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6934637 |
Method for comparing and correlating analyses of changes in cells and tissues
A method for comparing and correlating analyses of changes in cells and tissues wherein one or more analysts analyze features of medical importance in cytology specimens or surgical specimens to...
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6934636 |
Methods of genetic cluster analysis and uses thereof
The present invention is primarily directed to methods of genetic cluster analysis for use in determining the homogeneity and/or heterogeneity of a population or sub-population. Determination of...
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6931396 |
Biological data processing
A multi-database query system which queries a plurality of databases and servers, including an input which receives queries in a structured form and a translation server which translates at least a...
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6931329 |
Likelihood-based modification of experimental crystal structure electron density maps
A maximum-likelihood method for improves an electron density map of an experimental crystal structure. A likelihood of a set of structure factors {F h } is formed for the experimental crystal...
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6931328 |
Analyte detection system with software download capabilities
An analyte concentration monitoring system having network-based communication features which provide a link between an analyte detection system and a centralized computer. The analyte detection...
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6931326 |
Methods for obtaining and using haplotype data
Methods, computer program(s) and database(s) to analyze and make use of gene haplotype information. These include methods, program, and database to find and measure the frequency of haplotypes in...
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6931325 |
Three dimensional protein mapping
The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating...
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6929951 |
Method and system for molecular array scanner calibration
A method and system for calibrating molecular arrays to a reference molecular array, and for subsequently calibrating the molecular arrays to maintain a constant...
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6928368 |
Gene mining system and method
The present invention provides a system, method and apparatus for targeting gene sequences having one or more phenotypic characteristics using a computer. One or more phenotypic characteristics are...
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6925394 |
Crystal structure of the 30s ribosome
The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of...
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6925393 |
System for the extrapolation of glucose concentration
A system for the extrapolation of a glucose concentration has a data input device for entering administered insulin doses and their times of administration, a data input device for entering the...
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6925390 |
Customized microfluidic device design, ordering, and manufacturing
Processes and systems are described for designing microfluidic devices, via an interactive process involving communication between a requestor and a provider over an electronic network.
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6925389 |
Process for discriminating between biological states based on hidden patterns from biological data
The invention describes a process for determining a biological state through the discovery and analysis of hidden or non-obvious, discriminatory biological data patterns. The biological data can be...
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6925388 |
Heterocyclic nonnucleoside inhibitors of reverse transcriptase
Novel compounds that are potent inhibitors of HIV reverse transcriptase (RT) are described in the invention. Thes novel compounds also inhibit replication of a retrovirus, such as human...
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6924115 |
Process for identifying cell-specific target structures
This invention relates to a process for identifying cell-specific target structures. The process comprises automatically depositing a reagent solution that includes at least one marker molecule on...
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6924109 |
High-throughput transcriptome and functional validation analysis
Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity...
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6924107 |
Four dimensional biochip design for high throughput applications and methods of using the four dimensional biochip
The present invention provides a 4D biochip containing m 3D biochips having n capillaries, wherein the n capillaries each contain a biological factor, and methods for preparing and using the 4D...
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6922664 |
Method and apparatus for multi-sensor processing
Multi-sensor system for real-time embedded monitoring of object senses mixed-mode object conditions. Various sensors separately provide disparate analog signals representing different measurable...
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6922638 |
System and method for transacting and manipulating a multi-sequence search using biological data repositories
A system and method for transacting and manipulating a multi-sequence search using a biological data repository is described. A set of search query parameters specifying a plurality of sequence...
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6921640 |
Process for labeling a ribonucleic acid
The present invention relates to a process for labeling a synthetic or natural ribonucleic acid (RNA). It also relates to RNA fragments, which have been labeled by fragmenting the RNA to free a...
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6920397 |
Repeatable software-based active signal processing technique
A technique is disclosed that is useful for determining the presence of specific hybridization expression within an output pattern generated from a digitized image of a biological sample applied to...
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6920396 |
System and method for providing flexible access and retrieval of sequence data from a plurality of biological data repositories
A system and method for providing flexible access and retrieval of sequence data from a plurality of biological data repositories is described. A plurality of biological data repositories are...
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6919175 |
System for releasing and isolating nucleic acids
A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the...
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6917883 |
Efficient cis-element discovery method using multiple sequence comparisons based on evolutionary relationships
A method is described for efficiently searching non-coding DNA for known control elements. Short conserved DNA sequences can be identified among 3 or more species by selecting DNA sequences from...
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6917882 |
Methods for making character strings, polynucleotides and polypeptides having desired characteristics
“In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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6916613 |
Compositions, methods, kits and apparatus for determining the presence or absence of target molecules
The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have...
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6913880 |
Method for determining transcription factor activity and its technical uses
Certain transcription factors (enhancer binding proteins) significantly increase transcription rates from genes by nicking a single DNA strand in the vicinity of their DNA binding sites, thereby...
