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7326238 |
Method and apparatus for treating vulnerable plaque
An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to...
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7235096 |
Implantable device for promoting repair of a body lumen
An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise...
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7179287 |
Bioreactor mediated recellularization of natural and tissue engineered vascular grafts
Processes for producing a tissue graft comprising acellularizing or devitalizing a tubular tissue to produce a tissue matrix. The tissue matrix is then populated with at least some viable cells....
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7175658 |
Artificial vascular grafts, their construction and use
The present invention relates to artificial vascular grafts, methods for manufacturing and uses for them. The grafts are coated on their lumen with UP50. The grafts comprise an inner surface on...
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7169764 |
Promoter for smooth muscle cell expression
Disclosed is a smooth muscle cell specific promoter, the SM22α gene promoter as well as the murine cDNA and genomic SM22α nucleic acid sequences. Also disclosed are methods of preventing...
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7147846 |
Prosthetic grafts
An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant...
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7112218 |
Tissue engineered blood vessels and apparatus for their manufacture
The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood...
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7108717 |
Stent covered with heterologous tissue
A covered stent assembly comprising a tubular, expandable stent having a metallic framework covered with a cylinder of biocompatible, non-thrombogenic expandable material, such as heterologous...
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7056337 |
Natural tissue stent
A medical implant made from multiple layers of non-synthetic, natural tissues is provided. The medical device includes openings that extend radially through the wall of the medical implant. One...
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6926743 |
Biological stent-graft
A biological stent-graft and a method of making the same wherein a stent is surgically implanted in the lumen of an artery of a mammal, harvesting the stent-graft precursor after the stent has been...
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6709467 |
Arterial prosthesis
The arterial prosthesis is produced based on weaving technology using biologically inert polyester and polyuretan yarns, braided in a complicated structure. Then the prosthesis is impregnated with...
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6579313 |
Methods for implanting cells
A method for implanting cells onto a prosthesis includes the steps of: (a) providing a prosthesis including a porous tube, where at least 25% of the pores on the inner surface of the tube have...
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6544249 |
Biological microfistula tube and implantation method and apparatus
The present invention provides a microfistula tube including a soluble duct, defining a drainage canal having an inner surface, the duct being biocompatible, wherein the microfistula tube is coated...
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6503273 |
Tissue engineered blood vessels and methods and apparatus for their manufacture
The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood...
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6355055 |
Endovascular support device and method of use
An endovascular support device adapted for local delivery of a therapeutic agent and for minimizing the rate of restinosis having a cylindrical support body with an inside surface and an opposite...
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6187039 |
Tubular submucosal graft constructs
An easy-to-produce and mechanically strong tube of an implantable submucosal tissue has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct...
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6176874 |
Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
Solid free-form fabrication (SFF) methods are used to manufacture devices for allowing tissue regeneration and for seeding and implanting cells to form organ and structural components, which can...
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6117979 |
Process for making a bioprosthetic device and implants produced therefrom
Bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided as well as methods for their formation. The methods comprise combining...
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6117166 |
Apparatus and methods for grafting blood vessel tissue
Apparatus and methods especially useful for facilitating grafting of healthy blood vessel tissue onto the internal wall of a blood vessel are described. In one embodiment, the apparatus includes a...
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6087552 |
Method of producing fused biomaterials and tissue
It is a general object of the invention to provide a method of effecting tissue repair or replacement using a biomaterial. It is a specific object of the invention to provide a biomaterial suitable...
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6060640 |
Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted...
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5575815 |
Local polymeric gel therapy
A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of...
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5549700 |
Segmented prosthetic articulation
A ball and socket prosthetic joint device. A plurality of curved rigid segments are embedded within and extend out of a polymeric cushion to form a discontinuous hemispherical bearing surface for...
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5492826 |
Apparatus and method for seeding endothelial cells
An apparatus and method for culturing living endothelial cells is provided. The apparatus comprises a cell growth container, which in a preferred embodiment is a synthetic graft, heat crimped at...
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5383928 |
Stent sheath for local drug delivery
This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer...
