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7364592 |
Biointerface membrane with macro-and micro-architecture
Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the...
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7347876 |
Method for expansion of epithelial stem cells
Transplantation of epithelial stem cells, cultured ex vivo on specifically treated amniotic membrane, yields, with that amniotic membrane, a surgical graft having expanded epithelial stem cells....
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7296998 |
Hydrophilic high density PTFE medical barrier
A medical barrier includes a sheet of unsintered substantially unexpanded hydrophilic polytetraflouroethylene (PTFE) polymer material having a density in a range of about 1.2 gm/cc to about 2.3...
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7208171 |
Injectable and bioadhesive polymeric hydrogels as well as related methods of enzymatic preparation
The invention is related to biomimetic gels that are prepared enzymatically, using a transglutaminase to cross-link polymer-peptide conjugates of rational design.
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7192450 |
Porous membranes for use with implantable devices
A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity,...
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7163563 |
Unitary surgical device and method
Unitary surgical devices ( 10 ) are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors ( 16,18 ) connected to fixed lengths suture. The anchors (...
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7147813 |
Neovascularization promoting membrane for bioimplants
A method of addressing a condition of a living body comprising the steps of using an energy beam to form a set of pores in a work piece biocompatible membrane. The pores should have a mean area of...
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7131997 |
Tissue treatment
A method of treating tissue includes placing substantially spherical polymer particles in the tissue. The particles include an interior region having relatively large pores and a first region...
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7108721 |
Tissue regrafting
The present invention is based on the discovery of new methods for obtaining a tissue graft. The method can be carried out, for example, by implanting a biocompatible scaffold into a mammal and...
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7052518 |
Artificial bone and tissue engineering carrier
An artificial bone comprising a calcium phosphate-based ceramic porous body having a plurality of pores which are three-dimensionally distributed throughout an entire region of the porous body...
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7037332 |
Medical device with coating that promotes endothelial cell adherence
A medical device coated with one or more antibodies and one or more layers of a matrix is disclosed. The antibodies or fragments thereof react with an endothelial cell surface antigen. Also...
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7014661 |
Transcutaneous prosthesis
A transcutaneous prosthesis is disclosed comprising a first component ( 1 ) shaped for implantation into a bone ( 2 ), a second component ( 4 ) intended for location between the bone ( 2 ) and the...
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6991652 |
Tissue engineering composite
The invention provides a biocompatible composite for use in a living subject for purposes of repairing damaged tissues and reconstructing a new tissue. The composite includes a biodegradable or...
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6974625 |
Oxidized zirconium on a porous structure for bone implant use
A composition, a medical implant constructed from the composition, and a method of making the composition are described. The composition is a composite material, comprising a porous, reticulated,...
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6962814 |
Decellularized tissue engineered constructs and tissues
New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a...
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6916483 |
Bioabsorbable plugs containing drugs
Bioabsorbable modular drug delivery devices having shapes and sizes adapted to be inserted within a mating receptacle on the surface of an implantable prosthesis are disclosed. The devices may be...
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6875386 |
Neovascularization promoting membrane for bioimplants
A method of producing a biocompatible microporous membrane comprising the steps of providing a biocompatible membrane and using an energy beam to form a set of pores having a minor axis of less...
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6872387 |
Three-dimensional hydrogel/cell system
Methods and compositions are described that provide scaffolds for the support of cells. The scaffolds of the present invention have structural uniformity and desirable mechanical properties that...
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6840962 |
Tissue engineered tendons and ligaments
Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable...
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6783554 |
Pile mesh prosthesis
A method and apparatus relating to a biocompatible soft tissue implant is disclosed. The implant, in the form of a prosthesis, is constructed of a knitted pile mesh material arranged into either a...
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6746488 |
Method and apparatus for hindering osteolysis in porous implants
A prosthetic implant, and method for making same, is described. The prosthetic implant preferably has a porous coating containing a plurality of pores therein. A biodegradable material is...
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6726718 |
Medical articles prepared for cell adhesion
A prosthesis is formed from a biocompatible material having one or more associated cell adhesion stimulating proteins. The biocompatible material can be a ceramic material or a carbon coated...
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6702857 |
Membrane for use with implantable devices
The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the...
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6666893 |
Absorbable tissue expander
A method of reconstructing tissue is provided. The method includes implanting an absorbable tissue expander having a fluid-tight or semipermeable envelope and having a bio-absorbable biocompatible...
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6648922 |
Method for producing improved medical devices and devices so produced
Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation...
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6645644 |
Enhanced bonding of phosphoric and phosphoric acids to oxidized substrates
Ligand-containing coating layers on the surface of hydroxide-bearing substrates comprising transition metal atoms selected from the group consisting of Group IVB, Group VB and Group VIB of the...
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6626950 |
Composite scaffold with post anchor for the repair and regeneration of tissue
A prosthetic implant having a tissue scaffold and a fixation device with a scaffold support and an anchoring post. The anchoring post extends from a surface of the scaffold support at a selected...
