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7601883 |
Mammalian sour/acid taste and CSF receptor genes, polypeptides and assays
Acid/sour taste receptors are provided. CSF pH sensing receptors are provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals,...
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7592501 |
Methods for maintaining genetic stability of inbred animal strains
The present invention provides novel methods of maintaining genetic stability of non-human animal inbred strains. In the methods, pedigree-tracked cryopreserved embryos derived from a foundation...
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7586022 |
Transgenic non-human animal model of lung tumorigenesis
The present invention is a transgenic non-human animal whose genome contains a transgene containing a nucleic acid encoding a cyclin E protein operably linked to a regulatory element including a...
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7586021 |
Nucleic acid construct, metabolic disordered non-human animal and use thereof
The present invention provides a transgenic non-human animal comprising a human-derived LXRα mutant gene to express a human LXRα mutant protein, wherein the human LXRα mutant is an isoform of...
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7586020 |
Methods for determining effects of maternal treatments on offspring
The present invention provides animal models and methods for the evaluation of maternal treatments that could improve or compromise the epigenetic state, the imprinting, or the DNA methylation and...
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7579515 |
Increasing gamete production with a gene switch
A method of enhancing the production of gametes in a transgenic non-human animal is carried out by: (a) providing a transgenic non-human animal comprising cells that contain: (i) a response...
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7572949 |
SKN-1 and GSK-3 genes and proteins
The present invention relates, in part, to the C. elegans SKN-1 gene and protein (a transcription factor), and target genes thereof. The invention includes various therapeutic methods and...
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7566812 |
Transgenic mouse models of hepatitis C virus (HCV) and identification of HCV therapeutics
Disclosed herein is the discovery of novel NS3/4A compositions with enhanced expression abilities. Embodiments of the invention include codon optimized NS3/4A compositions and compositions with the...
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7560610 |
p27-deficient mouse exhibiting tissue hypertrophy
Hypercellular nonhuman organisms have functionally inactivated expression of a cyclin inhibitor gene, especially p27. The growth rate of nonhuman organisms are increased such that a desired size is...
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7556964 |
Transgenic cell and gene recombinant animal having a mutant SDHC gene derived from mammals
It is an object of the present invention to provide a transgenic cell and gene recombinant animal having a mutant SDHC gene, which enables the examination of the action of reactive oxygen species...
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7554003 |
Invertebrate animal model with neurodegenerative phenotype for screening and testing substances
The present invention claims an invertebrate animal that has been modified to express a set of genes, the set comprising the gene coding for a modified version of the gamma subunit of AMP-activated...
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7550649 |
Transgenic non-human mammal
An object of the present invention is to provide a model animal of Parkinson's disease comprising an α-synuclein gene introduced therein. The present invention provides a transgenic non-human...
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7550647 |
Transfected shrimp as production systems for therapeutic proteins
A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered....
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7544855 |
Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
In accordance with the present invention, it is demonstrated that selected mutations such as an Asp->Ala (D664A) mutation in APP (which prevents cleavage at the caspase cleavage site) prevent...
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7544854 |
Transgenic non-human animals for pharmacological and toxicological studies
The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from...
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7531712 |
P450 gene regulation
The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional...
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7524491 |
Non human animals with human-glial chimeric brains
The present invention is directed to a non-human mammal with at least 30% of all of its glial cells in its corpus callosum being human glial cells and/or at least 5% of all of its glial cells in...
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7521591 |
Transgenic chickens that lay eggs containing exogenous proteins
This invention provides eggs which contain exogenous proteins. The invention further provides transgenic chickens which express exogenous sequences in their oviducts, and vectors and methods for...
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7518033 |
Methods for the production of cells and mammals with desired genetic modifications
The present invention features novel methods for generating cell lines and mammals with site-specific genetic modifications of interest. The methods involve homologous recombination between an...
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7514594 |
Transgenic animal model of bone mass modulation
The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing...
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7507873 |
Transgenic avians containing recombinant ovomucoid promoters
Transgenic avians having a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.
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7491868 |
Mannose binding lectin knock-out mice and methods of use thereof
A transgenic non-human animal with alterations in the MBL gene is prepared by introduction of a gene encoding an altered MBL protein into a host non-human animal. Methods for using transgenic mice...
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7473414 |
Compositions and methods for wound healing
Mice in which enhance wound healing occurs can be used to identify genes and gene products which are involved in enhanced wound healing in mammals, including humans. Methods and compositions for...
