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7608750 |
Nonhuman model animal unresponsive to immunopotentiating synthetic compound
The present invention relates to provide a non-human animal model unresponsive to a synthetic compound wherein a gene function encoding TLR7 that recognizes an immunopotentiating synthetic compound...
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7608749 |
Monitoring APP cleavage in transgenic rodents comprising an APP Swedish mutation
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
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7601883 |
Mammalian sour/acid taste and CSF receptor genes, polypeptides and assays
Acid/sour taste receptors are provided. CSF pH sensing receptors are provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals,...
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7595430 |
Methods and animal model for analyzing age-related macular degeneration
Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and...
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7592502 |
Knock-in non-human animal producing human tissue factor
A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been...
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7592501 |
Methods for maintaining genetic stability of inbred animal strains
The present invention provides novel methods of maintaining genetic stability of non-human animal inbred strains. In the methods, pedigree-tracked cryopreserved embryos derived from a foundation...
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7586022 |
Transgenic non-human animal model of lung tumorigenesis
The present invention is a transgenic non-human animal whose genome contains a transgene containing a nucleic acid encoding a cyclin E protein operably linked to a regulatory element including a...
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7586021 |
Nucleic acid construct, metabolic disordered non-human animal and use thereof
The present invention provides a transgenic non-human animal comprising a human-derived LXRα mutant gene to express a human LXRα mutant protein, wherein the human LXRα mutant is an isoform of...
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7585963 |
Chicken ovalbumin nucleotide sequence
The present invention provides isolated and recombinant avian nucleic acid molecules comprising at least one avian MAR and an avian nucleic acid sequence encoding an ovalbumin transcriptional...
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7579515 |
Increasing gamete production with a gene switch
A method of enhancing the production of gametes in a transgenic non-human animal is carried out by: (a) providing a transgenic non-human animal comprising cells that contain: (i) a response...
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7576258 |
Transgenic transchromosomal rodents for making human antibodies
The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
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7566812 |
Transgenic mouse models of hepatitis C virus (HCV) and identification of HCV therapeutics
Disclosed herein is the discovery of novel NS3/4A compositions with enhanced expression abilities. Embodiments of the invention include codon optimized NS3/4A compositions and compositions with the...
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7560610 |
p27-deficient mouse exhibiting tissue hypertrophy
Hypercellular nonhuman organisms have functionally inactivated expression of a cyclin inhibitor gene, especially p27. The growth rate of nonhuman organisms are increased such that a desired size is...
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7557258 |
Endotoxin-nonresponsive model animal
The present invention is to provide a non-human animal model non-responsive especially to endotoxin being a Gram-negative bacteria cell wall fraction, which is useful to elucidate the function of...
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7554004 |
Allelic series of genomic modifications in cells
The present invention relates to methods of producing an allelic series of modifications in genes of interest in a cell. In particular, the invention provides methods for using nucleic acid...
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7550649 |
Transgenic non-human mammal
An object of the present invention is to provide a model animal of Parkinson's disease comprising an α-synuclein gene introduced therein. The present invention provides a transgenic non-human...
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7550648 |
Inducing neurofibrillary tangles in transgenic mice expressing a mutant tau protein
The present invention discloses a method and an in-vivo assay system useful for the identification and testing of modulating agents as well as for the validation of therapies of neurodegenerative...
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7547817 |
Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
The present invention provides fully human antibodies in a transgenic animal of a desired isotype in response to immunization with any virtually any desired antigen. The human immunoglobulin heavy...
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7544855 |
Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
In accordance with the present invention, it is demonstrated that selected mutations such as an Asp->Ala (D664A) mutation in APP (which prevents cleavage at the caspase cleavage site) prevent...
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7544854 |
Transgenic non-human animals for pharmacological and toxicological studies
The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from...
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7541511 |
Mouse exhibiting characteristics of Rothmund-Thomson syndrome and preparation method thereof
A non-human mammal, especially a mouse exhibiting a characteristic of Rothmund-Thomson syndrome prepared by introducing a mutation into exon 13 of RECQL4 gene; and method of preparation thereof are...
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7538258 |
Transgenic mouse expressing an APP 670/671 mutation
The invention provides an isolated nucleic acid characteristic of human amyloid precursor protein 770 including the nucleotides encoding codon 670 and 671, wherein the nucleic acid encodes an amino...
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7531714 |
Melusin a muscle specific protein, as a drug target for prevention and treatment of heart failure
The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be...
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7531712 |
P450 gene regulation
The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional...
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7524490 |
Clusterin-mediated inhibition of apoptosis via stromal bone marrow cell delivery to a cardiac site
Methods and compositions are disclosed for inhibiting, deterring or preventing apoptosis of cardiac myocytes, transplanted stem cells, vascular stem cells, and vascular smooth muscle cells by means...