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6607557 |
Artificial bone graft implant
An implant for replacing the supporting function of an intervertebral space defined between adjacent vertebrae includes a prosthetic implant member dimensioned for insertion within a space provided...
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6579322 |
Biomedical material for improving the adhesion and proliferation of cells and a modified artificial vessel
A novel biomedical material, which is characterized by coating a genetically engineered CBD-RGD peptide layer on the surface of a biomedical material consisting of PU to improve the attachment of...
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6508838 |
Compositions for medical implantation
A composition or device suitable for orthopedic or dental implantation to bone, characterized by tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum.
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6461385 |
Method and apparatus for augmenting osteointegration of prosthetic implant devices
Bone augmentation in a mammalian body to enhance the mechanical strength of a prosthesis is provided by reinforcement of bone in the region surrounding the implant device. A number of fibrillar...
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6454811 |
Composites for tissue regeneration and methods of manufacture thereof
Composite devices for tissue engineering are provided having a gradient of one or more of the following: materials, macroarchitecture, microarchitecture, or mechanical properties, which can be used...
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6451059 |
Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
The present invention provides a hard tissue scaffold comprising a resorbable ceramic. The scaffold is formed by first creating unfired (green) bioresorbable ceramic fibers via the viscous...
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6447551 |
Flat implant, process for its production and use in surgery
A flat implant for use in surgery is described. The implant includes a flexible fabric comprising two sides and having on one side a substantially closed surface and on the other side a...
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6428579 |
Implantable prosthetic devices coated with bioactive molecules
Coated implantable prosthetic devices are disclosed. The device is a prosthetic having a gold layer on the surface to which bioactive molecules are attached through a gold-sulfhydryl bond. The...
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6409764 |
Methods and articles for regenerating bone or peridontal tissue
There are numerous medical situations involving deficiencies of living bone or periodontal tissue and where increase of living bone or periodontal tissue mass is desired. Methods are described...
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6391060 |
Prosthetic implant for obstructing an anatomical duct, and obstructing assembly comprising same
A prosthetic implant for obturating an anatomical duct, cavity or orifice, has a porous textile element obtained from a prosthetic fabric, having a flat and nongathered up configuration in the...
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6387693 |
Method for producing cartilage tissue and implants for repairing enchondral and osteochondral defects as well as arrangement for carrying out the method
Cartilage tissue and implants comprising tissue are produced in vitro starting from cells having the ability to form an extracellular cartilage matrix. Such cells are brought into a cell space ( 1...
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6383201 |
Surgical prosthesis for repairing a hernia
A surgical prosthesis for repairing a hernia in a sturdy tension-free manner. The prosthesis includes a layer of adhesion resistant material and a first layer of tissue ingrowth receptive mesh...
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6371992 |
Acellular matrix grafts: preparation and use
Acellular matrix grafts are provided with are isolated from natural sources and consist essentially of a collagen and elastin matrix which is devoid of cellular components. The grafts are useful...
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6352558 |
Method for promoting regeneration of surface cartilage in a damage joint
A method of promoting regeneration of surface cartilage of a joint includes the steps of forming punctures in a subchondral plate of an area of the joint to be treated, covering the puncture and...
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6350285 |
Implant holder
The implant holder comprises a screen ( 21 ) comprising on one side a tissue-compatible fibre material ( 25 ) to which the body cells grow and on the other side a smooth contact surface ( 23 ) for...
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6328765 |
Methods and articles for regenerating living tissue
There are numerous medical situations involving deficiencies of living tissue and where increase of living tissue mass is desired. Methods are described wherein a configured, shell-like device that...
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6302913 |
Biomaterial and bone implant for bone repair and replacement
This invention relates to a biomaterial useful in bone repair and replacement, and to implants for cranofacial, orthopaedic, and especially dental applications. The implants have a unique geometric...
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6270530 |
Prosthetic repair fabric
A prosthetic repair fabric including a sheet of tissue infiltratable fabric and a second sheet, also preferably including tissue infiltratable fabric, which is united with the first sheet. The...
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6193761 |
Implantable prosthesis with metallic porous bead preforms applied during casting
An implantable prosthesis having porous textured surface regions and methods for making the same provide improved prostheses and prosthesis manufacturing methods. The implantable prostheses contain...
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6187053 |
Process for producing a natural implant
In a process for producing a natural implant for tissue of a human or animal body, the body's own cells are multiplied and/or differentiated on a cell base using a culture medium to form the implant.
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6171344 |
Bladder submucosa seeded with cells for tissue reconstruction
Methods and materials for tissue reconstruction, repair, and/or augmentation are disclosed. The invention provides isolated bladder submucosa seeded with cells for use in tissue reconstruction. The...
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6132470 |
Apparatus and method for protecting prosthetic joint assembly from wear
The disclosure relates to a tissue and debris barrier for use in association with implanted joint replacement devices. The barrier comprises a biocompatible membrane that is impermeable to debris....
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6131580 |
Template imprinted materials by RFGD plasma deposition
Template-imprinted structures 10 are provided having at least one template-imprinted surface 12 defining indentations 14 that are capable of specifically binding cells and/or molecules, such as...
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