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7216041 |
Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket
The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of...
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7212924 |
Method of inferring three-dimensional structure of protein
A method of predicting a scaffold of a protein comprising a query sequence, using a database which contains environmental information on the side chain of each amino acid residue contained in the...
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7211388 |
Method for profiling and identifying persons by using data samples
A method for profiling and identifying persons by using data samples provides a collapsed list of one or more aggregated matching samples having consistent STR profiles. Each of the one or more...
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7212951 |
Method for characterizing and analyzing 3-D shapes of molecules utilizing steric multiplets
Steric features inherent in the three dimensional disposition of atoms in molecules can be represented as multiplets using a defined set of steric descriptors. The resulting multiplets can be...
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7211438 |
Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample
Methods for predicting the presence of haemostatic dysfunction in a patient from a time-dependent measurement profile include performing a time-dependent measurement on an unknown sample and...
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7209861 |
Methods for improved forewarning of critical events across multiple data channels
This disclosed invention concerns improvements in forewarning of critical events via phase-space dissimilarity analysis of data from mechanical devices, electrical devices, biomedical data, and...
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7209835 |
Algorithmic testing in laboratory medicine
A method of pipelining a disease specific diagnostic algorithm on an n-bit data word stored in a memory whereby the n-bit data word is divided into clinical tests describing ranges of normal...
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7209836 |
Method and system for automatically creating crosstalk-corrected data of a microarray
A method and system are disclosed for automatically creating crosstalk-corrected data of a microarray utilizing calibration dye spots each of which comprises a single pure dye. A microarray...
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7205400 |
Array fabrication
A method, apparatus, and computer program, for fabricating multiple arrays arranged successively in a first direction on a substrate and each having multiple feature sets arranged successively in...
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7206699 |
Methods for measuring therapy resistance
The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic...
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7202037 |
Electrochemical sensor using intercalative, redox-active moieties
Compositions and methods for electrochemical detection and localization of genetic point mutations, common DNA lesions and other base-stacking perturbations within oligonucleotide duplexes adsorbed...
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7200495 |
Method and apparatus for analyzing spatial and temporal processes of interaction
Devices and techniques for estimating the concentration of one or more agents in a fluid environment employ a plurality of measurements of a sensor attribute that changes in response to an agent....
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7199809 |
Graphic design of combinatorial material libraries
Computer-implemented methods, programs and apparatus for generating a library design for a combinatorial library of materials. A library design includes a set of sources representing components to...
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7200493 |
Method for screening crystallization or amorphous stage conditions for molecules
A system and a method for screening of nucleation tendency of a molecule, such as a macromolecule, based on acoustic, electrostatic or hybrid acoustic/electrostatic levitation of a droplet for...
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7200531 |
Conformation-activity relationship of apoptosis-inducing phosphodiester oligonucleotides
The present invention facilitates in silico evaluation of molecules for biological activity by providing a computer-based method to predict whether oligonucleotides may possess biological activity...
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7197400 |
System and computer software products for comparative gene expression analysis
Methods and computer software products are provided for analyzing gene expression data. In one embodiment, methods, systems and computer software are provided for comparative gene expression...
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7191068 |
Proteomic analysis of biological fluids
The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin,...
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7188031 |
Method for acquiring information of a biochip using time of flight secondary ion mass spectrometry and an apparatus for acquiring information for the application thereof
A measurement method is provided, which enables to obtain a two-dimensional image with better quantitative-ability by suppressing the influence of the charge-up, when the two-dimensional secondary...
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7188033 |
Method and system of computing and rendering the nature of the chemical bond of hydrogen-type molecules and molecular ions
Provided is a system of computing and rendering a nature of a chemical bond based on physical, Maxwellian solutions of charge, mass, and current density functions of hydrogen-type molecules and...
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7188030 |
Automatic threshold setting for quantitative polymerase chain reaction
Disclosed are systems and methods for identifying and quantitating the presence of one or more DNA species in a sample population through PCR amplification. DNA species quantitation includes a...
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7186510 |
Method for evaluating uniformity of spots on an array
A method for evaluating a uniformity of spots on a DNA microarray having a plurality of spots, these spots undergoing specific emissions as a result of the hybridization of target DNA and tagged...
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7188032 |
Incremental determination of Teiresias patterns
A method for determining Teiresias patterns. Provided as input to the method are: a set S′ 0 of n sequences denoted as S 1 , S 2 , . . . S n ; positive integers L, W, and K; and Teiresias...
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7184893 |
Method for selecting an optimally diverse library of small molecules based on validated molecular structural descriptors
The use for biological screening purposes of a subset (library) of a large combinatorially accessible chemical universe increases the efficiency of the screening process only if the subset contains...
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7184259 |
Portable entertainment device
A portable entertainment device including a right bay, a center bay and a left bay. The right and left bays are used to house the electrical speakers used in the portable entertainment device and...
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7181349 |
Identification of compounds for modulating dimeric receptors
The invention includes the fitted quaternary structure of insulin receptor. It also includes methods of identifying compounds that modulate insulin receptor activity by producing a compound that...
