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7608749 |
Monitoring APP cleavage in transgenic rodents comprising an APP Swedish mutation
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
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7554003 |
Invertebrate animal model with neurodegenerative phenotype for screening and testing substances
The present invention claims an invertebrate animal that has been modified to express a set of genes, the set comprising the gene coding for a modified version of the gamma subunit of AMP-activated...
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7550648 |
Inducing neurofibrillary tangles in transgenic mice expressing a mutant tau protein
The present invention discloses a method and an in-vivo assay system useful for the identification and testing of modulating agents as well as for the validation of therapies of neurodegenerative...
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7538258 |
Transgenic mouse expressing an APP 670/671 mutation
The invention provides an isolated nucleic acid characteristic of human amyloid precursor protein 770 including the nucleotides encoding codon 670 and 671, wherein the nucleic acid encodes an amino...
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7479579 |
Triple transgenic mouse model of Alzheimer's disease
The present invention relates to a triple transgenic animal model for Alzheimer's disease as well as to methods for generating multi-transgenic animals. The present invention also relates to...
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7459601 |
Human α synuclein expressing transgenic mice
In methods for screening treatments for, and treatment of, neurodegenerative diseases, aggregation in neurons of NACP/α-synuclein is measured and expression of a non-amyloidogenic protein is...
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7432414 |
Transgenic mouse having an amyloid precursor protein with a modified beta secretase cleavage site
The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the β secretase cleavage site are NF and EV. The invention also provides...
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7371920 |
Transgenic mouse model of neurodegenerative disorders
The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology...
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7330841 |
Modeling decision making processes
A computer implemented method of predicting decisions uses the knowledge of one or more individuals. The individuals, referred to as a team, are knowledgeable about the domain in which decisions...
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7309811 |
Transgenic mice knockouts of BACE-1
The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for...
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7265259 |
GSK-3β expressed in a transgenic mouse
A transgenic animal in which GSK-3β protein is over-expressed is useful as a model for neurodegenerative disease.
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7250551 |
Transgenic mice expressing inducible human p25
Disclosed are improved methods of treating individuals with Alzheimer's disease (AD) as well as methods to diagnose AD in an individual. Also included are compounds and methods of identifying...
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7247766 |
Double transgenic mice overexressing human beta secretase and human APP-London
The present invention relates to a novel animal model for amyloidopathies, especially Alzheimer' disease overexpressing human BACE and human APP London. This novel animal model exhibits several...
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7186881 |
Testing compounds for effects on synaptophysin in transgenic mice expressing an Alzheimer's disease FAD DNA sequence
The construction of transgenic animal models of human Alzheimer's disease, and methods of using the models to screen potential Alzhe## disease therapeutics, are described. The models are...
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7179953 |
Monitoring APP cleavage in transgenic rodents comprising an APP-Swedish mutation
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
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7107092 |
Methods for diagnosing a neurodegenerative condition
A method of diagnosing, prognosing, staging, and/or monitoring a mammalian amyloidogenic disorder or a predisposition thereto by detecting a protein or polypeptide aggregate in the cortical and/or...
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7098374 |
Human disease modeling using somatic gene transfer
This invention provides a system for modeling neurodegenerative and other diseases through somatic gene transfer. In addition, methods of multiple gene transfer, disease analysis and drug testing...
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7060870 |
Transgenic mice over-expressing ABAD and mutant APP in brain as model of Alzheimer's disease and uses thereof
The present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter operatively linked to a DNA sequence which...
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7022893 |
Knockin gene-mutated mouse comprising a mutant presenilin-1 gene
A gene-mutated animal such as a mouse which comprises a mutant prsenilin-1 gene comprising a DNA having a sequence encoding a mutant presenilin-1 protein in which an amino acid is substituted with...
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6958433 |
Transgenic mice overexpressing aspartyl protease 2 (ASP2)
The present invention provides a recombinant DNA construct comprising a coding sequence encoding human ASP2 and a brain-specific calcium calmodulin kinase promoter sequence which is operably linked...
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6943278 |
Transgenic Drosophila having a disrupted Parkin gene and exhibits reduced climbing ability
The present invention relates to animal models for neuronal function, e.g., spontaneous changes in motor ability related to neuronal degeneration. For example, the present invention provides a ...
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6900367 |
Transgenic Drosophila melanogaster expressing a β42 in the eye
Transgenic flies displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of these flies in a method to identify Drosophila genes and...
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6891081 |
Transgenic mice over-expressing amyloid-beta alcohol dehydrogenase (ABAD) in brain as model of alzheimer's disease and uses thereof
The present invention provides for a transgenic non-human animal whose cells contain a recombinant DNA sequence comprising a nerve tissue specific promoter operatively linked to a DNA sequence...
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6838592 |
Methods for the identification of compounds for the treatment of alzheimer's disease
The invention features methods for identifying compounds useful for the treatment of Alzheimer's disease.
