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6537256 Microfabricated devices for the delivery of molecules into a carrier fluid  
Apparatus and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparatus include microchip devices which have reservoirs containing the molecules for release....
6530901 Portable painkilling system  
A portable painkilling system comprises: a first continuous injector ( 1 ) for liquid medicine which continuously discharges liquid medicine through a control path ( 131 ) in an outlet portion ( 13...
6511473 Implantable bioartificial active secretion system  
An implantable bioartificial active secretion system for providing a physiological secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a...
6510341 Iontophoresis device and drug unit  
Herein disclosed is an iontophoresis device suitable for effective use of a drug supported on a drug support. A donor electrode-printed portion ( 6 ) and a reference electrode-printed portion ( 7 )...
6500141 Apparatus and method for treating body tissue, in particular soft surface tissue with ultrasound  
An apparatus for treating body tissue, in particular superficial soft tissue, with ultrasound, comprises an ultrasonic generation unit and an applicator, by means of which the ultrasound can be...
6485462 Fluid delivery device with heat activated energy source  
An implantable fluid delivery apparatus for infusing medicinal fluids into a patient that includes a novel heat responsive polymer gel material that, upon being heated by a heating coil uniquely...
6468263 Implantable responsive system for sensing and treating acute myocardial infarction and for treating stroke  
Disclosed is a completely implantable system that can detect the occurrence of a myocardial infarction, i.e., a heart attack, and automatically inject a thrombolytic and/or anti-thrombogenic agent...
6464671 Medical system  
Implantable drug delivery system comprising a reservoir module provided with a drug reservoir and a drug expelling means arranged to expel a drug from said drug reservoir, and a dispenser module...
6464999 Bioadhesive medical devices  
Disclosed herein are bioadhesive medical devices formed in whole or in part of a cohesive bioadhesive copolymer of a carboxyl functional monomer and a hydrophobic functional monomer.
6458118 Drug delivery through microencapsulation  
An implantable drug delivery device comprising a microencapsulated drug contained within at least one capsule, a carrier fluid that will dissolve the drug when freed from the capsule, a drug...
6443942 Medication device with protein stabilizing surface coating  
The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention,...
6432438 Biodegradable vehicle and filler  
A biodegradable vehicle and filler (referred to in this invention as biodegradable vehicle), which can be mixed with one or more biologically active substances (BAS), or can be used as a...
6416496 Medication delivery apparatus  
It is a primary object of the present invention to provide an automated system based on an integral fluid bag for administering a variety of intravenous drug regimens and reducing the vagaries of...
6361771 ARPE-19 as a platform cell line for encapsulated cell-based delivery  
ARPE-19 cells were evaluated as a platform cell line for encapsulated and un-encapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under...
6340360 System for cell growth  
An implantable infection shield and system for drug delivery in vascular tissue includes a relatively non-biodegradable porous linked fibrous biomaterial which controls and directs cell growth and...
6326019 Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries  
A method for making, storing and using a surgical graft from human amniotic membrane; the resulting graft; and the storage solution. The amniotic membrane is obtained from human placenta, from...
6326017 Methods for the localized delivery of agents to blood vessels  
Methods for the localized delivery of agents to blood vessels are disclosed. The methods of the present invention provide advantages over existing methods for treating, diagnosing, or preventing,...
6317700 Computational method and system to perform empirical induction  
The present invention is an improved computational method and system of empirical induction that can be used to arrive at generalized conclusions and make predictions involving longitudinal...
6298521 Door knob sanitizing device  
A housing containing a sublimable disinfectant with the housing having an adhesive on the rear end for securing the housing to the backing plate behind a door knob. The housing has circumferential...
6296632 Ball-shaped fiber implant, and method and device for inserting the implant  
In the method proposed, the implant material in the form of a fibre is unwound from a bobbin (10) with the aid of a stream of air (24) and injected through a tube (19) into the body (22). In front...
6284726 Inhibition of angiogenesis by peptide analogs of high molecular weight kininogen domain 5  
Peptide analogs of the high molecular weight kininogen domain 5 are potent inhibitors of angiogenesis. The peptides have the formula X 1 -(HGLGHGHEQQHGKGH)-X 2 (I) wherein X 1 is from zero...
6277095 Fluid delivery device with full adapter  
A fluid delivery device for infusing medicinal fluids at a precisely controlled rate which includes adapter sleeve means for insuring that only a proper medicament can be used to fill the fluid...
6254883 Composition for transdermal delivery of drugs  
A pharmaceutical composition for the controlled transdermal delivery of a drug containing a combination of a drug and an ion exchanger group to a carrier, and a pharmaceutically acceptable salt...
6251098 Fluid container for use with platen pump  
Disclosed is an infusion pump and a fluid container for expelling a fluid from the fluid container to a patient. The pump comprises a housing having a chamber therein for receiving the fluid...