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7177766 |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
The invention provides criteria and methods for selecting optimum subsequence(s) from a target gene for targeting by a zinc finger protein. Some of the methods of target site selection seek to...
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7177767 |
Systems and methods for the detection of short and long samples
Methods and systems are provided for detecting the accidental use of short and long samples in the clinical analysis of a sample, specimen, or assay. The systems can include a clinical analyzer for...
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7172902 |
Quality control material for reagentless measurement of analytes
A method of monitoring calibration of a spectrophotometric apparatus that includes one or more than one calibration algorithm for one or more than one analyte, involves measuring absorbance of a...
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7171311 |
Methods of assigning treatment to breast cancer patients
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to...
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7163816 |
Alpha-amylase variants
The present invention relates to a method of constructing a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and at least one altered property as compared...
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7164991 |
Specific identifiers of amino-acid base sequences
In order to assign specific identifiers to amino-acid sequences and base sequences, specific identifiers of sequences are generated from data representing connection order of residues in the...
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7161147 |
Biological whole cell mass spectrometer
A method for identifying a biological organism that includes providing a biological sample corresponding to the biological organism, ionizing the biological sample to produce an ionized sample of...
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7162371 |
Differentially-expressed conifer cDNAs, and their use in improving somatic embryogenesis
The invention relates to a method for staging embryos of plants. In particular, this invention relates to a method for creating a relational database by determining transcript levels of sets of...
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7160680 |
Mutation analysis by mass spectrometry using photolytically cleavable primers
The invention relates to a method of a mass-spectrometric analysis of known mutation sites in the genome, such as single nucleotide polymorphisms (SNPs), using the method of restricted primer...
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7162372 |
Least-square deconvolution (LSD): a method to resolve DNA mixtures
Least Square Deconvolution (LSD) uses quantitative allele peak data derived obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each...
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7158890 |
System and method for processing information related to laboratory tests and results
A system and method are provided that addresses the need for an improved microbiology validation system that monitors and validates clinical culture laboratory test results as they occur throughout...
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7158862 |
Method and system for mining mass spectral data
A method, system, and computer program product for mining mass spectral data to detect chemical-specific characteristic features in large databases and/or files, including specifying spectral...
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7158889 |
Gene finding using ordered sets
A method, system and computer program product for identifying occurrences of a sequence of ordered marker strings in a string are disclosed. The method includes the steps of identifying sub-strings...
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7158891 |
Method and system to build optimal models of 3-dimensional molecular structures
The present invention relates to a method to build 3-dimensional models of molecular structures corresponding to the lowest value of the potential energy function from knowledge of their chemical...
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7158888 |
Determining structures by performing comparisons between molecular replacement results for multiple different biomolecules
A method is provided for identifying a search model to use in molecular replacement for determining a structure of a target biomolecule, such as a protein, from X-ray diffraction data, the method...
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7155273 |
Blanching response pressure sore detector apparatus and method
A portable, hand-holdable Blanching Response Tester apparatus (BRT) pressable against the skin of a human patient to provide an indication of a non-blanchable erythema indicative of an incipient...
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7155344 |
Distributed database for analytical instruments
Techniques for controlling analytical instruments are provided. A sequence of steps can be utilized to specify wells of a microfluidic device, mobility to be applied to fluid in the wells, and the...
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7155345 |
System for regulating the handling of milk during the milking process and a method for regulating said milking process
The present invention concerns a system and a method for regulating the handling of milk during the milking process in order to separate mastitis infected milk from milk for human consumption and...
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7155346 |
Crystal structure of yqeJ and uses thereof
This invention is directed to the crystal structure of yqeJ, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of yqeJ. Such...
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7149631 |
Alternative splicing and nonsense-mediated decay: computational methods and gene regulation
Computational methods identify alternate splice forms of known gene transcripts and isoforms that are subject to NMD (nonsense-mediated decay). These methods were used to identify thousands of...
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7146278 |
Method of selecting marker molecules for prediction of molecular activity
A method predicts at least one property of a candidate molecule. A set of reference molecules is classified as either possessing or not possessing at least one property. A subset of the molecules...
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7146277 |
NMR assisted design of high affinity ligands for structurally uncharacterized proteins
Methods of using NMR spectroscopy for identifying ligands that bind to structurally uncharacterized proteins, and improving the binding affinity of ligands for biological targets are disclosed. One...
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7144699 |
Iterative resequencing
The invention provides iterative methods of analyzing a target nucleic acid that represents a variant of a reference nucleic acid. An array of probes is designed to be complementary to an estimated...
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7145135 |
Apparatus and method for MALDI source control with external image capture
A method of MALDI sample plate processing includes capturing an image of a plate positioned outside a mass spectrometer. The image is processed to identify one or more attributes of an individual...
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7146231 |
Smart process modules and objects in process plants
An operator interface within a process plant includes an execution engine that implements process flow modules made up of interconnected smart process objects that are aware of devices and other...
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