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6537256 |
Microfabricated devices for the delivery of molecules into a carrier fluid
Apparatus and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparatus include microchip devices which have reservoirs containing the molecules for release....
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6530901 |
Portable painkilling system
A portable painkilling system comprises: a first continuous injector ( 1 ) for liquid medicine which continuously discharges liquid medicine through a control path ( 131 ) in an outlet portion ( 13...
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6511473 |
Implantable bioartificial active secretion system
An implantable bioartificial active secretion system for providing a physiological secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a...
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6510341 |
Iontophoresis device and drug unit
Herein disclosed is an iontophoresis device suitable for effective use of a drug supported on a drug support. A donor electrode-printed portion ( 6 ) and a reference electrode-printed portion ( 7 )...
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6500141 |
Apparatus and method for treating body tissue, in particular soft surface tissue with ultrasound
An apparatus for treating body tissue, in particular superficial soft tissue, with ultrasound, comprises an ultrasonic generation unit and an applicator, by means of which the ultrasound can be...
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6485462 |
Fluid delivery device with heat activated energy source
An implantable fluid delivery apparatus for infusing medicinal fluids into a patient that includes a novel heat responsive polymer gel material that, upon being heated by a heating coil uniquely...
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6468263 |
Implantable responsive system for sensing and treating acute myocardial infarction and for treating stroke
Disclosed is a completely implantable system that can detect the occurrence of a myocardial infarction, i.e., a heart attack, and automatically inject a thrombolytic and/or anti-thrombogenic agent...
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6464671 |
Medical system
Implantable drug delivery system comprising a reservoir module provided with a drug reservoir and a drug expelling means arranged to expel a drug from said drug reservoir, and a dispenser module...
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6464999 |
Bioadhesive medical devices
Disclosed herein are bioadhesive medical devices formed in whole or in part of a cohesive bioadhesive copolymer of a carboxyl functional monomer and a hydrophobic functional monomer.
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6458118 |
Drug delivery through microencapsulation
An implantable drug delivery device comprising a microencapsulated drug contained within at least one capsule, a carrier fluid that will dissolve the drug when freed from the capsule, a drug...
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6443942 |
Medication device with protein stabilizing surface coating
The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention,...
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6432438 |
Biodegradable vehicle and filler
A biodegradable vehicle and filler (referred to in this invention as biodegradable vehicle), which can be mixed with one or more biologically active substances (BAS), or can be used as a...
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6416496 |
Medication delivery apparatus
It is a primary object of the present invention to provide an automated system based on an integral fluid bag for administering a variety of intravenous drug regimens and reducing the vagaries of...
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6361771 |
ARPE-19 as a platform cell line for encapsulated cell-based delivery
ARPE-19 cells were evaluated as a platform cell line for encapsulated and un-encapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under...
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6340360 |
System for cell growth
An implantable infection shield and system for drug delivery in vascular tissue includes a relatively non-biodegradable porous linked fibrous biomaterial which controls and directs cell growth and...
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6326019 |
Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
A method for making, storing and using a surgical graft from human amniotic membrane; the resulting graft; and the storage solution. The amniotic membrane is obtained from human placenta, from...
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6326017 |
Methods for the localized delivery of agents to blood vessels
Methods for the localized delivery of agents to blood vessels are disclosed. The methods of the present invention provide advantages over existing methods for treating, diagnosing, or preventing,...
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6317700 |
Computational method and system to perform empirical induction
The present invention is an improved computational method and system of empirical induction that can be used to arrive at generalized conclusions and make predictions involving longitudinal...
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6298521 |
Door knob sanitizing device
A housing containing a sublimable disinfectant with the housing having an adhesive on the rear end for securing the housing to the backing plate behind a door knob. The housing has circumferential...
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6296632 |
Ball-shaped fiber implant, and method and device for inserting the implant
In the method proposed, the implant material in the form of a fibre is unwound from a bobbin (10) with the aid of a stream of air (24) and injected through a tube (19) into the body (22). In front...
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6284726 |
Inhibition of angiogenesis by peptide analogs of high molecular weight kininogen domain 5
Peptide analogs of the high molecular weight kininogen domain 5 are potent inhibitors of angiogenesis. The peptides have the formula X 1 -(HGLGHGHEQQHGKGH)-X 2 (I) wherein X 1 is from zero...
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6277095 |
Fluid delivery device with full adapter
A fluid delivery device for infusing medicinal fluids at a precisely controlled rate which includes adapter sleeve means for insuring that only a proper medicament can be used to fill the fluid...
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6254883 |
Composition for transdermal delivery of drugs
A pharmaceutical composition for the controlled transdermal delivery of a drug containing a combination of a drug and an ion exchanger group to a carrier, and a pharmaceutically acceptable salt...
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6251098 |
Fluid container for use with platen pump
Disclosed is an infusion pump and a fluid container for expelling a fluid from the fluid container to a patient. The pump comprises a housing having a chamber therein for receiving the fluid...
