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7608750 |
Nonhuman model animal unresponsive to immunopotentiating synthetic compound
The present invention relates to provide a non-human animal model unresponsive to a synthetic compound wherein a gene function encoding TLR7 that recognizes an immunopotentiating synthetic compound...
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7601884 |
Method of producing cloned animals by demecolcine treatment
A cloned animal is produced by demecolcine treatment characterized by culturing the nuclear transfer embryo in vitro and transferring the embryo in vivo. This significantly improves in vitro...
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7586021 |
Nucleic acid construct, metabolic disordered non-human animal and use thereof
The present invention provides a transgenic non-human animal comprising a human-derived LXRα mutant gene to express a human LXRα mutant protein, wherein the human LXRα mutant is an isoform of...
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7560610 |
p27-deficient mouse exhibiting tissue hypertrophy
Hypercellular nonhuman organisms have functionally inactivated expression of a cyclin inhibitor gene, especially p27. The growth rate of nonhuman organisms are increased such that a desired size is...
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7544855 |
Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
In accordance with the present invention, it is demonstrated that selected mutations such as an Asp->Ala (D664A) mutation in APP (which prevents cleavage at the caspase cleavage site) prevent...
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7531715 |
Double nuclear transfer method and results thereof
A method is described for the production of an animal (offspring) by the process of nuclear transfer. The animal may be produced using donor genetic material in cells taken directly from any stage...
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7521590 |
Phospholipase C β1 (PLCβ1) knockout mice as a model system for testing schizophrenia drugs
The present invention relates to a method for screening therapeutic drugs of schizophrenia using an animal model of the disease. More specifically, this invention relates to a screening method...
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7514594 |
Transgenic animal model of bone mass modulation
The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing...
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7501554 |
Transgenic animals producing low-lactose milk and newly identified human small intestinal extracellular lactase-phlorizin hydrolase (ecLPH) gene
The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal...
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7501553 |
Non-human transgenic mammal comprising a modified MSP-1 nucleic acid
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is...
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7485769 |
Transgenic mammals
This invention provides a nonhuman transgenic mammal carrying transgene comprising the regulatory genes capable of functioning in the hyperacute rejection-occurring local cells and gene encoding...
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7482506 |
Ras p27 mouse models and uses thereof
The subject invention pertains to a transgenic animal model for tumorigenesis having a genome comprising a ras transgene and which is heterozygous or homozygous for a null p27 gene, and methods of...
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7462757 |
Animal with gene hypoexpression
The present invention relates to non-human animal embryonic stem cells in which a lecithin:cholesterol acyltransferase-like lysophospholipase endogenous gene is inactivated; non-human animals...
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7453021 |
Transgenic animal model for degenerative diseases of cartilage
The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly...
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7446239 |
SCA2 knockout animal and methods of use
The invention provides a mutant non-human mammal having a disrupted SCA2 gene, in particular, a mutant mouse having a disrupted SCA2 gene. The invention also provides methods of identifying a...
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7435872 |
Role of p62 in aging-related disease
The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality,...
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7435869 |
Transgenic nonhuman mammals producing fibrinogen in milk and methods of producing fibrin
A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain...
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7414171 |
PD-1-lacking mouse and use thereof
The invention relates to BALB/c mice that are deficient in the programmed cell death-1 receptor (PD-1), a screening method for autoimmune disease medicine using these mice, an IgG self-reactive...
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7411111 |
Method for cloning of the rat by nuclear transfer
The invention relates to a method for cloning in the rat by nuclear transfer. The invention further relates to the rats obtained thus, in the foetal or adult state, as well as use thereof for the...
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7402725 |
WIP, a WASP-associated protein
Described herein is a novel gene and its product, WIP, which associates with WASP. The subject invention relates to the isolated WIP gene or cDNA and transgenic mammals that have the WIP gene...
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7402724 |
Longevity and PAPP-A
This document provides materials and methods related to PAPP-A polypeptides, aging, and transgenic non-human mammals whose genomes comprise a disrupted PAPP-A allele. Methods for making such...
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7399902 |
Mouse cardiac conduction system model
The present invention relates to a transgenic mouse which has integrated a reporter gene in the locus of the Cx40 gene, wherein said reporter gene is expressed in the different components of the...
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7385103 |
Animal model, cells, and treatment for malignant melanoma
The present invention provides transgenic non-human animal models and cell lines which express a metabotropic glutamate receptor 1 in a melanocyte-specific manner and, as a result, exhibit a...
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7378569 |
Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
The invention provides a transgenic animal carrying two transgenes, one encoding a human decay accelerating factor (hDAF) and the other encoding a human heme oxygenase-1 (hHO)-1, which are useful...
