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7142987 |
Apparatus, system, and method of archival and retrieval of samples
A sample archive method and system implement a plurality of sample carriers configured to support a plurality of sample nodes in a predetermined spatial relationship, sample storage devices for...
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7139665 |
Computational method for designing enzymes for incorporation of non natural amino acids into proteins
The instant invention provides methods, reagents, and computational tools for designing non-natural substrate analogs for enzymes, especially for designing unnatural amino acid analogs for...
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7139620 |
Prediction method and apparatus of a processing result
In a method and apparatus for predicting process results of objects being processed in a processing chamber of a processing apparatus, operation data and process result data obtained at the time of...
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7139677 |
Methods for consistent forewarning of critical events across multiple data channels
This invention teaches further method improvements to forewarn of critical events via phase-space dissimilarity analysis of data from biomedical equipment, mechanical devices, and other physical...
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7136760 |
Visualization method of RNA pseudoknot structures
Disclosed is a visualization method of RNA pseudoknot structures. The method of the invention comprises the steps of setting criteria required for visualizing RNA pseudoknots, setting structural...
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7136759 |
Method for enhanced accuracy in predicting peptides using liquid separations or chromatography
A method for predicting the elution time of a peptide in chromatographic and electrophoretic separations by first providing a data set of known elution times of known peptides, then creating a...
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7136758 |
Virtual library searchable for possible combinatorially derived product molecules having desired properties without the necessity of generating product structures
The problem of how to select out of a large chemically accessible universe molecules representative of the diversity of that universe is resolved by the discovery of a method to validate molecular...
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7132254 |
Method and apparatus for detecting phycocyanin-pigmented algae and bacteria from reflected light
The present invention relates to a method of detecting phycocyanin algae or bacteria in water from reflected light, and also includes devices for the measurement, calculation and transmission of...
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7133781 |
Biopolymer sequence comparison
Disclosed are methods, software, and systems for comparing biopolymer sequences. The model includes at least two different characterizations of states of matching between segments of sequences at...
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7133811 |
Staged mixture modeling
A system and method for generating staged mixture model(s) is provided. The staged mixture model includes a plurality of mixture components each having an associated mixture weight, and, an added...
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7133780 |
Computer software for automated annotation of biological sequences
Methods, software products and systems are provided for automated high throughout gene characterization. In one exemplary embodiment, HMM models are used to characterize genes. Biological sequences...
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7130746 |
Computer systems and computer programs for determining protein activity levels using gene expression profiles
The present invention provides methods for determining the level of protein activity in a cell by: (i) measuring abundances of cellular constituents in a cell in which the activity of a specific...
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7130747 |
High throughput screening of ligand binding to macromolecules using high resolution powder diffraction
A process is provided for the high throughput screening of binding of ligands to macromolecules using high resolution powder diffraction data including producing a first sample slurry of a selected...
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7127357 |
Crystal structure of WW domains and methods of use thereof
A WW domain crystal structure of Pin1 is provided. In addition, methods of using the crystal structure and atomic coordinates for the development of WW domain binding agents is also provided. Also...
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7127354 |
Method of displaying gene data, and recording medium
A method of displaying gene data assists in discovering expression patterns specific to gene functions and inferring the function of a gene of which the function is unknown. A threshold value...
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7124034 |
Method for changing a target array, a method for analyzing a structure, and an apparatus, a storage medium and a transmission medium therefor
The objective of the present invention is the efficient analyzation of the structure of an array. By performing the prev(S) calculation for a character string S, if in S, a like variable is present...
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7124031 |
System for monitoring regulation of pharmaceuticals from data structure of medical and labortory records
A system is provided that integrates of records of clinical laboratory services into the assessment and optimization of patient health care and, in particular, regulation of the use of...
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7124032 |
System and method for reconstructing pathways in large genetic networks from genetic perturbations
A system and method for reconstructing pathways in large genetic networks from genetic perturbations comprises an analysis method and system that applies a recursive algorithm for determining the...
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7122111 |
Sample discriminating method
A glucose sensor system comprising the steps of using as a sample discriminating parameter a ratio (I/ΔI) of a measured current value I to the time-differential value of the current value ΔI,...
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7124033 |
Method for identifying matched groups
Methods, code, and apparatus are used to ensure that groups of experimental subjects selected for inclusion in a study are matched. Individuals are genotyped and the genotype data is used to...
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7117095 |
Methods for selecting nucleic acid probes
Methods and computer software products are provided for selecting nucleic acid probes. In one embodiment, dynamic programming is employed to select a set of k probes from n probes so that the...
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7117096 |
Structure-based selection and affinity maturation of antibody library
The present invention provides a structure-based methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as...
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7117097 |
Methods, computer software products and systems for correlating gene lists
In some embodiment of the invention, methods are provided to compare lists of genes. In one embodiment, the genes are ranked with the lists. The ranks are analyzed using Spearman correlation.
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7113870 |
Prediction of molecular polar surface area and bioabsorption
The polar surface area of molecules is computed without reference to three dimensional molecular structures using a linear equation incorporating counts of nitrogens, oxygens, and related atom...
