Patents in Class 800/11

Matches 1 - 50 out of 51

1 2 >

Match	Document	Document Title
1	7332645	IL-21 as a regulator of immunoglobin production A transgenic mouse is disclosed herein whose somatic and germ cells comprise a disrupted IL-21 receptor gene, the disruption being sufficient to inhibit the binding of IL-21 to an IL-21 receptor,...
2	6660904	HIV and CD4 transgenic animals and uses therefor The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further...
3	6627792	Human T cell-engrafted mouse, method for developing same and use thereof The present invention provides a method for developing a human T cell-engrafted mouse, which includes transplanting a human-derived bone tissue into an inbred line mouse deficient in immune cells,...
4	6610905	Transgenic mouse model for Kaposi's sarcoma The present invention relates to a non-human transgenic mouse containing a constitutively active G-protein coupled receptor, which produces Kaposi's sarcoma-like symptoms. The transgenic mouse is...
5	6593511	Models of chronic and acute inflammatory diseases Methods and compositions are provided for the creation and screening of non-human animal models having chronic inflammation. Immunocompromised host animals are injected with a population of...
6	6563014	Self-contained system for sustained viral replication Transgenic non-human animals are described comprising a transgene for a species-specific pathogen and transgene(s) for at least one receptor restricting infection of the pathogen to the host...
7	6455756	Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice Immunocompromised mammalian hosts are sub-cutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up...
8	6444872	Large animal model of invasive pulmonary aspergillosis in an immunocompromised host A model of systemic mold/Aspergillus infection in a profoundly immunocompromised host has been established in the beagle dog. The beagle was rendered immunosuppressed using a combination of total...
9	6384298	Transgenic mice depleted in a mature lymphocytic cell-type Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is...
10	6316691	Atrichia mouse The invention relates to an atrichia mouse which grows juvenile hair but is deficient in the ability to grow pelage hair and, more particularly, to an atrichia mouse such that the spontaneous...
11	6307122	Infection of human neural xenografts Immunocompromised or immunosuppressed non-primate chimeric mammalian hosts comprising a neuronal graft in the eye are provided for studying various events associated with humans. Particularly, the...
12	6248721	Method of using mouse model for evaluation of HIV vaccines The present invention provides animals and methods for the evaluation of vaccines. In particular, the present invention provides humanized animal models for the evaluation of vaccines designed to...
13	6232522	Non-human animal model for systemic lupus erythematosis A specific method has been developed to produce an autoimmune response and resulting clinical symptoms for a particular disease process. Peptides or other structures derived from an autoantigen and...
14	6184436	Transgenic mice expressing HIV-1 in immune cells The present invention relates to a transgenic mouse to serve as a small animal model of AIDS which comprises at least a DNA sequence coding for HIV-1 nef or a HIV-1 DNA genome essentially...
15	6172278	Ikaros transgenic cells and mice Transgenic cells, transgenic mice having an Ikaros transgene and methods for the use thereof.
16	6156952	HIV transgenic animals and uses therefor The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further...
17	6060643	Mouse model with human immune system The present invention provides a non-human genetically immunodeficient mammal the peripheral blood of which contains a non-lethal percent of T-cells of human origin which is at least 20% as well as...
18	6054116	Chimeric mouse for human and mouse immune systems This invention is directed to a chimeric mouse capable of mounting murine cellular and humoral immune response, where the chimeric mouse is tolerant of human tissue implanted therein. The chimeric...
19	6023010	Transgenic non-human animals depleted in a mature lymphocytic cell-type Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is...
20	6002066	H2-M modified transgenic mice A transgenic mouse with alterations in the H2-Ma gene is prepared by introduction of an altered H2-Ma gene into a host mouse. The resulting transgenic mice do not produce functional H2-M molecules.
21	5981829	ΔNur77 transgenic mouse The present invention provides a transgenic mouse containing a transgene, said transgene comprising a truncated Nur77 (ΔNur77) gene. Also provided is a double transgenic mouse, wherein said double...
22	5959172	Gender-specific fading down turkey breed The present invention relates to a method of rapidly determining the gender of fowl. The present invention further relates to a new breed of turkey.
23	5936138	Gene encoding mutant L3T4 protein which facilitates HIV infection and transgenic mouse expressing such protein Disclosed are (1) a DNA sequence encoding a mutant L3T4 protein which, when expressed on the surface of a cell, is capable of facilitating infection of the cell by human immunodeficiency virus; the...
24	5925802	Functional reconstitution of SCID-bo mice with bovine fetal hematopoietic tissues The present invention provides a non-human chimeric mammal, comprising a severe-combined immunodeficient mammal engrafted with bovine immune system tissues, wherein said chimeric mammal is...
25	5877396	Mice mutant for functional Fc receptors and method of treating autoimmune diseases Disclosed herein is a non-naturally occurring non-human vertebrate animal incapable of expressing a functional Fc receptor which may optionally be capable of expressing a protein which comprises a...
26	5859314	Mice with targeted tyrosine kinase, lyn, disruption A non-human animal carrying a disruption of a gene encoding a lyn protein tyrosine kinase provides a convenient system for the study of diseases associated with or caused by lyn deficiency, and for...
