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7615364 |
Polypeptide having activity of unsaturating W3-fatty acid, polynucleotide coding for the polypeptide and use thereof
The present invention provides a polypeptide having a wide substrate specificity and having a ω3 fatty acid desaturation activity, which makes efficiently unsaturated bond at ω3 position, and a...
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7576258 |
Transgenic transchromosomal rodents for making human antibodies
The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
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7531325 |
Method for cleavage of fusion proteins
An improved method for recovering recombinantly produced polypeptides is described. The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. The...
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7521591 |
Transgenic chickens that lay eggs containing exogenous proteins
This invention provides eggs which contain exogenous proteins. The invention further provides transgenic chickens which express exogenous sequences in their oviducts, and vectors and methods for...
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7501265 |
Method for producing and cleaving a fusion proteins with an n-terminal chymosin pro-peptide
An improved method for recovering recombinantly produced polypeptides is described. The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. The...
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7459599 |
Methods for producing proteins using silkworm middle silk gland-specific gene expression system
Transgenic silkworms comprising GFP whose expression is regulated by the sericin gene promoter were produced. Observation of the silk glands of the last instar larvae of the silkworms showed...
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7445907 |
Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples
Mass spectrometry-based methods are described for the detection or quantification of targeted proteins in biological samples e.g., plants, animals, and microorganisms, parts (e.g., tissue or cells)...
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7435871 |
Transgenic animals bearing human Igλ light chain genes
The invention relates to transgenic animals bearing one or more human λ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have...
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7416886 |
Porcine uroplakin II promoter and the production method of useful proteins using said promoter
The present invention relates to a porcine uroplakin II gene promoter, an expression vector containing the promoter, and a method for producing useful proteins using the vector. The promoter of the...
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7402729 |
Human artificial chromosome containing human antibody λ light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically,...
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7381712 |
In vivo transfection in avians
The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a...
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7355092 |
Genetic vaccines for the production of chicken egg-yolk antibodies against enterotoxigenic Escherichia coli and other pathogens
Genetic vaccine which comprises plasmid(s) containing genes coding for antigens of enterotoxigenic Escherichia coli (ETEC) strains is disclosed. Additionally, plasmids may consist of multiple...
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7294753 |
Method for preparing anti-MIF antibodies
The specification provides methods of preparing high-affinity antibodies to a macrophage migration inhibitory factor (MIF) in animals in which the MIF gene has been homozygously knocked-out (MIF...
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7253334 |
Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features...
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7220718 |
Oral treatment of hemophilia
Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the...
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7157615 |
Production of biofilaments in transgenic animals
Disclosed is a method for the recombinant production of biofilaments, such as spider silk or insect fibroins, using transgenic animals which secrete the biofilaments in their milk and/or urine, and...
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7132586 |
Protein production system
The invention relates to a method for producing a protein of interest comprising transforming a target insect with a non-viral expression system that expresses the protein in the insect larvae,...
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7119248 |
Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
This invention provides novel methods of obtaining autologous monoclonal antibodies (AMABs) to self-antigens or homologs thereof. The method involves obtaining a genetically engineered host animal...
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7115795 |
Transgenic animals expressing salivary proteins
The invention provides a transgenic animal having within its genome a transgene construct for gastrointestinal tract specific expression of a protein. In a preferred embodiment, the protein is a...
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RE39270 |
Process for continuous optimized protein production in insect larvae
The present invention provides for a recombinant insect larvae and a process of manufacturing proteins utilizing insect larvae that allows for the selection of individual larvae for harvest at the...
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7087808 |
Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals
The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine...
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7074983 |
Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and...
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7071373 |
Transgenic ungulate compositions and methods
Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for...
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7053262 |
Mammary gland tissue-specific expression system using β-casein promoter site of Korean native goat
The mammary gland-specific expression systems developed by the present inventors, named pGbc, pGbc_L and pGbc_S were deposited under the Budapest Treaty on the International Recognition of the...
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6962975 |
Prion protein standard and method of making the same
The invention provides prion protein standards for use as reference materials for prion detection. The standard may be species specific, i.e. the standard is comprised of a preparation for...
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6946266 |
Gene transfer in chicken bursal stem cells
The invention relates to a method of expressing proteins in higher eukaryotes in vitro. In general, the invention sets forth a method of expressing exogenous proteins as fusion partners with the...
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6924412 |
Means and methods for raising antibody concentration in compartments of the body of a non-human animal
Methods and processes for raising the concentration of a first class of immunoglobulin relative to at least a second class of immunoglobulin in a compartment of the body of a non-human animal or...
