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Document Title |
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7318278 |
Method of manufacture of a heart valve support frame
Methods for forming a support frame for flexible leaflet heart valves from a starting blank include converting a two-dimensional starting blank into the three-dimensional support frame. The...
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7189259 |
Tissue material and process for bioprosthesis
A biomaterial useful for bioprostheses such as bioprosthetic heart valves is provided in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further...
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7137184 |
Continuous heart valve support frame and method of manufacture
Methods for forming a support frame for flexible leaflet heart valves from a starting blank include converting a two-dimensional starting blank into the three-dimensional support frame. The...
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6974474 |
Multiple-sided intraluminal medical device
A multiple-sided medical device comprises a closed frame of a single piece of wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat...
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6936298 |
Antithrombogenic membrane mimetic compositions and methods
The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other...
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6875230 |
Mechanical heart valve and production method thereof
An artificial heart valve comprising a tubular base body having sinuse(s) of Valsalva and valve cusp(s) provided inside the base body, characterized in that the base body and the valve cusps...
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6837903 |
Vascular biomaterial devices and methods
Vascular biomaterial structures may be coated with a plasma-induced layer on their surface. Vascular biomaterial structures may include cardiovascular devices such as heart valves, stents, vascular...
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6797000 |
Tri-composite, full root, stentless valve
A bioprosthetic heart valve is disclosed. In a first aspect of the invention, a prosthetic heart valve comprises three mammalian heart valve leaflets, each valve leaflet including a full root...
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6761736 |
Medical article with a diamond-like carbon coated polymer
Implantable vascular devices and implantable cardiovascular devices suitable for contacting a patient's blood or bodily fluids include a polymer substrate that is at least partly coated with a...
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6726718 |
Medical articles prepared for cell adhesion
A prosthesis is formed from a biocompatible material having one or more associated cell adhesion stimulating proteins. The biocompatible material can be a ceramic material or a carbon coated...
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6695879 |
Cardiovascular components for transplantation and methods of making thereof
Cardiovascular components such as biocompatible heart valves and annular sewing rings are disclosed, as well as, methods for making the same. The heart valves include biodegradable polymer fiber...
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6669725 |
Annuloplasty ring for regeneration of diseased or damaged heart valve annulus
An improved, non-resorbable annuloplasty ring that will provide support for the valve annulus while also promoting healing and/or regeneration of the annulus tissue is disclosed. Healing and/or...
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6666886 |
Tissue equivalent approach to a tissue-engineered cardiovascular valve
The invention provides a molded valve leaflet containing a molded biopolymer having fibrils and cells within the molded biopolymer, wherein the fibrils of the molded biopolymer have...
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6596024 |
Polymeric heart valve fabricated from polyurethane/polysiliconeurethane blends
Biocompatible prostheses, specifically, biocompatible heart valves, are described which comprise a blend of a polyurethane (PU) and a polysiliconeurethane (PSU). Preferably, the polyurethane is a...
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6585767 |
Antimicrobial suturing ring for heart valve
A suturing ring to attach the body of an implantable heart valve to heart tissue by sutures is composed of a fabric containing an inorganic antimicrobial agent. The fabric can have a material...
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6572642 |
Method for treating a prosthesis having an apertured structure and associated devices
A prosthesis having an apertured structure is located in a chamber ( 11 ) which is taken to sub-atmospheric pressure. Once sub-atmospheric pressure has been reached, a liquid, optionally containing...
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6569197 |
Heart valve prosthesis
The present invention relates to a heart valve prosthesis having an annular body with a pair of flanges, and a closing element in the form of two or three flaps mounted through bearings into the...
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6471723 |
Biocompatible prosthetic tissue
Crosslinked tissue is contacted with one or more toxicity reducing solutions to remove cytotoxicity associated with the crosslinking process. In particular, crosslinked tissue can be contacted with...
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6437073 |
Non-elastomeric polyurethane compositions
A non-elastomeric polyurethane composition which includes a first chain extender of the general formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are the same or different and selected...
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6407067 |
Salts of thrombin inhibitors
Compounds having thrombin inhibiting activity of the general formula I or II where n is 0.5, 1, 2 and HX is and HX is optionally substituted once or twice by methyl, ethyl or hydroxyl, and the...
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6383732 |
Method of preparing xenograft heart valves
The invention provides an article of manufacture comprising a substantially non-immunogenic heart valve xenograft for implantation into humans. The invention further provides methods for preparing...
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6328763 |
Optimized geometry of a tissue pattern for semilunar heart valve reconstruction
A new and unique, optimized, two-dimensional heart valve tissue pattern, valve, and a method of reconstructing a three-dimensional semilunar heart valve, or portion thereof. In one preferred...
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6322588 |
Medical devices with metal/polymer composites
Medical devices are formed from metal/polymer composites that have improved characteristics. The metal/polymer composites have a relatively thick metal coating with an average metal thickness of...
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6302909 |
Calcification-resistant biomaterials
The invention involves a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structures having collectively greater than...
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6280760 |
Peptide-coated implants and methods for producing same
The invention describes the possibility of the biofunctionalization of biomaterials, in particular implants, by their made-to-measure coating with synthesized cell- or tissue-selective RGD peptides...
