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6895340 |
Method of molecular structure recognition
An analytical method and apparatus using principal component analysis of nuclear magnetic resonance (NMR) data for rapid molecular structure/function pattern recognition. The presence of a...
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6892139 |
Determining the functions and interactions of proteins by comparative analysis
The invention provides novel methods for characterizing the function of nucleic acids and polypeptides. The invention provides a novel method for identifying a nucleic acid or a polypeptide...
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6892140 |
Immunogenic cancer peptides and uses thereof
This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer.
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6889143 |
Methods and systems for estimating the melting temperature (TM) for polynucleotide molecules
The invention relates to methods and systems for predicting or estimating the melting temperature of duplex nucleic acids, particularly duplexes of oligonucleotides which may be used, for example,...
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6882939 |
Rapid determination of protein global folds
This invention provides a method for rapidly obtaining accurate three-dimensional structure of proteins including large or multi-sub unit proteins, using a combination of NMR analysis of backbone...
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6878523 |
Molecular interaction assays on a solid surface
The present invention relates to novel methods for the analysis of molecular interactions. In particular, the present invention relates to compositions and methods for molecular interaction assays...
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6879916 |
Data processing of the maize prolifera genetic sequence
The invention provides isolated prolifera nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering prolifera levels in plants. The...
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6878517 |
Multispecies food testing and characterization organoleptic properties
A testing system useful for food products employs a multispecies testing array to test for presence or amount of a plurality of organisms in a sample by detecting plural characteristic sequences...
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6879915 |
Chemical array fabrication and use
A method of using an addressable array of biopolymers on a substrate includes receiving the addressable array and an associated machine readable identifier carried on an array substrate or array...
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6876929 |
Process for removing systematic error and outlier data and for estimating random error in chemical and biological assays
A method for improving the reliability and/or accuracy of physical measurements obtained from array hybridization studies performed on an array having a large number of genomic samples uses a small...
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6876932 |
Maltogenic alpha-amylase variants
The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic...
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6876930 |
Automated pathway recognition system
There is a pressing need for computer-implemented tools that can summarize and present the enormous amounts of public literature to facilitate analysis of gene expression data. The present...
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6873914 |
Methods and systems for analyzing complex biological systems
The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and...
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6871147 |
Automated method of identifying and archiving nucleic acid sequences
A method of identifying and archiving a nucleic acid sequence includes a) creating a directory of files in a computer, for storing information related to the nucleic acid sequence; b) inputting a...
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6869763 |
Microarray chip and method for indexing the same
A method for indexing and coding element information of at least one biological element provided on a microarray chip thereby identifying the microarray chip. Some of the element spots arranged on...
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6868343 |
Interactions between substances and surfaces that are made up of amphiphilic molecules
The invention relates to the analysis of interactions of substances or materials with surfaces or interfaces made from amphiphilic materials and in particular partition coefficients and/or binding...
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6863791 |
Method for in-situ calibration of electrophoretic analysis systems
An electrophoretic system having a plurality of separation lanes is provided with an automatic calibration feature in which each lane is separately calibrated. For each lane, the calibration...
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6865491 |
Method for sequencing polynucleotides
A method for obtaining a nucleotide sequence that is indicative of the sequence of a target polynucleotide molecule T. The method makes use of hybridization data obtained by incubating T with...
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6862532 |
Apparatus for manifesting latent characteristics existing in sequences of symbols
A computer processor converts a symbolic sequence I j (j=1˜m) into a parallel sequence A(k), in which the suffix j is aligned in the following positional relationship:
j = 1, 2, . . . k − 1,...
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6861234 |
Method of epitope discovery
A method of epitope discovery comprising the step of selecting an epitope from a population of peptide fragments of an antigen associated with a target cell, wherein the fragments have a known or...
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6859735 |
Computer systems for identifying pathways of drug action
The present invention provides methods and computer systems for identifying and representing the biological pathways of drug action on a cell The present invention also provides methods and...
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6859736 |
Method for protein structure alignment
This invention provides a method for protein structure alignment. More particularly, the present invention provides a method for identification, classification and prediction of protein structures....
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6856914 |
Method, apparatus, media and signals for identifying associated cell signaling proteins
Methods, apparatus, media and signals for identifying associated cell signaling proteins are disclosed. The method involves producing and storing a comparison value for each pair of the cell...
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6856915 |
Methods of identifying organism based on its genotype
A method for identifying a microorganism, wherein the method comprises the steps of: 1) preparing one or more kind(s) of double-stranded DNA fragments by the random PCR using at least a part of a...
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6856913 |
Decentralized patient management method
A system ( 2 ) for evaluating the efficiency of therapeutic treatments of patients ( 40 ) located at remote sites ( 6 ) by communicating a cognitive task to the remote site via a network ( 10 )...
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6850846 |
Computer software for genotyping analysis using pattern recognition
Methods, systems and computer software products are provided for determining genotype of a sample using a plurality of probes. In one preferred embodiment, a tentative genotype call is made based...
