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9028545 Method of delivering a prosthetic heart valve  
A method of delivering a prosthetic heart valve to a native aortic valve is disclosed. The prosthetic heart valve comprises a radially compressible and expandable metallic stent and a flexible...
9028465 Therapeutic delivery devices, systems, and methods  
Devices, systems, and methods for delivery of therapeutics, in particular thrombolytic agents, in particular plasmin, are provided. The devices, systems, and methods also provide for occlusion of...
9028443 Weeping balloon catheter with drug delivery balloon in fluid communication with combination lumen  
A weeping balloon catheter includes a catheter having an elongate tubular body defining an inflation lumen and a combination lumen that terminates at an open distal end of the elongate tubular...
9023010 Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof  
Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be...
9017285 Occlusion perfusion catheter  
Catheters for occluding, visualizing, irrigating, evacuating, and delivering agents to a treatment area are disclosed. The catheters comprise a catheter body comprising five lumens, first and...
9011374 Balloon catheter with three lumens  
A balloon catheter is provided with three lumens. The first lumen may be used as a guide wire lumen. The second lumen may be used as an inflation lumen. The third lumen may be used to provide...
9011476 Method and apparatus for occluding a physiological opening  
A method and apparatus for suture-less placement of an occluding patch in which release of the device can be accelerated. In one embodiment, an inactive form of an adhesive is applied on the area...
9005284 Method and apparatus for treating dilating the ethmoid infundibulum  
A method of dilating an infundibular space within the human head includes directing at least a distal portion of an elongate member of a medical device into a nasal cavity of the human head, the...
9005163 Balloon catheter with external delivery tube  
A balloon catheter having a shaft, a balloon, and an external delivery tube, as well as methods of use thereof. In one example, the balloon catheter is an agent delivery catheter including a...
8992513 Endovascular plasma treatment device and method of use  
A device and method for treating a hollow anatomical structure using matter in a plasma state. Device includes a tubular delivery device comprising a tubular body, a hub, and a distal end, wherein...
8992465 Surgical instrument for injecting a drug into prostate tissue  
A needleless injector including a body at a proximal end, a shaft extending distally from the body, at least one injection orifice at a distal end of the shaft in fluid communication with a fluid...
8992504 Vena cava filter catheter and method of use  
A vena cava filter catheter includes a catheter having a lumen disposed therethrough and at least one strand of biocompatible wire. The at least one strand has a first state in which the at least...
8986282 Methods, compositions and apparatus for delivering heterologous molecules to cells  
A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic...
8986244 Needleless delivery systems  
A method of treating a prostate condition, including the steps of providing a needleless injector that includes a body at a proximal end, an injection shaft extending from the body to a distal end...
8986241 Apparatus and methods for clot dissolution  
Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter...
8979793 Methods and devices for percutaneous and surgical interventions  
Methods and devices for performing percutaneous and surgical interventions. The devices comprising a tubular portion and retractable mechanism at the distal end of the tubular portion. The...
8974520 Method for producing a bioactive surface on the balloon of a balloon catheter  
The invention relates to a method for producing a bioactive surface on the balloon (3) of a balloon catheter (1). According to said method, the surface of the balloon (3) is at least partially...
8961494 Endovascular devices and methods for exploiting intramural space  
Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen...
8956639 Multiple drug delivery from a balloon and prosthesis  
System for treating vascular disease comprising a balloon having an outer surface for temporary contact with a vessel wall when in an expanded state, a coating disposed on at least a portion of...
8945160 Apparatus and methods for treating obstructions within body lumens  
An apparatus is provided that is operable in different modes to perform various functions for treating a body lumen. The apparatus includes a shaft including proximal and distal ends, a lumen...
8932326 Method and apparatus for repairing vascular abnormalities and/or other body lumen abnormalities using an endoluminal approach and a flowable forming material  
Apparatus and method for repairing an abnormality in the wall of a body lumen, the method comprising isolating the abnormality in the wall of the body lumen from flow in the body lumen;...
8929988 Methods and systems for submucosal implantation of a device for diagnosis and treatment of a body  
Instruments, systems and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle...
8900214 Expandable trans-septal sheath  
Disclosed is an expandable transluminal sheath, for introduction into the body while in a first, low cross-sectional area configuration, and subsequent expansion of at least a part of the distal...
