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8173859 Epilepsy model animal  
An epilepsy model animal (CHRNA4:S284L) developing spontaneous epileptic seizure during sleep, which is a nonhuman animal established by ontogenesis of a totipotent cell into which a polynucleotide...
8173861 Transgenic pig model for a hereditary neurodegenerative autosomal dominant disease  
The present invention discloses a non-human animal model for a hereditary autosomal dominant disease. The non-human animal model expresses at least one phenotype associated with the disease and is...
8148143 Method and composition for genetically modifying non-human cells and animals  
A vector and its use to generate genetically modified animals and cells is disclosed. One aspect involves a vector that comprises a sperm cell and one or more polynucleotide molecules bound to a...
8134044 Transgenic reptiles  
A transgenic animal such as a transgenic snake or other reptile that expresses a heterologous expression product is described, along with methods of making the same. In general, the animal...
8101816 RGMc modified transgenic animals  
The invention provides a new reproducible transgenic mouse model for the study of iron accumulation in the body. In particular, the invention concerns the study of iron overload in an RGMc knockout...
RE42704 Production of fibrinogen in transgenic animals  
Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding Aα, Bβ and γ chains of fibrinogen are introduced into the germ line of a no...
8008540 Transgenic non-human animal for use in research models for studying Parkinson's disease  
The invention relates to a transgenic mouse model with deficient respiratory chain function in dopamine (DA) neurons. By suppressing or deleting the mitochondrial transcription factor A (Tfam) in...
8003847 Non-human mutant mammals deficient in Sigma receptors and their applications  
The genome of the non-human mutant mammal, deficient in an endogenous Sigma receptor, contains a mutation that comprises a disruption in an endogenous Sigma receptor gene, wherein said gene...
7956238 Porcine pancreatic amylase gene promoter and transgenic pigs expressing heterologous digestive enzymes  
The present invention relates to a novel promoter and its use in driving expression of foreign genes in transgenic animals (especially pigs). Accordingly, the present invention provides a method...
7947448 Use of regulatory sequences for specific, transient expression in neuronal determined cells  
The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant...
7943815 Transgenic mouse for screening and for studies of the pharmacodynamics and pharmacokinetics of ligands acting on the oestrogen receptor and its intracellular receptors, and method for the preparation thereof  
The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any...
7868223 Method for modifying chromosomes  
The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign...
7834237 Materials and methods relating to protein aggregation in neurodegenerative disease  
Disclosed is a method of inducing or modeling a disease associated with pathological tau protein aggregation. The method can be carried out in vitro and animal models, and may be used to screen for...
7745688 Model mouse of Alzheimer's disease expressing FAD APP 716 and use thereof  
The present invention provides a non-human model mammal of Alzheimer's disease (AD) containing chimeric amyloid precursor protein (APP) gene capable of producing human amyloid β peptide (Aβ) or a l...
7732659 Injecting Drosophila embryos  
The present invention provides systems that allow reliable multiplexed transformation of Drosophila embryos. The present invention provides methods and reagents that allow preparation of...
7732658 Composition and method for imaging cells  
The invention relates to compositions containing a polynucleotide encoding for a reporter gene, a selectable marker and a regulatory element, that provide a method for imaging cells in vivo.
7718846 Animal models of long QT syndrome and uses thereof  
Provided are animal models of long QT syndrome (LQTS). The animal models are useful, for example, in screening of drugs for adverse effects in subjects with LQTS, in screening candidate...
7709695 Transgenic mouse expressing arctic mutation E693G  
A transgenic non-human animal expressing at least one transgene including a DNA sequence encoding a heterologous Amyloid Precursor Protein (APP) including at least the Arctic mutation (E693G) and a...
7700825 Recombinant constructs and transgenic fluorescent ornamental fish therefrom  
The present invention relates to the method and use of reef coral fluorescent proteins in making transgenic red, green and yellow fluorescent zebrafish. Preferably, such fluorescent zebrafish are...
7663019 Transgenic snakes and methods of making  
A transgenic animal such as a transgenic snake or other reptile that expresses a heterologous expression product is described, along with methods of making the same. In general, the animal...
7663018 Tau hyperphosphorylation in transgenic mice expressing the APP double mutation  
Animal model involving transgenic manipulation of amyloid precursor protein, useful for testing potential therapeutic agents for the treatment of neurodegenerative disorders, in particular...
