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7547816 |
α(1,3)-galactosyltransferase knockout swine, tissues and organs
The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The...
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7491867 |
Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and...
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7485769 |
Transgenic mammals
This invention provides a nonhuman transgenic mammal carrying transgene comprising the regulatory genes capable of functioning in the hyperacute rejection-occurring local cells and gene encoding...
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7446240 |
Method for the production of porcine nuclear transfer embryos
Methods for the production of nuclear transfer embryos, nuclear transfer embryos and animals derived therefrom are described. The method generally comprises at least the steps of: providing at...
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7435869 |
Transgenic nonhuman mammals producing fibrinogen in milk and methods of producing fibrin
A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain...
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7378569 |
Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
The invention provides a transgenic animal carrying two transgenes, one encoding a human decay accelerating factor (hDAF) and the other encoding a human heme oxygenase-1 (hHO)-1, which are useful...
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7371922 |
Nuclear transfer with porcine embryonic stem cells
Provided is a method for the production of transgenic animals, especially pigs, by the use of nuclear transfer from genetically modified or other embryonic stem cells to either enucleated oocytes...
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7361804 |
Unactivated oocytes in nuclear transfer to produce ungulates
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7355094 |
Methods of ungulate nuclear transfer
A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit...
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7354594 |
Merozoite surface protein 1 lacking glycosylation sites
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is...
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7326824 |
Unactivated ungulate oocytes to produce a transgenic ungulate by nuclear transfer
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7321076 |
Unactivated ungulate oocytes to produce a cloned ungulate by nuclear transfer
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7307198 |
Ungulates produced by nuclear transfer of G1 cells
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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7291764 |
Cloning pigs using non-quiescent differentiated donor cells or nuclei
An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful...
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7238797 |
Nucleic acid encoding a pig heat shock protein 70
The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can...
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7238851 |
Non-human transgenic mammals expressing an n-3 desaturase gene
The present invention features compositions (e.g, nucleic acids encoding fat-1, optionally and operably linked to a constitutively active or tissue-specific promoter or other regulatory sequence...
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7232938 |
Cloning ungulates from a quiescent donor cell
A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit...
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7220718 |
Oral treatment of hemophilia
Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the...
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7199281 |
Method of generating a transgenic livestock animal
The present invention provides methods of producing transgenic livestock animals. The methods generally involve first introducing a nucleoprotein made up of nucleic acid and a recombinase into a...
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7169963 |
Mammals expressing IGF-1 and alpha-lactalbumin in their milk
The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also...
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7141716 |
Inbred miniature swine and uses thereof
The invention provides a swine which is homozygous for a major histocompatibility complex haplotype and at least 60% homozygous at all other genetic loci and such animal is propagatable, and a cell...
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7126039 |
Animal tissue with carbohydrate antigens compatible for human transplantation
This disclosure provides a system for generating animal tissue with carbohydrate antigens that are compatible for transplantation into human patients. The tissue is inactivated homozygously for...
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7115795 |
Transgenic animals expressing salivary proteins
The invention provides a transgenic animal having within its genome a transgene construct for gastrointestinal tract specific expression of a protein. In a preferred embodiment, the protein is a...
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7115796 |
Transgenic pig containing heat shock protein 70 transgene
The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can...
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7087808 |
Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals
The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine...
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7067713 |
C1 Inhibitor produced in the milk of transgenic non-human mammals
The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring...
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7045677 |
Fusion proteins incorporating lysozyme
A process for the production of a peptide is disclosed, the process comprising expressing in the milk of a transgenic, non-human, placental mammal a fusion protein which comprises the peptide to be...
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7041870 |
Transgenic transchromosomal rodents for making human antibodies
The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
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7038107 |
Elimination of endogenous porcine retrovirus
Porcine nucleic acid sequences flanking potentially infectious porcine endogenous retroviral (PERV) insertion sites have been identified and isolated. The unique flanking sequences include porcine...
