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7611481 |
Transdermal delivery device
A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover...
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7591618 |
Machining method for micro abraders and micro abraders produced thereby
A method for manufacturing microabraders by machining a surface of a workpiece, each of the microabraders having a plurality of sides; for each of the microabraders the method comprising:
...
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7588552 |
Devices and methods for transporting fluid across a biological barrier
A device ( 10 ) and method for transporting fluids across biological barriers enhances penetration of a biological barrier by the use of directional insertion, preferably with asymmetric...
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7560036 |
System and method for drug delivery and microfluidic applications using microneedles
The invention relates to a method of fabricating a microneedle array in a substrate, a drug delivery device comprising one or more microneedles extending upwards from the front surface of the...
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7527802 |
Vaccine for transcutaneous immunization
A vaccine delivered by transcutaneous immunization provides an effective treatment against infections by pathogens such as, for example, enterotoxigenic Escherichia coli (ETEC) and/or for...
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7522955 |
Method and apparatus for the ultrasonic cleaning of biofilm coated surfaces
To treat body surfaces, such as the sinuses, which are coated with biofilms, the surface is irrigated and suctioned with a fluid which may contain a biocide or other chemical agent for disrupting...
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7495146 |
Wound dressing
A wound dressing or bandage that provides a galvanic current for extended periods of time before having to change the dressing or bandage is addressed in the present invention. The present...
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7455654 |
Method and apparatus for reducing the incidence of tobacco use
An apparatus for transdermally delivering a nicotine-based agent to a tobacco or nicotine user comprising a microprojection member having a plurality of microprojections that are adapted to pierce...
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7422567 |
Microabrader with controlled abrasion features
An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed in...
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7419481 |
Apparatus and method for piercing skin with microprotrusions
A method and device are described for applying a microprotrusion member ( 44 ) including a plurality of microprotrusions ( 90 ) to the stratum corneum with impact. The method and device are used to...
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7351219 |
Method and instrumentation for cooling a surgical incision
An infusion sleeve of an ultrasonic vibrating needle. The sleeve is collapsible and serrated or scalloped at a distal end. Fluid flows through a passage between the needle and the infusion sleeve...
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7347835 |
Process for producing pad base for endermism, and pad base for endermism, and injection needle
The present invention provides a production process for obtaining a pad base for endermism capable of administering a drug in the skin without vibration. One side end of a thin metal wire is...
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7316671 |
Microprotrusion arrays and methods for using same to deliver substances into tissue
Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of...
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7316665 |
Method and device for the delivery of a substance including a covering
An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also...
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7211062 |
Solid solution perforator for drug delivery and other applications
A solid drug perforator (SSP) system and an associated drug reservoir are provided for delivering theraputic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting....
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7166086 |
Substance delivery via a rotating microabrading surface
A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a...
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7141034 |
Transdermal drug delivery device, method of making same and method of using same
A transdermal drug delivery device for forming a micropore in a tissue membrane of an animal comprising a substrate and a porator that is located on or within the substrate. The porator is...
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7131960 |
Apparatus and method for piercing skin with microprotrusions
A method and device are described for applying a microprotrusion member ( 44 ) including a plurality of microprotrusions ( 90 ) to the stratum corneum with impact. The method and device are used to...
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7097631 |
Self-actuating applicator for microprojection array
An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The...
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7074210 |
Universal protector cap with auto-disable features for needle-free injectors
Disclosed is a medical device used to prevent the cross-contamination of patients or injectors in which various components placed on the injector minimize or eliminate back splash contamination of...
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7047070 |
Valved intradermal delivery device and method of intradermally delivering a substance to a patient
An intradermal delivery device for delivery a substance into the skin of a patient has a fluid chamber for containing the substance, at least one micro skin penetrating member, and a valve...
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6881203 |
Microneedle arrays and methods of manufacturing the same
Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle arrays. The microneedles in the microneedle arrays may be in the form of tapered structures that include...
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6855131 |
Microprotrusion member retainer for impact applicator
A retainer ( 34 ) is provided for holding a microprotrusion member ( 44 ) for application of the microprotrusion member ( 44 ) to the stratum corneum with an impact applicator ( 10 ). The...
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6835184 |
Method and device for abrading skin
A device includes a plurality of microneedles for abrading the stratum corneum of the skin to form a plurality of grooves in the tissue having a controlled depth and width. The microneedles have a...
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6821264 |
Gene delivery device and gene delivery method
A gene delivery device for localizing and enhancing the efficacy of gene transfer that provides a contact surface for contacting with a tissue site. By applying a pharmaceutical composition...
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6726649 |
Medical needle assemblies
A shielded, sterile, single-use unit dose needle assembly includes a unit dose needle with a hub and two packaging shields sealingly mated to one another encasing the hub and unit dose needle. The...
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6692456 |
Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
The invention provides for improved devices and methods for forming openings in a biological membrane for delivering substances into an animal through the biological membrane for treatment...
