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6030375 |
Compressible vaginal insert and method for treating urogenital disorders
The present invention is directed to a vaginal insert for delivering an agent to a urogenital tract in a patient. The patient has a vagina, and the vagina has a vaginal wall. The vaginal insert...
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6024734 |
Treatment methods using homeopathic preparations of growth factors
The present invention comprises homeopathic dilutions of growth factors and methods for their use. Disorders which may be effectively treated with the compositions of the present invention include...
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6010482 |
Apparatus for indicating fluid pressure in a conduit
An apparatus for visually indicating fluid flow through a fluid system or apparatus such as a medical infusion device. The apparatus comprises a pair of thin, indicia bearing films disposed in an...
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6001090 |
Thermal pharmaceutical delivery system
A preferred thermal pharmaceutical delivery apparatus (10) includes a drug delivery unit (12) including a drug absorbent gel body (16) capable of desorbing a drug upon being heated, a heating...
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6001386 |
Implantable controlled release device to deliver drugs directly to an internal portion of the body
A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that...
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5994151 |
Selenium carrier conjugates
The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and...
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5980508 |
Controlled release device and method
A device for dispensing one or more active agents, the device including: a housing (112) having an opening; at least one active agent (118) located within the housing; a driving means (124) located...
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5980928 |
Implant for preventing conjunctivitis in cattle
A method to reduce the likelihood of conjunctivitis in farm animals, especially cattle, includes the step of injecting an implant containing an antibiotic effective against the microbes associated...
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5980927 |
Method and apparatus for administering analgesics, and method for making same device
A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is...
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5980509 |
Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
A delivery system is disclosed for delivering a fluid-sensitive beneficial agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system...
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5964804 |
Close vascularization implant material
A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host...
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5957891 |
Fluid delivery device with fill adapter
A fluid delivery device having a self-contained stored energy membrane for expelling fluids at a precisely controlled rate which is of a compact, laminate construction. The device also includes a...
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5954675 |
Method of ultrasonic therapy
Methyl nicotinate, when swabbed onto the skin prior to the application of therapeutic ultrasound, produces a surprising enhancement of the effect of the ultrasound treatment, making it possible to...
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5955439 |
Pharmaceutical aerosol containing at least one sugar
This invention relates to aerosol formulations of use for the administration of medicaments by inhalation and in particular to a pharmaceutical aerosol formulation which comprises (a) particulate...
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5951512 |
Infusion port with modified drug reservoir
An implantable infusion port which comprises a fluid reservoir with inlet means and outlet means, the reservoir preferably having a toroid-like shape and outlet means directed along a tangent to...
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5938923 |
Microfabricated filter and capsule using a substrate sandwich
A microfabricated filter made up of two bonded substrate structures, each consisting of single crystalline silicon can optionally be formed into a capsule. The pores of the filter consist of one or...
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5935594 |
Process and device for treating and healing a tissue deficiency
An improved method or process and device for treating and healing a bone void is disclosed, and in particular a method employing a surfactant for efficiently incorporating a biologically active...
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5928194 |
Self-contained liquid microdispenser
A compact, small, self-contained liquid containment and dispensing device is disclosed which included an elongated fluid reservoir/conduit, a liquid dispenser in the form of a liquid retentive...
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5925030 |
Orally administrable delivery device
Oral drug delivery device having a housing with walls of water permeable material and having at least two chambers separated by a displaceable membrane. The first chamber receives drug and has an...
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5921962 |
Fluid delivery device with flow indicator and rate control
A fluid delivery device for infusing medicinal fluids having a self-contained stored energy membrane for expelling fluids at a precisely controlled rate. The device is of a compact, low profile,...
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5922353 |
Interlocking couplings for osmotic delivery devices
A delivery system is disclosed for delivering a fluid-sensitive active agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system...
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5906592 |
Fluid delivery apparatus
An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time and the method for making same. The apparatus includes one or more dispensers of a low...
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5904144 |
Method for treating ophthalmic diseases
The present invention provides novel devices and methods for continuous, controlled delivery of a biologically active molecule to the eye, either intraocularly or periocularly, to treat ophthalmic...
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5902598 |
Sustained release drug delivery devices
A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained...
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5900408 |
Methods of creating a unique chitosan and employing the same to form complexes with drugs, delivery of the same within a patient and a related dosage form
A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and...
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5897527 |
Portable analgesic system
A portable analgesic system comprises a liquid medicine supply unit which stores a given amount of liquid medicine temporarily and then discharges the liquid medicine automatically, a first...
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5895372 |
Implantable dosaging system
An implantable dosaging system for medications, active substances, etc. administered in the form of dissolved or suspended fluids having a medication reservoir, a pump for administering the...
