|
Match
|
Document |
Document Title |
|
|
7164055 |
HSPC150-like gene disruptions, compositions and methods related thereto
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
|
|
|
7157615 |
Production of biofilaments in transgenic animals
Disclosed is a method for the recombinant production of biofilaments, such as spider silk or insect fibroins, using transgenic animals which secrete the biofilaments in their milk and/or urine, and...
|
|
|
7138562 |
Transgenic animals
The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid...
|
|
|
7135612 |
Identification of the gene causing the mouse scurfy phenotype and its human ortholog
Isolated nucleic acid molecules are provided which encode Fkh sf , as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and...
|
|
|
7135611 |
Compositions and methods for characterizing and regulating Wnt pathways
The present invention relates to transgenic animal models for altered Wnt expression. The present invention also provides methods for generating animal models and screening methods for identifying...
|
|
|
7122714 |
Mouse models of human prostate cancer
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
|
|
|
7115795 |
Transgenic animals expressing salivary proteins
The invention provides a transgenic animal having within its genome a transgene construct for gastrointestinal tract specific expression of a protein. In a preferred embodiment, the protein is a...
|
|
|
7098376 |
Transgenic mouse expressing constitutively active hydrocarbon receptor
The present invention makes available powerful tools for the study of cancer, based on a novel expression construct for a constitutively active hydrocarbon receptor CA-AhR. The invention further...
|
|
|
7081561 |
Gene-targeted animal model of apolipoprotein E4 domain interaction and uses thereof
The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further...
|
|
|
7071373 |
Transgenic ungulate compositions and methods
Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for...
|
|
|
7067714 |
N-calcium channel knockout animal
A non-human animal in which a gene coding for the N-type calcium channel is disrupted to lack functional N-type calcium channel, and a method for screening for a substance having a pharmacological...
|
|
|
7067713 |
C1 Inhibitor produced in the milk of transgenic non-human mammals
The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring...
|
|
|
7060871 |
Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function
The present invention deals with gene therapy for treating chronic heart failure and other cardiac disease states which are accompanied by a reduced number or functioning of myocardial...
|
|
|
7045677 |
Fusion proteins incorporating lysozyme
A process for the production of a peptide is disclosed, the process comprising expressing in the milk of a transgenic, non-human, placental mammal a fusion protein which comprises the peptide to be...
|
|
|
7045676 |
Transgenic animals secreting proteins into milk
A DNA sequence containing a gene encoding a protein, the gene being under the transcriptional control in the DNA sequence of a mammalian milk protein promoter which does not naturally control the...
|
|
|
7041870 |
Transgenic transchromosomal rodents for making human antibodies
The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
|
|
|
7038107 |
Elimination of endogenous porcine retrovirus
Porcine nucleic acid sequences flanking potentially infectious porcine endogenous retroviral (PERV) insertion sites have been identified and isolated. The unique flanking sequences include porcine...
|
|
|
7034201 |
Developmental animal model of temporal lobe epilepsy
Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the...
|
|
|
7030289 |
Stabilization of milk from transgenic animals
The present invention relates to the stabilization of milk from transgenic animals. In particular, the invention relates to the protection of proteins (e.g. fibrinogen) expressed in milk from...
|
|
|
7030291 |
CYT28 serpentine receptor disruptions, compositions and methods relating thereto
The present invention relates to compositions and methods relating to the characterization and function of CYT28. Specifically, the present invention provides transgenic animals comprising...
|
|
|
7019193 |
Treatments using transgenic goat produced antithrombin III
This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition...
|
|
|
7019194 |
SCCE modified transgenic mammals and their use as models of human disease
Genetic evidence that an imbalance in the activity of serine proteases can cause severe skin disease has recently been presented. The serine protease SCCE is preferentially expressed in cornifying...
|
|
|
6987211 |
Transgenic non-human mammals producing a cholinesterase in their milk
The present invention relates to novel alternative forms of human acetylcholinesterase (AChE) and nucleotide sequences encoding the same. The genes encoding the novel forms of human AChE have been...
|
|
|
6984772 |
Transgenic non-human mammals producing fibrinogen in their milk
A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain...
|
|
|
6982361 |
Method of screening a compound for anxiolytic activity in an Apolipoprotein e knockout animal
Methods and compositions for use in treating anxiety are provided. In the subject methods, an effective amount of an agent having ApoE3 activity is administered to a host suffering from an anxiety,...
|
|
|
6977157 |
Clock gene promoter
The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a...
|
|
|
6962688 |
Methods for modulation of cholesterol transport
Methods for regulation of lipid and cholesterol uptake are described which are based on regulation of the expression or function of the SR-BI HDL receptor. The examples demonstrate that estrogen...
