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7610156 |
Methods for rational pegylation of proteins
The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the...
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7606670 |
Crystal structure of the 30S ribosome and its use
The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of...
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7603180 |
Method and system for orthogonalizing input signals
A method for the orthogonalization of initially overlapping vectors, the uses for which include the re-encoding and decoding of representations triggered by sensory arrays.
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7596455 |
Crystallization of IGF-1
Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising...
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7596454 |
Method for separating detection channels of a microscope system
A method for separating detection channels is disclosed, a sample ( 15 ) being equipped with at least two different fluorescent dyes. Firstly the emission spectrum of at least two fluorescent dyes...
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7595485 |
Data analysis to provide a revised data set for use in peptide sequencing determination
In one aspect of the present invention, the less “useful” spectral data is disregarded from the spectral data resulting from the fragmentation by ETD and candidate charge states for the...
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7593820 |
Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof
The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to a...
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7590494 |
Drug design based on the structure of LTA4 hydrolase
The present invention relates to an isolated leukotriene A 4 (LTA 4 ) hydrolase, which LTA 4 hydrolase is present in its naturally occurring three dimensional form. It is the first...
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7587286 |
Methods for rational pegylation of proteins
The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the...
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7584087 |
Structure of protein kinase C theta
A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
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7580799 |
Method for characterizing and analyzing 3-D shapes of molecules utilizing steric multiplets
Steric features inherent in the three dimensional disposition of atoms in molecules can be represented as multiplets using a defined set of steric descriptors. The resulting multiplets can be...
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7564041 |
Method of using self-positioning radiation counters
A method of collecting data on radioactive material includes: positioning a detector unit at a first position relative to the environment; collecting at least a part of a first set of data from a...
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7558717 |
Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure...
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7555415 |
Methods for the design of estrogen receptor ligands
Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.
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7544931 |
Mass-analyzing method
In a mass analysis of a sample, candidate compositions Y of a fragment ion produced by a dissociating operation are deduced from the mass of that fragment ion (Steps S 6 to S 9 ). If the number of...
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7544930 |
Tandem type mass analysis system and method
The present invention provides a tandem type mass analysis system capable of carrying out the differential analysis with high efficiency by the tandem type mass analysis. A predetermined number of...
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7538321 |
Method of identifying substances using mass spectrometry
An object of the present invention is to provide a mass spectrometry system capable of improving an efficiency of obtaining information on a structure of substances, shortening a time taken for a...
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7532985 |
Process for identifying polycrystalline materials by electron diffraction
A relational database is built and used for the identification of polycrystalline solids by electron diffraction. Selected area electron diffraction (SAED) patterns (rings) produced in an electron...
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7529630 |
Method of analyzing mass analysis data and apparatus for the method
The present invention provides a method and an apparatus for analyzing mass analysis data for selecting a component similar to a target component quickly and accurately, based on MS n analysis for...
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7523026 |
Proteome analysis method and proteome analysis system
A proteome analysis method includes using a tandem type mass spectrometer to calculate bond dissociation energy by using molecular simulation, using the bond dissociation energy to obtain...
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7516031 |
Apparatus and method for correcting for aberrations
A method of correcting for aberrations in scattering data is described which does not require prior knowledge about the sample microstructure properties or calculations based on the modelling of...
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7516018 |
Structural unit analysis
A computer implemented method is disclosed for analyzing a large data set of chemical compounds for which there is a measured activity in the same assay for each compound to determine the...
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7514275 |
Molecular contaminant film modeling tool
A system and method for modeling the effect of a molecular contaminant film on performance of an optical system is disclosed. A mass of material outgassed from materials of the optical system is...
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7514240 |
EGR-EGFR complex
The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating...
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7511267 |
Data-dependent accurate mass neutral loss analysis
A method is disclosed for data-dependent neutral loss analysis of biomolecules and other materials in a hybrid mass spectrometer. Candidate product ions are selected by identifying peaks in a MS/MS...
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7507552 |
Crystallization of histone deacetylase 2
Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.
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7504230 |
Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins
The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires...
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7501621 |
Data acquisition system for a spectrometer using an adaptive threshold
A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector and a processing circuit. The processing...