6245753 Amphiphilic polysaccharide derivatives  
Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong...
6238693 Transdermal administration of fenoldopam  
Transdermal administration of fenoldopam, both the racemic mixture and the active R-fenoldopam enantiomer, is described. Also described are transdermal patches for therapeutically effective...
6228111 Biodegradable implant manufactured of polymer-based material and a method for manufacturing the same  
The invention relates to a biodegradable implant or the like manufactured of polymer-based material and intended to be installed in tissue conditions. In the macroscopic structure of the implant...
6213973 Vascular access port with elongated septum  
An elongated access port has a needle-impenetrable housing enclosing a fluid reservoir. The housing includes a base having a floor with an upstanding encircling sidewall and a cap having a top wall...
6214370 Method and device for administering analgesics  
A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is...
6199554 Method and apparatus for combining injury-mediated therapy and drug delivery  
A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, such as coronary artery disease, is described. The method involves (i) creating injury in a tissue...
6198966 Recirculating implantable drug delivery system  
A drug delivery system recirculate carrier fluid in closed-loop fashion, thereby requiring only a relatively small amount of carrier fluid for operation. A pump provides continuous flow of carrier...
6197331 Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity  
The invention is directed to a controlled-release solid composition for the oral cavity or "pharmaceutical oral patch" that adheres to hard dental surfaces, such as teeth and dentures, and releases...
6193991 Biodegradable delivery systems of biologically active substances  
Biodegradable delivery systems of physiologically, pharmacologically and biologically active substance(s) (BAS) are provided. These systems are obtained by incorporating the BAS into a blend of...
6180129 Polyurethane-containing delivery systems  
A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the...
6178348 Method and apparatus for maintenance of pierced orifices  
A needle for use with an apparatus for injecting fluid into a pierced body orifice has a hollow body having an axis and an internal bore along the axis, a blunt, closed first end, an open second...
6165499 Transdermal therapeutic system with small application-area thickness and great flexibility, and production process  
A transdermal therapeutic system for the release of active substances to a substrate is characterized by the structure of the system comprising a substrate (1) provided with a separating layer (2),...
6132419 Electroporetic gene and drug therapy  
A method and apparatus are provided for introducing molecules such as genes and pharmaceutical compounds into living blood cells of a patient for therapeutic purposes. A device is placed into...
6126637 Fluid delivery device with collapsible needle cover  
A fluid delivery device having a self-contained stored energy membrane for defining in conjunction with a base a fluid reservoir and for expelling fluids from the reservoir. The device includes...
6124037 Articles coated with in vivo polymerizable ophthalmic compositions  
Coatings for surgical instruments which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated...
6123700 Method and apparatus for sealing implantable membrane encapsulation devices  
A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner...
6110155 Anti-inflammatory-agent-loaded catheter and method for preventing tissue fibrosis  
At least a portion of a catheter which is intended to be in contact with bodily tissue for more than a nominal period of time is loaded with an anti-inflammatory agent such as dexamethasone sodium...
6099495 Implantable electrical transducer powered from capacitive storage energy source  
An implantable system for treating a patient by an implantable electrical transducer and an implantable and rechargeable power source comprising a capacitive energy storage unit. A circuit is...
6096076 Hybrid intrastromal corneal ring  
This invention is an intrastromal corneal ring having at least one outer layer of a physiologically compatible polymer having a low modulus of elasticity, which polymer may be hydratable and may be...
6083190 Device for enhanced electrotransport agent delivery  
An electrotransport composition comprises at least one C 2 -C 4 lower alcohol, unsaturated derivatives thereof, or mixtures thereof, and at least one C 8 -C 4 higher alcohol, unsaturated...
6077714 Method for the preparation of free radical pharmaceuticals diagnostics and devices using selenium conjugates  
The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and...
6074661 Sterile bioerodible occular implant device with a retinoid for improved biocompatability  
An implantable device is provided which incorporates a retinoid for improving the biocompatability of the device in eye tissue. The device may be bioerodible for the purpose of systemically or...
6068853 Temporally controlled drug delivery systems  
A delivery mechanism and device for the passive periodic release of a drug or an active ingredient which avoids the need for external power sources and/or electronic controllers. By taking...
6050988 Device for enhancing transdermal agent flux  
A device (2) comprising a sheet member (6) having a plurality of microprotrusions (4) extending from a bottom edge (5) for penetrating the skin of a patient. The sheet member (6) when in use being...
6045533 Fluid delivery device with conformable ullage and fill assembly  
A fluid delivery apparatus for continuous basal infusion, together with controlled bolus infusion of injectable medicaments, which embodies a stored energy source such as distendable elastomeric...
6042561 Non-intravascular infusion access device  
A non-intravascular infusion access device and method for long-term continuous infusion of drugs. The infusion access device includes a porous membrane made of a material which is biocompatible for...