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7560609 |
Diabetic model
The invention relates to an animal model for diabetes and a method for obtaining said animal model. The invention also relates to the uses of the animal model for screening for or testing compounds...
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7554003 |
Invertebrate animal model with neurodegenerative phenotype for screening and testing substances
The present invention claims an invertebrate animal that has been modified to express a set of genes, the set comprising the gene coding for a modified version of the gamma subunit of AMP-activated...
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7531714 |
Melusin a muscle specific protein, as a drug target for prevention and treatment of heart failure
The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be...
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7514594 |
Transgenic animal model of bone mass modulation
The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing...
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7514592 |
Inducible heart attack animal model
An animal model of coronary heart disease has been developed where myocardial infarct can be induced by altering the animal's diet. In all embodiments, this animal model is a result of reduced...
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7507871 |
Rat model of diabetic nephropathy
A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound's effect of diabetic nephropathy is disclosed. In one embodiment,...
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7495147 |
Neuregulin-1 transgenic mouse and methods of use
Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides;...
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7465269 |
Bone growth stimulator
A bone growth stimulator is provided. In one embodiment, the device has an elliptically shaped transducer coil. The coil provides increased therapeutic benefit to a wearer. An elliptically shaped...
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7462757 |
Animal with gene hypoexpression
The present invention relates to non-human animal embryonic stem cells in which a lecithin:cholesterol acyltransferase-like lysophospholipase endogenous gene is inactivated; non-human animals...
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7459602 |
Mammalian cancer cell and transgenic mammal carrying human protooncogene and kit for diagnosing cancer using said protooncogene
The present invention provides a mammalian cell transfected with an expression vector comprising a human protooncogene which has the nucleotide sequence of SEQ ID NO: 1; a mammalian embryo carrying...
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7439415 |
Population of Hoxb8 mutants and uses in identifying agents for treating repetitive behaviors
This invention provides in vivo and in vitro methods of screening for an agent or a combination of agents that reduces one or more repetitive behaviors, comprising contacting neuronal cells of an...
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7420100 |
Methods and compositions relating to HDAC 4 and 5 regulation of cardiac gene expression
The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically,...
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7417175 |
Interstitial prostatism model animal
The present invention provides an animal model for prostatic stromal hyperplasia, and a method for screening for a substance effective for preventing/treating human benign prostatic hyperplasia...
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7414169 |
Therapeutic and diagnostic tools for impaired glucose tolerance conditions
Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for...
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7402728 |
Transgenic mice expressing human CD20 and/or CD16
The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and/or preferably CD16.
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7402727 |
Non-human animal exhibiting bone metastasis of tumor cells
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for...
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7399900 |
Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene
The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and...
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7388124 |
Non-traumatic model for neurogenic pain
A method for producing a non-human mammalian model for neurogenic pain is provided, which includes altering a peripheral nerve of a non-human mammal by non-surgically placing a gel substance into...
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7355093 |
Model animal with overexpression of regucalcin
The present invention provides an animal model which overexpresses regucalcin, a calcium-binding protein that is inherently expressed in the liver and the like of the higher animal, and which is...
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7342146 |
Neurodegenerative non-human transgenic mammal expressing TrkA fusion protein
The present invention provides a neurodegenerative, non-human transgenic mammal whose cells contain a TrkA-hFc transgene for encoding at least a TrkA fusion protein and the use thereof.
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7332645 |
IL-21 as a regulator of immunoglobin production
A transgenic mouse is disclosed herein whose somatic and germ cells comprise a disrupted IL-21 receptor gene, the disruption being sufficient to inhibit the binding of IL-21 to an IL-21 receptor,...
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7332644 |
Non-human animal model of oligodendrocyte developmental disorder
The objects of the present invention is to provide a preventive method for the progress of neuropsychiatric disorders, a therapeutic agent for neuropsychiatric disorders, a screening method...
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7323616 |
Genetically altered mice deficient in functional caspase-9
The invention relates to genetically manipulated animals that are deficient in the expression of Caspase-9, a protein involved in programmed cell death. The invention further relates to methods for...
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7309812 |
Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses
The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and an amyloid encoding...
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7309810 |
Nonhuman model animal suffering from Guillain-Barré syndrome and/or fisher syndrome
The present invention intends to provide a non-human animal model of Guillain-Barré syndrome, which can be obtained by immunizing FcγRIIB-gene-deficient non-human animal with ganglioside GQ1 b ,...
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7276644 |
Transgenic mouse comprising a myosin heavy chain atpase loop 1 mutation
The invention provides a transgenic mouse that is a model for myocardial function. Also provided are methods for using the transgenic mouse model to study heart muscle, cardiac disease and identify...
