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7615676 |
Transgenic screen and method for screening modulators of brain-derived neurotrophic factor (BDNF) production
A transgenic screen and method for screening biological and chemical test substances or molecules for their ability to influence or modulate the production of BDNF in cells, includes a fusion gene...
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7608749 |
Monitoring APP cleavage in transgenic rodents comprising an APP Swedish mutation
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
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7601883 |
Mammalian sour/acid taste and CSF receptor genes, polypeptides and assays
Acid/sour taste receptors are provided. CSF pH sensing receptors are provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals,...
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7595431 |
Mouse models of human prostate cancer
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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7595430 |
Methods and animal model for analyzing age-related macular degeneration
Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and...
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7592501 |
Methods for maintaining genetic stability of inbred animal strains
The present invention provides novel methods of maintaining genetic stability of non-human animal inbred strains. In the methods, pedigree-tracked cryopreserved embryos derived from a foundation...
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7586022 |
Transgenic non-human animal model of lung tumorigenesis
The present invention is a transgenic non-human animal whose genome contains a transgene containing a nucleic acid encoding a cyclin E protein operably linked to a regulatory element including a...
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7585963 |
Chicken ovalbumin nucleotide sequence
The present invention provides isolated and recombinant avian nucleic acid molecules comprising at least one avian MAR and an avian nucleic acid sequence encoding an ovalbumin transcriptional...
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7569681 |
Caterpiller gene family
The present invention relates to a new family of structurally and functionally related nucleic acids and proteins, designed the CATERPILLER family, which is characterized by landmark structural...
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7560279 |
Method of proliferating human hepatocytes and method for obtaining human hepatocytes
Transplanting human hepatocytes into a liver of an immunodeficient hepatopathy mouse, and then feeding the mouse transplanted with the human hepatocytes under such a condition as being protected...
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7557258 |
Endotoxin-nonresponsive model animal
The present invention is to provide a non-human animal model non-responsive especially to endotoxin being a Gram-negative bacteria cell wall fraction, which is useful to elucidate the function of...
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7556964 |
Transgenic cell and gene recombinant animal having a mutant SDHC gene derived from mammals
It is an object of the present invention to provide a transgenic cell and gene recombinant animal having a mutant SDHC gene, which enables the examination of the action of reactive oxygen species...
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7550648 |
Inducing neurofibrillary tangles in transgenic mice expressing a mutant tau protein
The present invention discloses a method and an in-vivo assay system useful for the identification and testing of modulating agents as well as for the validation of therapies of neurodegenerative...
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7544855 |
Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
In accordance with the present invention, it is demonstrated that selected mutations such as an Asp->Ala (D664A) mutation in APP (which prevents cleavage at the caspase cleavage site) prevent...
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7544854 |
Transgenic non-human animals for pharmacological and toxicological studies
The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from...
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7538258 |
Transgenic mouse expressing an APP 670/671 mutation
The invention provides an isolated nucleic acid characteristic of human amyloid precursor protein 770 including the nucleotides encoding codon 670 and 671, wherein the nucleic acid encodes an amino...
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7531715 |
Double nuclear transfer method and results thereof
A method is described for the production of an animal (offspring) by the process of nuclear transfer. The animal may be produced using donor genetic material in cells taken directly from any stage...
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7531714 |
Melusin a muscle specific protein, as a drug target for prevention and treatment of heart failure
The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be...
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7531713 |
Assay for toxin induced neuronal degeneration and viability in C. elegans
Provided are in vivo screening methods to detect and identify substances that affect neuronal viability, and/or prevent neurodegeneration, and/or confer neuroprotective effects The screening...
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7531712 |
P450 gene regulation
The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional...
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7525011 |
Transgenic cancer models in fish
The present invention provides transgenic fish whose genome has stably-integrated therein an oncogene operably linked to a promoter. Methods of making the transgenic fish and methods for their use...
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7524491 |
Non human animals with human-glial chimeric brains
The present invention is directed to a non-human mammal with at least 30% of all of its glial cells in its corpus callosum being human glial cells and/or at least 5% of all of its glial cells in...
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7521590 |
Phospholipase C β1 (PLCβ1) knockout mice as a model system for testing schizophrenia drugs
The present invention relates to a method for screening therapeutic drugs of schizophrenia using an animal model of the disease. More specifically, this invention relates to a screening method...
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7514592 |
Inducible heart attack animal model
An animal model of coronary heart disease has been developed where myocardial infarct can be induced by altering the animal's diet. In all embodiments, this animal model is a result of reduced...