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7521590 |
Phospholipase C β1 (PLCβ1) knockout mice as a model system for testing schizophrenia drugs
The present invention relates to a method for screening therapeutic drugs of schizophrenia using an animal model of the disease. More specifically, this invention relates to a screening method...
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7518033 |
Methods for the production of cells and mammals with desired genetic modifications
The present invention features novel methods for generating cell lines and mammals with site-specific genetic modifications of interest. The methods involve homologous recombination between an...
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7514594 |
Transgenic animal model of bone mass modulation
The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing...
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7514593 |
Animal model for chronic obstructive pulmonary disease and cystic fibrosis
A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter...
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7514592 |
Inducible heart attack animal model
An animal model of coronary heart disease has been developed where myocardial infarct can be induced by altering the animal's diet. In all embodiments, this animal model is a result of reduced...
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7507872 |
Transgenic toll-like receptor 9 (TLR9) mice
The present invention provides a receptor protein specifically recognizing bacterial DNA having an unmethylated CpG sequence, a genomic DNA encoding it, an experimental animal model useful for...
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7501554 |
Transgenic animals producing low-lactose milk and newly identified human small intestinal extracellular lactase-phlorizin hydrolase (ecLPH) gene
The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal...
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7501552 |
Transgenic non-human animals for producing chimeric antibodies
The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial...
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7498479 |
Animal model having a chimeric human liver
The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a...
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7495147 |
Neuregulin-1 transgenic mouse and methods of use
Nucleic acids comprising the neuregulin 1 gene (NRG1) and encoding NRG1 polypeptides are disclosed. Also described are related nucleic acids encoding NRG1 polypeptides; NRG1 polypeptides;...
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7491868 |
Mannose binding lectin knock-out mice and methods of use thereof
A transgenic non-human animal with alterations in the MBL gene is prepared by introduction of a gene encoding an altered MBL protein into a host non-human animal. Methods for using transgenic mice...
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7491865 |
Mouse models of prostate cancer development and metastasis through expression of a hepsin transgene
Transgenic, non-human animal model of cancer, methods of making such animals and methods of using such animals to screen test compounds are provided.
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7488865 |
Urocortin-deficient mice and uses thereof
The present invention provides transgenic mice deficient in urocortin. Urocortin null mutant mice are hypersensitive to stress and display heightened anxiety-like behaviors in the elevated plus...
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7482506 |
Ras p27 mouse models and uses thereof
The subject invention pertains to a transgenic animal model for tumorigenesis having a genome comprising a ras transgene and which is heterozygous or homozygous for a null p27 gene, and methods of...
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7462757 |
Animal with gene hypoexpression
The present invention relates to non-human animal embryonic stem cells in which a lecithin:cholesterol acyltransferase-like lysophospholipase endogenous gene is inactivated; non-human animals...
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7459602 |
Mammalian cancer cell and transgenic mammal carrying human protooncogene and kit for diagnosing cancer using said protooncogene
The present invention provides a mammalian cell transfected with an expression vector comprising a human protooncogene which has the nucleotide sequence of SEQ ID NO: 1; a mammalian embryo carrying...
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7459601 |
Human α synuclein expressing transgenic mice
In methods for screening treatments for, and treatment of, neurodegenerative diseases, aggregation in neurons of NACP/α-synuclein is measured and expression of a non-amyloidogenic protein is...
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7459600 |
Isolation, selection and propagation of animal transgenic stem cells
Animal stem cells are obtained and maintained by culturing cells containing, in the genome, a selectable marker. Differential expression of the selectable marker enables preferential survival...
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7456333 |
Transgenic non-human mammals as models for human pathologies of stem cell origin
Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia,...
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7453021 |
Transgenic animal model for degenerative diseases of cartilage
The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly...
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7449615 |
Non-invasive evaluation of physiological response in a transgenic mouse
The present invention relates to panels of reporter expression cassettes and the generation of transgenic non-human animals, wherein said reporter expression cassettes have selected control...
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7446239 |
SCA2 knockout animal and methods of use
The invention provides a mutant non-human mammal having a disrupted SCA2 gene, in particular, a mutant mouse having a disrupted SCA2 gene. The invention also provides methods of identifying a...
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7435872 |
Role of p62 in aging-related disease
The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality,...
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7435871 |
Transgenic animals bearing human Igλ light chain genes
The invention relates to transgenic animals bearing one or more human λ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have...
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7435869 |
Transgenic nonhuman mammals producing fibrinogen in milk and methods of producing fibrin
A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain...
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