|
Match
|
Document |
Document Title |
|
|
7294144 |
Preserved implantable vessel derived from a human umbilical cord or placenta
A preserved vessel isolated from a human umbilical cord or placenta and lyophilized for use as an allograft which improves blood supply to human tissue without antigenicity.
|
|
|
7156881 |
Counteracting bioprosthetic calcification
Adapting crosslinking with triglycidyl amine (TGA) to incorporate the use of a particular type of anti-calcification agent provides a broad-reaching solution to the problem in vivo bioprosthesis...
|
|
|
7029434 |
Methods for treating implantable biological tissues to mitigate post—implantation calcification
A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue...
|
|
|
6878168 |
Treatment of bioprosthetic tissues to mitigate post implantation calcification
Bioprosthetic tissues are treated by immersing or otherwise contacting fixed, unfixed or partially fixed tissue with a glutaraldehyde solution that has previously been heat-treated or pH adjusted...
|
|
|
6837907 |
Method for debriding bone, and bone debrided thereby
The invention is directed to a method of debriding bone including incubating the bone and associated soft tissue, with one or more debriding solutions where the debriding solution may include one...
|
|
|
6761735 |
Heart valve fixation process and apparatus
A method and apparatus for limiting longitudinal stretch during fixation of a harvested aortic root including valve leaflets and the product produced. The apparatus includes an inflow plug inserted...
|
|
|
6630001 |
Compliant dehyrated tissue for implantation and process of making the same
A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a...
|
|
|
6592618 |
In vitro modification of cardiac valvular xenografts
The present invention is directed to methods for obtaining heart valves from a donor animal that have a reduced tendency to cause inflammation when implanted into a human patient. The valves...
|
|
|
6547827 |
Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a...
|
|
|
6540790 |
Tanning leather
Leather is tanned by cross-linking collagen with tris(hydroxymethyl)phosphine or a condensate of a tetrakis(hydroxymethyl)phosphonium salt with an amide or amine in a main tannage or retannage.
|
|
|
6302909 |
Calcification-resistant biomaterials
The invention involves a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structures having collectively greater than...
|
|
|
6294041 |
Method for an osteoimplant manufacture
The invention relates to an osteoimplant fabricated from a solid aggregate of bone derived elements possessing chemical linkages between their adjacent surface-exposed collagen. Also described are...
|
|
|
6200640 |
Polymer composition and process for treating leather and fur skins
Aqueous solutions or dispersions of copolymers obtainable by free-radical copolymerization of (a) from 20 to 90% by weight of at least one monoethylenically unsaturated C 4 -6 -dicarboxylic acid...
|
|
|
6166184 |
Process for making a bioprosthetic device
Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of...
|
|
|
6027530 |
System, apparatus and method for chemical fixation of stentless cardiac valvular bioprostheses
A system, apparatus and method for tanning of a stentless aortic bioprosthesis, and articles manufactured by such method. The system includes a circulating bath which contains a tanning solution,...
|
|
|
6008292 |
Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials
A method for preparing collagenous biological tissues for use as implantable bioprosthetic material, and articles prepared thereby. The method generally comprises the steps of a) contacting the...
|
|
|
5948123 |
Coloring method for hides
A coloring method, wherein coloring agent or pigment is injected into active cells of an animal hide before the hide is harvested, and a coloring agent injection device with one or more needles,...
|
|
|
5935168 |
Glutaraldehyde-fixed bioprostheses
Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate there propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and...
|
|
|
5931969 |
Methods and apparatuses for treating biological tissue to mitigate calcification
A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue...
|
|
|
5891196 |
Method for actively binding heparin to crosslinked biological tissues
Methods for binding heparin to biological or synthetic materials which are to be implanted within a mammalian body. In instances where connective tissue proteins or other components of the material...
|
|
|
5882850 |
Method for reducing calcification of biological tissue used implantable bioprostheses
Biological materials are treated with an organic chemical agent, dimethyl sulfoxide, to delay the onset of in vivo calcification. The biological materials so treated become resistant to...
|
|
|
5873812 |
Method of preparing biological implantation material
A method of preparing biological implantation material fixed by means of aldehydes, in which the excess aldehyde is bound by treatment with an aminocarboxylic acid and the acid is selected from...
|
|
|
5862806 |
Borohydride reduction of biological tissues
A method of using sodium or potassium borohydride to reduce dehydrated, aldehyde treated biological tissues is disclosed. The method comprises the steps of: providing the tissue, such as porcine...
|
|
|
5843181 |
Biological material pre-fixation treatment
Disclosed is a controlled autolysis method for making biological tissue substantially acellular by exposing the biological material, prior to any fixation thereof, to at least one buffered solution...
|
|
|
5830239 |
Natural tissue heart valve fixation apparatus and method
An apparatus and a method for fixing a heart valve is disclosed that produces a differential pressure across the outflow section of the heart valve to the exterior of the valve that may be made...
|
|
|
5827680 |
Three reagent gram staining method and kit
A method for Gram staining a specimen containing bacteria includes the steps of staining Gram positive bacteria in the specimen, fixing the stain to the Gram positive bacteria, and simultaneously...
|
|
|
5817153 |
Method of photo-oxidative treatment of tissues containing collagen
In the method of a photo-oxidative treatment of tissue containing collagen tissue, the tissue is pre-treated with an aqueous conditioning solution prior to an irradiation with light. In this...
