrying...
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7439415 |
Population of Hoxb8 mutants and uses in identifying agents for treating repetitive behaviors
This invention provides in vivo and in vitro methods of screening for an agent or a combination of agents that reduces one or more repetitive behaviors, comprising contacting neuronal cells of an...
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7420100 |
Methods and compositions relating to HDAC 4 and 5 regulation of cardiac gene expression
The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically,...
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7417175 |
Interstitial prostatism model animal
The present invention provides an animal model for prostatic stromal hyperplasia, and a method for screening for a substance effective for preventing/treating human benign prostatic hyperplasia...
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7414169 |
Therapeutic and diagnostic tools for impaired glucose tolerance conditions
Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for...
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7402727 |
Non-human animal exhibiting bone metastasis of tumor cells
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for...
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7402728 |
Transgenic mice expressing human CD20 and/or CD16
The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and/or preferably CD16.
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7399900 |
Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene
The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and...
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7355093 |
Model animal with overexpression of regucalcin
The present invention provides an animal model which overexpresses regucalcin, a calcium-binding protein that is inherently expressed in the liver and the like of the higher animal, and which is...
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7342146 |
Neurodegenerative non-human transgenic mammal expressing TrkA fusion protein
The present invention provides a neurodegenerative, non-human transgenic mammal whose cells contain a TrkA-hFc transgene for encoding at least a TrkA fusion protein and the use thereof.
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