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6218596 |
Enhancement of musculature in non-human mammals expressing c-ski
The present invention relates to DNA segments encoding chicken c-ski protein, to DNA constructs comprising the DNA segments and to cells transformed therewith. The present invention further relates...
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6218597 |
Transgenic model and treatment for heart disease
The invention provides a transgenic mouse that is a model for heart muscle disease and heart failure. Also provided are methods of using the transgenic mouse model to study heart muscle disease and...
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6218595 |
Dopamine transporter knockout mice
A recombinant rodent comprises cells containing a pair genomic dopamine transporter protein alleles, wherein at least one of said alleles is incapable of expressing endogenous dopamine transporter...
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6215040 |
IL-5 transgenic mouse
A transgenic mouse is provided, the cells of which contain and express IL-5 in a cell type- or tissue-specific manner and in an amount which results in an IL-5-associated pathology. Also provided...
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6211428 |
Transgenic mouse expressing a familial form of human amyloid precursor protein
Transgenic non-human mammals which express in their brains a nucleic acid construct comprising a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717...
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6207878 |
Sarcospan-deficient mouse as a model for clinical disorders associated with sarcospan mutations
Disclosed is a transgenic knockout mouse whose genome has a homozygous disruption in its endogenous sarcospan gene, wherein the disruption prevents the synthesis of functional sarcospan in cells of...
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6207877 |
Transgenic coagulation factor XIII defective animal and its use for testing wound healing and bleeding
The invention provides a transgenic mouse which is heterozygous or homozygous for an at least partially defective coagulation factor XIII gene.
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6207876 |
Adenosine deaminase deficient transgenic mice and methods for the use thereof
The present invention relates to the production of adenosine deaminase (ADA) deficient mice and the use of such mice as an animal model for dysfunctions associated with elevated adenosine levels....
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6204432 |
PA28 modified transgenic mice
A transgenic mouse with alterations in a 8β gene is prepared by introduction of an altered 8β gene into a host mouse. The resulting transgenic animals do not produce functional 8 molecules....
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6204431 |
Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
The subject invention relates to methods of producing non-human transgenic mammals which produce various oligosaccharides and glycoconjugates in their milk. Additionally, the subject invention...
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6201168 |
Pathogenesis of cardiomyopathy
Disclosed is a mouse, cells derived therefrom, and methods for using the mouse, the mouse being homozygous for a disrupted δ-sarcoglycan gene, the disruption in the gene having been introduced...
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6201167 |
Production of recombinant proteins in semen
The present invention relates to a method for the production and secretion into animal's semen of an exogenous recombinant protein comprising the steps of: a) producing a non-human transgenic...
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6201166 |
Transgenic mouse hepatitis C virus model comprising a hepatitis C viral fragment
Transgenic mice are described which serve as a model for Hepatitis C infection. The transgenic mice contain, in their germline and somatic cells, the Hepatitis C viral fragment CN2, N24 or CR under...
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6194632 |
Mouse model for congestive heart failure
The present invention relates to transgenic mice which express CREB. These transgenic mice provide a genetic model of dilated cardiomyopathy.
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6194633 |
Non-human animal having a functionally disrupted SLP-76 gene
A nonhuman animal having somatic and germ cells in which at least one allele of an endogenous SLP-76 gene is functionally disrupted is provided. The animal may be heterozygous or, more preferably,...
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6194634 |
Apt-sensitive potassium channel gene-defective animals
A Kir6.2 gene-defective, non-human mammal, a mouse in particular, its tissues and cells are provided, wherein the ATP-sensitive potassium channel Kir6.2 gene, one of the subunits of K ATP channels...
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6191342 |
Transgenic mice expressing the HIK-ras 4B chimeric gene
A transgenic mouse whose genome comprises the H/K-ras 4B chimeric gene to form a mammary tumor and, particularly, the expression vector producing H/K-Ras 4B chimeric protein by using MMTV (mouse...
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6187993 |
Transgenic animals as model of psoriasis
A nucleic acid construct comprising a promoter capable of directing expression in the suprabasal cells of the epidermis and means to cause expression of an integrin subunit in the suprabasal cells....
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6187992 |
Transgenic mouse having a disrupted amyloid precursor protein gene
The present invention relates to a transgenic nonhuman animal lacking native amyloid precursor protein. The transgenic mouse of the invention may be used in the study of Alzheimer's Disease and...
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6184435 |
Transgenic mouse expressing APP770-V717F
Methods for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also...
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6184436 |
Transgenic mice expressing HIV-1 in immune cells
The present invention relates to a transgenic mouse to serve as a small animal model of AIDS which comprises at least a DNA sequence coding for HIV-1 nef or a HIV-1 DNA genome essentially...
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6180849 |
Trangenic mice with a disruption in the tiar gene
The invention features transgenic non-human mammals containing a mutation in one or both alleles of the endogenous TIAR gene, and cell lines derived from some of these mammals. The mammals and cell...
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6177610 |
Major basic protein deficient animals
Major basic protein deficient non-human mammals that contain an inactivated major basic protein allele are described. A nucleic acid construct including an inactivated major basic protein gene is...
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6175057 |
Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
The present invention features non-human transgenic animal models for Alzheimer's disease (AD) and CAA, wherein the transgenic animal is characterized by 1) overexpression of bioactive transforming...
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6172277 |
Non-transgenic rodent model of alzheimer's disease
The invention features a method of inducing amyloid plaque deposition in a mammal by infusing into the brain of the mammal an amyloid peptide at a basic pH, a nontransgenic animal model for...
