Matches 151 - 200 out of 248 < 1 2 3 4 5 >
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6194633 Non-human animal having a functionally disrupted SLP-76 gene  
A nonhuman animal having somatic and germ cells in which at least one allele of an endogenous SLP-76 gene is functionally disrupted is provided. The animal may be heterozygous or, more preferably,...
6187991 Transgenic animal models for type II diabetes mellitus  
The generation of transgenic animal models for testing various treatments of Type II Diabetes Mellitus are described. The DNA construct allows pancreatic β cell-specific expression of human islet...
6180849 Trangenic mice with a disruption in the tiar gene  
The invention features transgenic non-human mammals containing a mutation in one or both alleles of the endogenous TIAR gene, and cell lines derived from some of these mammals. The mammals and cell...
6177610 Major basic protein deficient animals  
Major basic protein deficient non-human mammals that contain an inactivated major basic protein allele are described. A nucleic acid construct including an inactivated major basic protein gene is...
6172278 Ikaros transgenic cells and mice  
Transgenic cells, transgenic mice having an Ikaros transgene and methods for the use thereof.
6166287 Corticotropin-releasing factor overproducing transgenic mice  
In accordance with the present invention, there are provided CRF overproducing transgenic mice which exhibit endocrine abnormalities involving the hypothalamic-pituitary-adrenal axis, such as...
6156952 HIV transgenic animals and uses therefor  
The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further...
6137029 PEPCK-insulin gene construct and transgenic mouse  
The chimeric gene is directed by a promoter or fusion of promoters which preferably are regulable and activated by the diabetic process. Preferably, it is obtained by fusion of the human insulin...
6127598 NKX-2.2 and NKX-6.1 transgenic mouse models for diabetes, depression, and obesity  
The present invention features mouse models for Nkx-2.2 gene function and for Nkx-6.1 gene function, wherein the transgenic mouse is characterized by having a defect in Nkx-2.2 gene function or a...
6111166 Transgenic mice expressing human Fcα and β receptors  
Transgenic animals expressing Fc receptors and uses for the animals in testing the efficacy of human antibodies and in generating novel antibodies are described.
6096876 1-α-hydroxylase materials and methods  
The invention is directed to polynucleotides encoding all or a fragment of the P450 moiety of vitamin D1 α-Hydrdoxylase and polypeptides encoded thereby. It encompasses antibodies to the...
6091000 SCID mouse engrafted with human synovium tissue  
The present invention relates, in general, to severe combined immunodeficiency disease (SCID) mice yand, in particular, to SCID mice engrafted with synovium and the methods of using same.
6087555 Mice lacking expression of osteoprotegerin  
Disclosed is a mouse in which expression of the gene encoding Osteoprotegerin is suppressed. Also disclosed is a nucleic acid construct useful in preparing such a mouse, and a cell line containing...
6080911 Mice models of growth hormone insensitivity  
The present invention provides mouse models of growth hormone insensitivity including Laron syndrome. In particular, the present invention provides transgenic mice incapable of expressing...
6066778 Transgenic mice expressing APC resistant factor V  
The present invention relates to compositions and methods for the screening of compounds for anticoagulant activity. In particular, the present invention relates to non-human transgenic animals...
6060642 Serotonin 5-HT6 receptor knockout mouse  
The present invention features transgenic mice models for gene function, wherein the transgenic mice are characterized by having altered serotonin 5-HT6 receptor gene function. The transgenic mice...
6054116 Chimeric mouse for human and mouse immune systems  
This invention is directed to a chimeric mouse capable of mounting murine cellular and humoral immune response, where the chimeric mouse is tolerant of human tissue implanted therein. The chimeric...
6040172 Defective DNA viral vector comprising a neural tissue-specific promoter for in vivo expression of a gene  
A replication defective DNA viral vector that comprises a gene of interest encoding a protein having a demonstrated therapeutic effect on a host cell is disclosed. The vector comprises the gene in...
6040495 Hairless mouse sensitive to helicobacter pylori  
A hairless mouse designated NS:Hr/ICR is sensitive to H. pylori. This NS:Hr/ICR hairless mouse can be easily infected with H. pylori in its alimentary canal, and is therefore useful as an...
6037521 Transgenic mouse expressing an β-Amyloid transgene  
The invention relates to an animal model of human Alzheimer's disease that is useful for determining the mechanism of the disease and for developing and testing potential therapeutic drugs. More...
6034297 In vivo, animal model for expression of hepatitis C virus  
Disclosed is a method for expressing hepatitis C virus in an in vivo, animal model. Viable, hepatitis C virus-infected, human hepatocytes are transplanted into a liver parenchyma of a scid/scid...
6031150 Sulfonylurea receptor trangenic rodents  
The present invention is directed to a method of detecting persistent hyperinsulinemic hypoglycemia of infancy comprising obtaining a sample comprising patient nucleic acids from a patient tissue...
6030806 Human chromosome 16 genes, compositions, methods of making and using same  
In accordance with the present invention, there are provided isolated nucleic acids encoding a human netrin, a human ATP binding cassette transporter, a human ribosomal L3 subtype, and a human...
6028245 Transgenic animals overexpressing MDM2  
The present invention relates to transgenic, non-human animals overexpressing a MDM2 gene. These animals model MDM2 over-expression associated with human tumors, display a major phenotype...
6018096 Animal model for engraftment, proliferation and differentiation of human hematopoietic stem cells  
A chimeric, non-human, genetically-immunocompetent mammal is disclosed. The hematopoietic system of the mammal has human passaged bone marrow stromal cells and human hematopoietic stem cells...
