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8632608 Treatment of bioprosthetic tissues to mitigate post implantation calcification  
Bioprosthetic tissues are treated by immersing or otherwise contacting fixed, unfixed or partially fixed tissue with a glutaraldehyde solution that has previously been heat-treated or pH adjusted...
8328878 Yarn of animal collagen fiber and manufacture process thereof  
A kind of yarn of animal collagen fiber and the manufacture process thereof, characterized in that the yarn is made of 1-100 WT % of collagen fiber of animal leather, and 0-99 WT % of textile...
8137411 Thin collagen tissue for medical device applications  
This invention relates to processes of preparing heterogeneous graft material from animal tissue. Specifically, the invention relates to the preparation of animal tissue, in which the tissue is...
7918899 Variably crosslinked tissue  
Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. A solution containing a sterilizing agent, such as EDC, in combination...
7879103 Vertebral disc repair  
A sterile implant for treatment of a spinal disc defect comprising an allograft cortical bone demineralized to a Type I collagen having a specific shape which is treated to eliminate...
7652077 Graft prosthesis, materials and methods  
A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure...
7479164 Calcification-resistant fixation  
Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. An aqueous solution containing a coupling agent, such as EDC, in...
RE40570 Apparatuses and methods for treating biological tissue to mitigate calcification  
An apparatus for treating fixed biological tissue to inhibit calcification of the biological tissue following implantation thereof in a mammalian body. The apparatus includes a container for...
7422607 Anti-calcification treatments for heart valves and vascular grafts  
The present invention provides processes for fixation of biological tissue and/or post-fixation treatment of such tissue that result in modified tissues with reduced susceptibility to in vitro...
7294144 Preserved implantable vessel derived from a human umbilical cord or placenta  
A preserved vessel isolated from a human umbilical cord or placenta and lyophilized for use as an allograft which improves blood supply to human tissue without antigenicity.
7156881 Counteracting bioprosthetic calcification  
Adapting crosslinking with triglycidyl amine (TGA) to incorporate the use of a particular type of anti-calcification agent provides a broad-reaching solution to the problem in vivo bioprosthesis...
7029434 Methods for treating implantable biological tissues to mitigate post—implantation calcification  
A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue...
6878168 Treatment of bioprosthetic tissues to mitigate post implantation calcification  
Bioprosthetic tissues are treated by immersing or otherwise contacting fixed, unfixed or partially fixed tissue with a glutaraldehyde solution that has previously been heat-treated or pH adjusted...
6837907 Method for debriding bone, and bone debrided thereby  
The invention is directed to a method of debriding bone including incubating the bone and associated soft tissue, with one or more debriding solutions where the debriding solution may include one...
6761735 Heart valve fixation process and apparatus  
A method and apparatus for limiting longitudinal stretch during fixation of a harvested aortic root including valve leaflets and the product produced. The apparatus includes an inflow plug...
6630001 Compliant dehyrated tissue for implantation and process of making the same  
A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a...
6592618 In vitro modification of cardiac valvular xenografts  
The present invention is directed to methods for obtaining heart valves from a donor animal that have a reduced tendency to cause inflammation when implanted into a human patient. The valves...
6547827 Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby  
A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a...
6302909 Calcification-resistant biomaterials  
The invention involves a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structures having collectively greater than...
6294041 Method for an osteoimplant manufacture  
The invention relates to an osteoimplant fabricated from a solid aggregate of bone derived elements possessing chemical linkages between their adjacent surface-exposed collagen. Also described are...
6200640 Polymer composition and process for treating leather and fur skins  
Aqueous solutions or dispersions of copolymers obtainable by free-radical copolymerization of (a) from 20 to 90% by weight of at least one monoethylenically unsaturated C4-6 -dicarboxylic acid or...
6166184 Process for making a bioprosthetic device  
Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of...
6027530 System, apparatus and method for chemical fixation of stentless cardiac valvular bioprostheses  
A system, apparatus and method for tanning of a stentless aortic bioprosthesis, and articles manufactured by such method. The system includes a circulating bath which contains a tanning solution,...
6008292 Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials  
A method for preparing collagenous biological tissues for use as implantable bioprosthetic material, and articles prepared thereby. The method generally comprises the steps of a) contacting the...
5948123 Coloring method for hides  
A coloring method, wherein coloring agent or pigment is injected into active cells of an animal hide before the hide is harvested, and a coloring agent injection device with one or more needles,...
5935168 Glutaraldehyde-fixed bioprostheses  
Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate there propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and...
5931969 Methods and apparatuses for treating biological tissue to mitigate calcification  
A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue...
5891196 Method for actively binding heparin to crosslinked biological tissues  
Methods for binding heparin to biological or synthetic materials which are to be implanted within a mammalian body. In instances where connective tissue proteins or other components of the...
