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7622146 |
Rate limiting barriers for implantable devices and methods for fabrication thereof
A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a...
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7611532 |
Coated implantable medical device
Disclosed in one embodiment is a medical device including an expandable metal vascular stent including at least one surface. A coating layer including parylene or a parylene derivative is...
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7611533 |
Coated implantable medical device
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one...
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7597924 |
Surface modification of ePTFE and implants using the same
A method for modifying an ePTFE surface by plasma immersion ion implantation includes the steps of providing an ePTFE material in a chamber suitable for plasma treatment; providing a continuous low...
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7591844 |
Medical devices, drug coatings and methods for maintaining the drug coatings thereon
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to...
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7563279 |
Stent having an ultrasonic emitter
A system and method that minimizes plaque accumulation on a stent and thereby restenosis that could require a subsequent invasive medical procedure following stent implantation. The stent,...
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7563278 |
Drug-eluting intravascular prostheses and methods of use
The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis...
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7452373 |
Stent coated with magnesium-based compound for reducing thrombosis
Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications.
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7364585 |
Medical devices comprising drug-loaded capsules for localized drug delivery
A medical device comprising a plurality of capsules, and a method of administering therapeutic agent to a patient using the same. The capsules further comprise a therapeutic agent and a multilayer...
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7311980 |
Polyactive/polylactic acid coatings for an implantable device
A polymeric coating for a medical device that comprises poly(lactic acid) and a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) is provided.
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7279183 |
Method of reducing thrombosis and complications after arterial angioplasty using stent coated with magnesium-based compound
Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications.
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7268134 |
Medical devices employing triazine compounds and compositions thereof
The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is...
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7175658 |
Artificial vascular grafts, their construction and use
The present invention relates to artificial vascular grafts, methods for manufacturing and uses for them. The grafts are coated on their lumen with UP50. The grafts comprise an inner surface on...
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7169179 |
Drug delivery device and method for bi-directional drug delivery
A drug delivery device is provided with openings for directional delivery of a plurality of therapeutic agents to blood vessels or other lumens or organs. In particular, the invention relates to...
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7077860 |
Method of reducing or eliminating thrombus formation
An implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is...
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7060022 |
Decellularized vascular prostheses resistant to thrombus occlusion and immunological rejection
The present invention relates to decellularized vascular prostheses that are resistant to thrombus occlusion and have a low level of immunogenicity. The vascular prostheses are denuded of cells,...
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7014913 |
Rate-reducing membrane for release of an agent
A membrane that reduces the rate at which a therapeutic substance is released from an implantable medical device, such as a stent, is disclosed.
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6979347 |
Implantable drug delivery prosthesis
An apparatus and associated method for delivering a therapeutic substance to a vascular lumen, using an implantable prosthesis, such as a stent, which has grooves or trenches formed thereon. The...
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6939375 |
Apparatus and methods for controlled substance delivery from implanted prostheses
The present invention provides improved devices and methods for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides luminal...
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6926735 |
Multi-lumen vascular grafts having improved self-sealing properties
The present invention provides an implantable graft, including a primary tubular body having a first outer wall surface and a first inner wall surface defining a primary blood contacting lumen, and...
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6908624 |
Coating for implantable devices and a method of forming the same
Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active...
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6833004 |
Stent
A stent wherein a biologically/physiologically active substance is loaded on the stent main body is provided. The active substance is gradually released for a prolonged period without being rapidly...
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6776792 |
Coated endovascular stent
An implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is...
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6746773 |
Coatings for medical devices
The present invention includes biocompatible coatings and films for use on implantable medical devices and medical devices containing such coatings and films applied to a surface thereof, which...
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6730120 |
Medical device for delivering a therapeutic substance and method therefor
A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material...
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6713119 |
Biocompatible coating for a prosthesis and a method of forming the same
A coating for a prosthesis, for example a stent, and a composition for forming the coating is disclosed. The coating can serve as a primer, allowing substances, such as polymers, to be effectively...
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6702850 |
Multi-coated drug-eluting stent for antithrombosis and antirestenosis
A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a...
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6692772 |
Prevention of in-stent thrombosis and complications after arterial angioplasty with stent placement using magnesium
Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications.
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6689161 |
Decellularized vascular prostheses resistant to thrombus occlusion and immunologic rejection
Decellularized vascular prostheses that are resistant to thrombus occlusion and have a low level of immunogenicity and methods of making same are disclosed. The prostheses have high mechanical...