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6850876 |
Cell based binning methods and cell coverage system for molecule selection
A cell-based binning method (“Data Driven” binning method) allows the inclusion of all molecules, generates a high percentage of occupied cells, and provides adequate division of the molecules...
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6849456 |
Test strip qualification system
In connection with a fluidic medical diagnostic device that permits measurement of the coagulation time of blood, software, methods and associated devices for quality control are provided. The...
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6847897 |
Method and system for analyzing biological response signal data
A system, method, and computer program product for enhanced computer-aided analysis of biological response data is disclosed. In a preferred embodiment, biological datasets are graphically selected...
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6844149 |
Method, system, and apparatus for measurement and recording of blood chemistry and other physiological measurements
A multi-component test strip for analyzing a plurality of blood components in a single blood sample. The test strip comprises a porous medium having a sample receiving region, and two or more...
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6845328 |
Screening methods using the crystal structure of ribosomal protein L11/GTPase activating region rRNA complex
The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution...
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6842703 |
Profile searching in nucleic acid sequences using the fast fourier transformation
One embodiment of the present invention provides methods for detecting known blocks of functionally aligned protein sequences in a test nucleic acid sequence, e.g., in an uncharacterized EST. The...
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6842233 |
Method of classifying particles on two-dimensional frequency distribution map and blood analyzer utilizing the same
A method of classifying particles indicated on a two-dimensional frequency distribution map into particle clusters, includes the steps of: dividing the particles into a first cluster and a second...
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6839634 |
Method for predicting reaction characteristics of molecules
A molecule surrounding surface ( 20 ) is set so as to be reflected in the spatial dimension of a molecule. A molecule surrounding space surrounded by the molecule surrounding surface is divided...
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6838266 |
Method for producing DNA
DNA is produced by preparing oligomers having partial sequences selected according to a specific scheme based on a target nucleotide sequence, and performing PCR using two of single strand DNAs...
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6838054 |
Biochemical devices and their methods of manufacture
Biochemical devices comprising a sensing surface that is at least partially covered by a nanocrystalline metal oxide semiconductor film which provides a recipient surface for immobilizing...
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6836748 |
Method for correlating behavior between two elements of a system to determine the presence of mutual interaction between the elements
A method for correlating behavior between two elements of a system to determine the presence of mutual interaction between the elements, the method including measuring the behavior of two elements...
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6835572 |
Magnetic resonance spectroscopy of breast biopsy to determine pathology, vascularization and nodal involvement
Robust classification methods analyse magnetic resonance spectroscopy (MRS) data (spectra) of fine needle aspirates taken from breast tumours. The resultant data when compared with the...
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6834237 |
Method and system for classifying a biological sample
The present invention relates to a method of training a classification system for characterising a biological sample, a diagnostic classification system, as well as a method of characterising a...
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6834239 |
Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
The present invention determines properties of combinatorial library products from features of library building blocks. At least one feature is determined for each building block of a combinatorial...
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6832162 |
Methods of ab initio prediction of α helices, β sheets, and polypeptide tertiary structures
The present invention provides a novel four stage ab initio approach for predicting the tertiary structure of polypeptides. The methods of the invention combine the classical and modern views of...
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6832163 |
Methods of identifying heterogeneous features in an image of an array
Methods are provided for identifying heterogeneous features, including heterogeneous background regions, in an image of an array, e.g., in an image of a biopolymeric array, such as a nucleic acid...
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6829376 |
Computer software system, method, and product for scanned image alignment
An image alignment tool is described for adjusting the alignment of a grid with an image. An initial grid aligner determines an initial, approximately aligned, position of the grid. An intensity...
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6829540 |
Drug discovery using multiple membrane mimetic affinities
The measurement of multiple membrane affinities of test compounds, methods and compositions useful for acquiring data characteristic of such affinities, and a method and system for using such data...
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6826488 |
Crystals, molecular complexes, and methods of developing lead compounds for inhibitors of bacterial IMPDH
The present invention relates to a data storage medium encoded with the structural coordinates of crystallized molecules and molecular complexes which comprise the active site binding pockets of...
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6826487 |
Method for defining an experimental space and method and system for conducting combinatorial high throughput screening of mixtures
A method comprises (A) defining a first experimental space comprising factors of at least two mixtures with at least one common factor, (B) defining a second experimental space by deleting...
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6820011 |
Three-dimensional structure of complement receptor type 2 and uses thereof
Disclosed is a crystalline human CR2 protein in complex with C3d, and the three dimensional structure of the crystalline complex. Also disclosed are methods of use of the structure, particularly...
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6816790 |
Method and apparatus for determining gene expression levels
Techniques for analyzing gene expression levels are provided. In one aspect of the invention, the technique provides a method for determining a concentration level of a target nucleic acid, the...
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6816789 |
Method and system for analyzing chromatograms
A method and system for chromatogram analysis is disclosed. An aspect of the invention is a method for reducing each chromatogram to a data set that can be compared to another such data set,...
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6813473 |
Remote laboratory
Teaching apparatus, which includes an experimental setup ( 50 ) at a laboratory site ( 32 ) and a teaching setup at a teaching facility ( 12 ) remote from the laboratory site. The laboratory site...
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