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6245753 |
Amphiphilic polysaccharide derivatives
Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong...
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6238693 |
Transdermal administration of fenoldopam
Transdermal administration of fenoldopam, both the racemic mixture and the active R-fenoldopam enantiomer, is described. Also described are transdermal patches for therapeutically effective...
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6228111 |
Biodegradable implant manufactured of polymer-based material and a method for manufacturing the same
The invention relates to a biodegradable implant or the like manufactured of polymer-based material and intended to be installed in tissue conditions. In the macroscopic structure of the implant...
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6213973 |
Vascular access port with elongated septum
An elongated access port has a needle-impenetrable housing enclosing a fluid reservoir. The housing includes a base having a floor with an upstanding encircling sidewall and a cap having a top wall...
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6214370 |
Method and device for administering analgesics
A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is...
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6199554 |
Method and apparatus for combining injury-mediated therapy and drug delivery
A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, such as coronary artery disease, is described. The method involves (i) creating injury in a tissue...
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6198966 |
Recirculating implantable drug delivery system
A drug delivery system recirculate carrier fluid in closed-loop fashion, thereby requiring only a relatively small amount of carrier fluid for operation. A pump provides continuous flow of carrier...
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6197331 |
Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity
The invention is directed to a controlled-release solid composition for the oral cavity or "pharmaceutical oral patch" that adheres to hard dental surfaces, such as teeth and dentures, and releases...
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6193991 |
Biodegradable delivery systems of biologically active substances
Biodegradable delivery systems of physiologically, pharmacologically and biologically active substance(s) (BAS) are provided. These systems are obtained by incorporating the BAS into a blend of...
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6180129 |
Polyurethane-containing delivery systems
A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the...
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6178348 |
Method and apparatus for maintenance of pierced orifices
A needle for use with an apparatus for injecting fluid into a pierced body orifice has a hollow body having an axis and an internal bore along the axis, a blunt, closed first end, an open second...
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6165499 |
Transdermal therapeutic system with small application-area thickness and great flexibility, and production process
A transdermal therapeutic system for the release of active substances to a substrate is characterized by the structure of the system comprising a substrate (1) provided with a separating layer (2),...
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6132419 |
Electroporetic gene and drug therapy
A method and apparatus are provided for introducing molecules such as genes and pharmaceutical compounds into living blood cells of a patient for therapeutic purposes. A device is placed into...
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6126637 |
Fluid delivery device with collapsible needle cover
A fluid delivery device having a self-contained stored energy membrane for defining in conjunction with a base a fluid reservoir and for expelling fluids from the reservoir. The device includes...
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6124037 |
Articles coated with in vivo polymerizable ophthalmic compositions
Coatings for surgical instruments which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated...
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6123700 |
Method and apparatus for sealing implantable membrane encapsulation devices
A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner...
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6110155 |
Anti-inflammatory-agent-loaded catheter and method for preventing tissue fibrosis
At least a portion of a catheter which is intended to be in contact with bodily tissue for more than a nominal period of time is loaded with an anti-inflammatory agent such as dexamethasone sodium...
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6099495 |
Implantable electrical transducer powered from capacitive storage energy source
An implantable system for treating a patient by an implantable electrical transducer and an implantable and rechargeable power source comprising a capacitive energy storage unit. A circuit is...
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6096076 |
Hybrid intrastromal corneal ring
This invention is an intrastromal corneal ring having at least one outer layer of a physiologically compatible polymer having a low modulus of elasticity, which polymer may be hydratable and may be...
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6083190 |
Device for enhanced electrotransport agent delivery
An electrotransport composition comprises at least one C 2 -C 4 lower alcohol, unsaturated derivatives thereof, or mixtures thereof, and at least one C 8 -C 4 higher alcohol, unsaturated...
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6077714 |
Method for the preparation of free radical pharmaceuticals diagnostics and devices using selenium conjugates
The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and...
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6074661 |
Sterile bioerodible occular implant device with a retinoid for improved biocompatability
An implantable device is provided which incorporates a retinoid for improving the biocompatability of the device in eye tissue. The device may be bioerodible for the purpose of systemically or...
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6068853 |
Temporally controlled drug delivery systems
A delivery mechanism and device for the passive periodic release of a drug or an active ingredient which avoids the need for external power sources and/or electronic controllers. By taking...
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6050988 |
Device for enhancing transdermal agent flux
A device (2) comprising a sheet member (6) having a plurality of microprotrusions (4) extending from a bottom edge (5) for penetrating the skin of a patient. The sheet member (6) when in use being...
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6045533 |
Fluid delivery device with conformable ullage and fill assembly
A fluid delivery apparatus for continuous basal infusion, together with controlled bolus infusion of injectable medicaments, which embodies a stored energy source such as distendable elastomeric...
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6042561 |
Non-intravascular infusion access device
A non-intravascular infusion access device and method for long-term continuous infusion of drugs. The infusion access device includes a porous membrane made of a material which is biocompatible for...
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