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6950756 |
Rearrangement of microarray scan images to form virtual arrays
A system and methods for selecting single-features from a microarray scan image of genomic data and rearranging the selected single-features of the microarray into a virtual array having a format...
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6950755 |
Genotype pattern recognition and classification
Interpreting data obtained by analysis of nucleic acids (DNA) by obtaining nucleic acid data in a spatial domain, transforming the nucleic acid data from the spatial domain into a frequency domain,...
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6949384 |
Method for monitoring degradation of Hb-based blood substitutes
The present invention provides a method for monitoring degradation of Hb-based blood substitutes, in a sample. This method involves determining a concentration of met-Hb within the sample, by...
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6947586 |
Multi-neural net imaging apparatus and method
A multi-neural net imaging apparatus and method for classification of image elements, such as biological particles. The multi-net structure utilizes subgroups of particle features to partition the...
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6947845 |
Method of identifying molecules that bind to the large ribosomal subunit
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution...
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6947810 |
System for automated monitoring and maintenance of crops including sensors and emitters associated with plants
A system for automating the growing of crops, such as grapevines. Combinations of data from sensors local to a vineyard, and from optional remote stations and sensors, is combined with a control...
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6947846 |
Non-metric tool for predicting gene relationships from expression data
Techniques for processing gene expression data and predicting gene relationships are provided. More specifically, a method for processing gene expression ratios may include discretizing a first...
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6942971 |
Apparatus for analysis of a nucleic acid amplification reaction
An apparatus for determining a threshold value (e.g., a threshold cycle number or a time value) in a nucleic acid amplification reaction comprises a detection mechanism for measuring, at a...
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6939848 |
Crystals of the large ribosomal subunit
The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of...
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6941229 |
Method of designing agonists and antagonists to EGF receptor family
The present invention relates to a method of designing compounds able to bind to a molecule of the EGF receptor family and to modulate the activity mediated by the receptor molecule based on the...
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6937257 |
Unit tracking and notification in a graphical drug model editor
A method for maintaining consistent unit relationships during graphical pharmacological computational model construction is disclosed. A graphical user interface is presented through which a user...
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6937955 |
Method for automatic alignment of metering system for a clinical analyzer
A method for calibrating a clinical analyzer having a dispenser, and for automatically aligning the dispenser of the clinical analyzer includes loading a calibration element at a portion of the...
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6934637 |
Method for comparing and correlating analyses of changes in cells and tissues
A method for comparing and correlating analyses of changes in cells and tissues wherein one or more analysts analyze features of medical importance in cytology specimens or surgical specimens to...
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6934636 |
Methods of genetic cluster analysis and uses thereof
The present invention is primarily directed to methods of genetic cluster analysis for use in determining the homogeneity and/or heterogeneity of a population or sub-population. Determination of...
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6934639 |
Methods for designing agents that interact with MMP-13
The present invention relates to the three dimensional structure of human collagenase 3 (MMP-13), as well as to (i) methods of using the MMP-13 structure to rationally design or identify compounds...
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6931328 |
Analyte detection system with software download capabilities
An analyte concentration monitoring system having network-based communication features which provide a link between an analyte detection system and a centralized computer. The analyte detection...
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6931329 |
Likelihood-based modification of experimental crystal structure electron density maps
A maximum-likelihood method for improves an electron density map of an experimental crystal structure. A likelihood of a set of structure factors {F h } is formed for the experimental crystal...
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6929951 |
Method and system for molecular array scanner calibration
A method and system for calibrating molecular arrays to a reference molecular array, and for subsequently calibrating the molecular arrays to maintain a constant...
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6931396 |
Biological data processing
A multi-database query system which queries a plurality of databases and servers, including an input which receives queries in a structured form and a translation server which translates at least a...
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6931326 |
Methods for obtaining and using haplotype data
Methods, computer program(s) and database(s) to analyze and make use of gene haplotype information. These include methods, program, and database to find and measure the frequency of haplotypes in...
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6931325 |
Three dimensional protein mapping
The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating...
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6924109 |
High-throughput transcriptome and functional validation analysis
Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity...
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6925389 |
Process for discriminating between biological states based on hidden patterns from biological data
The invention describes a process for determining a biological state through the discovery and analysis of hidden or non-obvious, discriminatory biological data patterns. The biological data can be...
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6924115 |
Process for identifying cell-specific target structures
This invention relates to a process for identifying cell-specific target structures. The process comprises automatically depositing a reagent solution that includes at least one marker molecule on...
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6925394 |
Crystal structure of the 30s ribosome
The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of...
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6925393 |
System for the extrapolation of glucose concentration
A system for the extrapolation of a glucose concentration has a data input device for entering administered insulin doses and their times of administration, a data input device for entering the...
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6925388 |
Heterocyclic nonnucleoside inhibitors of reverse transcriptase
Novel compounds that are potent inhibitors of HIV reverse transcriptase (RT) are described in the invention. Thes novel compounds also inhibit replication of a retrovirus, such as human...
