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7098373 |
IL-18 transgenic animal
Transgenic non-human mammals comprising a DNA with an exogenous IL-18 gene incorporated in it such that the exogenous IL-18 gene is skin-specifically expressed, or their offsprings. The transgenic...
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7094946 |
Animal model for allergic disorders
An animal suitable as a model for an allergic disorder, wherein the animal is an immuno-modulated animal which has been sensitized with an antigen under a specific pathogen free environment such...
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7081561 |
Gene-targeted animal model of apolipoprotein E4 domain interaction and uses thereof
The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further...
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7078584 |
Salmonella typhimurium-infected Caenorhabditis elegans for identifying inhibitors of infection
Disclosed are screening methods for identifying the interplay between environmental and host signals (e.g., host-dependent or host-independent signals) and physiological pathogenic pathways that...
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7067714 |
N-calcium channel knockout animal
A non-human animal in which a gene coding for the N-type calcium channel is disrupted to lack functional N-type calcium channel, and a method for screening for a substance having a pharmacological...
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7060868 |
Autoimmune disease model animal
Pemphigus vulgaris (PV) is an autoimmune disease with a possible fatality of the skin and mucosae which is induced by an antibody against desmoglein 3 (Dsg3). Persistent production of anti-Dsg3...
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7053263 |
Mouse models of human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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7038107 |
Elimination of endogenous porcine retrovirus
Porcine nucleic acid sequences flanking potentially infectious porcine endogenous retroviral (PERV) insertion sites have been identified and isolated. The unique flanking sequences include porcine...
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7034201 |
Developmental animal model of temporal lobe epilepsy
Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the...
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7022892 |
Non-human genetically modified mammal lacking the alpha-fetoprotein
The present invention is related to a non-human genetically modified mammal comprising a mutation, a partial or total deletion of the genetic sequence encoding the wild type mammal alpha-fetoprotein.
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7018617 |
Methods and compositions associated with nociceptive pain
Provided are methods and compositions corresponding to a genetic locus associated with nociceptive pain. In addition, method of identifying or modulating nociceptive pain and associated disorders...
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6998513 |
Human inflammatory breast carcinoma xenograft capable of lymphovascular invasion and methods for its use
The present invention provides human transplantable inflammatory breast carcinoma xenografts. Such xenografts exhibit a number of unique characteristics which allows their use in experimental...
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6995299 |
Propagation of human hepatocytes in non-human animals
The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at...
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6984771 |
Mice heterozygous for WFS1 gene as mouse models for depression
The present invention describes a recombinant rodent model for depression. More particularly, the rodent comprises cells expressing mutations in the WFS1 gene. The rodent is preferably a mouse...
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6953874 |
Transgenic animals having a modified glycoprotein V gene
The present invention relates to nonhuman transgenic animals in which the GP V gene has been modified. The invention is also useful for identifying agents that modulate the biological functions of...
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6949692 |
Method for identifying mutants and molecules
Methods for breeding mutagenized mice permit detection of genetic loci that in heterozygous mutated form can modify a known index phenotype involves crossing a mutagenized founder strain and a...
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6949690 |
Methods of assessing the effect of a gene of interest on human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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6943025 |
Method for identifying genes involved in cell proliferation
The present invention provides fish system as a powerful forward genetic tool to directly identify a number of novel genes involved in cell proliferation in vertebrates without the time consuming...
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6930222 |
In vivo animal model of human leukemia
The present invention provides a process for making an in vivo model of human leukemia. The process includes the steps of: pre-conditioning an immunodeficient rodent by administering to the rodent...
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6924413 |
Experimental animals for evaluation of therapeutic effects on corneal epithelial damages
This invention provides experimental animals suffering corneal epithelial damages, such as dry eye, and methods of using the same to assay a variety of compounds for evaluating the therapeutic...
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6924415 |
Transgenic mice comprising a constitutively-activated MEK5 and exhibiting cardiac hypertrophy and dilated cardiomyopathy
The present invention relates to compositions and methods relating to MEK5 and its role in heart disease. This protein has now been identified as a target for therapeutic intervention due to its...
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6891081 |
Transgenic mice over-expressing amyloid-beta alcohol dehydrogenase (ABAD) in brain as model of alzheimer's disease and uses thereof
The present invention provides for a transgenic non-human animal whose cells contain a recombinant DNA sequence comprising a nerve tissue specific promoter operatively linked to a DNA sequence...
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6878858 |
Rodent model for Parkinson's Disease
The present invention provides an animal model for Parkinson's Disease and a method for generating such a model. The method comprises the steps of transfecting dopaminergic neurons in the...
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6869935 |
Gene Therapy for proliferative vitreoretinopathy
A method of treating ocular disorders (such as, for example, proliferative vitreoretinopathy or PVR) associated with replicating ocular cells by transfecting replicating ocular cells in vivo with a...
