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7620500 |
Optimization of crossover points for directed evolution
Methods and devices for more efficiently engineering diversity into recombinant polypeptides and/or nucleic acids are provided herein. For example, a variety of methods of selecting and/or...
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7617171 |
Process for the iterative construction of an explanatory model
A process for iterative construction of an explanatory model including at least one rule calculated from a plurality of experiments, each of which rules is associated with at least one indicator of...
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7617080 |
Image enhancement by spatial linear deconvolution
Data from a target system ( 616 ) that exhibits a non-linear relationship between system properties and measurement data, is processed by applying a linear filter (F) to improve resolution and...
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7610155 |
Methods for processing spectral data for enhanced embryo classification
A method is disclosed for classifying plant embryos according to their quality using a logistic regression model. First, sets of image or spectral data are acquired from plant embryos of known...
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7606670 |
Crystal structure of the 30S ribosome and its use
The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of...
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7599800 |
Apparatus and method for coding genetic information
Provided are an apparatus and a method for coding genetic information. An aligning unit aligns sample genetic information, wild-type probe genetic information, and mutant-type probe genetic...
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7599799 |
Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the...
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7596455 |
Crystallization of IGF-1
Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising...
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7593820 |
Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof
The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to a...
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7590517 |
Methods, systems, and computer program products for computational analysis and design of amphiphilic polymers
Methods, systems, and computer program products for computational polymer processing including, without limitation, computational amphiphilic polymer design, conformational energy minimization,...
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7590494 |
Drug design based on the structure of LTA4 hydrolase
The present invention relates to an isolated leukotriene A 4 (LTA 4 ) hydrolase, which LTA 4 hydrolase is present in its naturally occurring three dimensional form. It is the first...
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7584087 |
Structure of protein kinase C theta
A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
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7584059 |
Inhibition of immune complex formation
Polypeptides and other compounds that can bind specifically to the C H 2-C H 3 cleft of an immunoglobulin molecule, and methods for using such polypeptides and compounds to inhibit Fc-mediated...
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7580799 |
Method for characterizing and analyzing 3-D shapes of molecules utilizing steric multiplets
Steric features inherent in the three dimensional disposition of atoms in molecules can be represented as multiplets using a defined set of steric descriptors. The resulting multiplets can be...
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7567870 |
Multiparameter analysis for predictive medicine
The invention provides a method of determining a comparative expression profile in an individual by comparing the expression levels of a sample of molecules in a population of molecules in a...
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7561971 |
Methods and devices relating to estimating classifier performance
Methods and devices, including methods and devices for estimating classifier performance such as generalization performance, are disclosed. One method includes providing multiple samples. Each...
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7558717 |
Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure...
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7558681 |
Method of determining plant species with pyrolysis-gas chromatography
A method of identifying a plant species includes the steps of: preparing a fragment of the plant; heating the fragment to obtain lignin from the fragment; gasifying the lignin at a high temperature...
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7555415 |
Methods for the design of estrogen receptor ligands
Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.
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7555392 |
Method for determining metabolic flux
A method for determining metabolic flux distribution of a cell, which comprises the steps of:
1) creating a stoichiometric matrix based on formulas of biochemical reactions from a substrate to a...
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7553834 |
Method for the targeted treatment of depression
A method for determining the appropriate medication for a patient suffering from depression. A patient will take a questionnaire wherein the patient answers a number of questions with scaled...
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7552039 |
Method for sample processing and integrated reporting of dog health diagnosis
A physical blood sample of animal is sent to a satellite laboratory facility. The blood sample is pre-processed into sub-samples of the sample and the sub-samples are coded. The coded blood...
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7539607 |
Computer system and method of calculating a pharmacokinetic behavior of a chemical substance in insects
Computer system for calculating a pharmacokinetic behavior of a chemical substance in insects, comprising:
a physiologically based pharmacokinetic simulation model ( 102 ) of an insect for...
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7529628 |
Methods for identifying modified tumor necrosis factor-alpha converting enzyme inhibitors
The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein...
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7526415 |
Grid based computation for multiple body simulation.
A method and a corresponding software and a system for processing a charge distribution according to a spreading function and a predefined operation are described.
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7523026 |
Proteome analysis method and proteome analysis system
A proteome analysis method includes using a tandem type mass spectrometer to calculate bond dissociation energy by using molecular simulation, using the bond dissociation energy to obtain...
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7518611 |
Extensible library for storing objects of different types
A library can store different types of multimedia objects, including effects (for example, behaviors, filters, fonts, and particle effects) and content (for example, audio clips, video clips, and...
