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6553253 |
Method and system for electrokinetic delivery of a substance
An electrokinetic system for delivering a substance into tissue includes an alternating current source of a predetermined frequency. A first electrode is coupled to a first terminal of the...
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6553255 |
Use of background electrolytes to minimize flux variability during iontophoresis
A device and method are provided that minimize the changes in flux encountered during iontophoresis and reduce inter-subject variability. For drug delivery, the active agent to be delivered is...
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6546283 |
High current density iontophoretic device and method of use thereof
A high current density iontophoretic device, comprising a reservoir, an applicator, an orientation maintaining member and an iontophoretic medicament administering member. The reservoir is capable...
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6546282 |
Device for Iontophoresis
A handling-convenient device for iontophoresis, which can supply spotted regions suffering from disease with a proper quantity of current at the same time. The device for iontophoresis includes a...
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6546284 |
Fluid retention assembly for an iontophoretic delivery device and associated method for preparing the same
A fluid retention assembly for use in association with an iontophoretic drug delivery device comprising: a matrix, wherein the matrix is fabricated from a hydroxylated polyvinyl acetal; a first...
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6546281 |
Integrated apparatus for controlled heat aided dermal drug delivery
An integrated apparatus for controlled heat aided dermal drug delivery is disclosed. The apparatus has a temperature control component and a drug delivery component. The temperature control...
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6544256 |
Electromagnetically induced cutting with atomized fluid particles for dermatological applications
An electromagnetically induced mechanical cutting mechanism provides accurate cutting and ablating operations on soft tissues such as skin. Electromagnetic energy is concentrated into moist air...
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6542765 |
Method for the iontophoretic non-invasive determination of the in vivo concentration level of an inorganic or organic substance
The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b)...
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6539250 |
Programmable transdermal therapeutic apparatus
A programmable transdermal therapeutic apparatus provides facile programming instruction means to query for a patient's attributes and to translate these attributes into customized patient limits...
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6539251 |
Ocular iontophoretic apparatus
An ocular iontophoretic apparatus comprising a reservoir which includes a outer rim. The outer rim includes a barrier. The barrier is positionable upon the surface of the eye and serves to provide...
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6530755 |
Micropump
The ejection orifice ( 7 ) of a micropump including a baseplate ( 3 ) of glass and a cover plate ( 4 ) of silicon and intended for ejecting small liquid drops, has a diameter of about 50 μm, and...
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6532386 |
Electrotransort device comprising blades
The present invention relates to an apparatus for transporting a compound through a barrier membrane of a mammal comprising: (a) a vessel having a membrane contacting surface, said surface having a...
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6527716 |
Microporation of tissue for delivery of bioactive agents
A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a 20 plant to a permeant is described utilizing microporation of...
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6526316 |
Iontophoresis method
A method for transdermal administration of parathyroid hormone by iontophoresis, which comprises applying electric current at least 2 times a day, which method is repeated one to four times each...
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RE38000 |
Electrokinetic drug delivery apparatus
A portable iontophoresis apparatus for facilitating delivery of medication across the cutaneous membrane into adjacent underlying tissues and blood vessels. The apparatus employs a modular,...
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6522919 |
Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
An iontophoresis system includes a transdermal patch for placement against the skin of a patient and a controller electrically connected to the patch. The patch includes an anode and cathode...
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6522918 |
Electrolytic device
An electrolytic device ( 20 ) comprising a structure ( 22 ) having a first surface ( 24 ) with a first surface area, a thickness region ( 29 ) and a plurality of openings ( 30 ) in the thickness...
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6520981 |
Significance of dosimetry in photodynamic therapy of injured arteries
Photodynamic therapy (PDT), the light activation of methylene blue or benzoporphyrin derivatives to produce free-radicals, was shown in vivo to inhibit intimal hyperplasia (IH) and restenosis. The...
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6512950 |
Methods for delivering agents using alternating current
A variety of methods for transporting different agents such as pharmaceutical agents, nutrients and genetic materials across a tissue are provided. The methods utilize an AC signal to maintain a...
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6510341 |
Iontophoresis device and drug unit
Herein disclosed is an iontophoresis device suitable for effective use of a drug supported on a drug support. A donor electrode-printed portion ( 6 ) and a reference electrode-printed portion ( 7 )...
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6508784 |
Balloon catheter having adjustable centering capabilities and methods thereof
A radiation treatment system comprising a balloon catheter and a treatment apparatus. A method for delivering radioactive dose adequately to treat eccentric atheroma comprises positioning a...
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6506791 |
Method of treatment of protozoan infections in fish
A method of treating protozoan infections in fish comprising introducing a sufficient quantity of one or more photoactive dyes to an aqueous environment containing one or more fish infected with...
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6505069 |
Electrochemically reactive cathodes for an electrotransport device
The present invention relates generally to improved cathodes ( 24 ) for use in an electrotransport device ( 10 ) for transdermally or transmucosally delivering a beneficial agent (e.g., a drug) to,...
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6500141 |
Apparatus and method for treating body tissue, in particular soft surface tissue with ultrasound
An apparatus for treating body tissue, in particular superficial soft tissue, with ultrasound, comprises an ultrasonic generation unit and an applicator, by means of which the ultrasound can be...
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6500165 |
Active antisepsis device
A device for maintaining antisepsis of embedded devices with a body is provided. The device comprises a housing having a first active surface and a second active surface with the housing being...
