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7384660 |
Implantable device having substances impregnated therein and a method of impregnating the same
A method of impregnating an implantable device, such as a vasclar graft or a covering adapted to be disposed over a prosthesis, is provided. The substances may be impregnated within the implantable...
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7374570 |
Polymer compositions for intraluminal stent
A polymer composition for use in forming a stent is described. The composition includes a monomer of an aliphatic ester of acrylic acid which has a glass transition temperature less than 25° C....
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7371256 |
Composite vascular constructs with selectively controlled properties
This invention deals with a composite vascular construct, which is formed of a first, blood contacting component and a second, tissue contacting component. Preferably, the present vascular...
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7364586 |
C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis
This invention provides a stent for implantation in a blood vessel or other tissue, wherein the stent is coated with or contains C3 exoenzyme, a chimeric version thereof or an inhibitor of RhoA....
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7364585 |
Medical devices comprising drug-loaded capsules for localized drug delivery
A medical device comprising a plurality of capsules, and a method of administering therapeutic agent to a patient using the same. The capsules further comprise a therapeutic agent and a multilayer...
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7344563 |
Angioplasty stents
A stent for use at an implant site in a vessel having recesses containing one or more active agents. The stent is a tubular body having a plurality of sinusoidal shaped annular elements and...
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7341756 |
Coated implants and methods of coating
A method including forming a first coating layer derived from an alkoxide on a substrate having a dimension suitable for an implant and forming a second coating layer on the first coating layer...
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7335314 |
Method of making an implantable medical device
An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more...
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7326238 |
Method and apparatus for treating vulnerable plaque
An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to...
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7314484 |
Methods and devices for treating aneurysms
Methods and devices provide delivery of one or more therapeutic agents to a treatment site at or near an aneurysm, such as an abdominal aortic aneurysm (“AAA”). Methods typically include...
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7312299 |
Bioabsorbabl, biobeneficial polyester polymers for stent coatings
This disclosure covers polymers, some of which are useful in medical device applications. Some of these medical devices are implantable within a mammalian body, such as in a body lumen. The...
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7311980 |
Polyactive/polylactic acid coatings for an implantable device
A polymeric coating for a medical device that comprises poly(lactic acid) and a block copolymer including blocks of poly(ethylene glycol) and poly(butylene terephthalate) is provided.
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7303758 |
Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to...
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7300662 |
Drug/drug delivery systems for the prevention and treatment of vascular disease
A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered...
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7297159 |
Selective coating of medical devices
Methods for coating different regions of an implantable device are disclosed. An embodiment of the method includes dipping a first portion of the implantable device into a first coating substance,...
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7294145 |
Stent with differently coated inside and outside surfaces
A medical device, e.g., a stent, is provided with different coatings on different surfaces, or with a coating on only one of the inside or outside surface. In accordance with certain embodiments,...
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7288084 |
Drug-loaded medical device
A medical device is designed to be placed in a patient's body and release one or more therapeutic agents therefrom. The medical device includes an elongated member defining a passage for passing...
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7285130 |
Stent delivery system
A medical device for delivery of a self-expanding stent comprises a catheter assembly having a catheter shaft and a self-expanding stent disposed thereabout. A retractable sheath is disposed about...
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7279175 |
Stent coated with a sustained-release drug delivery and method for use thereof
An intraluminal medical device comprises a stent having a coating applied to at least part of an interior surface, an exterior surface, or both. The coating comprises a sustained release...
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7261946 |
Block copolymers of acrylates and methacrylates with fluoroalkenes
A block copolymer comprising a fluorinated block and a non-fluorinated block and method of making the block copolymer are provided. Also provided herein are a coating on an implantable device...
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7261735 |
Local drug delivery devices and methods for maintaining the drug coatings thereon
Local drug delivery medical devices are utilized to deliver therapeutic dosages of drugs, agents or compounds directly to the site where needed. The local drug delivery medical devices utilize...
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7261734 |
Resorption-controllable medical implants
Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including...
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7244441 |
Stents and intra-luminal prostheses containing map kinase inhibitors
A coated stent or intra-luminal prosthesis containing a MAP kinase inhibitor controls, reduces, or prevents restenosis, inflammation, and complications associated with stent or intra-luminal...
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7244272 |
Vascular prosthesis and method for production thereof
A vascular prosthesis comprising a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein the first layer and the second layer are each...
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7238199 |
Method and apparatus for stent deployment with enhanced delivery of bioactive agents
A stent for use in animals including humans is disclosed which includes unprotected and protected regions, each protected regions including a bioactive or biopenetrating agent containing therein...