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5882677 |
Iontophoretic patch with hydrogel reservoir
An improved hydrogel reservoir for use in two-compartment iontophoretic patches is described. The hydrogel reservoir contains a water soluble polyelectrolyte and a fluid. The reservoir may also...
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5882330 |
Drugs and methods for treating diseases
A method for treating a disease and drug units for use in performing such method. The method involves invading and flooding select cells of a living being with a drug or medical material to correct...
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5871770 |
Implantable system for delivery of fluid-sensitive agents to animals
A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery...
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5871484 |
Apparatus and method for administering a biologically active substance to a bone
A bone fastener is adapted to deliver biologically active substances to a bone site. An applicator is saturated with the substance and is disposed within an inner cavity of the fastener, near the...
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5868720 |
Indwelling catheter with stable enzyme coating
An improved indwelling catheter adapted for long-term usage includes a stable enzyme coating to prevent occlusion of the catheter lumen. The enzyme coating includes a fibrinolytic and/or lipolytic...
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5858017 |
Urologic irrigation solution and method for inhibition of pain, inflammation and spasm
A method and solution for perioperatively inhibiting a variety of pain, inflammation and smooth muscle spasm processes resulting from urologic procedures. The solution preferably includes multiple...
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5848991 |
Intradermal drug delivery device and method for intradermal delivery of drugs
An intradermal drug delivery device for delivering a liquid drug to a subject via the subject's skin includes a housing having a lower surface provided with an adhesive coating for adhering the...
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5840074 |
Method and apparatus for delivering first agent followed by second agent
The invention provides a dispensing device (10) comprising a loading dose (32) (first agent delivery device) for short-term and continuous delivery of agent, retained together with a long-term...
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5840335 |
System for the controlled release of active agents and a process for its preparation
A system for the controlled release of an active agent to an environment of use, said system having a predetermined release rate of the active agent to the environment of use, comprising: a) a...
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5836935 |
Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
An implantable, refillable, rate-controlled drug delivery device, with a hollow reservoir, and a drug delivery tube communicating with the hollow reservoir. The drug delivery tube includes at least...
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5833647 |
Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery
The present invention comprises a method of transdermal drug delivery where a drug is contained in or must pass through a hydrogel or lipogel together with an enhancement method to improve mass...
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5830546 |
Reservoir system for prolonged diffusion of an active principle
A reservoir system consisting of a nonwoven made from thermoplastic polymer filaments, shaped into a closed bag containing a water-soluble active principle. The bag is intended to ensure a...
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5830207 |
Electromagnetically triggered, responsive gel based drug delivery device
A system for remotely inducing a phase transition in a gel is provided. The system includes a gel capable of volume change in response to an environmental stimulus, a seed material in contact with...
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5820622 |
Analyte-controlled liquid delivery device and analyte monitor
A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable...
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5813999 |
Implantable atrial defibrillator providing reduced cardioversion discomfort
An implantable atrial cardiovertor applies cardioverting electrical energy to atria of a heart with reduced discomfort to a patient. The cardiovertor includes a storage capacitor having a...
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5810755 |
Medicated wound dressing
A wound dressing, suitable for use in protecting an open wound or burned tissue from direct exposure to air and capable of maintaining an aqueous environment of wounded tissue with which it is in...
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5807581 |
Collagen-based injectable drug delivery system and its use
Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes...
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5797898 |
Microchip drug delivery devices
Microchips are provided, which control both the rate and time of release of multiple chemical substances and which allow for the release of a wide variety of molecules in either a continuous or...
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5798119 |
Osmotic-delivery devices having vapor-permeable coatings
An osmotic device that, following the imbibition water vapor, provides for the controlled release of a beneficial agent to a non-aqueous environment. The device comprises a hydrophilic formulation...
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5795591 |
Osmotic drug delivery devices with hydrophobic wall materials
Osmotically driven drug delivery devices with walls of porous hydrophobic material as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the...
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5792110 |
Systems and methods for delivering therapeutic agents to selected sites in a subject
Systems for delivering a therapeutic agent to a selected site in a subject are disclosed. These systems enable precise placement of selected amounts, e.g., very small amounts, of a therapeutic...
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5787900 |
Method for loading and reloading a therapeutical device in a vascularized implantable containment apparatus
This invention relates generally to a method of loading and reloading a therapeutical device in a vascularized implantable containment apparatus made of selectively permeable material. Suitable...
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5788979 |
Biodegradable coating with inhibitory properties for application to biocompatible materials
A method is disclosed for coating a biomaterial to be placed in contact with a patient's blood flow to inhibit blood coagulation from adhering to the biomaterial that would otherwise result from...
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