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7465535 |
Dehydration procedures for induction of cryptobiosis in insect larvae
This invention provides a method for effectively producing dehydrated larvae for educational materials without disrupting the environment. The cryptobiotic larvae for educational materials can be...
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7462757 |
Animal with gene hypoexpression
The present invention relates to non-human animal embryonic stem cells in which a lecithin:cholesterol acyltransferase-like lysophospholipase endogenous gene is inactivated; non-human animals...
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7459602 |
Mammalian cancer cell and transgenic mammal carrying human protooncogene and kit for diagnosing cancer using said protooncogene
The present invention provides a mammalian cell transfected with an expression vector comprising a human protooncogene which has the nucleotide sequence of SEQ ID NO: 1; a mammalian embryo carrying...
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7459600 |
Isolation, selection and propagation of animal transgenic stem cells
Animal stem cells are obtained and maintained by culturing cells containing, in the genome, a selectable marker. Differential expression of the selectable marker enables preferential survival...
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7459599 |
Methods for producing proteins using silkworm middle silk gland-specific gene expression system
Transgenic silkworms comprising GFP whose expression is regulated by the sericin gene promoter were produced. Observation of the silk glands of the last instar larvae of the silkworms showed...
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7420100 |
Methods and compositions relating to HDAC 4 and 5 regulation of cardiac gene expression
The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically,...
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7417175 |
Interstitial prostatism model animal
The present invention provides an animal model for prostatic stromal hyperplasia, and a method for screening for a substance effective for preventing/treating human benign prostatic hyperplasia...
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7416886 |
Porcine uroplakin II promoter and the production method of useful proteins using said promoter
The present invention relates to a porcine uroplakin II gene promoter, an expression vector containing the promoter, and a method for producing useful proteins using the vector. The promoter of the...
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7414169 |
Therapeutic and diagnostic tools for impaired glucose tolerance conditions
Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for...
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7405342 |
Transgenic mice expressing heterologous complement receptor type 1 (CR1) molecules on erythrocytes and uses therefor
The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding...
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7402730 |
Knockout animals manifesting hyperlipidemia
Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal...
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7402727 |
Non-human animal exhibiting bone metastasis of tumor cells
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for...
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7402726 |
Methods and compositions for screening for modulators of Parkinson's disease
Methods and compositions for identifying an agent (e.g., a gene product or small molecule compound) that modulates a Parkinson's disease phenotype are provided. In practicing the subject methods, a...
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7399900 |
Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene
The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and...
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7393683 |
Mammalian host cell modified by RNAi to inhibit α 1,6-fucosyltransferase
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a...
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7388124 |
Non-traumatic model for neurogenic pain
A method for producing a non-human mammalian model for neurogenic pain is provided, which includes altering a peripheral nerve of a non-human mammal by non-surgically placing a gel substance into...
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7374889 |
Human sphingosine-1-phosphate phosphatase and inhibition methods
The present invention provides polynucleotides and polypeptides of a human sphingosine-1-phosphate phosphatase, referred to herein as hSPP1. The polynucleotides and polypeptides are used to further...
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7371920 |
Transgenic mouse model of neurodegenerative disorders
The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology...
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7361804 |
Unactivated oocytes in nuclear transfer to produce ungulates
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7358416 |
Transgenic mouse expressing human FcRn protein
Disclosed is a transgenic knockout mouse whose genome comprises a homozygous disruption in its endogenous FcRn gene. The homozygous RcRn disruption prevents the expression of a functional FcRn...
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7335811 |
Method for collecting cells in M phase or G1 phase and method for nuclear transplantation using the cells
Methods for collecting cells in M phase or G 1 phase, by which the percentage of M phase or G 1 phase cells is higher than that attained by the conventional methods are disclosed.
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7326824 |
Unactivated ungulate oocytes to produce a transgenic ungulate by nuclear transfer
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7323618 |
Tissue specific expression of exogenous proteins in transgenic chickens
Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous...
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7321076 |
Unactivated ungulate oocytes to produce a cloned ungulate by nuclear transfer
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7309811 |
Transgenic mice knockouts of BACE-1
The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for...
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7291764 |
Cloning pigs using non-quiescent differentiated donor cells or nuclei
An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful...
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7282620 |
Type III allergic inflammation model animal
The present invention provides an experimental model animal which does not develop anaphylaxis, a type I allergy, can specifically induce Arthus reaction, a type III allergy, is not affected by...
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