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6214055 |
Method and kit for rapid preparation of autologous tissue medical devices
A method for the rapid chemical treatment of autologous connective tissues which enhances biocompatibility by reducing cytotoxicity, immunogenicity and calcification without impairing the...
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6193749 |
Calcification-resistant biomaterials
In general, the invention features a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structure having a quantity of...
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6165216 |
Human cardiac valve placement with marine mammal ventricular outflow (aortic or pulmonary) valve
The present invention provides a method of treating human cardiac valve dysfunction, by replacing the existing valve with a novel bioprosthesis of the present invention which comprises a marine...
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6120532 |
Graphite impregnated prosthetic vascular graft materials
The specification teaches thromboresistant compositions made of suitable biologically compatible plastic materials and a substance having a negative charge, e.g., graphite, incorporated therein in...
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6117979 |
Process for making a bioprosthetic device and implants produced therefrom
Bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided as well as methods for their formation. The methods comprise combining...
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6096347 |
Myocardial graft constructs
The use of submucosal tissue of a warm blooded vertebrate to manufacture a tissue graft composition that induces the formation of endogenous cardiac tissues in vivo upon contact of the cardiac...
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6093530 |
Non-calcific biomaterial by glutaraldehyde followed by oxidative fixation
This invention relates to tanning biomaterial to obtain calcification resistant biomaterial with good mechanical properties for bioprosthetic applications. The biomaterial of the invention is...
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6022553 |
Method of making a blood-compatible antimicrobial surface
A method for making antimicrobial, blood-compatible surfaces is provided, articles having surfaces made by this method, and the use of these articles in fields where controlling the spread of...
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5993844 |
Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as...
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5879383 |
Blood contact surfaces using endothelium on a subendothelial matrix
This invention relates to improved blood contact devices such as vascular prostheses rendered antithrombotic through the use of recipient endothelial cells grown on an appropriate subendothelial...
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5797887 |
Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
A surface of a foreign body exposed to the flowing blood of a living being which normally would promote the aggregation of platelets in that blood to form a layer affixed to that surface and thus...
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5725573 |
Medical implants made of metal alloys bearing cohesive diamond like carbon coatings
The present invention provides a method for coating a metal alloy component of a medical implant, particularly a component of a heart valve made of a titanium base alloy, with a strongly adhered...
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5387247 |
Prosthetic device having a biocompatible carbon film thereon and a method of and apparatus for forming such device
A prosthetic device which includes a biocompatible carbon film firmly adherent to a substrate. The carbon preferably is turbostratic and is preferably very thin, e.g., less than about one micron....
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5332402 |
Percutaneously-inserted cardiac valve
A cardiac valve implanted within the heart is given where a expansible valve maintained in a collapsed form by cold temperature is percutaneously inserted along a releasable guide wire in a cooled...
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5258022 |
Zirconium oxide and nitride coated cardiovascular implants
The invention provides synthetic metallic heart valves fabricated of zirconium or zirconium alloys that are coated with blue-black zirconium oxide or zirconium nitride to provide a surface that is...
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4822355 |
Heart valve assembly
Improved heart valve assembly 1(FIG. 4) includes: Sewing ring 2 made preferably of woven/knitted fabric of carbon/carbon coated polyester/polytetra-fluoroethylene; Metallic valve housing 3, with...
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4581028 |
Infection-resistant materials and method of making same through use of sulfonamides
Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices....
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4485061 |
Method and apparatus for forming rounded ends on plastic filaments
A method and apparatus for forming a round end on a small plastic filament which includes a die having a channel extending into one side with a hemispherical interior end and a bore extending into...
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4481009 |
Polymer incorporation into implantable biological tissue to inhibit calcification
A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the...
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4349498 |
Radio-opaque markers for pyrolytic carbon prosthetic members
Methods are provided for fully encasing radio-opaque markers in pyrocarbon prosthetic members. Inserts having a pyrolytic carbon portion joined to a radio-opaque marker are affixed to a mandrel...
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4173606 |
Method of manufacturing shaped articles from crystalline acrylonitrile polymers and copolymers
The invention relates to a method of manufacturing shaped articles from crystalline or quasi-crystalline acrylonitrile polymers and copolymers, said method consisting in cooling down a solution of...
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4093677 |
Macromolecular materials suitable for forming antithrombogenic prosthesis and artificial organs and process for preparing same
Novel block copolymers suitable to manufacture permanently antithrombogenic prosthetic devices are obtained by first preparing a polyamide-amine prepolymer ##STR1## WHEREIN R 1 and R 2 are alkyl...
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4069517 |
Migration-resistant plasticizer for vinyl halide polymers
Vinyl halide polymers containing migration-resistant polyester plasticizers are used in food and drink wrapping and containers and medical tubing and in medical devices for collecting, storing and...
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4042978 |
Prosthetics
A prosthetic device having at least part of the surface thereof made of a material having a surface energy, as hereinbefore defined, in the range 50 erg cm -2 to 100 erg cm -2 , for example, made...
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4038702 |
Electrochemical and chemical methods for production of non-thrombogenic metal heart valves
A method of improving the operation of metal heart valves according to which the surfaces of the heart valves are treated to render more negative the electrochemical potential which the valve part...
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