5882850 Method for reducing calcification of biological tissue used implantable bioprostheses  
Biological materials are treated with an organic chemical agent, dimethyl sulfoxide, to delay the onset of in vivo calcification. The biological materials so treated become resistant to...
5873812 Method of preparing biological implantation material  
A method of preparing biological implantation material fixed by means of aldehydes, in which the excess aldehyde is bound by treatment with an aminocarboxylic acid and the acid is selected from...
5862806 Borohydride reduction of biological tissues  
A method of using sodium or potassium borohydride to reduce dehydrated, aldehyde treated biological tissues is disclosed. The method comprises the steps of: providing the tissue, such as porcine...
5843181 Biological material pre-fixation treatment  
Disclosed is a controlled autolysis method for making biological tissue substantially acellular by exposing the biological material, prior to any fixation thereof, to at least one buffered...
5830239 Natural tissue heart valve fixation apparatus and method  
An apparatus and a method for fixing a heart valve is disclosed that produces a differential pressure across the outflow section of the heart valve to the exterior of the valve that may be made...
5827680 Three reagent gram staining method and kit  
A method for Gram staining a specimen containing bacteria includes the steps of staining Gram positive bacteria in the specimen, fixing the stain to the Gram positive bacteria, and simultaneously...
5817153 Method of photo-oxidative treatment of tissues containing collagen  
In the method of a photo-oxidative treatment of tissue containing collagen tissue, the tissue is pre-treated with an aqueous conditioning solution prior to an irradiation with light. In this...
5782931 Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods  
Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate their propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and...
5769780 Method of manufacturing natural tissue valves having variably compliant leaflets  
Variably compliant natural tissue valve leaflets and vascular bioprosthetics incorporating variably compliant leaflets are provided along with methods for their manufacture. The variably compliant...
5746775 Method of making calcification-resistant bioprosthetic tissue  
A method of treating a collagenous biomaterial, such as porcine aortic valve leaflets or bovine pericardium, by exposing the biomaterial to an alcohol to inhibit in vivo calcification. The...
5733339 Process for fixation of calcification-resistant biological tissue  
A process is provided for non-glutaraldehyde fixation of an organ or prosthesis to be implanted in a mammal. The process produces stable fixation of the tissue by forming amide linkages within and...
5720778 Method of producing high-molecular products from collagen-containing materials, and product produced by the same  
A method of producing a collagen-containing material has the steps of comminuting untanned collagen-containing raw material, preparing from the raw material a collagen solution, preparing a...
5718012 Method of strength enhancement of collagen constructs  
A method for improving the tensile strength of wet collagen threads or collagen thread constructs for implantation to replace or repair tissue or organs wherein the strength of the threads is...
5697972 Bioprosthetic heart valves having high calcification resistance  
The specification describes an invention of calcification resistant bioprosthetic heart valves which can be used for a long term, and have good blood compatibility and in vivo stability, and have...
5679112 Calcification-resistant materials and methods of making same through use of multivalent cations  
Bioprosthetic materials, either natural or synthetic, are treated with trivalent iron cations, or salts, to prevent in vivo calcification. Such bioprosthetic materials include porcine aortic valve...
5674298 Calcification-resistant bioprosthetic tissue and methods of making same  
Naturally-derived bioprosthetic materials are treated with epoxide crosslinking agents. In some embodiments, the tissue is crosslinked with low molecular weight epoxides in aqueous solutions at...
5476516 Anticalcification treatment for aldehyde-tanned biological tissue  
A method of treating aldehyde-tanned biological tissue minimizes in vivo calcification and reduces cytotoxicity without impairing the mechanical strength of the tanned tissue. The method includes...
5447536 Method for fixation of biological tissue  
A process is provided for the non-glutaraldehyde fixation of a prosthesis to be implanted in a mammal whereby the prosthesis is fixed by employing cross-linking agents to form amide linkages...
5279612 Dynamic fixation of porcine aortic valves  
A method of preserving porcine heart valves so that they may be incorporated into prosthetic heart valves for human implant. During fixation, the leaflets of the valves are repeatedly flexed...
5215541 Surfactant treatment of implantable biological tissue to inhibit calcification  
A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the...
5116552 Process for preparation of dried collagen sponge  
A process for preparing a crack-free, dried collagen sponge having a shrinkage factor of up to 14%, including the steps of impregnating crosslinked collagen sponge with an aqueous solution of a...
5116389 Method of obtaining collagen human-skin fibers, fibers thus produced, and a compound containing them  
Human-skin collagen fibers are obtained from sterile pieces of human skin by first comminuting the sterile skin and then mixing the comminuted sterile skin with a sterile aqueous solution of an...

Matches 1 - 50 out of 141 1 2 3 >