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5648597 Alpha-1-acid glycoprotein transgenic mice  
The mice of this invention heritably carry alpha-1-acid glycoprotein (AGP) genes which may be introduced by the transgenic methodology. These animal models are useful for various purposes including...
5612486 Transgenic animals harboring APP allele having swedish mutation  
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
5602305 Immunodeficient animal model for studying T cell-mediated immune  
The present invention describes a novel immunodeficient rodent model comprising an organ graft, such as a human skin graft, said graft containing microvessels lined by endothelial cells, human T...
5602299 Transgenic animal models for neurodegenerative disease  
The design, construction, and use of transgenic animals which exhibit features, including neurofibrillary tangles and aluminum sensitivity, is described. The founder transgenic animals of the...
5602307 Non-human animal having predefined allele of a cellular adhesion gene  
A transgenic mouse which contains a predefined, specific and desired alteration in at least one of its two chromosomal alleles of a cellular adhesion gene, such that at least one of these alleles...
5602309 Transgenic mice which overexpress nerve growth factor  
Transgenic mice that express increased levels of nerve growth factor (NGF) in the epidermis and other stratified, keratinized epithelium. The nerve growth factor expressing transgenic mice are...
5602300 Process for detecting mutations, transgenic mammal transgenic mammalian cell, and process for testing agents or conditioning for mutagenic properties  
Detection of mutations in a lacZ gene including lacZ operator sequence functioning as marker gene located in a plasmid whereof one or more copies are introduced into the DNA of a mammal or of a...
5602304 Hairless mouse  
The DEC strain of mouse which inherits by a dominant gene the following properties; (1) the mouse suffers from alopecia when 6 to 7 weeks old; (2) the alopecia gradually progresses, and over...
5589604 Expression of human protein C in mammary tissue of transgenic mammals  
Recombinant protein C characterized by a high percentage of active protein can be obtained in the milk of transgenic mammals that incorporate DNAs according to the present invention. Transgenic...
5583009 Method of preparing recombinant proteins in transgenic animals containing metallothionein gene elements that bestow tissue-independent copy number-dependent, position-indepedent gene expression  
Vertebrate gene locus control regions linked to a structural gene of interest and inserted into a transgenic animal are capable of bestowing tissue-independent, copy number-dependent,...
5583278 Recombination activating gene deficient mouse  
This invention relates to a recombinant mouse with both alleles of recombination activating gene 2 being functionally deficient. This invention discloses the method to make such mouse and the uses...
5574206 Transgenic mouse carrying a non-infectious HIV genome  
Disclosed herein is a transgenic mouse carrying a transgene which expresses non-infectious HIV ribonucleic acid, and the complementary proteins thereof. The transgenic mouse is useful as a source...
5569824 Transgenic mice containing a disrupted p53 gene  
A desired non-human animal or an animal cell or human cell which contains a predefined, specific and desired alteration in at least one of its two p53 chromosomal alleles, such that at least one of...
5556782 Transformed mammalian cells capable of expressing cecropin b  
Novel means have been discovered for increasing the resistance of a mammalian host (including humans) to diseases caused by intracellular bacteria, protozoa, and viruses. Novel means have also been...
5550316 Transgenic animal model system for human cutaneous melanoma  
The present invention relates to transgenic animal model systems for human cutaneous melanoma. It is based, at least in part, on the discovery that, in susceptible transgenic mice, accelerated...
5545806 Ransgenic non-human animals for producing heterologous antibodies  
The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect...
5545807 Production of antibodies from transgenic animals  
Chimaeric or wholly foreign immunoglobulin is obtained from cells or body fluid of a transgenic animal which has had inserted into its germline genetic material that encodes for at least part of an...
5530179 Transgenic immunodeficient animal models  
The invention features a transgenic mouse having a substantial deficiency in functionally active natural killer cells and T lymphocytes which is useful as a model system for immune diseases,...
5530177 Transgenic mice producing bovine α-lactalbumin in their milk  
The present invention relates to the use of a mammary specific α-lactalbumin regulatory sequence to assist in the production of recombinant proteins in mammals' milk. The invention also relates to...
5530178 Mutant mouse lacking CD8 surface marker  
A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology. In these mammals, for...
5516977 Xenogeneic tissue implant in ear pinna  
Immunocompromised hosts comprising xenogeneic fetal lymph node tissue implanted in the ear pinna are provided. The chimeric hosts are prepared by inserting the xenogeneic lymph node tissue into the...
5491284 Nude mouse model for neoplastic disease  
A nude mouse model for human neoplastic disease having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the...
5491283 BRC/ABL transgenic animals as models for Philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia  
The present invention relates to non-human transgenic animals which contain a transgene comprising a BCR/ABL gene fusion and which develop leukemia. In a preferred embodiment of the present...
5489743 Transgenic animal models for thrombocytopenia  
Transgenic mice and methods of preparing such mice are disclosed. The mice exhibit decreased platelet counts and/or megakaryocyte leukemia.
5434341 Xenogeneic lymph node in mammary fat pad  
Methods and chimeric immunocompromised hosts comprising functional xenogeneic organs are provided, particularly hematopoietic organs, where the xenogeneic organ is engrafted into a mammary fat pad....
5434340 Transgenic mice depleted in mature T-cells and methods for making transgenic mice  
Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by...
5416260 Homologous recombination for universal donor cells and chimeric mammalian hosts  
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the β 2 -microglobulin gene is inactivated for reducing or eliminating...
5387742 Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease  
Cloned recombinant or synthetic DNA sequences related to the pathology of Alzheimer's disease are injected into fertilized mouse eggs. The injected eggs are implanted in pseudo pregnant females and...
5221778 Multiplex gene regulation  
A transgenic mouse offspring produced by the mating of a first transgenic mouse carrying a transresponder transgene whose expression is regulated by a viral gene product of HSV-1 and a second...
5175383 Animal model for benign prostatic disease  
A male transgenic mouse containing germ cells and somatic cells which contain a recombinant gene which is a vertebrate gene in the int-2/FGF family which is capable of promoting benign prostatic...
5175385 Virus-resistant transgenic mice  
A transgenic mouse with enhanced viral resistance transmissible to its offspring is prepared by introduction of a gene encoding a human interferon having antiviral activity into a host mouse. The...
4873316 Isolation of exogenous recombinant proteins from the milk of transgenic mammals  
This invention relates to the production of recombinant proteins in mammals' milk. Particularly, this invention relates to an expression system comprising the mammal's casein promoter which when...
4736866 Transgenic non-human mammals  
A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.
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