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7491865 |
Mouse models of prostate cancer development and metastasis through expression of a hepsin transgene
Transgenic, non-human animal model of cancer, methods of making such animals and methods of using such animals to screen test compounds are provided.
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7459602 |
Mammalian cancer cell and transgenic mammal carrying human protooncogene and kit for diagnosing cancer using said protooncogene
The present invention provides a mammalian cell transfected with an expression vector comprising a human protooncogene which has the nucleotide sequence of SEQ ID NO: 1; a mammalian embryo carrying...
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7402728 |
Transgenic mice expressing human CD20 and/or CD16
The present invention generally relates to non-human transgenic animals expressing human cellular markers, including CD20 and/or preferably CD16.
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7402727 |
Non-human animal exhibiting bone metastasis of tumor cells
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for...
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7253333 |
Drosophila strain carrying bradeion gene(s) transferred thereinto
Provided is a special Drosophila strain having a Bradeion gene artificially incorporated therein to exclusively express the gene in the compound eyes and thus to exhibit rough eye. The ...
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7220891 |
Feline bronchioloalveolar lung carcinoma xenograft and cell line
The present invention provides feline transplantable lung carcinoma xenografts and cell lines. Such xenografts and cell lines exhibit a number of unique characteristics which allows their use in...
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7186880 |
Adult T cell leukemia model animal
The present invention provides an adult T cell leukemia model animal, which is a T cell function deficient animal to which a cell line infected with human T cell leukemia virus-1 is transplanted....
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7135609 |
Non-human animal exhibiting bone metastasis of tumor cells and method of screening for bone metastasis inhibitors
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for...
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7122714 |
Mouse models of human prostate cancer
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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7053263 |
Mouse models of human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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6998513 |
Human inflammatory breast carcinoma xenograft capable of lymphovascular invasion and methods for its use
The present invention provides human transplantable inflammatory breast carcinoma xenografts. Such xenografts exhibit a number of unique characteristics which allows their use in experimental...
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6956145 |
Mice models of human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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6953875 |
Transgenic zebra fish embryo model for hematopoiesis and lymphoproliferative disorders
A transgenic zebrafish animal model is disclosed. The model can be used for study of hematopoetic cell differentiation, control, and screening of therapeutic agents and can include a transgenic...
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6949692 |
Method for identifying mutants and molecules
Methods for breeding mutagenized mice permit detection of genetic loci that in heterozygous mutated form can modify a known index phenotype involves crossing a mutagenized founder strain and a...
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6943025 |
Method for identifying genes involved in cell proliferation
The present invention provides fish system as a powerful forward genetic tool to directly identify a number of novel genes involved in cell proliferation in vertebrates without the time consuming...
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6930222 |
In vivo animal model of human leukemia
The present invention provides a process for making an in vivo model of human leukemia. The process includes the steps of: pre-conditioning an immunodeficient rodent by administering to the rodent...
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6825394 |
Conditionally immortalized cell lines derived from transgenic animals
The invention relates to mammalian cell lines and transgenic mammals. More particularly, it relates to a method for producing a rat cell line, a method for producing a transgenic rat, a transgenic...
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6815574 |
Methods of simulating human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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6797721 |
Phorboxazole derivatives for treating cancer
Synthetic Phorboxazole A and derivatives thereof for the treatment of cancer, including inhibition of cancer cell growth, induction of apoptosis, and inhibition of metastises.
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6759038 |
Metastasis models using green fluorescent protein (GFP) as a marker
A method to follow the progression of metastasis of a primary tumor, which method comprises removing fresh organ tissues from a vertebrate subject which has been modified to contain tumor cells...
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6706947 |
Method for screening for agents against cancer using an immunosuppression animal model
The invention relates to an animal model of cancer. The animal carries a tumour xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying...
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6639121 |
Inducible cancer model to study the molecular basis of host tumor cell interactions in vivo
A non-human mammal having incorporated into its genome an expression construct in which nucleic acid encoding an oncogene is operably linked to an inducible promoter; the mammal further has a...
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6632979 |
Rodent HER2 tumor model
The invention concerns HER 2 -transgenic non-human mammals, animal models for screening drug candidates for the treatment of diseases and disorders associated with the overexpression of HER 2 . In...
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6632975 |
Method for the production of in vivo model of hepatocellular carcinoma without lung metastasis
The present invention provides a method for producing an in vivo model of hepatocellular carcinoma without lung metastasis in an animal by injecting diethylnitrosamine and administering...
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6576811 |
Transgenic rat with human normal type c-Ha-ras gene
The present invention provides a human c-Ha-ras proto-oncogene transgenic rat and the methods of the screening of many carcinogens and the screenings of promoters of carcinogenesis and preventive...
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6541680 |
Nutritional methyl supplements change DNA methylation and related characteristics of mammalian offspring
Increasing methylation of DNA in an unborn offspring of a pregnant mammal results in changing the epigenetically determined phenotype of the unborn offspring, inhibiting parasitic DNA sequences in...
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6538174 |
Animal model for transplantation
The invention relates to an animal model of cancer. The animal carries a tumor xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying...
