|
Match
|
Document |
Document Title |
|
|
7145055 |
Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This...
|
|
|
7135607 |
Goodpasture's syndrome model mouse
The present invention provides a non-human model animal of Goodpasture's syndrome that contributes to the treatment of Goodpasture's syndrome where the development of therapy had been delayed due...
|
|
|
7135610 |
Mouse showing neurofibril change due to senile dementia
A transgenic mouse transformed with a DNA encoding a mutant human tau protein, wherein the mouse exhibits neurofibrillary tangles in its brain. The transgenic mouse is useful for the development of...
|
|
|
7126040 |
Mouse model for aging
A mouse model for mammalian aging is disclosed. In one embodiment, the invention comprises a mouse having a genomic mutation in the exonuclease domain II (ExoII) of a mitochondrial DNA polymerase...
|
|
|
7119249 |
Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The...
|
|
|
7115793 |
Isolation and identification of transcription control elements associated with mouse eosinophil peroxidase expression
The present invention relates to novel transcription control elements derived from a mouse eosinophil peroxidase gene. Such transcription control elements may comprise isolated polynucleotides,...
|
|
|
7112715 |
Transgenic mouse for targeted recombination mediated by modified Cre-ER
The present invention relates to a metazoan organism, with the exception of humans, and in particular a mouse, characterized in that at least one cell of this organism comprises at least one fusion...
|
|
|
7105717 |
Model rat with the onset of prostatic cancer
To provide a rat model with the onset of prostate cancer in which the prostate cancer including an invasive cancer can be developed and can be bred for generations stably. A rat model with the...
|
|
|
7098373 |
IL-18 transgenic animal
Transgenic non-human mammals comprising a DNA with an exogenous IL-18 gene incorporated in it such that the exogenous IL-18 gene is skin-specifically expressed, or their offsprings. The transgenic...
|
|
|
7098372 |
Pharmaceutical compositions and methods of using secreted frizzled related protein
Pharmaceutical compositions and methods of use in regulation of mammalian bone forming activities of SFRPs (secreted frizzled-related proteins) are disclosed. SFRPs are secreted receptors for Wnts...
|
|
|
7094948 |
Transgenic animals
There is discloses a transgenic mouse over-expressing a potassium channel BEC1, which can be used as an effective tool for screening a substance for antidementia or a substance to improve learning...
|
|
|
7081561 |
Gene-targeted animal model of apolipoprotein E4 domain interaction and uses thereof
The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further...
|
|
|
7078585 |
Bacterial cell component-unresponsive model mouse
A knockout mouse which is unresponsive to peptidoglycan, a lipoprotein/lipopeptide and the like, and is useful for elucidating the contribution of individual members of the TLR family to a...
|
|
|
7078584 |
Salmonella typhimurium-infected Caenorhabditis elegans for identifying inhibitors of infection
Disclosed are screening methods for identifying the interplay between environmental and host signals (e.g., host-dependent or host-independent signals) and physiological pathogenic pathways that...
|
|
|
7067714 |
N-calcium channel knockout animal
A non-human animal in which a gene coding for the N-type calcium channel is disrupted to lack functional N-type calcium channel, and a method for screening for a substance having a pharmacological...
|
|
|
7067712 |
Caspase 1 gene transfer animal
A transgenic rodent or its offspring which carries DNA having an exogenous caspase 1 gene integrated thereinto in such a manner as to express the gene specifically to the skin. The transgenic...
|
|
|
7064243 |
Screens and assays for agents useful in controlling parasitic nematodes
The invention provides a method of identifying anti-nematode compounds and further provides transgenic nematodes that may be used to practice the method. In particular, the invention provides a...
|
|
|
7060871 |
Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function
The present invention deals with gene therapy for treating chronic heart failure and other cardiac disease states which are accompanied by a reduced number or functioning of myocardial...
|
|
|
7060870 |
Transgenic mice over-expressing ABAD and mutant APP in brain as model of Alzheimer's disease and uses thereof
The present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter operatively linked to a DNA sequence which...
|
|
|
7057086 |
Therapeutic methods employing PAI-1 inhibitors and transgenic non-human animal for screening candidate PAI-1 inhibitors
A method of testing a candidate composition for PAI-1 inhibition activity is disclosed. The method includes the steps of obtaining a transgenic non-human warm blooded vertebrate animal having...
|
|
|
7056724 |
Storing data encoded DNA in living organisms
Current technologies allow the generation of artificial DNA molecules and/or the ability to alter the DNA sequences of existing DNA molecules. With a careful coding scheme and arrangement, it is...
|
|
|
7045674 |
Animal model for preeclampsia
The invention provides an animal model for preeclampsia that allows candidate compounds to be screened for their ability to treat preeclampsia.
|
|
|
7045678 |
Transgenic mouse for screening therapeutic agents for brain tumors
A transgenic, non-human mammal useful for assessing the effect of candidate chemotherapeutic drugs on the growth of brain tumors in vivo is provided. Incorporated into the genome of the transgenic...
|
|
|
7041869 |
Transgenic luciferase mouse
The present invention provides a transgenic animal expressing the reporter gene, luciferase, driven by a promoter (e.g. the E2F1 promoter) that acts as a sensor of cell cycle. The luciferase...
|
|
|
7038105 |
Transgenic mouse EDG2 knockout model
The present invention provides a transgenic non-human animal and method for using the same in evaluating a therapeutic agent for use in the treatment of Schizophrenia. More specifically, the...
|
|
|
7038106 |
Detection of neural activity
The present invention discloses an in situ method of screening a compound for pharmacological activity comprising the steps of detecting an initial pattern of neural activity in brain tissue,...