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7499808 |
Method and system for characterizing nanoparticles in a gun-shot residue
A method and system for characterizing gun-shot residue. More particularly, embodiments of the present invention provide a method that includes determining a size and an elemental composition of at...
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7499805 |
Method and apparatus for protein structure analysis
Techniques for analyzing one or more protein structures. In one aspect of the invention, the technique comprises the following steps. A normalized second-order hydrophobic moment is determined for...
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7496489 |
Design of progesterone receptor ligands
This invention relates to progesterone receptor/ligand complex, and related methods and software systems. Methods for designing and/or selecting ligands of the progesterone receptor using the...
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7493225 |
Method for calibrating mass spectrometry (MS) and other instrument systems and for processing MS and other data
A method for obtaining at least one calibration filter for a Mass Spectrometry (MS) instrument system. Measured isotope peak cluster data in a mass spectral range is obtained for a given...
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7493219 |
Method of discriminating particle groups and particle analyzer
A method for discriminating particle groups comprises generating, by a particle analyzer, a particle characteristic distribution histogram in which the abscissa indicates respective channels for...
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7485852 |
Mass analysis method and mass analysis apparatus
The present invention achieves a mass analysis method that can identify protein or peptide with high speed and high sensitivity. A mass spectrum is obtained from a standard sample of healthy...
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7474965 |
System and method for identifying molecules
A system and method for identifying molecules. Molecules are identified from a gaseous matter having the molecules and flowing at two different flow rates. A system and method for identifying a...
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7472023 |
Gas analysis system and method
A gas analysis system. The system includes a Fourier transform infrared (FTIR) spectrometer, a signal transformation module, an unknown chemical analysis module, a calibration model determination...
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7469036 |
Analysis of macromolecules, ligands and macromolecule-ligand complexes
A method for determining atomic level structures of macromolecule-ligand complexes through high-resolution powder diffraction analysis and a method for providing suitable microcrystalline powder...
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7460961 |
N-TRADD active site and uses thereof
The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and...
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7460237 |
Inspection method and apparatus, lithographic apparatus, lithographic processing cell and device manufacturing method
In a method of determining a structure parameter of a target pattern in a lithographic process, a series of calibration spectra are calculated from a reference pattern. Spectral analysis is...
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7456399 |
Calibrating multiple photoelectron spectroscopy systems
A method comprising obtaining a first set of spectral data for a first sample film measured by a first system, extracting intensities for one or more elemental species associated with the first...
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7444273 |
Crystallization of aurora/LPL1P-related kinase
Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.
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7442921 |
Protein profiles with atmospheric pressure ionization
The invention relates to the acquisition of mass spectra of complex protein mixtures, often called protein profiles, for example to search for biomarkers which indicate stress situations, or to...
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7442554 |
Compositions and methods involving glucocorticoid receptor site II
A binding site in nuclear hormone receptors is described and its structural coordinates are provided. The invention provides machine-readable data storage media comprising structure coordinates of...
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7429727 |
Method, apparatus, and program product for quickly selecting complex molecules from a data base of molecules
The disclosed technology relates to the analysis of dissociation spectrum data that includes spectral peaks that represent fragments of a parent ion. The parent ion includes molecular subunits that...
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7416524 |
System, method and computer program product for fast and efficient searching of large chemical libraries
A system, method, and computer program product for fast and efficient searching of large virtual combinatorial libraries based on a fitness function. According to the method of the present...
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7415361 |
Methods and systems for analyzing and determining ligand-residue interaction
A method implemented in the form of a computer simulation code for evaluating the free energy of binding between polypeptide amino acid residues and one or more molecular fragment types is...
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7415144 |
Cell observation device and cell observation method
The cell observation device and method aims to easily study the correlation between initial states of cells and their reactions without using a synchronous culture method. For this purpose, the...
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7407810 |
Methods and apparatus for characterizing polymeric mixtures
The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental...
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7400982 |
Automated generation of multi-dimensional structure activity and structure property relationships
The present invention relates to automated generation of multi-dimensional structure activity and structure property relationships.
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7398162 |
Quantum mechanical model-based system and method for global optimization
A model-based system and method for global optimization that utilizes quantum mechanics in order to approximate the global minimum of a given problem (e.g., mathematical function). A quantum...
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