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5230693 |
Implantable prosthetic device for implantation into a human patient having a surface treated with microvascular endothelial cells
The present invention provides a synthetic or naturally occurring implant, such as a vascular graft, for implantation into a human patient. Uncultured, microvascular endothelial cells, isolated...
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4932964 |
Artificial body for a prosthesis
A prosthesis wall for an artificial organ, e.g. an artificial arterial blood vessel, to be coated without gaps on one side with biologically active epithelial, e.g. endothelial cells is provided...
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4902289 |
Multilayer bioreplaceable blood vessel prosthesis
Process for forming a multilayer blood vessel prosthesis. Each layer is formed from bioreplaceable materials which include those produced by contacting collagen with an aminopolysaccharide and...
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4820626 |
Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself
The present invention provides a novel method of treating a synthetic or naturally occurring implant, such as a vascular graft, intended for implantation in a human patient, comprising obtaining...
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4804382 |
Artificial vessel
The artificial vessel has a membrane of at least semi-permeable bio-inert synthetic material with a monolayer of endothelial cells on the internal surface and a layer of smooth elastic...
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4795459 |
Implantable prosthetic device with lectin linked endothelial cells
An implantable prosthetic device made of biocompatible polymer and having a substantially continuous layer of autologus living cells attached via oligosaccharidelectin recognition linkages.
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4686098 |
Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
Recombinant DNA constructs having an avian retroviral long terminal repeat (LTR) ligated to the bovine growth hormone gene, were co-transformed into a mammalian cell (mouse) culture in order to...
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4681588 |
Biomaterial
Material for use in a biological environment is produced by subjecting a sheet of parietal pleura to glutaraldehyde tanning. The pleura is stretched and cleansed of excessive tissue to result in a...
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4662885 |
Percutaneously deliverable intravascular filter prosthesis
An intravascular prosthesis comprises a lining rolled upon itself around an axis so that it is introducible into a vascular lumen. An inflatable channel is included for unrolling the lining when...
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4648881 |
Implantable biological tissue and process for preparation thereof
A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of...
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4575372 |
Intraocular lens and method of manufacture using ultrasonic bonding
An intraocular lens loop, with an eyelet formed on the loop, and a method of forming the eyelet employing ultrasound energy. There is also disclosed a special fixture for use in manufacturing the...
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4553272 |
Regeneration of living tissues by growth of isolated cells in porous implant and product thereof
A method of repair of patient tissues by implant including providing a living cell sample which is introduced into an implant member having a porous open structure. The cell sample may be cultured...
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4502159 |
Tubular prostheses prepared from pericardial tissue
Novel tubular prostheses, e.g. vascular or ureteral prostheses, prepared by sewing the opposed edges of a sheet of pericardial tissue together with a thread to form a longitudinal seam are...
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4485097 |
Bone-equivalent and method for preparation thereof
A bone-equivalent, useful in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by fibroblast cells and containing demineralized bone powder.
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4485096 |
Tissue-equivalent and method for preparation thereof
A tissue-equivalent, useful in the treatment of burns or other skin wounds and in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by a...
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4466139 |
Vascular prostheses
A vascular prosthesis is produced by subjecting a length of animal ureter to glutaraldehyde tanning. The lumen of the ureter is dilated and the ureter is set in the dilated configuration by the...
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4309776 |
Intravascular implantation device and method of using the same
An intravascular device having a chamber for containing transplanted cells. The device is adapted to be implanted in a wall of a blood vessel with a porous chamber-forming wall of the chamber...
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3974526 |
Vascular prostheses and process for producing the same
A process for producing tubular prostheses for use in vascular reconstructive surgery is described. The invention comprises chemically and structurally modifying the veins and arteries of the human...
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3938524 |
Compliant mandrel and mandrel assembly for growing graft tubes
A mandrel of sponge rubber or gel has a tension element for withdrawing the mandrel from a graft tube grown from living tissue. In a first embodiment the tension element comprises a strip of cloth...
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3894530 |
Method for repairing, augmenting, or replacing a body conduit or organ
The umbilical cord is used for grafts in the vascular system or other body conduits, such as the ureter.
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