|
|
|
7034200 |
Non-human transgenic animals expressing platelet-derived growth factor C (PDGF-C) and uses thereof
Non-human transgenic animals overexpressing PDGF-C and cells thereof have been created. The transgenic animals contain a nucleotide sequence that encodes for platelet derived growth factor C...
|
|
|
7030290 |
Caenorhabditis elegans strain HD8: a mutant exhibiting constitutive pharyngeal pumping
The invention provides methods of screening compounds for potential pharmacological activity using nematode worms, principally but not exclusively the nematode C. elegans . Specifically, the...
|
|
|
7022892 |
Non-human genetically modified mammal lacking the alpha-fetoprotein
The present invention is related to a non-human genetically modified mammal comprising a mutation, a partial or total deletion of the genetic sequence encoding the wild type mammal alpha-fetoprotein.
|
|
|
7022893 |
Knockin gene-mutated mouse comprising a mutant presenilin-1 gene
A gene-mutated animal such as a mouse which comprises a mutant prsenilin-1 gene comprising a DNA having a sequence encoding a mutant presenilin-1 protein in which an amino acid is substituted with...
|
|
|
7019194 |
SCCE modified transgenic mammals and their use as models of human disease
Genetic evidence that an imbalance in the activity of serine proteases can cause severe skin disease has recently been presented. The serine protease SCCE is preferentially expressed in cornifying...
|
|
|
6995298 |
Transgenic mammals expressing mutant GP IIIa
The present invention relates to mammals into which foreign DNA has been introduced or in which various modifications or substitutions have been made to an integrin β subunit, thereby generating...
|
|
|
6992234 |
FcRn-based therapeutics for the treatment of auto-immune disorders
Disclosed is a transgenic knockout mouse whose genome comprises a homozygous disruption in its endogenous FcRn gene. The homozygous FcRn disruption prevents the expression of a functional FcRn...
|
|
|
6984771 |
Mice heterozygous for WFS1 gene as mouse models for depression
The present invention describes a recombinant rodent model for depression. More particularly, the rodent comprises cells expressing mutations in the WFS1 gene. The rodent is preferably a mouse...
|
|
|
6982361 |
Method of screening a compound for anxiolytic activity in an Apolipoprotein e knockout animal
Methods and compositions for use in treating anxiety are provided. In the subject methods, an effective amount of an agent having ApoE3 activity is administered to a host suffering from an anxiety,...
|
|
|
6977157 |
Clock gene promoter
The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a...
|
|
|
6962688 |
Methods for modulation of cholesterol transport
Methods for regulation of lipid and cholesterol uptake are described which are based on regulation of the expression or function of the SR-BI HDL receptor. The examples demonstrate that estrogen...
|
|
|
6962815 |
AAV2 vectors and methods
The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation...
|
|
|
6953874 |
Transgenic animals having a modified glycoprotein V gene
The present invention relates to nonhuman transgenic animals in which the GP V gene has been modified. The invention is also useful for identifying agents that modulate the biological functions of...
|
|
|
6953875 |
Transgenic zebra fish embryo model for hematopoiesis and lymphoproliferative disorders
A transgenic zebrafish animal model is disclosed. The model can be used for study of hematopoetic cell differentiation, control, and screening of therapeutic agents and can include a transgenic...
|
|
|
6949692 |
Method for identifying mutants and molecules
Methods for breeding mutagenized mice permit detection of genetic loci that in heterozygous mutated form can modify a known index phenotype involves crossing a mutagenized founder strain and a...
|
|
|
6949337 |
Cellular receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle
The present invention provides methods of identifying anti-HIV compound by contacting human Vpr Interacting Protein (hVIP), or a fragment thereof known to interact with Vpr, with Vpr, or a fragment...
|
|
|
6949691 |
Human albumin animal models for drug evaluation, toxicology and immunogenicity studies
An animal model is provided which is genetically engineered to express human serum albumin, and such animals may be advantageously used in assessing drugs, vaccines or other therapeutic compounds...
|
|
|
6949690 |
Methods of assessing the effect of a gene of interest on human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
|
|
|
6943277 |
Transgenic mice containing stefin homolog protease inhibitor gene disruptions
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
|
|
|
6943278 |
Transgenic Drosophila having a disrupted Parkin gene and exhibits reduced climbing ability
The present invention relates to animal models for neuronal function, e.g., spontaneous changes in motor ability related to neuronal degeneration. For example, the present invention provides a ...
|
|
|
6933422 |
Nav2 channel gene-deficient mice
An object of the present invention is to provide a null mutant non-human animal showing salt intake behavior similar to that of wild-type animals under water-sufficient conditions and showing much...
|
|
|
6924414 |
Muir-torre-like syndrome in Fhit deficient mice
The invention provides nonhuman transgenic animals with a disrupted FHIT gene. The invention further provides transgenic mice in which one or both Fhit alleles have been inactivated. Preferably,...
|
|
|
6921845 |
Use of animal model deficient in p53 and having memory deficiency and/or behavioral disorders for therapeutic purposes
Mice that are deficient in p53 are found to have memory disorders and/or behavioral disorders such as increased anxiety. A method of using p53-deficient mice to screen compounds for memory...
|
|
|
6909030 |
PTTG knockout rodent as a model to study mechanisms for various physiological phenomena, including diabetes
Disclosed is a null mutant (or knockout) rodent comprising in its germ cells an artificially induced PTTG null mutation. In some embodiments, the null mutant rodent can be generated by way of...
|