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7393994 |
Transgenic mouse model for neurodegenerative diseases
Alzheimer's disease, Parkinson's disease and Lewy body disease are the most commonly found neurodegenerative disorders in the elderly. The invention is a transgenic mouse that contains two...
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7388124 |
Non-traumatic model for neurogenic pain
A method for producing a non-human mammalian model for neurogenic pain is provided, which includes altering a peripheral nerve of a non-human mammal by non-surgically placing a gel substance into...
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7371921 |
Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide
An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a...
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7365239 |
In vivo models for rabGEF1-dependent signaling and functions
Non-human transgenic animal models and cells derived therefrom are provided for RabGEF1 function. RabGEF1 is a negative regulator of FcεRI-dependent mast cell activation and T cell activation via...
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7358415 |
Methods and compositions relating to modulation of hepatocyte growth, plasma cell differentiation or T cell subset activity by modulation of XBP-1 activity
The invention demonstrates that the transcription factor XBP-1 is a regulator of hepatocyte growth, plasma cell differentiation and T cell subset activity. Methods for identifying modulators of...
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7351874 |
Mouse model for fatty acid amide-related neurobehaviors
The invention relates to an animal model for studying behavior related to fatty acid amide and hydrolysis of fatty acid amide. The invention provides transgenic animals in which the protein fatty...
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7351875 |
FcγRIIa transgenic animal model for autoimmune disease
The present invention provides a FcγRIIa transgenic non-human animal model for autoimmune disease, particularly arthritis. This invention also provides a method of using this model to screen...
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7348156 |
7B2 knockout transgenic animals as models of endocrine disease
In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous...
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7342146 |
Neurodegenerative non-human transgenic mammal expressing TrkA fusion protein
The present invention provides a neurodegenerative, non-human transgenic mammal whose cells contain a TrkA-hFc transgene for encoding at least a TrkA fusion protein and the use thereof.
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7332643 |
Ferritin light subunit variant-encoding nucleic acids, polypeptides, transgenic animals comprising the same, antibodies thereto, and methods of use thereof
Nucleic acids encoding a novel ferritin light chain variant, a ferritin light chain variant polypeptide, ferritin light chain variant polypeptide-specific antibodies, and methods of use thereof are...
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7329795 |
Model animals non-responsive to mycobacterial-origin lipoprotein/lipopeptide
The present invention is to provide TLR1 knockout mice specifically recognizing mycobacterial lipoproteins/lipopeptides, being useful to clarify the role of TLR1 in vivo, or a method for screening...
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7323617 |
Tie-2 driven overexpression of calreticulin as an inducer of non-small cell carcinoma of lung
A transgenic mouse whose genome comprises a Tie-2 promoter operably linked to a cDNA encoding calreticulin (CRT) is described.
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7323616 |
Genetically altered mice deficient in functional caspase-9
The invention relates to genetically manipulated animals that are deficient in the expression of Caspase-9, a protein involved in programmed cell death. The invention further relates to methods for...
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7314968 |
Transgenic fish and β-catenin signaling pathway model
The present invention is directed a Lef1/β-catenin-dependent reporter and to transgenic fish containing this reporter. The present invention is also directed to the use of the reporter and the...
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7309812 |
Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses
The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and an amyloid encoding...
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7309810 |
Nonhuman model animal suffering from Guillain-Barré syndrome and/or fisher syndrome
The present invention intends to provide a non-human animal model of Guillain-Barré syndrome, which can be obtained by immunizing FcγRIIB-gene-deficient non-human animal with ganglioside GQ1 b ,...
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7309811 |
Transgenic mice knockouts of BACE-1
The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for...
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7301068 |
Nonhuman model animal of Th2-mediated hyperimmune response
An object of the present invention is to provide a nonhuman model animal of Th2-mediated hyperimmune response lacking PIR-B gene function on its chromosome by which the Th2-mediated immune response...
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7301067 |
Mice which are +/− or −/− for the elastin gene as models for vascular disease
Elastin, the main component of arterial extracellular matrix, was thought to have a purely structural role. Consistent with this view, elastin hemizygous mice maintain arterial extensibility by...
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7297836 |
Methods of detecting neurological disorders
The present invention provides methods of detecting an amyloid peptide-related neurological disorder in an individual; and methods for staging an amyloid peptide-related neurological disorder in an...
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7276644 |
Transgenic mouse comprising a myosin heavy chain atpase loop 1 mutation
The invention provides a transgenic mouse that is a model for myocardial function. Also provided are methods for using the transgenic mouse model to study heart muscle, cardiac disease and identify...
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7276643 |
Transgenic animals, cell lines derived therefrom, and methods for screening for anti-amyloidogenic agents
The methodologies of the present invention demonstrate that a critical balance between pro- and anti-amyloidogenic molecules exists that regulates amyloid formation and cell death in Alzheimer's...
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7273963 |
Malarial animal model having a chimeric human liver
The present invention features a non-human animal model of malaria, e.g., Plasmodium , particularly Plasmodium falciparum . The model is based on a non-human, immunocompromised transgenic animal...
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7271311 |
Mammalian model for diabetes
An object of the present invention is to provide a model mammal for diabetes onset, being useful for elucidating the onset mechanism of diabetes caused by a blockage of signal transduction from...