27	5859307	Mutant RAG-1 deficient animals having no mature B and T lymphocytes Immunodeficient animals are generated by introducing a mutation in RAG-1 into the germline of the animals via gene targeting in embryonic stem cells. The production of mutant RAG-1 deficient mice...
28	5850004	Transgenic mouse deficient in inducible nitric oxide synthase The present invention provides an inducible nitric oxide synthase ("iNOS")-deficient transgenic mouse, novel replacement vectors designed for the disruption of the iNOS gene, embryonic stem (ES)...
29	5850001	Transgenic mouse for the neuronal expression of HIV gp160 The present invention relates to a transgenic non-human mammal, whose germ cells and somatic cells contain a recombinant env gene sequence which is operably linked to a promoter effective for the...
30	5849994	Animal model for HIV-1 induced disease HIV-1 does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing or ameliorating disease caused by this virus....
31	5847257	Transgenic mouse deficient in T-cells The present invention relates to a transgenic mouse deficient in T-cells, which is provided by fusing human heat shock protein (Hsp) gene with H2K promoter and transferring it to a mouse....
32	5831142	Regulatory elements controlling tissue-specific gene expression The invention includes recombinant DNA regulatory elements which control expression of the CD19 gene in a B-lineage-restricted manner.
33	5777193	Animals with targeted gene disruption The invention provides transgenic non-human animals in which genes encoding colony-stimulating factors have been specifically disrupted, so that the animals do not express the respective factors....
34	5731490	Mutant mouse lacking the expression of interferon regulatory factor 1 (IRF-1) Interferon regulatory factor-1 (IRF-1) is implicated in the regulation of type I interferons (IFN) and cell growth. The invention is a mutant mouse lacking expression of the IRF-1 gene. Mice...
35	5714667	Mice lacking expression of CTLA-4 receptor Disclosed is a mouse in which expression of the gene encoding the CTLA-4 receptor is suppressed. Also disclosed is a nucleic acid construct useful in preparing such a mouse, and a cell line...
36	5698767	Human immune system in non-human animal Laboratory non-human animals in which the immune system of a donor is induced in and thrives in vivo and expresses the immune response of the donor animal in a recipient non-human animal of a...
37	5698765	Mouse having a disrupted CD4 gene A mutant mouse strain without CD4 expression has been generated by disrupting the CD4 gene using embryonic stem cell technology. In these mice CD4 + T lymphocytes are not present in peripheral...
38	5675059	Mouse lacking the expression of interferon regulatory factor 2 (IRF-2) The transcription factors, IRF-1 and IRF-2 are induced by interferons (IFNs) and a variety of other cytokines. IRF-1 functions as an activator whereas IRF-2 represses IRF-1 action by competing for...
39	5663481	Animal model of the human immune system The present invention relates to a non-human chimeric mammal having characteristics of a functional human immune system and having functional human lymphocytes reconstituted in the mammal's...
40	5644065	Genetically engineered mice containing alterations in the MHC class II genes The present invention provides mice which are deficient in the normal expression of one or more MHC class II genes, to mice heterozygous for such deficiency, and to cell lines, preferably...
41	5639939	Chimeric immunocompromised mammal comprosing vascularized fetal organ tissue Xenogeneic tissue is introduced into an immunocompromised host for interacting with agents and using such interaction for evaluating efficacy of drugs and vaccines, producing xenogeneic monoclonal...
42	5633426	In vivo use of human bone marrow for investigation and production Chimeric immunocompromised hosts are provided, comprising human bone marrow of at least 4 weeks from the time of implantation. The bone marrow is found to assume the normal population of bone...
43	5625122	Mouse having a disrupted lck gene A mutant non-human mammal lacking expression of the lymphocyte-specific tyrosine kinase p56 lck . Lck deficient mice possess few peripheral T lymphocytes and a pronounced thymic atrophy. The...
44	5602305	Immunodeficient animal model for studying T cell-mediated immune The present invention describes a novel immunodeficient rodent model comprising an organ graft, such as a human skin graft, said graft containing microvessels lined by endothelial cells, human T...
45	5583278	Recombination activating gene deficient mouse This invention relates to a recombinant mouse with both alleles of recombination activating gene 2 being functionally deficient. This invention discloses the method to make such mouse and the uses...
46	5574206	Transgenic mouse carrying a non-infectious HIV genome Disclosed herein is a transgenic mouse carrying a transgene which expresses non-infectious HIV ribonucleic acid, and the complementary proteins thereof. The transgenic mouse is useful as a source...
47	5530179	Transgenic immunodeficient animal models The invention features a transgenic mouse having a substantial deficiency in functionally active natural killer cells and T lymphocytes which is useful as a model system for immune diseases,...
48	5530178	Mutant mouse lacking CD8 surface marker A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology. In these mammals, for...
49	5516977	Xenogeneic tissue implant in ear pinna Immunocompromised hosts comprising xenogeneic fetal lymph node tissue implanted in the ear pinna are provided. The chimeric hosts are prepared by inserting the xenogeneic lymph node tissue into the...
50	5434340	Transgenic mice depleted in mature T-cells and methods for making transgenic mice Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by...

Matches 1 - 50 out of 51

1 2 >