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7507871 |
Rat model of diabetic nephropathy
A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound's effect of diabetic nephropathy is disclosed. In one embodiment,...
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7507565 |
Bioluminescence resonance energy transfer (BRET) systems and methods of use thereof
Briefly described, embodiments of this disclosure include bioluminescence resonance energy transfer (BRET) systems, methods of detecting a protein-protein interaction, noninvasive methods for...
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7495147 |
Neuregulin-1 transgenic mouse and methods of use
Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides;...
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7491865 |
Mouse models of prostate cancer development and metastasis through expression of a hepsin transgene
Transgenic, non-human animal model of cancer, methods of making such animals and methods of using such animals to screen test compounds are provided.
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7482507 |
Methods of screening agents for activity using teleosts
The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity...
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7482506 |
Ras p27 mouse models and uses thereof
The subject invention pertains to a transgenic animal model for tumorigenesis having a genome comprising a ras transgene and which is heterozygous or homozygous for a null p27 gene, and methods of...
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7479579 |
Triple transgenic mouse model of Alzheimer's disease
The present invention relates to a triple transgenic animal model for Alzheimer's disease as well as to methods for generating multi-transgenic animals. The present invention also relates to...
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7465848 |
Zebrafish assay
The invention includes a zebrafish assay for cardiac response.
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7462757 |
Animal with gene hypoexpression
The present invention relates to non-human animal embryonic stem cells in which a lecithin:cholesterol acyltransferase-like lysophospholipase endogenous gene is inactivated; non-human animals...
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7453021 |
Transgenic animal model for degenerative diseases of cartilage
The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly...
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7449615 |
Non-invasive evaluation of physiological response in a transgenic mouse
The present invention relates to panels of reporter expression cassettes and the generation of transgenic non-human animals, wherein said reporter expression cassettes have selected control...
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7449567 |
Isolation and identification of mouse and human transcription control elements associated with cytochrome expression
The present invention relates to transcription control elements derived from mouse and human genes associated with cytochrome expression, e.g., Cyp3A11 and CYP3A4, respectively. Isolated...
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7445907 |
Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples
Mass spectrometry-based methods are described for the detection or quantification of targeted proteins in biological samples e.g., plants, animals, and microorganisms, parts (e.g., tissue or cells)...
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7435868 |
Screening assay based on the forkhead transcription factor-dependent sod-3 promoter
The invention relates to the identification and use of the DAF-2/IR responsive sod-3 promoter. Transgenic C. elegans containing sod-3 reporter gene constructs are described which are useful for,...
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7432414 |
Transgenic mouse having an amyloid precursor protein with a modified beta secretase cleavage site
The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the β secretase cleavage site are NF and EV. The invention also provides...
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7427489 |
Screening assay to identify modulators of the sleep/wake cycle
Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are...
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7427392 |
Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
This invention provides methods useful in aiding in the diagnosis of Alzheimer's disease. The methods involve measuring the amount of amyloid-β peptide (x−≧41) in the cerebrospinal fluid of a...
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7420100 |
Methods and compositions relating to HDAC 4 and 5 regulation of cardiac gene expression
The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically,...
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7414169 |
Therapeutic and diagnostic tools for impaired glucose tolerance conditions
Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for...
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7405342 |
Transgenic mice expressing heterologous complement receptor type 1 (CR1) molecules on erythrocytes and uses therefor
The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding...
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7402730 |
Knockout animals manifesting hyperlipidemia
Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal...
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7402725 |
WIP, a WASP-associated protein
Described herein is a novel gene and its product, WIP, which associates with WASP. The subject invention relates to the isolated WIP gene or cDNA and transgenic mammals that have the WIP gene...
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7402724 |
Longevity and PAPP-A
This document provides materials and methods related to PAPP-A polypeptides, aging, and transgenic non-human mammals whose genomes comprise a disrupted PAPP-A allele. Methods for making such...
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7399900 |
Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene
The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and...
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7393994 |
Transgenic mouse model for neurodegenerative diseases
Alzheimer's disease, Parkinson's disease and Lewy body disease are the most commonly found neurodegenerative disorders in the elderly. The invention is a transgenic mouse that contains two...
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7388124 |
Non-traumatic model for neurogenic pain
A method for producing a non-human mammalian model for neurogenic pain is provided, which includes altering a peripheral nerve of a non-human mammal by non-surgically placing a gel substance into...
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