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6925390 |
Customized microfluidic device design, ordering, and manufacturing
Processes and systems are described for designing microfluidic devices, via an interactive process involving communication between a requestor and a provider over an electronic network.
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6924107 |
Four dimensional biochip design for high throughput applications and methods of using the four dimensional biochip
The present invention provides a 4D biochip containing m 3D biochips having n capillaries, wherein the n capillaries each contain a biological factor, and methods for preparing and using the 4D...
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6921640 |
Process for labeling a ribonucleic acid
The present invention relates to a process for labeling a synthetic or natural ribonucleic acid (RNA). It also relates to RNA fragments, which have been labeled by fragmenting the RNA to free a...
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6922664 |
Method and apparatus for multi-sensor processing
Multi-sensor system for real-time embedded monitoring of object senses mixed-mode object conditions. Various sensors separately provide disparate analog signals representing different measurable...
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6922638 |
System and method for transacting and manipulating a multi-sequence search using biological data repositories
A system and method for transacting and manipulating a multi-sequence search using a biological data repository is described. A set of search query parameters specifying a plurality of sequence...
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6920396 |
System and method for providing flexible access and retrieval of sequence data from a plurality of biological data repositories
A system and method for providing flexible access and retrieval of sequence data from a plurality of biological data repositories is described. A plurality of biological data repositories are...
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6919175 |
System for releasing and isolating nucleic acids
A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the...
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6920397 |
Repeatable software-based active signal processing technique
A technique is disclosed that is useful for determining the presence of specific hybridization expression within an output pattern generated from a digitized image of a biological sample applied to...
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6916613 |
Compositions, methods, kits and apparatus for determining the presence or absence of target molecules
The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have...
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6917883 |
Efficient cis-element discovery method using multiple sequence comparisons based on evolutionary relationships
A method is described for efficiently searching non-coding DNA for known control elements. Short conserved DNA sequences can be identified among 3 or more species by selecting DNA sequences from...
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6913880 |
Method for determining transcription factor activity and its technical uses
Certain transcription factors (enhancer binding proteins) significantly increase transcription rates from genes by nicking a single DNA strand in the vicinity of their DNA binding sites, thereby...
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6912469 |
Electronic hybridization assay and sequence analysis
An electronic hybridization assay implements a hybridization reaction, or a sequence analysis, on sequences representative of the sequences of the molecules under examination to provide an output...
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6911327 |
Method for quantitative analysis of a nucleic acid amplification reaction
A method for determining an unknown starting quantity of a target nucleic acid sequence in a test sample comprises amplifying the unknown starting quantity of the target nucleic acid sequence in...
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6909971 |
Method for gene mapping from chromosome and phenotype data
The present invention relates to a method for gene mapping from chromosome and phenotype data, which utilizes linkage disequilibrium between genetic markers m i , which are polymorphic nucleic acid...
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6905823 |
Cellular arrays and methods of detecting and using genetic disorder markers
A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array,...
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6905817 |
Ret-independent signaling pathway for GDNF
Methods for screening for agonists and antagonists of GPI-anchored independent intracellular signaling resulting in [Ca 2+ ] i elevation, ERK1, ERK2 and CREB phosphorylation, and Src family kinase...
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6907350 |
Method, system and apparatus for handling information on chemical substances
This invention provides libraries of information on chemical substances (which are termed “chenes”) as they interact with various biological systems, efficient methods to construct such...
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6904370 |
System, method, and computer-readable medium for collection of environmental data and generation of user report for compliance with FDA requirements
A system, method, and computer-readable medium for the collecting and storing of environmental data, and generating a user report of the environmental data, the user report providing document...
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6904369 |
Conjugated ligands for the stimulation of blood cell proliferation by effecting dimerization of the receptor for stem cell factor
This invention provides a computer based method for preparing a stem cell factor (SCF) analog comprising the steps of: (a) providing computer expression of the three dimensional structure of an SCF...
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6898453 |
Method and apparatus for calculating blood flow parameters
A method for determining tissue type includes quantitatively determining a tissue blood flow (TBF) by deconvoluting Q(t) and C a (t), where Q(t) represents a curve of specific mass of contrast, and...
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6898531 |
Algorithms for selection of primer pairs
The presently claimed invention provides methods for amplifying a DNA target sequence. One embodiment of the present invention provides robust methods for amplification of target sequences. In a...
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6898530 |
Method and apparatus for extracting attributes from sequence strings and biopolymer material
Systems for creating high-dimensional vectors representing sequence strings and biopolymer materials are provided. A first system for divides respective sequence strings into blocks of at least...
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6893821 |
Agents that modulate DNA-PK activity and methods of use thereof
The present invention provides methods for modulating cell death in a eukaryotic cell, and methods for reducing DNA damage in a eukaryotic cell. The methods generally comprise modulating a...
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