|
|
|
5782931 |
Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods
Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate their propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and...
|
|
|
5769780 |
Method of manufacturing natural tissue valves having variably compliant leaflets
Variably compliant natural tissue valve leaflets and vascular bioprosthetics incorporating variably compliant leaflets are provided along with methods for their manufacture. The variably compliant...
|
|
|
5746775 |
Method of making calcification-resistant bioprosthetic tissue
A method of treating a collagenous biomaterial, such as porcine aortic valve leaflets or bovine pericardium, by exposing the biomaterial to an alcohol to inhibit in vivo calcification. The...
|
|
|
5733339 |
Process for fixation of calcification-resistant biological tissue
A process is provided for non-glutaraldehyde fixation of an organ or prosthesis to be implanted in a mammal. The process produces stable fixation of the tissue by forming amide linkages within and...
|
|
|
5720778 |
Method of producing high-molecular products from collagen-containing materials, and product produced by the same
A method of producing a collagen-containing material has the steps of comminuting untanned collagen-containing raw material, preparing from the raw material a collagen solution, preparing a leather...
|
|
|
5718012 |
Method of strength enhancement of collagen constructs
A method for improving the tensile strength of wet collagen threads or collagen thread constructs for implantation to replace or repair tissue or organs wherein the strength of the threads is...
|
|
|
5697972 |
Bioprosthetic heart valves having high calcification resistance
The specification describes an invention of calcification resistant bioprosthetic heart valves which can be used for a long term, and have good blood compatibility and in vivo stability, and have...
|
|
|
5679112 |
Calcification-resistant materials and methods of making same through use of multivalent cations
Bioprosthetic materials, either natural or synthetic, are treated with trivalent iron cations, or salts, to prevent in vivo calcification. Such bioprosthetic materials include porcine aortic valve...
|
|
|
5674298 |
Calcification-resistant bioprosthetic tissue and methods of making same
Naturally-derived bioprosthetic materials are treated with epoxide crosslinking agents. In some embodiments, the tissue is crosslinked with low molecular weight epoxides in aqueous solutions at...
|
|
|
5476516 |
Anticalcification treatment for aldehyde-tanned biological tissue
A method of treating aldehyde-tanned biological tissue minimizes in vivo calcification and reduces cytotoxicity without impairing the mechanical strength of the tanned tissue. The method includes...
|
|
|
5447536 |
Method for fixation of biological tissue
A process is provided for the non-glutaraldehyde fixation of a prosthesis to be implanted in a mammal whereby the prosthesis is fixed by employing cross-linking agents to form amide linkages...
|
|
|
5279612 |
Dynamic fixation of porcine aortic valves
A method of preserving porcine heart valves so that they may be incorporated into prosthetic heart valves for human implant. During fixation, the leaflets of the valves are repeatedly flexed...
|
|
|
5215541 |
Surfactant treatment of implantable biological tissue to inhibit calcification
A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the treatment...
|
|
|
5116552 |
Process for preparation of dried collagen sponge
A process for preparing a crack-free, dried collagen sponge having a shrinkage factor of up to 14%, including the steps of impregnating crosslinked collagen sponge with an aqueous solution of a...
|
|
|
5116389 |
Method of obtaining collagen human-skin fibers, fibers thus produced, and a compound containing them
Human-skin collagen fibers are obtained from sterile pieces of human skin by first comminuting the sterile skin and then mixing the comminuted sterile skin with a sterile aqueous solution of an...
|
|
|
4990131 |
Tubular prostheses for vascular reconstructive surgery and process for preparing same
Arteries and veins of umbilical cords are treated by processes described, fitted with a biodegradable mesh support and used as tubular prosthesis for vascular reconstructive surgery.
|
|
|
4976733 |
Prevention of prosthesis calcification
A method for retarding or preventing the calcification of a prosthesis implanted in a mammal by covalently coupling to the prosthesis before implantation an effective amount of an anticalcification...
|
|
|
4911915 |
Method of processing tissue specimens and dehydrant solvent for use therein
A liquid dehydrating agent suitable for treating histological and cytological tissue in the processing thereof for microscopic examination, consisting essentially of a blend of between 30 and 45...
|
|
|
4911713 |
Method of making vascular prosthesis by perfusion
A method of making an impermeable vascular prosthesis is disclosed which comprises the steps of treating a porous textile conduit with a first solution of cross-linking agent; perfusing the conduit...
|
|
|
4838888 |
Calcification mitigation of implantable bioprostheses
A process for treating biological tissue prior to implantation to mitigate the calcification of the tissue following implantation comprises incorporating acetylsalicylic acid into the tissue in an...
|
|
|
4813964 |
Crosslinked anisotropic xenogeneic diaphragm tissue in flexor tendon pulley reconstruction
A xenogeneic tissue replacement for nonfunctional flexor tendon pulley comprising crosslinked, bovine or porcine or other anisotropic mammalian diaphragm and method of use are disclosed.
|
|
|
4813958 |
Crosslinked anisotropic mammalian diaphragm in surgical reconstruction
Anisotropic mammalian diaphragm is crosslinked using, for example, glutaraldehyde and used as a surgical implant graft for repair of tissues which accommodate to relative movement of tendons,...
|
|
|
4801299 |
Body implants of extracellular matrix and means and methods of making and using such implants
A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular...
|