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6663880 |
Permeabilizing reagents to increase drug delivery and a method of local delivery
A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for...
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6656217 |
Medical device coated with a polymer containing a nitric oxide releasing organometallic nitrosyl compound useful for the prevention of platelet aggregation
The aggregation of platelets on the surface of a foreign body exposed to the flowing blood of a living being (such as plastic tubing, a balloon or the end of a catheter surgically inserted in a...
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6627209 |
Surgical stent and method for preventing occlusion of stented vessels and conduits after implantation of stents
The invention is of the design for, and a method of use of, an improved surgical stent. The stent is coated with a slow-release calcium channel blocker agent which interrupts the accumulation or...
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6620194 |
Drug coating with topcoat
A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material,...
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6605114 |
Heparin delivery method
A method for delivering heparin, wherein an implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing...
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6602287 |
Stent with anti-thrombogenic coating
A glycocalyx-like material is applied to a stent in order to mimic the outer surface of the cells lining arteries and veins to prevent thrombogenesis. The glycocalyx material is applied over a base...
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6579313 |
Methods for implanting cells
A method for implanting cells onto a prosthesis includes the steps of: (a) providing a prosthesis including a porous tube, where at least 25% of the pores on the inner surface of the tube have...
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6562898 |
Resin composition and manufacturing method therefor
The present invention relates to resin composition with superior antioxidant properties, mechanical strength and insulating properties. A mixture of a thermoplastic resin in pellet or granular form...
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6547812 |
Radiation therapy using a radioactive implantable device and a radiosensitizer agent
A method and apparatus for inhibiting vascular restenosis using a radioactive implantable medical device and a radiosensitizer agent. In one embodiment, the method of the invention includes...
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6471979 |
Apparatus and method for delivering compounds to a living organism
A method of treating or preventing vascular disease in a living organism. The method includes delivering an effective amount of a composition including a sex hormone, anti-hormone, sex-hormone...
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6461665 |
Process for preparing surface modification substances
The present invention relates to a process for preparing surface modifications having an improved antithrombogenic activity, whereby the improvement is achieved by treating heparin at a temperature...
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6440166 |
Multilayer and multifunction vascular graft
A multi-zone, multifinctional graft with two or more zones that have different chemical and biological characteristics is provided. The vascular conduit that has of an inner zone that is...
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6406488 |
Healing transmyocardial implant
A transmyocardial implant establishes a blood flow path through a myocardium between a heart chamber and a lumen of a coronary vessel residing on an exterior of the heart. The implant includes a...
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6407067 |
Salts of thrombin inhibitors
Compounds having thrombin inhibiting activity of the general formula I or II where n is 0.5, 1, 2 and HX is and HX is optionally substituted once or twice by methyl, ethyl or hydroxyl, and the...
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6398806 |
Monolayer modification to gold coated stents to reduce adsorption of protein
A stent has a body and a surface with at least a portion of the surface comprising metal with a coating thereon. The coating is selected from the group consisting of thiols and disulfides and...
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6379381 |
Porous prosthesis and a method of depositing substances into the pores
An implantable prosthesis, for example a stent, is provided that is capable of being loaded with substances. In one example, the prosthesis is a cylindrical-shaped body having depots or pores...
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6338904 |
Polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
Disclosed are bio-active coating compositions for polymeric substrates. In particular, a bio-active coating is described which is the reaction product formed by providing a polymer backbone with at...
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6306165 |
ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin
Disclosed are implantable medical devices with enhanced patency. Expanded polytetrafluoroethylene small caliber vascular grafts coated with polymer bound bio-active agents that exhibit enhanced...
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6273908 |
Stents
A stent having cavities has been developed that can be quickly and easily used in a wide variety of situations, that keeps vessels open with a minimum degree of recoil and shortening lengthwise,...
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6231600 |
Stents with hybrid coating for medical devices
A device such as a stent is provided with a hybrid coating including a time released, restenosis inhibiting coating and a non-thrombogenic coating to prevent clotting on the device. One first coat...
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6187038 |
Small bore biologic graft with therapeutic delivery system
A composite graft for a fluid-carrying vessel in a living body, comprising: an inner vessel comprising a biologic collagenic material that has been stabilized, an outer member surrounding at least...
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