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7235096 |
Implantable device for promoting repair of a body lumen
An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise...
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7223286 |
Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent
Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of...
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7217286 |
Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent
Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of...
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7214661 |
Methods of therapy with thrombin derived peptides
The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative...
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7214383 |
Stent for delivery of drugs to the endothelium
The present invention provides for a stent for treatment and prevention of arterial stenosis and re-stenosis. The stent for intraluminal placement within an artery and subsequent expansion for...
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7208011 |
Implantable medical device with drug filled holes
The present invention relates to implantable medical devices for delivery of therapeutic agents, such as drugs, to a patient. More particularly, the invention relates to a device having therapeutic...
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7195640 |
Coated medical devices for the treatment of vulnerable plaque
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to...
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7195628 |
Atrial fibrillation therapy with pulmonary vein support
A system and method for treatment of paroxysmal atrial fibrillation by destruction of conductive pathways between the pulmonary veins and the left atrium. A stent is delivered by catheter to the...
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7186789 |
Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings
This disclosure covers polymers, some of which are useful in medical device applications. Some of these medical devices are implantable within a mammalian body, such as in a body lumen. The...
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7179289 |
Expandable medical device for delivery of beneficial agent
An expandable medical device has a plurality of elongated struts, the plurality of elongated struts being joined together to form a substantially cylindrical device. The device is expandable from a...
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7169179 |
Drug delivery device and method for bi-directional drug delivery
A drug delivery device is provided with openings for directional delivery of a plurality of therapeutic agents to blood vessels or other lumens or organs. In particular, the invention relates to...
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7169178 |
Stent with drug coating
Coatings for stents that include a polymer and a drug are provided. A method of forming the coatings is also provided.
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7163555 |
Drug-eluting stent for controlled drug delivery
The present invention provides a stent for delivering drugs to a vessel in a body, including a stent framework with a plurality of reservoirs formed therein, a drug polymer positioned in the...
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7144422 |
Drug-eluting stent and methods of making the same
An intravascular stent having a prefabricated, patterned polymeric sleeve for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood...
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7144419 |
Drug-polymer coated stent with blended phenoxy and styrenic block copolymers
The present invention provides a system for treating a vascular condition, including a catheter, a stent coupled to the catheter, a drug-polymer coating on the stent including a polymeric blend of...
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7135039 |
Intraluminar perforated radially expandable drug delivery prosthesis and a method for the production thereof
The radially expandable prosthesis for implantation in a lumen comprises a tubular wall produced from sheet metal and showing cuts enabling the prosthesis to expand. By using water guided laser...
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7135038 |
Drug eluting stent
Stents having struts with narrowed portions are described. The narrowed portions have a coating disposed thereon for the local delivery of a drug.
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7128755 |
Expandable biodegradable polymeric stents for combined mechanical support and pharmacological or radiation therapy
An expandable biodegradable polymeric stent is fabricated with biodegradable polymer fibers (Poly-L-lactic acid, PLLA) in a coil shape that is constructed with both central and external or internal...
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7122048 |
Hypotube endoluminal device
A self-expanding endoluminal device comprising at least one tubular filamentary member having a hollow core for receiving a guidewire, the tubular member having a straightened configuration with...
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7115691 |
Polymer compositions for intraluminal stent
A polymer composition for use in forming a stent is described. The composition includes a monomer of an aliphatic ester of acrylic acid which has a glass transition temperature less than 25° C....
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7101394 |
Energetically-controlled delivery of biologically active material from an implanted medical device
A medical device and system capable of providing on-demand delivery of biologically active material to a body lumen patient, and a method of making such medical device. A first coating layer...
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7096554 |
Protective loading of stents
A system for protecting a stent from contact during loading comprises a stent, a protective sleeve disposed about the stent and a loading tool. The inner diameter of the protective sleeve is...
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7083822 |
Overlapping coated stents
The present invention avoids a patient receiving a double dose of a therapeutic agent when a coated stent is overlapped with another coated stent within a vessel. A stent having a therapeutic...
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7083643 |
Methods for treating aneurysms
This invention is directed to methods for treating aneurysms wherein the aneurysmal sac is filled with a non-particulate agent or plurality of such agents and/or with a fluid composition which...
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7083642 |
Delivery of therapeutic capable agents
The present invention provides improved stents and other prostheses for delivering substances to vascular and other luminal and intracorporeal environments. In particular, the present invention...
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