|
Match
|
Document |
Document Title |
|
|
7291764 |
Cloning pigs using non-quiescent differentiated donor cells or nuclei
An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful...
|
|
|
7282620 |
Type III allergic inflammation model animal
The present invention provides an experimental model animal which does not develop anaphylaxis, a type I allergy, can specifically induce Arthus reaction, a type III allergy, is not affected by...
|
|
|
7273963 |
Malarial animal model having a chimeric human liver
The present invention features a non-human animal model of malaria, e.g., Plasmodium , particularly Plasmodium falciparum . The model is based on a non-human, immunocompromised transgenic animal...
|
|
|
7273727 |
Fusion proteins for prodrug activation
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity...
|
|
|
7270998 |
Method of concentrating and separating dopaminergic neurons
The invention of this application provides a method comprising introducing a reporter nucleic acid molecule that expresses a fluorescent protein under control of the promoter/enhancer of a gene...
|
|
|
7259290 |
Animal model of human hematopoietic tumor
Production and utilization of model mouse, in which human hematopoietic tumor cells can be grown, expressing symptom of human hematopoietic tumor, and can be used in the screening of anticancer...
|
|
|
7259289 |
MCH1R deficient mice
The present invention features viable MCH1R deficient mice. MCH1R deficient mice contain an alteration in one or both MCH1R alleles that substantially reduces expression of a functional MCH1R from...
|
|
|
7253333 |
Drosophila strain carrying bradeion gene(s) transferred thereinto
Provided is a special Drosophila strain having a Bradeion gene artificially incorporated therein to exclusively express the gene in the compound eyes and thus to exhibit rough eye. The ...
|
|
|
7253334 |
Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features...
|
|
|
7235709 |
Transgenic animals with increased slow-twitch muscle fibers and methods of using such animals
Transgenic non-human mammals over-expressing MHCI in skeletal muscle are provided herein, as are methods of using these transgenic non-human mammals for screening candidate compounds for treating...
|
|
|
7220891 |
Feline bronchioloalveolar lung carcinoma xenograft and cell line
The present invention provides feline transplantable lung carcinoma xenografts and cell lines. Such xenografts and cell lines exhibit a number of unique characteristics which allows their use in...
|
|
|
7220718 |
Oral treatment of hemophilia
Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the...
|
|
|
7217411 |
CeSERT genes, proteins, and modulatory compounds
The invention features substantially pure nucleic acid sequences encoding wild-type or mutant serotonin reuptake transporter (SERT) polypeptides, as well as the polypeptides themselves. The...
|
|
|
7214850 |
Transgenic mouse expressing Prkag3
Transgenic non-human animals that express the γ3 subunit of PRKAG are described, as well as methods of using the transgenic non-human animals as models for improving treatment, prevention, or...
|
|
|
7202392 |
In vivo screening array
The invention features methods of evaluating the effect of a plurality of different treatments or compounds on a tissue. The method includes providing a tissue from an animal; contacting the tissue...
|
|
|
7196242 |
Methods for identifying novel therapeutics and diagnostics in the p53 pathway
The present invention identifies a p53 homolog gene, cep-1, and mutations thereof in the nematode C. elegans which allows for the application of molecular genetic methods to identify new...
|
|
|
7196243 |
Transgenic animal containing CD200 and uses therefor
The present invention is directed toward a transgenic non-human animal and uses thereof, wherein each of the cells of the animal contain a transgene comprising a nucleic acid sequence encoding CD200.
|
|
|
7186882 |
Transgenic mouse over-expressing calreticulin (CRT) in vascular smooth muscle cells
A transgenic mouse whose genome comprises a transcriptional control region operably linked to a cDNA encoding calreticulin (CRT) is described.
|
|
|
7186879 |
Screening systems and methods for identifying modulators of xenobiotic metabolism
The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify CAR ligands, including...
|
|
|
7166763 |
Mouse model of myxomatous valvular disease
An animal selected for lacking heparan sulfate 3-O-sulfotransferase-1 activity is provided. This animal exhibits characteristics associated with myxomatous valvular disease and is useful for...
|
|
|
7163806 |
Somatic cells with ablated PrP gene and methods of use
The present invention comprises a method for producing mammalian therapeutics free from prion contamination and cells for use in such methods. Such therapeutics are produced in somatic cells having...
|
|
|
7163808 |
Artery smooth muscle- and vein smooth muscle-specific proteins and uses therefor
Arterial and venous smooth muscle cells are molecularly distinct from the earliest stages of angiogenesis through to adulthood. This distinction is revealed by expression on arterial cells (e.g.,...
|
|
|
7163679 |
Versican and epithelial-mesenchymal interaction
The invention describes versican activation and modulation of hair growth, e.g., versican expressing dermal papilla cells exhibit hair induction ability.
|
|
|
7161059 |
Human hookworm model and method for maintaining human hookworm in a non-human primate
A method for maintaining a human hookworm strain is provided by infecting a non-human primate with a non-adapted or non-passaged human hookworm and maintaining the non-human primate. Methods of...