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6496998 |
Proton motive force toothbrush
The present invention is used to obtund tooth decay and periodontal lesions by obstructing the proton motive force that exists in bacteria. The result is that glycolysis, DNA synthesis and...
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6497887 |
Membrane delivery system
The present invention relates to a delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a...
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6496728 |
Methods for extracting substances using alternating current
A variety of methods for extracting different substances such as endogenous substances, pharmaceutical substances, markers of disease, and their metabolites across a tissue are provided. The...
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6496727 |
Medicament-loaded transdermal reservoir and method for its formation
A transdermal reservoir and method for loading a material into a reservoir includes providing a bibulous reservoir blocking a backing with an interior surface having a patient contact surface with...
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6493570 |
Method for improved imaging and photodynamic therapy
The present invention is directed to an apparatus and method of imaging and treatment using at least one photodynamic therapy (“PDT”) agent. In particular, the apparatus and method is for...
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6490482 |
Apparatus and method for in vivo delivery of therapeutic agents
Electroporation electrodes are laminated to a permeable membrane to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent...
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6488959 |
Transdermal drug patch with attached pocket for controlled heating device
The present invention relates to a transdermal drug delivery system comprising a dermal drug delivery patch and a heating element compartment securable to the dermal drug delivery patch. A freely...
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6488428 |
Fluid assembly containing a breaking component for release of fluid and method therefore
A fluid assembly for a bioelectrode for use in a drug delivery device and a method for using such an assembly. The fluid assembly includes a reservoir for containing a fluid, and a barrier member...
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6482204 |
Method and apparatus for controlled contraction of soft tissue
An apparatus and method are provided for control contraction of tissue that includes collagen fibers. The apparatus includes a handpiece, and an electrode with an electrode proximal end associated...
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6484052 |
Optically generated ultrasound for enhanced drug delivery
High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics,...
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6477411 |
Bioelectrode having a crushable hydrating assembly and associated method
A hydratable bioelectrode for use in an iontophoretic delivery device comprising a hydrating component and a bioelectrode component. The hydrating component includes a cradle having a chamber...
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6471691 |
Ophthalmic treatment apparatus
An ophthalmic treatment apparatus uses therapy and diagnostic laser light sources whose beams are deflected two-dimensionally via an optical deflector and a galvanomirror and directed on the eye...
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6454755 |
Method and apparatus for transdermal delivery of compounds utilizing disruption of the epidermis
A drug delivery system including an apparatus for mechanically disrupting a layer of skin having a known thickness without substantially disrupting underlying dermis layers below the layer of skin...
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6447499 |
Use of a polarized field to modify the efficacy of a bioactive agent
A bioactive agent ( 53 ) is administered to a patient ( 1 ), and the efficacy of the bioactive agent ( 53 ) is modified by exposing the patient ( 1 ) to a polarizing field ( 39, 41, 52 ). The...
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6443976 |
Methods for treating conditions and illnesses associated with abnormal vasculature
Use of radiation-absorbing dyes (e.g., indocyanine green (ICG), fluorescein, rose bengal) and photodynamic dyes (e.g., hematoporphyrins, aminolevulinic acids, porphyrins, merocyanines, porphycenes,...
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6442423 |
Device for iontophoretic administration of drugs
The present invention concerns a device ( 10 ) for administration of charged drugs to the eye comprising an applicator with a receiving portion for holding a hydrogel carrier loaded with the drug....
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6440123 |
Metal probe for use in intracorporeal lithotripsy
A metal probe for intracorporeal shock wave lithotripsy has a point at its distal end with one or several lateral notches next to the probe end, These notches secure a calculus laterally against an...
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6440155 |
Device for heating a biotissue employing a strong light
A device for heating a biotissue employing a strong light, characterized in that, in thermotherapy comprising leading a biotissue to necrosis by heating the biotissue by a strong light from a light...
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6436128 |
Ink like or cream-like exothermic composition, exothermic device made thereof and manufacturing method of exothermic device
The present invention relating to an exothermic decomposition has, as essential components, a water absorptive polymer and/or tackifier, carbon component and/or metal chloride and features that the...
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6438414 |
Collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems
The invention relates generally to consumable components of a device used for continually or continuously measuring the concentration of target chemical analytes present in a biological system....
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6432384 |
Breathing gas mixture containing perfluorocarbons
A breathing gas mixture is provided for the treatment of lung diseases, containing an amount of perfluorocarbon and oxygen containing 5 vol. % to 40 vol. % of perfluorocarbon relative to the amount...
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6428477 |
Delivery of theraputic ultrasound by two dimensional ultrasound array
A fully steerable two-dimensional ultrasound array delivers a therapy by steering and selective focusing of beams. In some systems, the ultrasound array also includes an imaging functionality to...
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6425873 |
Irradiation enhanced permeation and collection
The present invention provides a method of collecting biomolecules via permeation through the skin of a subject, by energizing the stratum corneum in conjunction with various collection means...
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6424862 |
Iontophoresis electroporation and combination patches for local drug delivery to body tissues
Patch-based devices for enhancing the local delivery of drugs, pharmaceuticals, plasmids, genes, and other agents into the tissues of the living body. The patch devices provide an electrical...
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6424863 |
Delivery of pharmaceutical compounds and collection of biomolecules using electromagnetic energy and uses thereof
A method/system to enhance continuous delivery of pharmaceutical compounds in a target by utilizing non-ionizing electromagnetic energy.
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