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7273964 |
Non-human transgenic animals for the study of neurodegenerative syndromes
A non-human transgenic animal that is transgenic for an antibody or fragments thereof and having a phenotype reminiscent of human pathology. The human pathology includes neurodegenerative...
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7273963 |
Malarial animal model having a chimeric human liver
The present invention features a non-human animal model of malaria, e.g., Plasmodium , particularly Plasmodium falciparum . The model is based on a non-human, immunocompromised transgenic animal...
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7265259 |
GSK-3β expressed in a transgenic mouse
A transgenic animal in which GSK-3β protein is over-expressed is useful as a model for neurodegenerative disease.
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7259289 |
MCH1R deficient mice
The present invention features viable MCH1R deficient mice. MCH1R deficient mice contain an alteration in one or both MCH1R alleles that substantially reduces expression of a functional MCH1R from...
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7253333 |
Drosophila strain carrying bradeion gene(s) transferred thereinto
Provided is a special Drosophila strain having a Bradeion gene artificially incorporated therein to exclusively express the gene in the compound eyes and thus to exhibit rough eye. The ...
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7235709 |
Transgenic animals with increased slow-twitch muscle fibers and methods of using such animals
Transgenic non-human mammals over-expressing MHCI in skeletal muscle are provided herein, as are methods of using these transgenic non-human mammals for screening candidate compounds for treating...
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7220891 |
Feline bronchioloalveolar lung carcinoma xenograft and cell line
The present invention provides feline transplantable lung carcinoma xenografts and cell lines. Such xenografts and cell lines exhibit a number of unique characteristics which allows their use in...
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7220890 |
Chimeric mouse model for endometriosis
A non-human animal model for endometriosis is provided as well as methods of making and using the animal.
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7202393 |
Mouse model for Type II diabetes
The present invention relates to a Type II diabetes model mouse, having a causative gene responsible for the following characteristics (1) to (3) in the heterologous or homologous state, wherein...
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7186882 |
Transgenic mouse over-expressing calreticulin (CRT) in vascular smooth muscle cells
A transgenic mouse whose genome comprises a transcriptional control region operably linked to a cDNA encoding calreticulin (CRT) is described.
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7166763 |
Mouse model of myxomatous valvular disease
An animal selected for lacking heparan sulfate 3-O-sulfotransferase-1 activity is provided. This animal exhibits characteristics associated with myxomatous valvular disease and is useful for...
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7166762 |
Method of constructing heart failure model animal
A non-human mammal which is usefully and effectively applicable to the screening of a substance to be employed for preventing and treating heart failure. This animal is an animal model of heart...
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7166761 |
Method of screening PTPζ activity promoter or inhibitor
An object of the present invention is to provide a remedy for dysfunction of central monoamine pathway, a method for screening a PTPζ inhibitor or activator, and a non-human model animal being...
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7161059 |
Human hookworm model and method for maintaining human hookworm in a non-human primate
A method for maintaining a human hookworm strain is provided by infecting a non-human primate with a non-adapted or non-passaged human hookworm and maintaining the non-human primate. Methods of...
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7135609 |
Non-human animal exhibiting bone metastasis of tumor cells and method of screening for bone metastasis inhibitors
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for...
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7135607 |
Goodpasture's syndrome model mouse
The present invention provides a non-human model animal of Goodpasture's syndrome that contributes to the treatment of Goodpasture's syndrome where the development of therapy had been delayed due...
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7122714 |
Mouse models of human prostate cancer
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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7119249 |
Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The...
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RE39337 |
Nude mouse model for human neoplastic disease
A nude mouse model for human neoplastic diseases having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the...
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7112716 |
Methods for screening and identifying host pathogen defense genes
Disclosed are methods for identifying nematodes having enhanced susceptibility to a pathogen; for identifying pathogen defense response genes; and for identifying compounds that enhances a host's...
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7107092 |
Methods for diagnosing a neurodegenerative condition
A method of diagnosing, prognosing, staging, and/or monitoring a mammalian amyloidogenic disorder or a predisposition thereto by detecting a protein or polypeptide aggregate in the cortical and/or...
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7098377 |
IEX-1 knockout animals
The invention provides methods and materials related to animals having a disrupted IEX-1 sequence. For example, the invention provides homozygous knockout (IEX-1 −/− ) animals and heterozygous...
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7098374 |
Human disease modeling using somatic gene transfer
This invention provides a system for modeling neurodegenerative and other diseases through somatic gene transfer. In addition, methods of multiple gene transfer, disease analysis and drug testing...
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7098373 |
IL-18 transgenic animal
Transgenic non-human mammals comprising a DNA with an exogenous IL-18 gene incorporated in it such that the exogenous IL-18 gene is skin-specifically expressed, or their offsprings. The transgenic...
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