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7113898 |
Method for modeling signal transduction in cells
The present invention provides a model that can be use to describe biological processes having a complex spatial geometry, for example, cell signaling processes. The models can also be used to...
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7113875 |
Humoral testing unit and a humoral testing apparatus
A plurality of different kinds of reagents are supported at different positions on a reagent layer. A humoral testing apparatus irradiates measuring light which has a wavelength adapted to one of...
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7108984 |
Methods of identifying modulators of the FGF receptor
The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is...
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7110885 |
Efficient methods and apparatus for high-throughput processing of gene sequence data
One disclosed method of processing gene sequence data includes the steps of reading gene sequence data corresponding to a gene sequence and coding sequence data corresponding to a plurality of...
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7107156 |
Method and apparatus for estimating solvation energies of membrane bound molecules
The disclosure relates to a method of estimating the polar component of the solvation energy for a molecule embedded in different media. In one embodiment, the molecule is partially embedded in a...
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7107089 |
Automated planning volume contouring algorithm for adjuvant brachytherapy treatment planning in sarcoma
A mathematical contouring algorithm that automatically determines the planning volume of a sarcoma prior to designing a brachytherapy treatment plan. The algorithm, utilizing computational...
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7107155 |
Methods for the identification of genetic features for complex genetics classifiers
A candidate single nucleotide polymorphism (SNP) combination is selected from a plurality of candidate SNP combinations for a gene associated with a genetic trait. Haplotype data associated with...
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7099778 |
Method for determining diffusivity and molecular weight in a microfluidic device
The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having...
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7096125 |
Architectures of sensor networks for biological and chemical agent detection and identification
A sensor network provides the ability to detect, classify and identify a diverse range of agents over a large area, such as a geographical region or building. The network possesses speed of...
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7096167 |
System and method for molecular dynamic simulation
A system and method for molecular dynamic simulation includes a database for storing data pertaining to at least one biomolecular system, a memory device for storing instructions for performing at...
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7096162 |
Computer-implemented method of merging libraries of molecules using validated molecular structural descriptors and neighborhood distances to maximize diversity and minimize redundancy
The use for biological screening purposes of a subset (library) of a large combinatorially accessible chemical universe increases the efficiency of the screening process only if the subset contains...
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7094531 |
Nucleic acid sequencing
Provided is a method for sequencing DNA, which comprises: (a) obtaining a target DNA population comprising one or more single-stranded DNAs to be sequenced, each of which is present in a unique...
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7092825 |
Protein engineering
A method of protein engineering is provided wherein a searchable computer database is created comprising entries in the form of descriptions of a location and orientation in 3D space of side chains...
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7089121 |
Methods for monitoring the expression of alternatively spliced genes
Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The...
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7087373 |
Methods for determining plasma free drug concentration by direct measurement of binding affinity of protease inhibitors to plasma proteins
Methods for isothermal titration calorimetry analysis of the binding affinity of protease inhibitors to plasma proteins. A method that can quantitatively calculate free drug concentrations of...
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7089120 |
Process for evaluating chemical and biological assays
An analytical process is disclosed, for discriminating data acquired from samples with overlapping distributions, and for improving and assessing the statistical validity of hybridization signal in...
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7085651 |
Method and device for assembling nucleic acid base sequences
An object of the present invention is to perform the clustering and assembling of nucleic acid base sequences at a high speed. Partial sequences 102 are extracted from each input sequence 101 ...
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7085653 |
Method for removing atomic-model bias in macromolecular crystallography
Structure factor bias in an electron density map for an unknown crystallographic structure is minimized by using information in a first electron density map to elicit expected structure factor...
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7085765 |
Methods to increase the capacity of high content cell-based screening assays
The present invention involves the pooling of multiple high content cell-based screening assays, and carrying out a primary screen in a one or more channels of a fluorescence detection device,...
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7082369 |
Distributed biohazard surveillance system and apparatus for adaptive aerosol collection and synchronized particulate sampling
A distributed biohazard surveillance system including a plurality of robust miniaturized remote monitoring stations for the detection, localized analysis and reporting of a broad range of...
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7079956 |
Crystal structure of antibiotics bound to the 30S ribosome and its use
The invention provides high resolution X-ray crystal structures of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 to which are bound...
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7079993 |
Automated generator of optimal models for the statistical analysis of data
Provided is an automated process for producing accurate statistical models from sample data tables. The process solves for optimal parameters of each statistical model considered, computes test...
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7076371 |
Non-invasive diagnostic and monitoring method and apparatus based on odor detection
A set of volatile markers are determined which are characteristic of a particular condition or disease, and which will be found in the exhaled breath of a person or odor from other parts of a body...
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7076372 |
Crystal structure of MvaS
Provided are structure coordinates relating to MvaS and its various uses.
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7070936 |
Method for designing protein kinase inhibitors
The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase...
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7069152 |
Apparatus for identifying peptides and proteins by mass spectrometry
An apparatus for identifying a protein, polypeptide or peptide by means of mass spectrometry and especially by tandem mass spectrometry is disclosed. The apparatus preferably functions to model the...
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