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7615063 |
Nerve regeneration-inducing tube comprising
The present invention provides a nerve regeneration-inducing tube in which nerve is inserted into a tubular structure and can be easily sutured and fixed without resort to any special instruments...
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7377930 |
Nerve protecting tube
The device is a tube for placement around a living, human nerve fiber to protect the nerve from external damage. The device includes two concentric tubes, each of which are semi-circular in cross...
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7285125 |
Compression anastomosis device and method
An anastomotic device for use in the joining of a first tubular structure and a second tubular structure is provided. The anastomotic device includes a cylindrical sleeve configured and dimensioned...
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7163545 |
Spinal cord surgical implant
An implant for bridging a gap in a severed spinal cord or nerve and for promoting nerve regeneration has a matrix comprising a biocompatible, biodegradable, polymeric material. The matrix has a...
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7147647 |
Sintered titanium tube for the management of spinal cord injury
A device and method for the treatment of damaged nerves and, more particularly, a tubular membrane having a microtextured surface for the treatment of central or peripheral nerve injuries. The...
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7041140 |
Neuro decompression device
A method of using a neuro decompression device is disclosed that significantly reduces fibroplasia proximate to nerve tissue. The device used in the method utilizes particular surface topographies...
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6808530 |
Medical device for treatment of a gap or defect in the central nerve system
A medical device ( 1 ) of a biocompatible material for use in the treatment of a gap or defect in the central nervous system, which device has a proximal end ( 5 ) and a distal end ( 6 ) comprising...
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6749616 |
Surgical system for repairing and grafting severed nerves and methods of repairing and grafting severed nerves
The invention relates to a surgical system for repairing severed nerve ends. The severed nerve ends may be located on a single nerve or may be located on a nerve graft and a severed nerve. The...
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6740100 |
Tendon repair using adhesive
A reinforcing member or stent ( 7 ) is inserted into opposite end portions ( 1, 1′ ) of a lacerated tendon and secured within the tendon by adhesive so that tension applied to the tendon is...
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6716225 |
Implant devices for nerve repair
An implant device including a tubular matrix made of a biocompatible and bioresorbable biopolymeric material. The matrix has a first end and a second end, a wall of a homogeneous thickness; a...
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6712830 |
Soft tissue anchor
An apparatus and method for repairing severed or unattached soft tissue of the body, such as tendons, typically includes an anchor for engaging the soft tissue and a securement mechanism designed...
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6676675 |
Patterned substrates and methods for nerve regeneration
Micropatterned substrates and methods for fabrication of artificial nerve regeneration conduits and methods for regenerating nerves are provided. Guidance compounds or cells are seeded in grooves...
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6589257 |
Artificial neural tube
An artificial tube for a nerve is disclosed that has a controlled rate of decomposition in the body such that the tube remains in the body until the nerve regenerates, which induces axons...
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6579978 |
Biomaterials comprising N-sulphated hyaluronic acid compounds or derivatives thereof
The present invention is directed to novel sulphated compounds of hyaluronic acid and derivatives thereof, optionally salified, wherein the glucosamines are partially N-sulphated or partially...
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6214021 |
Multi-lumen polymeric guidance channel and method of manufacturing a polymeric prosthesis
A guidance channel or conduit for promoting nerve regeneration includes a body constructed of a biocompatible polymeric material and having a first end for connection to a proximal stump of a...
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6187020 |
Connecting device for anastomosis, device for fitting fasteners and implant including them
The invention concerns a connecting device for anastomosis of a vascular prosthesis to a tubular conduit in which a lateral or terminal opening has been formed, the prosthesis including, at a...
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6156572 |
Bioartificial extracellular matrix containing hydrogel matrix derivatized with cell adhesive peptide fragment
A bioartificial extracellular matrix for use in tissue regeneration or replacement is provided by derivatizing a three-dimensional hydrogel matrix with a cell adhesive extracellular matrix protein...
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6102921 |
Nerve anastomosis sling and method
A medical anastomosis sling for use in the repair or regeneration of nerves. Nerve ends are placed in a breathable semiporous membrane having sets of elongate and wide tabs which are secured and...
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6090117 |
Artificial neural canal
The present invention offers an artificial tube for nerve which can remain in the body until the nerve regenerates while does not remain as a foreign body in the body following nerve regeneration,...
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6031148 |
Implantable bioabsorbable article
An implantable bioabsorbable article for the separation and regeneration of tissue at a tissue defect site in the form of a fibrous matrix laminarly affixed to both surfaces of a cell-barrier sheet...
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5948020 |
Implantable bioresorbable membrane and method for the preparation thereof
An implantable bioresorbable membrane for the separation and regeneration of tissue in a defect site and augmentation of tissues surrounding other implants comprises: (a) porous bioresorbable...
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5916224 |
Tendon repair clip implant
A tendon repair clip implant system for placement on the dorsal side of a cerated or torn tendon to allow active range of motion post tendon repair, comprises: first and second clips. Each clip...
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5879359 |
Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids
The present invention is drawn to medical devices comprising biodegradable guide channels for use in the repair and regeneration of nerve tissue. The guide channels of the present invention...
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5834029 |
Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
A bioartificial three-dimensional hydrogel extracellular matrix derivatized with a cell adhesive peptide fragment is provided for use in tissue regeneration or replacement. The choice of adhesive...
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5798116 |
Stabilized materials comprised of copper ion-containing fibronectin mats
The invention concerns a complex comprising a cell adhesion protein or a fragment thereof and Cu ions. The cell adhesion protein may be, for example, fibronectin and the Cu ions may be, for...