8900215 Semi-compliant medical balloon  
A semi-compliant fiber-reinforced medical balloon having a folded wall thickness of from about 0.0010 to about 0.0060 inches and a rated burst pressure of at least 15 atmospheres and exhibiting...
8894614 Devices, systems and methods useable for treating frontal sinusitis  
Devices, systems and methods wherein a dilator, such as a balloon or other expandable member, is positionable within the frontal sinus ostium and adjacent frontal recess and useable to dilate the...
8895056 Regional delivery of therapeutic agents for the treatment of vascular diseases  
The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective...
8892182 Double balloon isolation catheters and methods therefor  
A system for examining a colon includes a catheter, such as a rectal catheter, having a proximal end, a distal end, and a central lumen extending from the proximal end to the distal end of the...
8876791 Collateral pathway treatment using agent entrained by aspiration flow current  
A method and system for increasing the flow resistance of collateral pathways in the lung by employing aspiration to establish an artificial convective flow current between compartments in the...
8870847 Blood vessel permeability-enhancement for the treatment of vascular diseases  
This invention is directed to a method of treating a vascular disease involving administration to a patient by means of an angioplasty balloon a composition comprising a permeability-enhancing...
8865857 Medical device with predefined activated cellular integration  
A medical device includes a substrate having at least a portion thereof functionalized with at least one reactive member and a chemotactic agent functionalized with at least one complementary...
8864743 Methods and systems for delivering substances into luminal walls  
Angioplasty and other dilatation devices are provided with scoring elements which incorporate a drug to be delivered to a body lumen, typically a blood vessel. The non-cutting scoring elements...
8864787 Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis  
Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to...
8852223 Fixed wire dilatation catheter with an elongateable distal end  
A fixed wire dilatation catheter for treating the vasculature of a patient. The dilatation catheter includes an elongated member that has a distal end portion which can be elongated to puncture...
8845614 Enhanced ultrasound visualization of intravascular devices  
Methods and devices for providing improved ultrasound visibility of medical devices intended for intravascular use are described. The inclusion of gas/solid boundary regions within a medical...
8840601 Intravascular tissue disruption  
Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of...
8821473 Methods and compositions to treat myocardial conditions  
Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other...
8808232 Needleless delivery systems  
A needleless injector including a body including a fluid chamber; an outer shaft extending from an outer shaft proximal end to an outer shaft distal end, wherein the outer shaft includes an outer...
8801692 Gradient coated stent and method of fabrication  
The gradient coated stent 150 of the present invention provides a coated stent having a continuous coating 130 disposed on the stent elements. The continuous coating 130 includes a first coating...
8801744 Expandable introducer sheath to preserve guidewire access  
An introducer sheath. The introducer sheath includes a tubular body. The tubular body extends from a distal end toward a proximal end. The tubular body includes a lumen. The lumen is defined at...
8790298 Infusion catheter tip for biologics  
A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed...
8784373 Drug delivery by carbon nanotube arrays  
The invention generally relates to carbon nanotube based drug delivery methods, devices, and compositions. More particularly, the invention relates to controlled drug delivery using anchored...
8777926 Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasel or paranasal structures  
Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used...
8777870 Functional discography catheter  
Catheter devices for diagnosing and treating discogenic pain are provided. The catheter devices comprise a tubular body configured for insertion into an intervertebral disc and a pressure...
8771226 Vena cava filter catheter and method  
A vena cava filter catheter includes a catheter having a lumen disposed therethrough and at least one strand of biocompatible wire. The at least one strand has a first state in which the at least...
8764725 Directional anchoring mechanism, method and applications thereof  
An anchoring mechanism and method for anchoring a device within a biological conduit include an expandable element configured for retaining the device at a desired angle relative to a central axis...
8764726 Devices, systems and methods useable for treating sinusitis  
Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used...
8764729 Frontal sinus spacer  
Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to...
8764709 Devices, systems and methods for treating disorders of the ear, nose and throat  
Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat...
8764727 Reinforced rapid exchange catheter  
A medical balloon catheter including a shaft comprised of a cross-wound coil tube and a sleeve surrounding the cross-wound coil tube. The cross-wound coil tube includes a monofilament inner coil...
8747353 Catheter balloon having improved flexibility and methods for making same  
A method for manufacturing a balloon catheter assembly includes forming a balloon from a polymer selected from the group consisting of polyamide, polyether block amide, and polyethylene...