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7514240 |
EGR-EGFR complex
The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating...
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7512497 |
Systems and methods for inferring biological networks
Described herein is a system for inferring one or a population of biochemical interaction networks, including topology and chemical reaction rates and parameters, from dynamical or statical...
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7508388 |
Method for extending the display of a 2D image of an object region
In a method to extend the display range of 2D image recordings of an object region, particularly in medical applications, first 2D or 3D image data are acquired from a larger object region, and at...
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7507552 |
Crystallization of histone deacetylase 2
Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.
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7499847 |
Crystalline VAP-1 and uses thereof
The present invention relates to crystalline vascular adhesion protein-1 (VAP-1) and in particular to methods for the use of structural information of crystalline human VAP-1 for ligand and/or...
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7496489 |
Design of progesterone receptor ligands
This invention relates to progesterone receptor/ligand complex, and related methods and software systems. Methods for designing and/or selecting ligands of the progesterone receptor using the...
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7493246 |
Device and method of calibration for a modelling tool and modelling tool incorporating such a device
This calibration device for a tool for modelling a system, on the basis of an observation of the outputs of the system, comprises means of processing the output data emanating from a device for...
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7483763 |
System and method for the digital specification of head shape data for use in developing custom hair pieces
The present invention is a system and method for specifying custom hair pieces using three-dimensional digital acquisition devices. The system and method described herein uses electronic data...
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7481780 |
Method of calibration for the representation of knee kinematics and harness for use therewith
A method for creating a frame of reference of a leg of a subject for subsequent 3-D kinematic analysis of the leg with non-invasive trackable references secured to the femur and the tibia of the...
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7476853 |
Ion fragmentation by reaction with neutral particles
The invention relates to a method and apparatus for the fragmentation of large molecules, especially biopolymers. The invention consists in reacting analyte ions with excited or radical neutral...
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7472050 |
Method and apparatus for computer modeling a joint
The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one...
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7467075 |
Three-dimensional finite-element code for electrosurgery and thermal ablation simulations
A system and method for performing a simulation of an electrosurgical procedure are disclosed. The method includes the steps of generating a three-dimensional medium, which includes one or more...
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7467046 |
Geranylgeranyl transferase type I (GGTase-I) structure and uses thereof
Protein geranylgeranyl transferase type I (GGTase-I), a Ca 1 a 2 X prenyltransferase, is an essential enzyme in eukaryotes. GGTase-I catalyzes the carboxyl-terminal lipidation of over one hundred...
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7457444 |
Method and apparatus for fast automatic centerline extraction for virtual endoscopy
A method for automatic centerline extraction for a virtual endoscopy image of an organ having a boundary surface includes centering on selected points of an initial path through the image, which is...
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7454322 |
Method for modeling hydrocarbon degradation in an oil deposit
Method of modeling the biodegradation of hydrocarbons trapped in an oil reservoir or trap through the action of the bacterial population in an underlying aquifer. From data relative to the...
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7447595 |
Heterologous protein production using the twin arginine translocation pathway
Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided,...
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7444273 |
Crystallization of aurora/LPL1P-related kinase
Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.
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7444243 |
Probabilistic method for determining nucleic acid coding features
The present invention is in the field of bioinformatics, particularly as it pertains to gene prediction. More specifically, the invention relates to the probabilistic analysis of nucleic acid...
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7429727 |
Method, apparatus, and program product for quickly selecting complex molecules from a data base of molecules
The disclosed technology relates to the analysis of dissociation spectrum data that includes spectral peaks that represent fragments of a parent ion. The parent ion includes molecular subunits that...
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7427200 |
Computer-based training methods for surgical procedures
A method is disclosed for analyzing surgical techniques using a computer system for gathering and analyzing surgical data acquired during a surgical procedure on a body portion and comparing that...
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7418374 |
Treatment protocol generation for diseases related to angiogenesis
A computer-implemented method for determining an optimal treatment protocol for a disease related to angiogenesis, comprising creating an angiogenesis model including pro-angiogenic and...
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7415398 |
Method of simulating viscoelastic material
The present invention relates to a method of simulating the deformation of a viscoelastic material in which filler is blended to a matrix made of rubber or resin, the method including the steps of...
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7415359 |
Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents
Systems and methods are presented for cell simulation and cell state prediction. For example, a cellular biochemical network intrinsic to a phenotype of a cell can be simulated by specifying its...
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