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6781029 |
Transgenic animal and methods
A transgenic animal, preferably a mouse, that expresses human antichymotrypsin (ACT) in brain tissues is provided, together with animal tissue-derived cell lines and progeny animals of said...
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6770797 |
Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid
The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated...
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6734336 |
Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring
The present invention provides a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD presenilin-1 (PS-1) gene, a human FAD Swedish mutation, and a...
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6717031 |
Method for selecting a transgenic mouse model of alzheimer's disease
The construction of transgenic animal models of human Alzheimer's disease, and methods of using the models to screen potential Alzheimer's disease therapeutics, are described. The models are...
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6710226 |
Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid...
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6693226 |
Transgenic mice expressing human p25
The invention provides transgenic, non-human animals and transgenic non-human mammalian cells harboring a transgene encoding a p25 (activator of the protein kinase cdk 5) polypeptide. The two...
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6664443 |
Pathogenic Tau mutations in transgenic mice
Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau...
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6664442 |
Selecting compounds to reduce inflammation associated with Alzheimer's disease
The invention includes identification of specific markers, the elevation of which in central nervous tissue is associated with Alzheimer's Disease. The invention also includes improved assay...
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6593512 |
Transgenic mouse expressing human tau gene
A bigenic mouse is provided whose germ cells and somatic cells contain (i) inactive mouse TAU genes, and/or (ii) a transgene encoding the human TAU gene, with the transgene including all regulatory...
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6586656 |
Transgenic rodents harboring APP allele having Swedish mutation
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
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6563015 |
Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) and mutant APP in brain and uses thereof
The invention provides for a non-human transgenic animal whose cells contain a recombinant DNA sequence comprising: (a) a nerve tissue specific promoter operatively linked to a DNA sequence which...
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6509515 |
Transgenic mice expressing mutant human APP and forming congo red staining plaques
Provided is a transgenic non-human eukaryotic animal whose germ cells and somatic cells contain the amyloid precursor protein sequence introduced into the animal, or an ancestor of the animal, at...
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6504080 |
Transgenic animal model for neurodegenerative disorders
Animal model useful for testing potential therapeutic agents for the treatment of neurodegenerative disorders, in particular disorders associated with the presence of Lewy pathology.
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6489535 |
Non-mammalian transgenic animal having an adult onset neurodegenerative phenotype
Transgenic non-mammalian animals, e.g. flies, that exhibit an adult onset neurodegenerative phenotype, as well as methods for preparing the same, are provided. Also provided are methods of using...
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6455757 |
Transgenic mice expressing human APP and TGF-β demonstrate cerebrovascular amyloid deposits
The present invention features non-human transgenic animal models for Alzheimer's disease (AD) and CAA, wherein the transgenic animal is characterized by 1) expression of bioactive transforming...
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6452065 |
Transgenic mouse expressing non-native wild-type and familial Alzheimer's Disease mutant presenilin 1 protein on native presenilin 1 null background
The present invention relates to a transgenic non-human animal embryo lacking native presenilin 1 and a transgenic non-human animal having only a non-native presenilin 1. The transgenic animals and...
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6436937 |
Use of desoxypeganine in the treatment of Alzheimer's dementia
The invention relates to a device and method for the treatment of Alzheimer's dementia with desoxypeganine and/or a pharmaceutically acceptable acid addition salt of desoxypeganine.
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6395960 |
Transgenic mice expressing human presenilin proteins
The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are...
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6340783 |
Rodent models of human amyloidoses
In vivo assays for selecting candidate therapeutics for inhibiting amyloidoses, such as congophilic and fibrillar β/A4 amyloid deposition in brain. A candidate reagent is administered to a first...
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6300540 |
Transgenic mouse expressing an APP-FAD DNA sequence
Model systems of Alzheimer's disease comprise a DNA sequence encoding an amyloid precursor protein (APP) isoform or fragment that has an amino acid substitution. The substituted amino acid may be...
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6278039 |
C. elegans deletion mutants
Provided are worms having deletions in genes associated with Alzheimer's disease and methods for detecting genes and compounds involved in the causation of Alzheimer's disease or useful for the...
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6262335 |
Transgenic mice expressing APP mutant at amino acids 717, 721 and 722
A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain the amyloid precursor protein sequence introduced into the animal, or an ancestor of the animal, at an embryonic...
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6245964 |
Transgenic rodent comprising APP-Swedish
The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
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6187992 |
Transgenic mouse having a disrupted amyloid precursor protein gene
The present invention relates to a transgenic nonhuman animal lacking native amyloid precursor protein. The transgenic mouse of the invention may be used in the study of Alzheimer's Disease and...
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6184435 |
Transgenic mouse expressing APP770-V717F
Methods for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also...
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6175057 |
Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
The present invention features non-human transgenic animal models for Alzheimer's disease (AD) and CAA, wherein the transgenic animal is characterized by 1) overexpression of bioactive transforming...
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