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7371920 |
Transgenic mouse model of neurodegenerative disorders
The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology...
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7365239 |
In vivo models for rabGEF1-dependent signaling and functions
Non-human transgenic animal models and cells derived therefrom are provided for RabGEF1 function. RabGEF1 is a negative regulator of FcεRI-dependent mast cell activation and T cell activation via...
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7355093 |
Model animal with overexpression of regucalcin
The present invention provides an animal model which overexpresses regucalcin, a calcium-binding protein that is inherently expressed in the liver and the like of the higher animal, and which is...
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7354594 |
Merozoite surface protein 1 lacking glycosylation sites
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is...
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7335811 |
Method for collecting cells in M phase or G1 phase and method for nuclear transplantation using the cells
Methods for collecting cells in M phase or G 1 phase, by which the percentage of M phase or G 1 phase cells is higher than that attained by the conventional methods are disclosed.
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7323620 |
Activation of equine oocytes
A method for activating an equine oocyte comprising exposing oocyte to a medium containing a concentration of calcium of at least about 4 mM. Preferably the oocyte is exposed to this concentration...
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7312373 |
Nonhuman model animal lacking the ability to control lymphocyte migration
The present invention provides a animal model useful in identifying a molecule controlling in a lymphocyte-specific manner migration and thus elucidating immune-related diseases and pathogenic...
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7309812 |
Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses
The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and an amyloid encoding...
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7304203 |
Transgenic TIEG non-human animals
Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic...
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7282620 |
Type III allergic inflammation model animal
The present invention provides an experimental model animal which does not develop anaphylaxis, a type I allergy, can specifically induce Arthus reaction, a type III allergy, is not affected by...
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7276644 |
Transgenic mouse comprising a myosin heavy chain atpase loop 1 mutation
The invention provides a transgenic mouse that is a model for myocardial function. Also provided are methods for using the transgenic mouse model to study heart muscle, cardiac disease and identify...
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7273963 |
Malarial animal model having a chimeric human liver
The present invention features a non-human animal model of malaria, e.g., Plasmodium , particularly Plasmodium falciparum . The model is based on a non-human, immunocompromised transgenic animal...
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7265260 |
Transgenic non-human mammals expressing constitutively activated tyrosine kinase receptors
A transgenic non-human mammal whose germ cells and somatic cells contain a constructively activated tyrosine kinase receptor introduced into the mammal, or an ancestor of the mammal, at an...
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7262336 |
Transgenic animal
A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS)...
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7259289 |
MCH1R deficient mice
The present invention features viable MCH1R deficient mice. MCH1R deficient mice contain an alteration in one or both MCH1R alleles that substantially reduces expression of a functional MCH1R from...
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7244874 |
Stearoyl CoA desaturase transgenic non-human animals
The present invention provides transgenic, non-human animals that include a transgene that encodes a fatty acid desaturase, e.g., stearoyl-CoA desaturase, and methods for producing such animals....
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7238851 |
Non-human transgenic mammals expressing an n-3 desaturase gene
The present invention features compositions (e.g, nucleic acids encoding fat-1, optionally and operably linked to a constitutively active or tissue-specific promoter or other regulatory sequence...
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7238797 |
Nucleic acid encoding a pig heat shock protein 70
The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can...
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7235709 |
Transgenic animals with increased slow-twitch muscle fibers and methods of using such animals
Transgenic non-human mammals over-expressing MHCI in skeletal muscle are provided herein, as are methods of using these transgenic non-human mammals for screening candidate compounds for treating...
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7220892 |
Transgenic mouse lacking PAPP-A activity
The invention provides materials and methods related to a transgenic non-human mammal whose genome comprises a disrupted PAPP-A allele. Methods for making such transgenic non-human mammals, and...
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7220718 |
Oral treatment of hemophilia
Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the...
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7199281 |
Method of generating a transgenic livestock animal
The present invention provides methods of producing transgenic livestock animals. The methods generally involve first introducing a nucleoprotein made up of nucleic acid and a recombinase into a...
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7196243 |
Transgenic animal containing CD200 and uses therefor
The present invention is directed toward a transgenic non-human animal and uses thereof, wherein each of the cells of the animal contain a transgene comprising a nucleic acid sequence encoding CD200.
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7179953 |
Monitoring APP cleavage in transgenic rodents comprising an APP-Swedish mutation
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
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7176346 |
SLC19A2 amino acid transporter gene disruptions, and compositions and methods related thereto
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
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7169963 |
Mammals expressing IGF-1 and alpha-lactalbumin in their milk
The present invention relates to animals that express exogenous growth factors in their milk, and in particular to pigs that express exogenous IGF-I in their milk. The present invention also...
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