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6838592 |
Methods for the identification of compounds for the treatment of alzheimer's disease
The invention features methods for identifying compounds useful for the treatment of Alzheimer's disease.
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6835866 |
Compositions and methods of modulating cholesterol metabolism
The present invention relates to compositions and methods for reducing cholesterolemia and its effects. More specifically, the invention is directed, in one embodiment, to methods for screening for...
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6815575 |
Animal model of polyglutamine toxicity, methods of use, and modulators of polyglutamine toxicity
The present invention is based on an in vivo animal model that mimics human cellular and tissue degenerative disorders. The animal model exhibits cellular toxicity in response to expanded...
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6815574 |
Methods of simulating human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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6759038 |
Metastasis models using green fluorescent protein (GFP) as a marker
A method to follow the progression of metastasis of a primary tumor, which method comprises removing fresh organ tissues from a vertebrate subject which has been modified to contain tumor cells...
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6756523 |
Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system particularly in brain
The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression an/or transcription of a selected nucleotide sequence in the cells of the central...
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6743425 |
Therapeutic agents for achondroplasia
The present invention aims to provide novel therapeutic agents for achondroplasia caused by mutations in FGFR3. Therapeutic agents for achondroplasia caused by the cartilage growth inhibition...
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6723893 |
Mice having a mutant SOD-1-encoding transgene
Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the...
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6706947 |
Method for screening for agents against cancer using an immunosuppression animal model
The invention relates to an animal model of cancer. The animal carries a tumour xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying...
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6664443 |
Pathogenic Tau mutations in transgenic mice
Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau...
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6660904 |
HIV and CD4 transgenic animals and uses therefor
The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further...
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6657104 |
Transgenic mouse model for cardiac hypertrophy and methods of use thereof
Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided...
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6639121 |
Inducible cancer model to study the molecular basis of host tumor cell interactions in vivo
A non-human mammal having incorporated into its genome an expression construct in which nucleic acid encoding an oncogene is operably linked to an inducible promoter; the mammal further has a...
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6632979 |
Rodent HER2 tumor model
The invention concerns HER 2 -transgenic non-human mammals, animal models for screening drug candidates for the treatment of diseases and disorders associated with the overexpression of HER 2 . In...
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6632977 |
Transgenic animal whose expression of the opiate receptors is modified
The invention concerns the use of a non-human transgenic mammal whose expression of a gene coding for an opiate receptor is modified, particularly in the nerve tissues with respect to a normal...
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6630612 |
5-HT3 receptor assay using transgenic mammal
The invention relates to transgenic mammals characterized by 5-HT 3 receptor over-expression in the central nervous system (CNS). The mammals have particular utility as models for studying the...
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6627792 |
Human T cell-engrafted mouse, method for developing same and use thereof
The present invention provides a method for developing a human T cell-engrafted mouse, which includes transplanting a human-derived bone tissue into an inbred line mouse deficient in immune cells,...
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6617312 |
Vasoactive amine binding molecules
A vasoactive amine binding protein (VABP) that binds to vasoactive amines with a dissociation constant of less than 10 −7 M, has a sequence homology to the VABP clones male specific histamine...
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6603058 |
Non-human animal model for obesity and uses thereof
Described is a genetically modified non-human animal model for studying the peripheral and central pathways of energy homeostasis. Also disclosed are methods of identifying compounds for regulating...
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6596924 |
Graft animal model for high induction of papillomas, the propagation of papillomavirus and evaluation of candidate therapeutic agents
The present invention relates to a graft animal model for propagating papilloma virus and for evaluating and testing candidate therapeutic agents against papilloma virus. The animal model...
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6593512 |
Transgenic mouse expressing human tau gene
A bigenic mouse is provided whose germ cells and somatic cells contain (i) inactive mouse TAU genes, and/or (ii) a transgene encoding the human TAU gene, with the transgene including all regulatory...
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6593511 |
Models of chronic and acute inflammatory diseases
Methods and compositions are provided for the creation and screening of non-human animal models having chronic inflammation. Immunocompromised host animals are injected with a population of...
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6589505 |
Cells that lack p19ink4d and p27kip1 activity and methods of use thereof
Non-human animals that have been manipulated so as not to express a functional p19 INK4d and p27 KIP1 proteins are described. One particular non-human animal exemplified is a p19 INK4d -double...
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6583334 |
Ovariectomized mouse model for human menopause
A method for determining a response to a biologically active agent in ovariectomized lower test mammals is described. The mammals are divided into those which have an early time post ovariectomy...
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6580016 |
Animal model for detection of vulnerable plaques
The present invention provides in vivo methods for detection of vulnerable plaque in a subject in need thereof. In the invention method the subject is administered a diagnostic amount of a...
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6566580 |
Neurological disease model
The use of a metabotropic glutamate receptor mGluR7 agonist for the facilitation of neurotransmitter release from a nerve ending and the treatment of neurological conditions, including epilepsy....
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