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5756457 |
Neural regeneration using human bone morphogenetic proteins
Methods and devices are disclosed for inducing growth of neural cells, and repairing neural defects in a mammal. The method comprises administering to said mammal at the site of neural defect,...
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5735863 |
Biodegradable and bioabsorbable guide channels for use in nerve treatment and regeneration
The present invention is drawn to medical devices comprised of biodegradable guide channels for use in repair and regeneration of nerve tissue. The guide channels are comprised of threads embedded...
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5667978 |
Antibody to the neural cell adhesion molecule and methods of use
The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on...
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5584885 |
Nerve regeneration chamber
A regeneration chamber for promoting and controlling the growth of biological nerves, including a chamber enclosing and defining a volume in which biological nerves are to be grown, an input port...
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5522879 |
Piezoelectric biomedical device
A piezoelectric medical device prepared by electrostatically spinning a copolymer of vinylidene fluoride and a second fluorinated hydrocarbon, and collecting the spun fibers on a suitable receiver....
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5480436 |
Method for preventing tissue adhesion
A device for preventing adhesions or binding of tissue to tissue or of tissue to bone which comprises a composite of a first layer and a second layer, each of which comprises a biodegradable...
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5464414 |
Disposable approximator for approaching nerve-endings in particular for facilitating sewing and replacement of injured nerves
Disposable approximator for approaching nerve-endings particularly to facilitate sewing and replacement of injured nerves. The disposable approximator according to the invention comprises surgical...
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5358475 |
High molecular weight bioresorbable polymers and implantable devices thereof
Nerve channels made from high molecular weight lactic acid polymers, preferably polymers having a molecular weight between about 234,000 and 320,000, provide an unexpectedly beneficial effect on...
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5354305 |
Nerve repair device
A nerve repair device includes a resilient, elongated implant, and transverse pins for retaining the implant fixedly within the ends of the severed nerve. A sharp tip extends longitudinally from at...
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5163948 |
Nerve tissue repair apparatus and method
A windlass is mounted in fixed position external to the body and close to the nerve tissue to be lengthened. A first path in the form of a hollow member is made between the windlass and a second...
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5147399 |
Method of treating nerve defects through use of a bioabsorbable surgical device
A method of using a bioabsorbable tube device for the repair of nerve defects or gaps comprising the steps of selecting a flexible, porous, bioabsorbable tube device and, then, suturing the nerve...
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5122151 |
Nerve connector and method
A method and apparatus for reconnecting stumps of transected cable-like organs, such as nerves, is disclosed. The apparatus comprises a template and a connector. The connector has inscribed guide...
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5092871 |
Electrically-charged nerve guidance channels
A medical device is disclosed for use in regenerating a severed nerve, including a tubular, biocompatible, electrically-charged membrane or guidance channel, having openings adapted to receive the...
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5061281 |
Bioresorbable polymers and implantation devices thereof
This invention relates to an implantable medical device capable of encouraging cellular growth and regeneration of function fabricated totally or in part from one or more bioresorbable polymers, as...
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5026381 |
Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
The present invention is directed to hollow conduits whose walls are comprised of Type I collagen and are characterized by having a multi-layered, semi-permeable structure, which conduits are used...
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5019087 |
Nerve regeneration conduit
The present invention is directed to a hollow conduit comprised of a matrix of Type I collagen and laminin-containing material which conduit is used to promote nerve regeneration across a gap of a...
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4955892 |
Neural cell adhesion protein nerve prosthesis
The neural cell adhesion molecule is used in nerve prostheses for the repair of peripheral nerve damage in mammals, both animal and man. In particular, in a process wherein a crushed or severed...
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4955893 |
Prosthesis for promotion of nerve regeneration
A method for producing a biodegradable polymer having a preferentially oriented pore structure and a method for using the polymer to regenerate damaged nerve tissue is disclosed. The preferentially...
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4920962 |
Splint-like element for use in end-to-end nerve suture
Disclosed is a splint-like element for use in end-to-end nerve suture to eliminate tension at the anastomosis site and thus allow optimal coaptation between the nerve ends to be sutured. The...
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4883618 |
Absorbable nerve repair device and method
Medical devices for the sutureless repair of lacerated, severed, or grafted nerves comprising longitudinally-openable, porous, rough-surfaced tubes of a body-absorbable polymer are disclosed. The...
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4877029 |
Semipermeable nerve guidance channels
Medical devices employing semipermeable materials, such as acrylic copolymers, polyurethane isocyanate, and other biocompatible semipermeable polymers, are disclosed for use as guidance channels in...
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4870966 |
Bioabsorbable surgical device for treating nerve defects
A bioabsorbable tube device for the repair of nerve defects or gaps comprising a flexible, porous, knitted or woven mesh tube. The tube device is crimped along its exterior to provide a tube which...
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4863668 |
Method of forming fibrin-collagen nerve and body tissue repair material
A method of forming material including alternating layers of fibrin and collagen, formed into tubes, is disclosed for use in repairing transected nerve fibers either by tubulization of the...
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4778467 |
Prostheses and methods for promoting nerve regeneration and for inhibiting the formation of neuromas
The present invention is directed to prosthesis and methods for promoting nerve regeneration. The proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a...
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4774967 |
Method and apparatus for mammalian nerve regeneration
The invention relates to method and apparatus for in vivo mammalian nerve regeneration of a damaged nerve using an electric current through the damaged nerve while the nerve ends are abutted...
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