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7030289 |
Stabilization of milk from transgenic animals
The present invention relates to the stabilization of milk from transgenic animals. In particular, the invention relates to the protection of proteins (e.g. fibrinogen) expressed in milk from...
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6987211 |
Transgenic non-human mammals producing a cholinesterase in their milk
The present invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding the novel forms of human AChE have been...
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6984772 |
Transgenic non-human mammals producing fibrinogen in their milk
A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain...
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6906238 |
Effective nuclear reprogramming in mammals using CDK2 inhibitors
The present invention provides methods of producing a cloned non-human mammalian nuclear transfer (NT) embryo and methods for producing a cloned non-human mammal. Embodiments of the methods include...
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6891082 |
Transgenic non-human animals expressing a truncated activintype II receptor
The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In...
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6888047 |
Transgenic animals as urinary bioreactors for the production of polypeptide in the urine, recombinant DNA construct for kidney-specific expression, and method of using same
The invention relates to recombinant DNA constructs, a method for producing a recombinant biologically active protein in vivo in the urine of a non-human mammal using a kidney-specific promoter,...
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6872868 |
Transgenic mammals
Genetic transformation of a zygote and the embryo and mature organism which result therefrom is obtained by placing or inserting exogenous genetic material into the nucleus of the zygote or into...
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6867347 |
Swine defective for transmission of porcine endogenous retrovirus and uses thereof
Miniature swine whose genomes contain sequences characteristic of pig endogenous retrovirus genes but which are non-infectious to humans are disclosed as sources of organs, tissues and cells for...
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6825395 |
Transgenic non-human mammals expressing the human complement inhibitor (DAF/CD55)
This invention provides transgenic mammals other than man carrying the gene of the human complement inhibitor (DAF/CD55) and expressing the human complement inhibitor in their organs and tissues,...
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6727405 |
Transgenic animals secreting desired proteins into milk
A DNA sequence containing a gene encoding a protein, the gene being under the transcriptional control in the DNA sequence of a mammalian milk protein promoter which does not naturally control the...
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6706947 |
Method for screening for agents against cancer using an immunosuppression animal model
The invention relates to an animal model of cancer. The animal carries a tumour xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying...
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6700037 |
Method of cloning porcine animals
The present invention relates to materials and methods for cloning porcine animals. The invention relates in part to totipotent cells useful for cloning porcine animals, porcine embryos produced...
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6677500 |
Ungulates expressing exogenous IGF-I in their milk
The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also...
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6639122 |
Transgenic swine having HLA-D gene, swine cells thereof and xenografts therefrom
The invention provides a transgenic swine having a transgene encoding a human HLA-DQ or HLA-DR protein, and the swine cells thereof. The invention also provides a graft derived from the transgenic...
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6603059 |
Method of cloning animals
The present invention relates to cloning technologies. The invention relates in part to immortalized and totipotent cells useful for cloning animals, the embryos produced from these cells using...
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6558663 |
Transgenic swine & swine cells having human HLA genes
Methods of promoting tolerance and inhibiting NK cell mediated attack in a human recipient to a swine graft are disclosed The methods include introducing into the recipient a swine hematopoietic...
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6548741 |
Developmental competence for assisted reproduction and nuclear transfer in pigs
An optimum time has been discovered for obtaining porcine oocytes with improved developmental competence. Harvested oocytes are matured by culturing in vitro, and then activated ˜42-46 hours after...
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6545199 |
Embryonic germ cells, method for making same, and using the cells to produce a chimeric porcine
Primordial germ cells are extracted from post blastocyst embryos of an ungulate such as extracting primordial germ cells from the gonadal ridges of 25-day porcine embryos or 34-40 day bovine...
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6538174 |
Animal model for transplantation
The invention relates to an animal model of cancer. The animal carries a tumor xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying...
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6525243 |
Unactivated oocytes as cytoplast recipients of quiescent cell nuclei while maintaining correct ploidy
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
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6518482 |
Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor
A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting...
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