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6531645 |
RAS/P21 transgenic mouse
A transgenic rodent that constitutively expresses a ras protein in at least one tissue, is p21 null in at least one chromosome, and exhibits enhanced and accelerated ras-dependent tumorigenesis,...
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6521815 |
Animal model system for squamous cell carcinoma
Non-human mammalian animals having a higher epidermal expression level of protein kinase Cε than their wild-type counterparts are phenotypically distinguished from wild-type animals in that the...
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6455756 |
Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice
Immunocompromised mammalian hosts are sub-cutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up...
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6362392 |
Nude mouse model for the growth and treatment of human neurally-derived tumors
A method for treating a neurofibrosarcoma tumor comprising administration of heparin and an angiostatic steroid is disclosed. Animal models for the growth of neurally-derived tumors and for testing...
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6323390 |
Transgenic mouse models for human bladder cancer
A transgenic mouse, containing an oncogene or a tumor suppressor gene operably linked to a urothelium-specific promoter in its germ cells and somatic cells serves as an animal model system for...
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6316690 |
Non-mammalian transgenic animal model for cellular proliferative diseases
Non-mammalian, transgenic animals, e.g. flies, that exhibit neoplastic phenotypes, i.e. spontaneously produce metastatic tumors, are provided. Also provided are methods of using the subject...
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6313373 |
Tissue specific promoters and transgenic mouse for the screening of pharmaceuticals
The present invention provides human involucrin (hINV) sequences having tissue specific and cell type specific promoter activity. The sequences provided herein direct expression to suprabasal cells...
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6284239 |
Murine model for human carcinoma
A murine model for human breast, ovarian and prostate cancer is provided. The model comprises either an immunodeficient mouse containing human primary breast, ovarian or prostate carcinoma tissue...
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6191342 |
Transgenic mice expressing the HIK-ras 4B chimeric gene
A transgenic mouse whose genome comprises the H/K-ras 4B chimeric gene to form a mammary tumor and, particularly, the expression vector producing H/K-Ras 4B chimeric protein by using MMTV (mouse...
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6180849 |
Trangenic mice with a disruption in the tiar gene
The invention features transgenic non-human mammals containing a mutation in one or both alleles of the endogenous TIAR gene, and cell lines derived from some of these mammals. The mammals and cell...
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6172278 |
Ikaros transgenic cells and mice
Transgenic cells, transgenic mice having an Ikaros transgene and methods for the use thereof.
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6107541 |
PRAD1 transgenic mice
The invention relates to isolated nucleic acid sequences encoding PRAD1, and fragments thereof. The invention further relates to transgenic mice bearing a transgene which includes a nucleic acid...
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6107540 |
Mice models of human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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6037520 |
Human breast carcinoma cell line capable of production of a spontaneously metastasizing tumor in animals for use in anticancer drug testing
An adherent, stable, continuous human breast carcinoma cell line (GI-101A) has been produced from an infiltrating ductal breast carcinoma xenograft (GI-101) which has been grown and maintained in...
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5925803 |
Testing method using transgenic mice expressing an oncogene
A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.
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5917124 |
Transgenic mouse model of prostate cancer
Disclosed are transgenic mice that produces prostate tumors and faithfully recapitulate many of the features of human prostatic carcinoma. It has been discovered that transcriptional regulatory...
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5907079 |
MSH2 disrupted mice develop lymphomas
Non-human mammals comprising a disrupted MSH2 gene are disclosed. More particularly, animals having a disruption in one or both alleles of the MSH2 gene or a homolog of the MSH2 gene are disclosed....
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5907078 |
Transgenic mouse model for prostate cancer
Several lines of transgenic mice have been generated using the prostate-specific rat probasin (PB) gene promoter to drive expression of the SV40 T antigen (Tag) coding region. Mice expressing high...
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5859314 |
Mice with targeted tyrosine kinase, lyn, disruption
A non-human animal carrying a disruption of a gene encoding a lyn protein tyrosine kinase provides a convenient system for the study of diseases associated with or caused by lyn deficiency, and for...
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5859307 |
Mutant RAG-1 deficient animals having no mature B and T lymphocytes
Immunodeficient animals are generated by introducing a mutation in RAG-1 into the germline of the animals via gene targeting in embryonic stem cells. The production of mutant RAG-1 deficient mice...
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5850004 |
Transgenic mouse deficient in inducible nitric oxide synthase
The present invention provides an inducible nitric oxide synthase ("iNOS")-deficient transgenic mouse, novel replacement vectors designed for the disruption of the iNOS gene, embryonic stem (ES)...
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5849996 |
BCR/ABL transgenic animals as models for Philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia
The present invention relates to non-human transgenic animals which contain a transgene comprising a BCR/ABL gene fusion and which develop leukemia. In a preferred embodiment of the present...
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5849990 |
Animal model for a non-hodgkin's lymphoma
A non-human animal model for CNS and eye-infiltrating lymphomas is produced by inoculating a rodent with the cells of a lymphoma causing cell line capable of infiltrating into the CNS or eye of the...
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