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7270998 |
Method of concentrating and separating dopaminergic neurons
The invention of this application provides a method comprising introducing a reporter nucleic acid molecule that expresses a fluorescent protein under control of the promoter/enhancer of a gene...
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7265259 |
GSK-3β expressed in a transgenic mouse
A transgenic animal in which GSK-3β protein is over-expressed is useful as a model for neurodegenerative disease.
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7262336 |
Transgenic animal
A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS)...
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7259290 |
Animal model of human hematopoietic tumor
Production and utilization of model mouse, in which human hematopoietic tumor cells can be grown, expressing symptom of human hematopoietic tumor, and can be used in the screening of anticancer...
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7258870 |
Poultry feed supplement for increasing poultry-based meat weight
The present invention relates to a method of increasing the live weight of poultry through the administration of a plasma product to the poultry through the animals' feed and/or water. The product...
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7259289 |
MCH1R deficient mice
The present invention features viable MCH1R deficient mice. MCH1R deficient mice contain an alteration in one or both MCH1R alleles that substantially reduces expression of a functional MCH1R from...
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7253334 |
Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features...
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7250551 |
Transgenic mice expressing inducible human p25
Disclosed are improved methods of treating individuals with Alzheimer's disease (AD) as well as methods to diagnose AD in an individual. Also included are compounds and methods of identifying...
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7247766 |
Double transgenic mice overexressing human beta secretase and human APP-London
The present invention relates to a novel animal model for amyloidopathies, especially Alzheimer' disease overexpressing human BACE and human APP London. This novel animal model exhibits several...
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7247767 |
Mouse model for psoriasis and psoriatic arthritis
A mouse that is deficient for c-Jun and JunB in the epidermis or in which deletion of c-Jun and JunB can be specifically induced in the epidermis, and methods for obtaining such mice. The mice and...
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7235709 |
Transgenic animals with increased slow-twitch muscle fibers and methods of using such animals
Transgenic non-human mammals over-expressing MHCI in skeletal muscle are provided herein, as are methods of using these transgenic non-human mammals for screening candidate compounds for treating...
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7230155 |
Method for identifying an agonist of neuronal calcium sensor-1 (NCS-1), for therapy of CNS disorders
Provided is a method for determining whether an agent is an agonist of the neuron-specific calcium sensor-1 (NCS-1), for consideration of an agonist of NCS-1 as a drug candidate for therapy of a...
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7227052 |
GFP expression vector localized in mitochondria
A system for observing the behaviors of mitochondria during ontogeny and the dynamics of mitochondria in various tissues during pathological development is provided. A pCAGGS expression vector...
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7214850 |
Transgenic mouse expressing Prkag3
Transgenic non-human animals that express the γ3 subunit of PRKAG are described, as well as methods of using the transgenic non-human animals as models for improving treatment, prevention, or...
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7202394 |
Animal with the mass expression of human gene and test method by using the animal
The present application provides a human gene over-expressing animal, which is a non-human animal carrying a human hematopoietic prostaglandin D 2 synthase gene in its somatic cell chromosome and...
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7202392 |
In vivo screening array
The invention features methods of evaluating the effect of a plurality of different treatments or compounds on a tissue. The method includes providing a tissue from an animal; contacting the tissue...
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7196243 |
Transgenic animal containing CD200 and uses therefor
The present invention is directed toward a transgenic non-human animal and uses thereof, wherein each of the cells of the animal contain a transgene comprising a nucleic acid sequence encoding CD200.
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7186881 |
Testing compounds for effects on synaptophysin in transgenic mice expressing an Alzheimer's disease FAD DNA sequence
The construction of transgenic animal models of human Alzheimer's disease, and methods of using the models to screen potential Alzhe## disease therapeutics, are described. The models are...
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7186879 |
Screening systems and methods for identifying modulators of xenobiotic metabolism
The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify CAR ligands, including...
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7186880 |
Adult T cell leukemia model animal
The present invention provides an adult T cell leukemia model animal, which is a T cell function deficient animal to which a cell line infected with human T cell leukemia virus-1 is transplanted....
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7179953 |
Monitoring APP cleavage in transgenic rodents comprising an APP-Swedish mutation
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
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7176345 |
Transgenic animals expressing light-emitting fusion proteins and diagnostic and therapeutic methods therefor
Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are...
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7166764 |
Noc2 knockout mouse
Disclosed are a mouse homozygous or heterozygous for the defect of the Noc2 gene, and a tissue and a cell of the mouse. The Noc2 knockout mice, which exhibit stress-related insulin hyposecretion...
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7166761 |
Method of screening PTPζ activity promoter or inhibitor
An object of the present invention is to provide a remedy for dysfunction of central monoamine pathway, a method for screening a PTPζ inhibitor or activator, and a non-human model animal being...
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7166762 |
Method of constructing heart failure model animal
A non-human mammal which is usefully and effectively applicable to the screening of a substance to be employed for preventing and treating heart failure. This animal is an animal model of heart...
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7161058 |
Animal model for identifying agents that inhibit or enhance CTLA4 signaling
The present invention relates to a non-human transgenic animal, particularly a knock in mouse, whose genome comprises a heterologous, chimeric CTLA4 gene. The chimeric CTLA4 gene comprises exon 2...
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