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Document Title |
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7519519 |
Signature projection score
Disclosed is a method for predicting the biological activity of a compound by the similarity of its drug signature score to the scores of a plurality of known drug signatures.
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7519478 |
Microprocessors, devices and methods for use in analyte monitoring systems
The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a...
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7517494 |
Test tray and test system for determining response of a biological sample
The present invention provides test trays and test tray systems for assessing the response of a biological sample to a compound or combination of compounds. The compounds or combinations are...
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7516017 |
Biological parameter output apparatus and program
It is an object of the invention to measure the change in action potential waveforms during administration of a drug by testing in cultured cells or in animals, and using this measurement to...
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7514209 |
Diagnosis and prognosis of breast cancer patients
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to...
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7516018 |
Structural unit analysis
A computer implemented method is disclosed for analyzing a large data set of chemical compounds for which there is a measured activity in the same assay for each compound to determine the...
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7512496 |
Apparatus, method, and computer program product for determining confidence measures and combined confidence measures for assessing the quality of microarrays
An apparatus, method, and computer program product are provided for determining a confidence measure for the output of a process for assessing proteomic and genomic information samples. Typically,...
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7512497 |
Systems and methods for inferring biological networks
Described herein is a system for inferring one or a population of biochemical interaction networks, including topology and chemical reaction rates and parameters, from dynamical or statical...
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7505989 |
System and method for creating customized ontologies
The invention relates generally to a system and method for creating custom multi-relational ontologies. The invention includes a system and method for creating a master ontology and the application...
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7504230 |
Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins
The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires...
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7502767 |
Computing a count of cases in a class
A count of cases in a target set classified in a class is computed using a classifier. In the method, one or more measures of behavior of the classifier are determined for a plurality of...
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7499805 |
Method and apparatus for protein structure analysis
Techniques for analyzing one or more protein structures. In one aspect of the invention, the technique comprises the following steps. A normalized second-order hydrophobic moment is determined for...
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7499847 |
Crystalline VAP-1 and uses thereof
The present invention relates to crystalline vascular adhesion protein-1 (VAP-1) and in particular to methods for the use of structural information of crystalline human VAP-1 for ligand and/or...
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7499806 |
Image processing in microsphere arrays
Described herein are methods for registering analytical images comprising obtaining an image of an array, wherein the image depicts fiducials that can be used to register the sequential images of...
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7497934 |
System and method
An analysis system for and method of enabling determination of the velocities of migrating objects and also classifying migrating objects into groups having a common constraint. In one aspect the...
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7496593 |
Creating a multi-relational ontology having a predetermined structure
The invention relates generally to a system and method for creating one or more structured multi-relational ontologies. The invention may include ontologies comprising assertions made up of...
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7496453 |
Classification of herbal medicines using wavelet transform
An efficient, effective and reliable method for authentication of herbal medicines (HMs) based on a novel wavelet-enhanced automated three-dimensional chromatograms classification system. The...
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7496489 |
Design of progesterone receptor ligands
This invention relates to progesterone receptor/ligand complex, and related methods and software systems. Methods for designing and/or selecting ligands of the progesterone receptor using the...
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7493219 |
Method of discriminating particle groups and particle analyzer
A method for discriminating particle groups comprises generating, by a particle analyzer, a particle characteristic distribution histogram in which the abscissa indicates respective channels for...
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7491367 |
System and method for providing a standardized state interface for instrumentation
An instrumentation interface that provides a standardized states of a plurality of devices to a control system. Coordinating the operation of the plurality of devices in an analytical system is...
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7493232 |
Device and method for monitoring hydration status
The invention relates to a device and method that provide an individualized guideline for fluid replacement during normal activity or inactivity. Preferred embodiments calculate the user's fluid...
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7479392 |
Quantitative analysis of a biological sample of unknown quantity
Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject...
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7475048 |
Pre-processed feature ranking for a support vector machine
A computer-implemented method is provided for ranking features within a large dataset containing a large number of features according to each feature's ability to separate data into classes. For...
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7475050 |
Systems for developing analytical device methods
Systems and processes for using the same for developing analytical device methods are provided. Also provided are computer program products for executing the subject processes.
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7469186 |
Finding usable portion of sigmoid curve
Various technologies are described by which the usable portion or threshold value of a sigmoid curve is found. Such techniques can be useful, for example, when determining the concentration or...
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7469185 |
Primary rat hepatocyte toxicity modeling
The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be...
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7467065 |
Computer interface for diagnostic meter
A smart interface assembly is provided which enables convenient, instant, and discreet communication between an analytical meter and a computer, the transfer of data from the analytical system,...
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7467047 |
Method of discovering patterns in symbol sequences
A method of discovering one or more patterns in two sequences of symbols S 1 and S 2 includes the formation, for each sequence, of a master offset table that groups for each symbol the position...