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6912469 |
Electronic hybridization assay and sequence analysis
An electronic hybridization assay implements a hybridization reaction, or a sequence analysis, on sequences representative of the sequences of the molecules under examination to provide an output...
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6911327 |
Method for quantitative analysis of a nucleic acid amplification reaction
A method for determining an unknown starting quantity of a target nucleic acid sequence in a test sample comprises amplifying the unknown starting quantity of the target nucleic acid sequence in...
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6909971 |
Method for gene mapping from chromosome and phenotype data
The present invention relates to a method for gene mapping from chromosome and phenotype data, which utilizes linkage disequilibrium between genetic markers m i , which are polymorphic nucleic acid...
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6909970 |
Fast microarray expression data analysis method for network exploration
A method for performing network reconstruction is provided. The method includes the steps of selecting a predictor set of features, adding a complement to the predictor set based on a quality of...
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6907350 |
Method, system and apparatus for handling information on chemical substances
This invention provides libraries of information on chemical substances (which are termed “chenes”) as they interact with various biological systems, efficient methods to construct such...
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6905825 |
Method for isolating and purifying nucleic acids
A method for isolating and purifying nucleic acids with an improved recovery yield is provided. A mixed solution containing the nucleic acids, salts, and an organic solvent is contacted with an...
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6905823 |
Cellular arrays and methods of detecting and using genetic disorder markers
A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array,...
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6905817 |
Ret-independent signaling pathway for GDNF
Methods for screening for agonists and antagonists of GPI-anchored independent intracellular signaling resulting in [Ca 2+ ] i elevation, ERK1, ERK2 and CREB phosphorylation, and Src family kinase...
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6904370 |
System, method, and computer-readable medium for collection of environmental data and generation of user report for compliance with FDA requirements
A system, method, and computer-readable medium for the collecting and storing of environmental data, and generating a user report of the environmental data, the user report providing document...
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6904369 |
Conjugated ligands for the stimulation of blood cell proliferation by effecting dimerization of the receptor for stem cell factor
This invention provides a computer based method for preparing a stem cell factor (SCF) analog comprising the steps of: (a) providing computer expression of the three dimensional structure of an SCF...
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6898532 |
Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample
A method is disclosed for predicting the presence of haemostatic dysfunction. At least one time-dependent measurement on an unknown sample is performed and a respective property of the sample is...
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6898531 |
Algorithms for selection of primer pairs
The presently claimed invention provides methods for amplifying a DNA target sequence. One embodiment of the present invention provides robust methods for amplification of target sequences. In a...
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6898530 |
Method and apparatus for extracting attributes from sequence strings and biopolymer material
Systems for creating high-dimensional vectors representing sequence strings and biopolymer materials are provided. A first system for divides respective sequence strings into blocks of at least...
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6898453 |
Method and apparatus for calculating blood flow parameters
A method for determining tissue type includes quantitatively determining a tissue blood flow (TBF) by deconvoluting Q(t) and C a (t), where Q(t) represents a curve of specific mass of contrast, and...
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6895340 |
Method of molecular structure recognition
An analytical method and apparatus using principal component analysis of nuclear magnetic resonance (NMR) data for rapid molecular structure/function pattern recognition. The presence of a...
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6893821 |
Agents that modulate DNA-PK activity and methods of use thereof
The present invention provides methods for modulating cell death in a eukaryotic cell, and methods for reducing DNA damage in a eukaryotic cell. The methods generally comprise modulating a...
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6892140 |
Immunogenic cancer peptides and uses thereof
This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer.
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6892139 |
Determining the functions and interactions of proteins by comparative analysis
The invention provides novel methods for characterizing the function of nucleic acids and polypeptides. The invention provides a novel method for identifying a nucleic acid or a polypeptide...
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6889143 |
Methods and systems for estimating the melting temperature (TM) for polynucleotide molecules
The invention relates to methods and systems for predicting or estimating the melting temperature of duplex nucleic acids, particularly duplexes of oligonucleotides which may be used, for example,...
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6882939 |
Rapid determination of protein global folds
This invention provides a method for rapidly obtaining accurate three-dimensional structure of proteins including large or multi-sub unit proteins, using a combination of NMR analysis of backbone...
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6879916 |
Data processing of the maize prolifera genetic sequence
The invention provides isolated prolifera nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering prolifera levels in plants. The...
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6879915 |
Chemical array fabrication and use
A method of using an addressable array of biopolymers on a substrate includes receiving the addressable array and an associated machine readable identifier carried on an array substrate or array...
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6878523 |
Molecular interaction assays on a solid surface
The present invention relates to novel methods for the analysis of molecular interactions. In particular, the present invention relates to compositions and methods for molecular interaction assays...
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