6013858 Mouse lacking heart-muscle adenine nucleotide translocator protein and methods  
Provided are transgenic mice genetically engineered for a deficiency of the heart-skeletal muscle isoform of the adenine nucleotide translocator protein (Ant1). These mice exhibit histological,...
6008435 Detecting cow, sheep and human prions in a sample and transgenic mice used for same  
Transgenic animals are produced which animals have (1) their endogenous PrP gene ablated; and (2) have an exogenous PrP gene from a genetically diverse animal. The transgenic animal is preferably a...
6002067 Transgenic mouse model for iduronidase deficiency and methods of making and using same  
A mouse which is homozygous for a disruption in the IDUA gene, but which has normal expression for the SAT-1 gene can be used for evaluating therapeutic agents for use in treating...
5985243 Mouse model for Helicobacter pylori infection  
A mouse model for Helicobacter pylori infection prepared by infecting a euthymic mouse with a dose of bacteria freshly isolated from an infected human.
5986171 Method for examining neurovirulence of polio virus  
The present invention relates to a method of examining the neurovirulence of a polio virus, which comprises inoculating a polio virus into the spinal cord of a transgenic mouse comprising a gene...
5965787 HLA-DRBI peptides with specific binding affinity for HLA-DQ molecules: prevention and treatment of rheumatoid arthritis  
Disclosed are transgenic mice carrying a human HLA-DQ sgene. The transgenic mice are deficient in mouse H-2 class II molecules. Such mice provide animal model systems to identify peptides useful...
5948952 Xeroderma pigmentosum-deficient mouse  
An Xeroderma pigmentosum-deficient mouse, as well as methods for screening for the damaging and tumorigenic effect of ultraviolet light or a chemical DNA damaging agent, are disclosed.
5948951 DNA vector for bone-specific gene expression  
An expression vector for use in producing transgenic animals and cell lines, the expression vector comprising a portion of the 5' flanking sequence of the human osteocalcin gene and a portion of...
5945576 Mouse model of psoriasis  
Methods and compositions for preparing a mouse model of an inflammatory skin condition are disclosed. The methods involve administering donor lymphocytes to a recipient immune deficient mouse to...
5939400 DNA vaccination for induction of suppressive T cell response  
A pro-inflammatory T response is specifically prevented by the injection into a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells...
5932780 Transgenic non-human animal assay system for anti-cholinesterase substances  
The present invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding the novel forms of human AChE have been...
5929299 Helicobacter pylori-colonized mongolian gerbils, method for preparation thereof, and method for screening anti-Helicobacter pylori substance using them  
Helicobacter pylori-colonized Mongolian gerbils prepared by oral inoculation of a broth culture obtained from a liquid culture of Helicobacter pylori, to the Mongolian gerbils for intragastric...
5917123 Transgenic mice containing a nucleic acid encoding tumor necrosis factor-α under the control of a cardiac specific regulatory region  
The present invention provides transgenic nonhuman mammals that exhibit elevated levels of tumor necrosis factor alpha in myocardium relative to nontransgenic control mammals, and methods for...
5885772 Method for the detection of anencephaly  
The invention includes methods and materials, including probes, to be used as diagnostic tools for detecting anencephaly. Such methods may be practiced by both manual and automated means, and in...
5877399 Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease  
Provided is a transgenic non-human eukaryotic animal whose germ cells and somatic cells contain the amyloid precursor protein sequence introduced into the animal, or an ancestor of the animal, at...
5877396 Mice mutant for functional Fc receptors and method of treating autoimmune diseases  
Disclosed herein is a non-naturally occurring non-human vertebrate animal incapable of expressing a functional Fc receptor which may optionally be capable of expressing a protein which comprises a...
5869718 Homologous recombination for animal model exhibiting reduced levels or elimination of a neuronal intermediate filament protein  
Transgenic non-human mammals and methods of preparing such mammals are disclosed. Homologous recombination is employed to inactivate genes, particularly genes coding for neuronal intermediate...
5866757 Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems  
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and optionally in which xenogeneic...
5866755 Animals transgenic for a tetracycline-regulated transcriptional inhibitor  
Transgenic animals carrying a transgene comprising a nucleic acid molecule encoding protein useful for regulating the expression of genes in eukaryotic cells and organisms in a highly controlled...
5859314 Mice with targeted tyrosine kinase, lyn, disruption  
A non-human animal carrying a disruption of a gene encoding a lyn protein tyrosine kinase provides a convenient system for the study of diseases associated with or caused by lyn deficiency, and for...
5859308 Transgenic animals and related aspects  
A transgenic animal, the genome of which comprises a transgene for superoxide dismutase (SOD), erythrocyte-glutathione peroxidase (GPE), or plasma-glutathione peroxidase (GPP), is disclosed. A...
5859312 Transgenic non-human animals having targeting endogenous lymphocyte transduction genes and cognate human transgenes  
The invention provides transgenic non-human animals and transgenic non-human mammalian cells having at least one functionally disrupted lymphocyte transduction locus, particularly a CD4 locus,...
5859310 Mice transgenic for a tetracycline-controlled transcriptional activator  
Transgenic mice carrying two transgenes, the first coding for a transactivator fusion protein comprising a tet repressor and a polypeptide which directly or indirectly activates transcription of a...
5858326 Methods of increasing amyloid deposition  
In vivo and in vitro methods of increasing amyloid deposition using amyloid-enhancing compounds are described. Methods of forming amyloid fibrils and screening for agents useful in treating...
5858328 Animal model for hepatitis virus infection  
A non-human chimeric animal is obtained by transplanting a non-human mammal host having a T cell deficiency with a human liver tissue preparation or with a liver tissue preparation from a non-human...
Matches 151 - 200 out of 248 < 1 2 3 4 5 >