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6632230 |
Ablation system with catheter clearing abrasive
An ablation system comprising an atherectomy device and an aspiration catheter, each routed to a position just proximal to a lesion within a patient's vessel to ablate the lesion. The atherectomy...
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6591124 |
Portable interstitial fluid monitoring system
A strip-like microneedle device is provided that includes an array of hollow microneedles, a diaphragm pump to extract interstitial fluid from skin, and a sensor that detects the concentration of...
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6572580 |
Set depth nail notcher with patch system and method for treating nail fungus
A kit including a patch laden with topical anti-fungal medication and a set depth nail notcher for cutting a notch of predetermined depth in a nail plate comprising a handle having a smooth flat...
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6522918 |
Electrolytic device
An electrolytic device ( 20 ) comprising a structure ( 22 ) having a first surface ( 24 ) with a first surface area, a thickness region ( 29 ) and a plurality of openings ( 30 ) in the thickness...
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6287276 |
Set depth nail notcher and method for treating nail fungus
A set depth nail notcher for cutting a notch of predetermined depth in a nail plate comprising a handle having a smooth flat surface, a longitudinal cutting edge protruding from the smooth flat...
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6230051 |
Device for enhancing transdermal agent delivery or sampling
A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent. The microblades having a...
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6159196 |
Methods and apparatus for transvascular muscular revascularization and drug delivery
Apparatus and methods for effecting controlled injury to a selected body region to induce muscular revascularization and to provide delivery of drugs and therapeutic agents. A transvascular or...
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6077229 |
Allergy testing apparatus
An allergen testing pick for receipt in the open top end of a vial of allergen and including a neck for close fit with the top end of such vial. The pick includes a stem depending downwardly from...
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6030356 |
Irrigation clip
A disposable irrigation device for a motorized surgical tool comprises a cannula with a cylindrical clip bonded near one end. The clip has a C-shaped cross-section with a slot. Both the cannula and...
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6024706 |
Quantitative skin allergic test device
The present invention relates to an improved quantitative skin allergic test device, which has a finger grip to be held by fingers and multiple legs longitudinally attached to the finger grip. Each...
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5985847 |
Devices for administration of naked polynucleotides which encode biologically active peptides
This invention relates to apparatus and compositions for administering antigens and immunostimulatory peptides to a mammalian host by the introduction of one or more naked polynucleotides to...
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5879326 |
Method and apparatus for disruption of the epidermis
A method and apparatus for mechanically disrupting a layer of skin having a known thickness without substantially disrupting underlying dermis layers below the layer of skin in question so as to...
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5843114 |
Skin perforating apparatus for transdermal medication
A skin perforating member for an insulin patch, which is for disposing a human skin before administering insulin transdermally. By a pressure sensing arrangement instailed on both sides of a skin...
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5823994 |
Method and apparatus for soft tissue fixation
An apparatus for repairing a wound in soft tissue includes an introducer trocar with a sharpened distal end and a hollow lumen. An elongated pin has a distal end, a proximal end and a central...
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5632728 |
Skin testing and vaccinating needles
A plastic skin testing and vaccinating needle characterized by an end bifurcated into two sharp points spaced sufficiently close so that the points will form a small hole in the skin when the...
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5569272 |
Tissue-connective devices with micromechanical barbs
A system for linking a first member with a second member. The system is comprised of a first plurality of micromechanical barbs disposed on the first member. The system is also comprised of a...
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5487726 |
Vaccine applicator system
A percutaneous vaccine applicator system which includes a percutaneous vaccine applicator and a packaging assembly for housing the vaccine applicator. The percutaneous vaccine applicator includes a...
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5387203 |
Subcutaneous extractor
A device for extracting pus, blood and other materials from beneath the skin. The device is made of a clear plastic tube open at both ends (10). One end is placed over the skin which has material...
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5380279 |
Animal vaccination gun
An animal vaccination gun for administering a vaccination to an animal has a movable needle assembly which is brought into engagement with a metering chamber having a spring-biased piston mounted...
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5273528 |
Livestock inoculator
A scarifier and dispensing device for inoculating livestock and other animals which includes an applicator at one end thereof and a scarifying tip extending from the opposite end thereof and which...
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5124316 |
Method for periodontal regeneration
A method for promoting bone, periodontium or ligament growth of a mammal comprising applying to the bone periodontium or ligament a growth-promoting amount of a composition comprising a partially...
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5104620 |
Disposable allergy skin testing kit
A disposable allergy skin testing kit that is formed from a top layer sheet, a membrane sheet, and a bottom layer sheet. The bottom sheet has a plurality of recesses formed at predetermined...
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5099857 |
Medical testing device with calibrated indicia
A disposable medical testing device (17) adapted to be held against the skin of a patient, which enables the performance of skin testing for the diagnosis of both immediate hypersensitivity and...
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