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7467046 |
Geranylgeranyl transferase type I (GGTase-I) structure and uses thereof
Protein geranylgeranyl transferase type I (GGTase-I), a Ca 1 a 2 X prenyltransferase, is an essential enzyme in eukaryotes. GGTase-I catalyzes the carboxyl-terminal lipidation of over one hundred...
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7465559 |
Method for calibrating antibiotic disk diffusion testing of microorganisms
A method for calibrating antimicrobic susceptibility testings of microorganisms comprises the steps of creating a histogram with a high response side and a low response side of isolates from a...
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7462354 |
Method and system for optimizing minigenes and peptides encoded thereby
The invention relates to the field of biology. In particular, the invention relates to a method and system for designing optimized multi-epitope vaccines having selected combinations of amino acid...
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7462818 |
Determination of chemical empirical formulas of unknown compounds using accurate ion mass measurement of all isotopes
A method of determining an empirical formula of an analyte ion from a measured mass spectrum including a main peak and one or more isotope peaks. The method comprises comparing a relative isotopic...
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7460961 |
N-TRADD active site and uses thereof
The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and...
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7457708 |
Methods and devices for identifying related ions from chromatographic mass spectral datasets containing overlapping components
Described are techniques for processing data sets produced by analyzing a sample. The input data set is represented as rows of intensities over time for a particular mass to charge (m/z) range. A...
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7454294 |
Monitoring Z-values for clinical data interpretation
Clinical data that are measured at a plurality of sequential time points are interpreted by monitoring the Z-value of the clinical data. The Z-value of the measured data is calculated at each of...
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7454293 |
Methods for enhanced detection and analysis of differentially expressed genes using gene chip microarrays
A method for enhanced detection and statistical analysis of differentially expressed genes in gene chip microarrays employs: (a) transformation of gene expression data into an expression data...
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7452727 |
Method for increasing clinical specificity when detecting tumors and their precursor stages by simultaneously measuring at least two different molecular markers
The present invention relates to an automatable method for the improved diagnosis of pathologically altered cells by simultaneously staining at least two different molecular markers, which exhibit...
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7449339 |
Spectroscopic method and apparatus for total hemoglobin measurement
A method and apparatus for measuring Tot-Hb in a sample are provided. The method involves collecting absorbance measurements of a sample using a spectroscopic apparatus that includes a first...
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7451047 |
System and method for programatic access to biological probe array data
An applications programming interface is described that includes code libraries that enable transfer of pixel data, intermediate results data, or both, from a data structure or data file directly...
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7447594 |
Molecular cardiotoxicology modeling
The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes...
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7447595 |
Heterologous protein production using the twin arginine translocation pathway
Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided,...
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7447597 |
Data processing/visualization method for two (multi) dimensional separation gas chromatography xmass spectrometry (GCxMS) technique with a two (multiply) dimensional separation concept as an example
This invention is a data processing/visualization method which includes the software development and operation to apply to any multi-dimensional separation. The GC-MS analysis of diesel is an...
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7444243 |
Probabilistic method for determining nucleic acid coding features
The present invention is in the field of bioinformatics, particularly as it pertains to gene prediction. More specifically, the invention relates to the probabilistic analysis of nucleic acid...
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7440856 |
System and method for determining clinical equivalence of test methods
A system, method and computer readable medium of instructions are provided which are useful for determining whether an evaluation testing method or device is clinically equivalent to a reference...
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7439856 |
Health care patient status event processing and reporting
The invention provides a method and system for communicating, processing and responding to information reporting the status of health care patients. In one aspect, the invention provides a...
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7440855 |
Identification of antibiotic targets and critical points in metabolic networks based on pathway analysis
A computational approach to identifying potential antimicrobial drug targets based on the structural capabilities of the microbe's metabolic network, which may be reconstructed from genomic and...
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7437249 |
Methods and systems for detrending signal intensity data from chemical arrays
Methods, systems and computer readable media for removing trends in signal intensity values from features on a chemical array. Inputted signal values from features on the array are surface fitted...
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7435602 |
Reducing effects of spectral nonuniformity
Method and system providing calibration of light detected from biological samples with a correction factor including components for each of a plurality of spectrally distinguishable species and/or...
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H002225 |
Method for testing for bioaccumulation
For use in estimating or predicting bioaccumulation of a chemical analyte, even a surfactant, log P ow values for the analyte may be determined by calculating the log of the ratio of the...
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7429727 |
Method, apparatus, and program product for quickly selecting complex molecules from a data base of molecules
The disclosed technology relates to the analysis of dissociation spectrum data that includes spectral peaks that represent fragments of a parent ion. The parent ion includes molecular subunits that...
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