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7381752 |
Selective, controlled manipulation of polymers
The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated...
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7364685 |
Method for producing implant parts from highly cross-linked UHMWPE and implant parts for human medicine
The invention relates to a method of manufacturing implant parts made of highly cross-linked polyethylene, wherein a blank made of ultra-high-molecular-weight polyethylene is irradiated with...
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7264634 |
Method and instrumentation for osteochondral repair using preformed implants
Osteochondral repair of damaged articular joint surfaces is achieved using implants in the form of cylindrical osteochondral plugs. The plugs have an articular surface formed on at least one end....
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7247364 |
Coating for implantable medical devices
An implantable medical device, such as a stent, is disclosed having a coating. The coating includes a poly(butylene terephthalate-co-ethylene glycol)polymer. The coating can also include a drug.
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7244445 |
Conformable, absorbable, solid composite preforms and their use for bone tissue engineering
The present invention is directed to an absorbable, conformable composite preform for use in making a solid bone filler which is an absorbable mixture of oppositely charged, solid microparticulate...
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7226484 |
Tear resistant gels and articles for every uses
Soft, tear resistant gel, gel composites and gel articles for various uses formed from one or a mixture of two or more block copolymers with or without one or more selected other polymers and...
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7156880 |
Devices and methods for treating defects in the tissue of a living being
An implantable material for deployment in select locations or select tissue for tissue regeneration is disclosed. The implant comprises collagen, ceramics, and or other bio-resorbable materials or...
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7063884 |
Stent coating
A stent comprising a coating layer is disclosed. The coating layer has a hydrophobic component and a hydrophilic component, wherein a region of the coating layer on or about the outermost surface...
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7004976 |
Biopolymers modified with superoxide dismutase mimics
This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor...
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7004974 |
Material for bone reconstruction
The invention relates to a preparation for restoring bone in the body of humans or animals in connection with an existing structure, a bone implant or some other prosthetic construction, as well as...
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6926919 |
Method for fabricating a coating for a medical device
Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include blends of hydrophilic and hydrophobic polymers. The methods provide for treatment of the...
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6919308 |
Osteogenic devices
Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains...
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6818020 |
Non-oxidizing polymeric medical implant
A medical implant made of polymeric material having an increased oxidation resistance is formed by a method including the steps of placing a resin powder in a sealed container. A substantial...
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6818018 |
In situ polymerizable hydrogels
Compositions and methods for forming hydrogels in situ through a combination of physical and chemical crosslinking processes are provided in which physical crosslinking is mediated by one or more...
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6786933 |
Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices
A medical prosthesis for use within a body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radial. Preferred prosthesis...
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6748834 |
Super finishing of polymeric implant components
A method for preparing a contact surface of an implantable bone, joint or similar prosthetic component subject to contact or motion includes the steps of mounting the prosthetic component on a...
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6723131 |
Composite bone marrow graft material with method and kit
A composite bone marrow graft material is provided having an enriched population of uniformly distributed progenitor cells. The graft material includes clot material preferably derived from...
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6716251 |
Implant for subcutaneous or intradermal injection
The invention concerns an injection implant for filling up wrinkles, thin lines, skin cracks and scars, for reparative or plastic surgery, aesthetic dermatology, and for filling up gums in dental...
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6699294 |
Injectable implants for tissue augmentation and restoration
A method for tissue augmentation in a mammal is provided comprising injecting a polymer at a tissue site in need of augmentation and having a tissue temperature, the polymer comprising repeating...
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6692528 |
Devices that change size/shape via osmotic pressure
Devices implantable in animal bodies, possibly configured as self-inflating spinal disc prostheses. Alternatively, non-implantable water-desalination and/or purification devices. The devices...
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6677415 |
Method of compression moulding of polymer powder and product produced
A process of compression moulding an article from a polymer powder comprising; a) applying a polymer powder to a mould; b) compacting the polymer powder by the application of a pressure P; c)...
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6664335 |
Polyurethane elastomer article with “shape memory” and medical devices therefrom
A polyurethane article with shape memory, comprising a mixture of thermoplastic polyurethane and reactive monomer cross-linker which is formed into a shaped article, irradiated, expanded and...
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6605117 |
Synthetic bone matrix
Disclosed is an osteogenic device capable of inducing the formation of endochondral bone in a shape conforming substantially to the shape of the device when implanted in a mammalian host. The...
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6602293 |
Polymeric composite orthopedic implant
An orthopedic implant comprising a thermoplastic polymer or a composite comprising, in one embodiment, polyetheretherketone reinforced with 10% by volume of glass fibers, with an elastic modulus...
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6582715 |
Antimicrobial orthopedic implants
An orthopedic surgical implant of one or more components having a surface which is to be contacted by body tissue and/or fluid. The surface contains an inorganic antimicrobial agent either...
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6569547 |
Hard tissue repairing materials and the process for producing the same
A hard tissue repairing material including a base material and a surface layer having a crystalline zirconia covering the base material, being characterized in that the film includes a Zr—OH...