|
|
|
6924415 |
Transgenic mice comprising a constitutively-activated MEK5 and exhibiting cardiac hypertrophy and dilated cardiomyopathy
The present invention relates to compositions and methods relating to MEK5 and its role in heart disease. This protein has now been identified as a target for therapeutic intervention due to its...
|
|
|
6924412 |
Means and methods for raising antibody concentration in compartments of the body of a non-human animal
Methods and processes for raising the concentration of a first class of immunoglobulin relative to at least a second class of immunoglobulin in a compartment of the body of a non-human animal or...
|
|
|
6909030 |
PTTG knockout rodent as a model to study mechanisms for various physiological phenomena, including diabetes
Disclosed is a null mutant (or knockout) rodent comprising in its germ cells an artificially induced PTTG null mutation. In some embodiments, the null mutant rodent can be generated by way of...
|
|
|
6906238 |
Effective nuclear reprogramming in mammals using CDK2 inhibitors
The present invention provides methods of producing a cloned non-human mammalian nuclear transfer (NT) embryo and methods for producing a cloned non-human mammal. Embodiments of the methods include...
|
|
|
6888047 |
Transgenic animals as urinary bioreactors for the production of polypeptide in the urine, recombinant DNA construct for kidney-specific expression, and method of using same
The invention relates to recombinant DNA constructs, a method for producing a recombinant biologically active protein in vivo in the urine of a non-human mammal using a kidney-specific promoter,...
|
|
|
6872868 |
Transgenic mammals
Genetic transformation of a zygote and the embryo and mature organism which result therefrom is obtained by placing or inserting exogenous genetic material into the nucleus of the zygote or into...
|
|
|
6825395 |
Transgenic non-human mammals expressing the human complement inhibitor (DAF/CD55)
This invention provides transgenic mammals other than man carrying the gene of the human complement inhibitor (DAF/CD55) and expressing the human complement inhibitor in their organs and tissues,...
|
|
|
6825394 |
Conditionally immortalized cell lines derived from transgenic animals
The invention relates to mammalian cell lines and transgenic mammals. More particularly, it relates to a method for producing a rat cell line, a method for producing a transgenic rat, a transgenic...
|
|
|
6791006 |
LKB1 gene knockout mice
A mammal is provided, in which the LKB1 gene can be deleted phase-specifically and tissue-specifically. These mammals are highly useful as tools to reveal the onset mechanism for diseases caused by...
|
|
|
6781030 |
Methods for cloning mammals using telophase oocytes
The present invention pertains to methods for cloning animals. In particular, the invention includes methods of cloning an animal by combining a genome from an activated donor cell with an...
|
|
|
6781029 |
Transgenic animal and methods
A transgenic animal, preferably a mouse, that expresses human antichymotrypsin (ACT) in brain tissues is provided, together with animal tissue-derived cell lines and progeny animals of said...
|
|
|
6774279 |
Use of FLP recombinase in mice
A method is disclosed for producing site-specific recombination of DNA in a transgenic non-human mammal at chromosomal regions containing Flp-recognition sites (e.g., a DNA sequence containing an...
|
|
|
6770260 |
Method preventing depletion of non-autologous hematopoietic cells and animal model systems for use thereof
The invention provides methods for preventing depletion of non-autologous hematopoietic cells. Animal model systems using the method are also provided as are methods of treatment using...
|
|
|
6770797 |
Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid
The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated...
|
|
|
6743966 |
Production of membrane proteins in the milk of transgenic mammals
Production of proteins not normally secreted through conventional pathways such as membrane proteins including, for example, CFTR associated with cystic fibrosis, is now made possible by collection...
|
|
|
6743425 |
Therapeutic agents for achondroplasia
The present invention aims to provide novel therapeutic agents for achondroplasia caused by mutations in FGFR3. Therapeutic agents for achondroplasia caused by the cartilage growth inhibition...
|
|
|
6727405 |
Transgenic animals secreting desired proteins into milk
A DNA sequence containing a gene encoding a protein, the gene being under the transcriptional control in the DNA sequence of a mammalian milk protein promoter which does not naturally control the...
|
|
|
6713662 |
Production of collagen in the milk of transgenic mammals
The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at...
|
|
|
6706947 |
Method for screening for agents against cancer using an immunosuppression animal model
The invention relates to an animal model of cancer. The animal carries a tumour xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying...
|
|
|
6693175 |
Method for diagnosing bone dysbolism
A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor. ...
|
|
|
6677501 |
P2X7 receptor-deficient mice and uses thereof
The invention provides non-human, genetically-modified mammals and genetically modified animals cells having a functionally disrupted P 2×7 receptor gene. Also provided are methods for producing...
|
|
|
6673987 |
Strategy for maintaining pregnancy
Pregnancy in animals such as the pig usually does not continue to term when there are only a few embryos in the uterus. Currently available technology for maintaining pregnancy involves a series of...
|
|
|
6664443 |
Pathogenic Tau mutations in transgenic mice
Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau...
|