7659442 Method for making homozygous genetic modifications  
Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a...
7659443 Method of constructing nucleus-implanted egg, parthenogenetic embryo and parthenogenetic mammal  
Disclosed is a method for constructing a nucleus-implanted egg, a parthenogenetic embryo and for producing a parthenogenetic mammal each having 2 haploid genome sets originating in mammalian ova,...
7622630 Chimeric cancer models  
Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells...
7608750 Nonhuman model animal unresponsive to immunopotentiating synthetic compound  
The present invention relates to provide a non-human animal model unresponsive to a synthetic compound wherein a gene function encoding TLR7 that recognizes an immunopotentiating synthetic compound...
7592502 Knock-in non-human animal producing human tissue factor  
A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been...
7576259 Method for making genetic modifications  
Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a...
7514592 Inducible heart attack animal model  
An animal model of coronary heart disease has been developed where myocardial infarct can be induced by altering the animal's diet. In all embodiments, this animal model is a result of reduced...
7501554 Transgenic animals producing low-lactose milk and newly identified human small intestinal extracellular lactase-phlorizin hydrolase (ecLPH) gene  
The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal...
7498479 Animal model having a chimeric human liver  
The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a...
7491865 Mouse models of prostate cancer development and metastasis through expression of a hepsin transgene  
Transgenic, non-human animal model of cancer, methods of making such animals and methods of using such animals to screen test compounds are provided.
7491868 Mannose binding lectin knock-out mice and methods of use thereof  
A transgenic non-human animal with alterations in the MBL gene is prepared by introduction of a gene encoding an altered MBL protein into a host non-human animal. Methods for using transgenic mice...
7485769 Transgenic mammals  
This invention provides a nonhuman transgenic mammal carrying transgene comprising the regulatory genes capable of functioning in the hyperacute rejection-occurring local cells and gene encoding...
7476536 Artificial human chromosome containing human antibody a light chain gene  
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically,...
7420099 Transgenic animals and uses thereof  
In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic...
7414170 Transgenic bovines capable of human antibody production  
The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy...
7405342 Transgenic mice expressing heterologous complement receptor type 1 (CR1) molecules on erythrocytes and uses therefor  
The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding...
7358416 Transgenic mouse expressing human FcRn protein  
Disclosed is a transgenic knockout mouse whose genome comprises a homozygous disruption in its endogenous FcRn gene. The homozygous RcRn disruption prevents the expression of a functional FcRn...
7355095 Method for producing heart-specific fluorescence of non-human eukaryotic animals  
A method of expressing in vivo heart-specific fluorescence in transgenic line of zebrafish is developed, which provides a research model for studying heart-related gene functions and performing...
7351875 FcγRIIa transgenic animal model for autoimmune disease  
The present invention provides a FcγRIIa transgenic non-human animal model for autoimmune disease, particularly arthritis. This invention also provides a method of using this model to screen ...
7341871 Nucleotide sequences for gene regulation and methods of use thereof  
The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression...
7323618 Tissue specific expression of exogenous proteins in transgenic chickens  
Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous...
7323616 Genetically altered mice deficient in functional caspase-9  
The invention relates to genetically manipulated animals that are deficient in the expression of Caspase-9, a protein involved in programmed cell death. The invention further relates to methods for...
7309811 Transgenic mice knockouts of BACE-1  
The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for...
7294754 Method for generating an animal homozygous for a genetic modification  
Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a...
7282621 Somatic recombination  
Recombination in mammalian somatic cell chromosomes is promoted and marked by a method called mosaic analysis with double marker (MADM). Mouse “knock-in” techniques are used to create pairs of chr...
7271311 Mammalian model for diabetes  
An object of the present invention is to provide a model mammal for diabetes onset, being useful for elucidating the onset mechanism of diabetes caused by a blockage of signal transduction from...
7265259 GSK-3β expressed in a transgenic mouse  
A transgenic animal in which GSK-3β protein is over-expressed is useful as a model for neurodegenerative disease.
7253334 Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells  
The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features...
7250551 Transgenic mice expressing inducible human p25  
Disclosed are improved methods of treating individuals with Alzheimer's disease (AD) as well as methods to diagnose AD in an individual. Also included are compounds and methods of identifying...
Matches 1 - 50 out of 263 1 2 3 4 5 6 >