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6533820 |
Biomaterials for bone replacements
The present invention involves compositions for use as granular bone replacements. The compositions of the present invention are comprised of hyaluronic acid esters or salts of hyaluronic acid in...
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6524345 |
Surgical implant
A surgical implant comprising biodegradable polymer interspersed with ceramic particulate that is visible to radioscopy.
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6503278 |
Under tissue conditions degradable material and a method for its manufacturing
This invention relates to a material that degrades after implantation into a patient's tissue, and resorbs into the patient's body, which material is manufactured of polymer, copolymer or polymer...
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6494917 |
Wear resistant surface-gradient crosslinked polyethylene
A method for improving the wear resistance of an implant, made of polyethylene, by crosslinking its bearing surface layer, while leaving its non-bearing interior uncrosslinked. Such crosslinking...
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6458148 |
Strand-like implant of resorbable polymer material, process for its production and use in surgery
A strand-like implant of resorbable polymer material is substantially formed as a random copolymer of L-lactide and glycolide, which are present in a composition in a range of more than 80 mole %...
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6447514 |
Polymer filled hip fracture fixation device
An orthopaedic implant includes a flexible bag; a structural support at least partially within the bag; and a hardened polymer within the bag. The orthopaedic implant is implanted within the bone...
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6436137 |
Compositions, processes and methods of improving the wear resistance of prosthetic medical devices
Methods and compositions for fabricating prosthetic medical devices exhibiting improved wear resistance include selectively cross-linking polymeric resins then curing and shaping the polymer into a...
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6425923 |
Contourable polymer filled implant
An orthopaedic implant includes a flexible bag having at least a portion thereof which is expandable under pressure; and a polymer within the bag. The orthopaedic implant is implanted within a bone...
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6419709 |
Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
An essentially non-osteoconductive medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a...
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6364912 |
Pleiotrophin-based compositions for enhancing connective tissue repair
Bioactive compositions that induce or enhance the repair of damaged or diseased connective tissues upon contact of the tissues with the compositions in vivo include an effective amount of...
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6358275 |
Tissue-derived vascular grafts and methods for making the same
Vascular grafts, and methods for making the same, are provided. The vascular grafts comprise a graft tissue derived from a biological source that is enclosed within an external synthetic sleeve....
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6332894 |
Polymer filled spinal fusion cage
An orthopaedic implant for implanting between adjacent vertebrae and a spine, includes a generally annular bag; and a hardened polymer with the bag. The method of fusing adjacent vertebrae in a...
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6328765 |
Methods and articles for regenerating living tissue
There are numerous medical situations involving deficiencies of living tissue and where increase of living tissue mass is desired. Methods are described wherein a configured, shell-like device that...
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6322588 |
Medical devices with metal/polymer composites
Medical devices are formed from metal/polymer composites that have improved characteristics. The metal/polymer composites have a relatively thick metal coating with an average metal thickness of...
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6309423 |
Self-cohering, continuous filament non-woven webs
A web of continuous filaments which are made of at least one semi-crystalline polymeric component covalently bonded as a linear block copolymer with or blended with one or more semi-crystalline or...
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6302916 |
Polyurethane and so forth containing joints
An article of manufacture for load bearing medical use such as a joint implant suitable for total joint replacement. The article comprises a polyurethane-containing component and is monolithic with...
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6281264 |
Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints
The present invention discloses a method for enhancing the wear-resistance of polymers by crosslinking them, especially before irradiation sterilization. In particular, this invention presents the...
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6280475 |
Hydrogel intervertebral disc nucleus implantation method
An article for use in the preparation of a hydrogel prosthetic nucleus, for an intervertebral disc, having equilibrium water contents (EWCs) of from about 30 to about 90% and compressive strengths...
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6262017 |
Peptides for altering osteoblast adhesion
Peptides containing the amino acid sequence, aa 1 -aa 2 -aa 3 -aa 4 -(Gly) n , devices for implantation coated with the peptides and methods for altering cell adhesion using the peptides are...
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6235061 |
Poly(organophosphazene) matrices for bone replacement
A highly porous three-dimensional biodegradable poly(organophosphazene) matrix with hydrolytically unstable side chains is prepared and used as a scaffold for the growth of osteoblast cells. In a...
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6231613 |
Methods for soft tissue augmentation in mammals
Disclosed are methods for soft tissue augmentation in a mammal wherein a composition comprising a biocompatible polymer having a water equilibrium content of less than about 15% and a biocompatible...
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6231605 |
Poly(vinyl alcohol) hydrogel
The present invention relate to a poly(vinyl alcohol) hydrogel construct having a wide range of mechanical strengths for use as a human tissue replacement. The hydrogel construct may include a...
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6203574 |
Prosthetic bone filler and process for the production of the same
A prosthetic bone filler including ceramic granules for use in a living body, the ceramic granules being bonded to each other with a polymeric substance, and having ventilation pores produced as a...
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6203573 |
Method of making biodegradable implant material and products made therefrom
This invention provides molded, biodegradable porous polymeric implant materials having a pore size distribution throughout the material which is substantially uniform. These materials can be...
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