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6172278 |
Ikaros transgenic cells and mice
Transgenic cells, transgenic mice having an Ikaros transgene and methods for the use thereof.
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6166287 |
Corticotropin-releasing factor overproducing transgenic mice
In accordance with the present invention, there are provided CRF overproducing transgenic mice which exhibit endocrine abnormalities involving the hypothalamic-pituitary-adrenal axis, such as...
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6166289 |
IRAK modified transgenic animals
A transgenic animal with alterations in an IRAK gene is prepared by introduction of an altered IRAK gene into a host animal. The resulting transgenic animals do not produce functional IRAK...
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6162963 |
Generation of Xenogenetic antibodies
The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or...
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6159680 |
Assay for pharmacological agents that block neurofibromin action
A targeted disruption of the NF1 gene in mice has been used to demonstrate that both neural crest- and placode-derived sensory neurons isolated from NF1(-/-) embryos develop, extend neurites, and...
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6153427 |
Erythropoietin-inducible, erythroid-specific DNA construct
An erythropoietin-inducible, erythroid-specific DNA construct is disclosed. The DNA construct comprises a promoter sequence from a sheep juvenile beta globin gene, an erythroid-specific enhancer...
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6147275 |
Corticotropin releasing factor receptor 1-deficient mice
Signaling pathways dependent on members of the corticotropin releasing factor (CRF) gene family exert pleiotropic effects within both the brain and peripheral tissues. Two biochemically and...
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6137029 |
PEPCK-insulin gene construct and transgenic mouse
The chimeric gene is directed by a promoter or fusion of promoters which preferably are regulable and activated by the diabetic process. Preferably, it is obtained by fusion of the human insulin...
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6133502 |
Monocyte chemoattractant protein and its receptor transgenic animal
Provided is a non-human animal in which an exogeneous gene, a mutant gene thereof of a monocyte chemoattractant protein and/or a receptor thereof is introduced. The present transgenic animals can...
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6127598 |
NKX-2.2 and NKX-6.1 transgenic mouse models for diabetes, depression, and obesity
The present invention features mouse models for Nkx-2.2 gene function and for Nkx-6.1 gene function, wherein the transgenic mouse is characterized by having a defect in Nkx-2.2 gene function or a...
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6114599 |
Recombinant β-cell and uses thereof
The present invention provides a recombinant, glucose-regulated insulin producing beta cell whose proliferation is controlled by tetracycline or a derivative thereof. The present invention also...
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6111165 |
Production of human recombinant collagen in the milk of transgenic animals
Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human...
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6111166 |
Transgenic mice expressing human Fcα and β receptors
Transgenic animals expressing Fc receptors and uses for the animals in testing the efficacy of human antibodies and in generating novel antibodies are described.
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6107541 |
PRAD1 transgenic mice
The invention relates to isolated nucleic acid sequences encoding PRAD1, and fragments thereof. The invention further relates to transgenic mice bearing a transgene which includes a nucleic acid...
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6107540 |
Mice models of human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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6100445 |
Transgenic knockout mouse having functionally disrupted interleukin-1β converting enzyme gene
A transgenic mouse having somatic and germ cells in which at least one allele of an endogenous interleukin-1β converting enzyme (ICE) gene is functionally disrupted is provided. The mouse may be...
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6100444 |
Prostate specific regulatory nucleic acid sequences and transgenic non-human animals expressing prostate specific antigen
The non-coding regulatory sequences of the prostate specific antigen (PSA) are described. Non-human transgenic animals are also provided which express human PSA, which is non-naturally occurring in...
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6096876 |
1-α-hydroxylase materials and methods
The invention is directed to polynucleotides encoding all or a fragment of the P450 moiety of vitamin D1 α-Hydrdoxylase and polypeptides encoded thereby. It encompasses antibodies to the...
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6093873 |
Genetically engineered mice containing alterations in the gene encoding RXR
The present invention is directed to mice which are genetically altered to be deficient in the normal expression of RXRγ, to mice heterozygous for such deficiency, and to cell lines, preferably...
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6087555 |
Mice lacking expression of osteoprotegerin
Disclosed is a mouse in which expression of the gene encoding Osteoprotegerin is suppressed. Also disclosed is a nucleic acid construct useful in preparing such a mouse, and a cell line containing...
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6087556 |
Transgenic animals capable of replicating hepatitis viruses and mimicking chronic hepatitis infection in humans
Transgenically modified animals which replicate hepatitis viruses are provided for use in evaluating virus-chemical and virus-drug interactions in chronic hepatitis infections.
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6087554 |
Transgenic animals for the determination of agents which stimulate or repress epidermal hyperproliferation and hair growth
A vertebrate, non-human transgenic animal whose cells, both somatic and germinal, contain a recombinant genetic construction formed of a marker gene and a regulator region capable of being induced...
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6080911 |
Mice models of growth hormone insensitivity
The present invention provides mouse models of growth hormone insensitivity including Laron syndrome. In particular, the present invention provides transgenic mice incapable of expressing...
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6080910 |
Transgenic knockout animals lacking IgG3
The present invention provides non-human transgenic animals in which an antibody subtype is selectively inactivated such that the transgenic animals express a reduced level of IgG3 relative to the...
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6077990 |
PAR2 modified transgenic mice
Transgenic mice with a non-functional proteinase activated receptor-2 (PAR2) gene are prepared by targeted disruption of the endogenous PAR2 gene. The resulting transgenic mice display a phenotype...
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