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6921846 |
Antibody production methods relating to disruption of peripheral tolerance in B lympho-cytes
The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized animal having antibody-producing cells with disrupted peripheral tolerance. The...
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6888047 |
Transgenic animals as urinary bioreactors for the production of polypeptide in the urine, recombinant DNA construct for kidney-specific expression, and method of using same
The invention relates to recombinant DNA constructs, a method for producing a recombinant biologically active protein in vivo in the urine of a non-human mammal using a kidney-specific promoter,...
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6872869 |
Method for establishing an expression system of spider dragline silk gene in bombyx mori
The present invention provides a method for establishing an expression system of spider dragline silk gene in Bombyx mori. The rate of transformation is about 0.5-1%. In the silk protein produced...
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6835866 |
Compositions and methods of modulating cholesterol metabolism
The present invention relates to compositions and methods for reducing cholesterolemia and its effects. More specifically, the invention is directed, in one embodiment, to methods for screening for...
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6800790 |
Method for maintenance and propagation of germline stem cells using members of the TFG-β family of growth factors
The TGF-β family of growth factors, particularly the bone morphogenetic protein (BMP)-2/4 homolog decapentaplegic (dpp), are specifically required to maintain germline stem cells and promote their...
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6800462 |
Production of recombinant proteins in vivo and use for generating antibodies
The invention is directed to methods of producing a protein by administering a nucleic acid encoding the protein to an animal. Following the administration of the nucleic acid to the animal, the...
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6734338 |
Transfection, storage and transfer of male germ cells for generation of transgenic species and genetic therapies
A composition for in vitro and in vivo transfection of vertebrate male germ cells comprises a nucleic acid or transgene, and a gene delivery system, and optionally a protective internalizing agent,...
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6730822 |
Vectors in avian transgenesis
This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the...
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6673987 |
Strategy for maintaining pregnancy
Pregnancy in animals such as the pig usually does not continue to term when there are only a few embryos in the uterus. Currently available technology for maintaining pregnancy involves a series of...
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6664443 |
Pathogenic Tau mutations in transgenic mice
Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau...
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6613957 |
Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human mammals
The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the...
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6610905 |
Transgenic mouse model for Kaposi's sarcoma
The present invention relates to a non-human transgenic mouse containing a constitutively active G-protein coupled receptor, which produces Kaposi's sarcoma-like symptoms. The transgenic mouse is...
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6608238 |
Trans-somatics with gene transfer into mammary epithelial cells
A method is described to transfer a gene encoding a valuable compound, such as a pharmaceutical, into the secretory cells of the mammary gland to produce a new compound into the milk or to alter...
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6570061 |
Targeted replacement of an immunoglobulin gene without endogenous and selectable residual sequences in mice
Transgenic mice that produce high levels of humanized antibodies are described. Targeted gene replacement exchanges constant regions of the mouse immunoglobulin heavy and light chain genes with...
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6548735 |
Production of heterologous protein in milk of transgenic non-human mammals comprising a construct with an intron
Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5′-flanking sequence from a mammalian milk protein...
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6545198 |
Transgenically produced prolactin
Transgenically produced prolactin and methods of making and using transgenically produced prolactin.
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6525241 |
Expression methods
The present invention relates to human bile salt-stimulated lipase (BSSL) obtainable from transgenic sheep. The invention further relates to transgenic sheep whose germ cells and somatic cells...
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6511830 |
Killer T cell receptor recognizing human immunodeficiency virus
The present invention relates to a polypeptide which is a constituent of a killer T cell receptor and is capable of injuring human immunodeficiency virus-infected cells; a DNA encoding this...
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6476290 |
Transgenic tilapia comprising a humanized insulin gene
In accordance with the present invention, there are provided humanized fish insulin genes. Humanized insulin the present invention encode human insulin alpha and/or beta chains while using...
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6462254 |
Dual-tagged proteins and their uses
The present invention provides improved methods for detection of recombinant proteins. The fusion proteins of the invention comprise a capture tag sequence, a detection tag sequence, and...
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6444871 |
Tetracycline repressor regulated mammalian cell transcription and viral replication switch
The present invention is directed to DNA constructs suitable for gene expression in mammalian cells and which are characterized by the presence of a mammalian promoter under the control of a tet...
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6395515 |
Directed switch-mediated DNA recombination
Switch regions derived from an immunoglobulin (Ig) gene are used to direct recombination between a targeting construct containing a promoter, a switch region (S 1 ), and 2) a target locus minimally...
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6372955 |
Methods for Producing B cells and antibodies from H2-O modified transgenic mice
A transgenic animal with alterations in an H2-O gene is prepared by introduction of an altered H2-O gene into a host animal. The resulting transgenic animals produce a substantially greater...
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