|
|
|
7145057 |
Chimeric bird from embryonic stem cells
Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem...
|
|
|
7141716 |
Inbred miniature swine and uses thereof
The invention provides a swine which is homozygous for a major histocompatibility complex haplotype and at least 60% homozygous at all other genetic loci and such animal is propagatable, and a cell...
|
|
|
7138562 |
Transgenic animals
The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid...
|
|
|
7135609 |
Non-human animal exhibiting bone metastasis of tumor cells and method of screening for bone metastasis inhibitors
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for...
|
|
|
7135608 |
Site-specific recombination in eukaryotes and constructs useful therefor
Site-specific recombinases provide a means of efficiently manipulating chromosomal sequences in mammalian cells in culture and in animals. Embryonic stem cells containing recombinase nucleic acid...
|
|
|
7135612 |
Identification of the gene causing the mouse scurfy phenotype and its human ortholog
Isolated nucleic acid molecules are provided which encode Fkh sf , as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and...
|
|
|
7135613 |
Chimeric gene constructs for generation of fluorescent transgenic ornamental fish
Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific and ubiquitously expressed, respectively, were isolated and ligated to the 5′ end of the EGFP...
|
|
|
7135611 |
Compositions and methods for characterizing and regulating Wnt pathways
The present invention relates to transgenic animal models for altered Wnt expression. The present invention also provides methods for generating animal models and screening methods for identifying...
|
|
|
7122714 |
Mouse models of human prostate cancer
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
|
|
|
RE39337 |
Nude mouse model for human neoplastic disease
A nude mouse model for human neoplastic diseases having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the...
|
|
|
7119249 |
Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The...
|
|
|
7115555 |
Hypohidrotic ectodermal dysplasia genes and proteins
The DNA and amino acid sequences are disclosed for a ligand (EDA1-II) and receptor (dl in mice and DL in humans) involved in ectodermal dysplasia. Also disclosed are variant DNA and amino acid...
|
|
|
7115795 |
Transgenic animals expressing salivary proteins
The invention provides a transgenic animal having within its genome a transgene construct for gastrointestinal tract specific expression of a protein. In a preferred embodiment, the protein is a...
|
|
|
7112716 |
Methods for screening and identifying host pathogen defense genes
Disclosed are methods for identifying nematodes having enhanced susceptibility to a pathogen; for identifying pathogen defense response genes; and for identifying compounds that enhances a host's...
|
|
|
7107092 |
Methods for diagnosing a neurodegenerative condition
A method of diagnosing, prognosing, staging, and/or monitoring a mammalian amyloidogenic disorder or a predisposition thereto by detecting a protein or polypeptide aggregate in the cortical and/or...
|
|
|
7105717 |
Model rat with the onset of prostatic cancer
To provide a rat model with the onset of prostate cancer in which the prostate cancer including an invasive cancer can be developed and can be bred for generations stably. A rat model with the...
|
|
|
7098376 |
Transgenic mouse expressing constitutively active hydrocarbon receptor
The present invention makes available powerful tools for the study of cancer, based on a novel expression construct for a constitutively active hydrocarbon receptor CA-AhR. The invention further...
|
|
|
7094949 |
Breeding and milking cows for milk free of β-casein A1
A milk or other dairy product, capable of minimizing the onset of disease such as coronary heart disease or enhancing the immune response is derived from animals which are substantially free of the...
|
|
|
7094946 |
Animal model for allergic disorders
An animal suitable as a model for an allergic disorder, wherein the animal is an immuno-modulated animal which has been sensitized with an antigen under a specific pathogen free environment such...
|
|
|
7094945 |
OSR-1 nucleic acids and proteins
The present invention relates to water-stress tolerance, in particular to the OSR-1 (osmotic stress resistant-1) protein, and nucleic acids encoding the OSR-1 protein. The present invention...
|
|
|
7083947 |
Assay techniques using nematode worms
Improved techniques for performing assays using nematode worms, such as nematode worms from the genus Caenorhabditis . The assays generally comprise exposing nematodes to at least one compound...
|
|
|
7078584 |
Salmonella typhimurium-infected Caenorhabditis elegans for identifying inhibitors of infection
Disclosed are screening methods for identifying the interplay between environmental and host signals (e.g., host-dependent or host-independent signals) and physiological pathogenic pathways that...
|
|
|
7071373 |
Transgenic ungulate compositions and methods
Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for...
|
|
|
7067285 |
Desaturase genes and uses thereof
The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e.,...
|
|
|
7060249 |
Neurodegeneration mutants, method for identifying same, and method for screening neuroprotective agents
A method for obtaining a Drosophila neurodegeneration mutant includes the steps of selecting at least one Drosophila mutant having an aberrant phenotype selected from the group consisting of...
|
|
|
7060868 |
Autoimmune disease model animal
Pemphigus vulgaris (PV) is an autoimmune disease with a possible fatality of the skin and mucosae which is induced by an antibody against desmoglein 3 (Dsg3). Persistent production of anti-Dsg3...
|